Metabolism is central to most biological processes that impact health and disease, from subcellular organelles to whole body homeostasis. Correct metabolic rewiring drives development and maintenance of tissues, whereas metabolic dysfunction is a factor in key issues that affect worldwide populations such as aging, cancer and metabolic diseases. Despite the huge advances in metabolism research, key questions need answering to translate our knowledge into impactful solutions, such as: 1. How do complex tissue metabolic microenvironments affect normal function? 2. How does metabolism drive aging and reduce healthspan? 3. How can diet affect therapeutic responses to disease? 4. Can we use new technologies to model metabolism in silico to aid drug discovery? This meeting will tackle these questions by bringing together researchers from different areas of biology, epidemiology, drug discovery and computation into a setting that fosters idea exchange and collaboration. 

Key Sessions

• Developmental and stem cell metabolism
• Aging metabolism
• Systemic metabolism in health and disease
• Organellar metabolism
• Metabolic drug discovery and dietary interventions
• Technology development
• Computational and AI-based approaches to study metabolism
• Metabolites as signaling and structural molecules

Confirmed Invited Speakers

Janelle Ayres (Salk Institute)
NUTRIENT CONTROL OF INFECTION DEFENSE
Donita Brady (University of Pennsylvania)
A TALE OF TWO COPPERS: MITOCHONDRIAL METABOLISM & THE PATHOGENESIS OF MASH
Navdeep S. Chandel (Northwestern University)
MITOCHONDRIA AS SIGNALLING ORGANELLES
Ed Chouchani (Dana-Farber Cancer Institute)
MECHANISMS OF METABOLITE REGULATION OVER PHYSIOLOGY
Heather Christofk (University of California, LA)
METABOLIC REGULATION OF CELL STATE
Katrien De Bock (ETH Zürich)
ENDOTHELIAL METABOLISM IN THE MUSCLE MICROENVIRONMENT
Mark Febbraio (The Baker Heart & Diabetes Institute)
INTER-ORGAN CROSS TALK DURING EXERCISE IN HEALTH AND DISEASE
Javier Garcia-Bermudez (UT Southwestern)
UNCOVERING A NEW REGULATOR OF HEPATIC PHOSPHOLIPID SYNTHESIS
Brian Kennedy (National University Singapore)
MAXIMISING HEALTHSPAN - INTERVENTIONS AND CLOCKS
Natalie Krahmer (Helmholtz Zentrum München)
ELUCIDATING THE CELL ARCHITECTURE OF METABOLIC LIVER DISEASE VIA SPATIAL PROTEOMICS
Lydia Lynch (Princeton University)
WHAT WE EAT AND HOW MUCH SHAPES ANTI-TUMOR IMMUNITY
Thales Papagiannakopoulos (The Salk Institute)
METABOLIC MECHANISMS OF LUNG CANCER PROGRESSION
Florian Rosenberger (Karolinska Institute)
THE DAWN OF SINGLE-CELL PROTEOMICS TO UNDERSTAND METABOLIC RESILIENCE AND FAILURE
Jessica Spinelli (UMass Chan Medical School)
METABOLIC AND PHYSIOLOGICAL IMPLICATIONS OF FLEXIBILITY IN THE ELECTRON TRANSPORT CHAIN
Anu Suomalainen Wartiovaara (University of Helsinki)
TISSUE-SPECIFIC MITOCHONDRIAL SIGNALING IN DEGENERATIVE DISEASES
Christina Towers (Salk Institute)
LEVERAGING AUTOPHAGY TO TARGET PANCREATIC CANCER
Karen Vousden (Francis Crick Institute)
METABOLIC CONTROL OF CANCER PROGRESSION
Martina Wallace (University College Dublin)
AMINO ACID METABOLIC REPROGRAMMING DURING HEPATIC STELLATE CELL ACTIVATION
Bing Zhang (Westlake University)
DIETARY REGULATION OF STEM CELLS AND TISSUE REGENERATION

Target Audience

The meeting will appeal to scientists from all career levels in academia and industry, from graduate students to institute directors. The shared goal of attendees will be to develop new approaches and collaborations that drive forward our knowledge of metabolism across all scales and throughout lifespan.

Educational Need

Most metabolism meetings are siloed into individual topics or take place as a small part of a larger conference, or are focused on a specific disease area. This intimate meeting has the major goal to bring together metabolism researchers across the spectrum, from those investigating individual molecules to those carrying out population studies and clinical trials. This unique goal will facilitate knowledge exchange and collaborations between world leaders in molecular biology, technology development, animal models, AI and drug pipelines, while also bringing in new voices from younger researchers.

Please note, whilst the below programme is our latest version, it is still subject to change. A final copy circulated to participants in the lead up to the conference.