Synopsis

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The first genetically engineered mice were created more than 40 years ago. Since then, steady improvements in the field have allowed for the generation of experimentally controllable and genetically accurate models for many human cancers. Recent technological advances in genome editing are pushing this frontier and new animal models are directly impacting precision medicine approaches by enabling the functional evaluation of larger numbers of genetic and epigenetic alterations, by providing pre-clinical and co-clinical platforms to evaluate new therapies, and by allowing for the detailed study of tumor biology that cannot be approached in cell-based systems, immunocompromised animals, or patients. While animal modeling has been a staple of the cancer biology community for decades, it is only now maturing to its fullest potential.

This conference will focus on three major areas: First, it will present new approaches to generate precise and complex genetic alterations in mice and other animals to better “humanize” models and allow for in vivo studies of cancer gene function. Second, it will highlight studies to investigate fundamental mechanisms of cancer initiation and progression, including the cell of origin of tumors, their evolution, their metabolism, and their interactions with the immune system. Finally, the meeting will explore how genetically engineered animal models can help evaluate the efficacy of novel therapeutic approaches and to decipher mechanisms of therapeutic resistance.

Key Sessions

• New technologies for cancer modelling
• Modeling pre-cancers and tumor initiation
• Cancer metabolism
• Cancer/immune interactions and tumor microenvironment
• Metastasis
• Preclinical trials and resistance

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying academics can bring a student for only €820. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 03, 04, 05 November 2021 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Chloe Trundle to obtain a special registration link for your student. 

Confirmed Keynote Speakers

Ronald DePinho (MD Anderson Cancer Center)
TARGETING INTERACTIONS IN THE GBM TUMOR MICROENVIRONMENT
Karen Vousden (Francis Crick Institute, CRUK)
METABOLIC CONTROL OF TUMOR DEVELOPMENT AND PROGRESSION

Confirmed Invited Speakers

Leila Akkari (The Netherlands Cancer Institute)
EXPLOITING THE POTENTIAL OF MYELOID CELL IMMUNOMODULATION IN BRAIN AND LIVER CANCERS: MACROPHAGES AT PLAY
Mariano Barbacid (Centro Nacional de Investigaciones Oncológicas)
USING GEM TUMOR MODELS FOR TARGET VALIDATION
Alain Charest (BIDMC, Harvard)
SINGLE-CELL RNA SEQUENCING REVEALS EVOLUTION OF IMMUNE LANDSCAPE DURING GLIOBLASTOMA PROGRESSION
Dannielle Engle (Salk Institute for Biological Studies)
ABERRANT GLYCOSYLATION PROMOTES PANCREATITIS AND PANCREATIC CANCER IN MICE
Sarah-Maria Fendt (VIB - KU Leuven Center for Cancer Biology)
THE ROLE OF METABOLISM IN METASTASIS FORMATION
Jos Jonkers (The Netherlands Cancer Institute)
IDENTIFICATION OF BREAST CANCER DRIVERS AND THERAPY RESISTANCE MECHANISMS IN MICE
Laurent Le Cam (Montpellier Cancer Center / INSERM)
THE P53 PATHWAY AND METABOLISM: IMPLICATIONS IN CANCER PROGRESSION 
Richard Marais (Cancer Research UK)
MODELLING UV INDUCED MELANOMA IN MICE
Martin McMahon (Huntsman Cancer Institute)
TARGETING RAF>MEK>ERK SIGNALING PLUS AUTOPHAGY FOR THE FUTURE TREATMENT OF RAS-DRIVEN CANCERS
Luis Parada (Memorial Sloan Kettering Cancer Center)
A QUIESCENT GLIOBLASTOMA STEM CELL
Katerina Politi (Yale School of Medicine)
LEVERAGING MOUSE MODELS TO STUDY DRUG RESISTANCE IN LUNG CANCER
Tannishtha Reya (UC, San Diego)
FROM STEM CELLS TO CANCER: TRACING DIVERGENT FATES IN ONCOGENESIS 
Mara Sherman (Oregon Health and Science University)
MECHANISMS AND CONSEQUENCES OF PANCREATIC CANCER STROMAL EVOLUTION
Rocio Sotillo (German Cancer Research Center)
UNDERSTANDING THE CELL OF ORIGIN OF LUNG ADENOCARCINOMA
Kwok-Kin Wong (NYU Langone Health)

Target Audience

• Basic scientists studying all aspects of cancer biology
• Scientists and clinicians performing translational work, especially those using mouse models for preclinical studies
• Investigators from the biotech and pharma industries who are interested in state-of-the-art animal modeling approaches

Educational Need

Cancer genome sequencing provides an unprecedented view of recurrent alterations in human cancers and the development of highly effective targeted therapies and immune-modulatory therapies constitutes major victories. Nevertheless, the function of genes identified from genomic studies is often poorly characterized, leaving no means of therapeutic intervention. Moreover, cancers that are initially sensitive to therapy inevitably become resistant, often through mechanisms that are not well understood. Mouse models represent an experimental system to study cancer gene function and to evaluate the efficacy and resistance mechanisms associated with specific therapies. In the past few years, other animal models have also been instrumental in studying mechanisms of tumorigenesis. This conference will provide a forum for discussion on the past, present, and future of animal models for cancer, in particular the role that these models will play in the era of precision medicine.

Supported By

Bronze

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