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2nd Epithelial Mesenchymal Interactions in Lung Development & Fibrosis Conference
#FusionLung22
19 May - 22 May 2022
Cancun, Mexico
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Stijn De Langhe
Mayo Cinic, Rochester
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Barry Stripp
Cedars-Sinai Medical Center
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Synopsis
Lung development is governed by epithelial-mesenchymal interactions. These pathways are recapitulated during injury and repair. This conference will focus on understanding key processes underlying lung development, injury and repair in the context of age, environment and species, with the hope of better understanding disease development and to discover novel therapeutic approaches.
We will highlight critical issues on lung epithelial biology such as stem cells and regenerative medicine, while expanding sessions to encompass themes such as single cell analytical approaches, cell-cell communication, dissect the biological distinctions mesenchymal proliferation as a repair mechanism and fibrosis; present the impact of new tools in single cell analysis on understanding lung development, repair, and disease; and characterize epithelial-mesenchymal interrelationships that maintain lung homeostasis and orchestrate repair and regeneration. The entire program has been designed to achieve a better understanding of the key clinical research issues and how they relate to basic mechanistic investigation.
Key Sessions
- Keynote and Emerging Topics
- Monogenic lung diseases
- Mechanotransduction in lung development and fibrosis
- Novel in vivo and in vitro models of IPF
- Stem cell niche interactions in lung health and disease
- In vivo and in vitro models of lung development
- Aging and Lung Fibrosis
Student Offer
Take advantage of this fantastic opportunity for students! Fully paying academics can bring a student for only $785. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 19, 20, 21 May 2022 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Amy Johnson to obtain a special registration link for your student.
Confirmed Invited Speakers
Timothy Blackwell (Vanderbilt University)
GENETIC LANDSCAPE OF FAMILIAL PULMONARY FIBROSIS
Wellington Cardoso (Columbia University)
ONTOGENY AND PLASTICITY OF THE AIRWAY STEM CELL COMPARTMENT IN DEVELOPMENT AND DISEASE
Brent Carter (University of Alabama at Birmingham)
ARE FIBROBLASTS AN END EFFECTOR OR DRIVER OF FIBROSIS?
Jichao Chen (MD Anderson Cancer Center)
ROLES OF AT1 CELLS DURING ALVEOLOGENESIS AND VIRAL INFECTION
Tushar Desai (Stanford Child Health Research Institute)
CARTOGRAPHY OF DYNAMIC WNT SIGNALING IN IPF
Susanne Herold (Justus Liebig University Giessen)
SINGLE CELL RNA SEQUENCING AND LUNG ORGANOID MODELS REVEAL NOVEL MECHANISMS OF MACROPHAGE-EPITHELIAL INTERACTIONS DURING LUNG REPAIR
Gisli Jenkins (Imperial College London)
Darrell Kotton (Boston University and Boston Medical Center)
PLURIPOTENT STEM CELLS TO MODEL AND TREAT LUNG DISEASE
Melanie Koenigshoff (University of Pittsburgh)
LUNG EPITHELIAL CELLS AND THE FIBROTIC NICHE
Joo-Hyeon Lee (University of Cambridge)
THE NICHES FOR ALVEOLAR REGENERATION AND DISEASE
Yuru Liu (University of Illinois at Chicago)
REGULATION OF ALVEOLAR TYPE II CELLS DURING LUNG HOMEOSTASIS AND REPAIR
Parviz Minoo (University of Southern California)
"UNDER CONSTRUCTION, ALVEOLAR EPITHELIAL NICHE”: IMPLICATIONS FOR REGENERATIVE CAPACITY IN IMMATURE LUNGS
Edward Morrisey (University of Pennsylvania)
CELLULAR AND MOLECULAR MECHANISMS UNDERLYING LUNG HOMEOSTASIS AND REGENERATION
Ana Pardo-Saganta (Institute for Lung Health)
DECIPHERING NOVEL EPITHELIAL-MESENCHYMAL INTERACTIONS INVOLVED IN PULMONARY FIBROSIS
Tanyalak Parimon (Cedars-Sinai Medical Center)
SYNDECAN-1 ACCELERATES EPITHELIAL CELL SENESCENCE TO PROMOTE LUNG FIBROSIS
Jin-Ah Park (Harvard University)
COLLECTIVE EPITHELIAL CELL MIGRATION BY THE UNJAMMING TRANSITION (UJT) IN THE ABSENCE OF THE EPITHELIAL–MESENCHYMAL TRANSITION (EMT)
Tien Peng (University of California, San Francisco)
REGULATION OF ALVEOLAR TYPE II CELLS DURING LUNG HOMEOSTASIS AND REPAIR
Jianwen Que (Columbia University)
FIBROBLAST-TO-MYOFIBROBLAST CONVERSION AT THE SINGLE-CELL LEVEL
David Schwartz (University of Colorado)
IDIOPATHIC PULMONARY FIBROSIS: A GENETIC AND EPIGENETIC DISEASE INITIATED BY MUC5B
Dean Sheppard (University of California, San Francisco)
PULMONARY FIBROBLAST HETEROGENEITY IN HEALTH AND DISEASE
Debora Sinner (Cincinnati Children’s Hospital Medical Center)
MOLECULAR AND CELLULAR MECHANISMS MEDIATING DIFFERENTIATION OF THE LARGE AIRWAYS
Jason Spence (University of Michigan)
EPITHELIAL-MESENCHYMAL INTERACTIONS GOVERNING PROGENITOR CELL FATE IN THE DEVELOPING HUMAN LUNG
Xin Sun (University of California, San Diego)
LUNG INTEROCEPTION: HOW THE LUNG SENSE AND RESPOND TO CUES
Purushothama Rao Tata (Duke University School of Medicine)
HUMAN DISTAL LUNG CELL DYNAMICS IN HEALTH AND DISEASE
Victor Thannickal (Tulane University School of Medicine)
CELLULAR BIOENERGETICS IN EPITHELIAL MESENCHYMAL INTERACTIONS
Daniel Tschumperlin (Mayo Clinic)
DOPAMINE SIGNALING IN FIBROSIS RESOLUTION
Target Audience
- Lung developmental biologists
- Stem cell researchers
- Fibrosis researchers
- Pulmonary fibrosis researchers
Educational Need
It is known that lung developmental pathways are reactivated in pulmonary fibrosis, yet few if any meetings bring lung developmental biologists and researchers studying lung fibrosis together. This meeting will provide a unique opportunity to bring these 2 fields together.
Confirmed Speakers
Chairs
Stijn De Langhe
Professor, Mayo Cinic, Rochester
Barry Stripp
Professor, Cedars-Sinai Medical Center
Invited Speakers
Dean Sheppard
Professor, UCSF
Ana Pardo-Saganta
Professor, Institute for Lung Health (ILH)
Yuru Liu
Associate Professor, University of Illinois at Chicago
Tushar Desai
Associate Professor, Stanford University School of Medicine
David Schwartz
Chair, Department of Medicine University of Colorado Anschutz Campus
Xin Sun
Professor, UCSD
Susanne Herold
Chair for pulmonary infections, Justus Liebig University Giessen
Jason Spence
Professor, University of Michigan
Tien Peng
Assistant Professor, University of California San Francisco
Daniel Tschumperlin
Professor, Mayo Clinic
Debora Sinner
Assistant Professor of Pediatrics, CCHMC
Jin-Ah Park
Assistant Professor, Harvard University
Edward Morrisey
Professorof Medicine, University of Pennsylvania
Victor Thannickal
Professor and Chair of Medicine, Tulane University School of Medicine
Joo-Hyeon Lee
Associate Member, Memorial Sloan Kettering Cancer Center
Parviz Minoo
professor of Pediatrics, University of Southern California and Childrens Hospital
Melanie Koenigshoff
Professor of Medicine, University of Pittsburgh
Jianwen Que
Professor, Columbia University
Wellington V. Cardoso
Director, Columbia University Medical Center
Gisli Jenkins
Margaret Turner Warwick Chair of Thoracic Medicine, Imperial College London
A. Brent Carter
Professor, University of Alabama at Birmingham
Darrell Kotton
Professor, Boston University
Tanyalak Parimon
Physician Scientist, Cedars-Sinai Medical Center
Timothy Blackwell
Professor of Medicine, VUMC
Purushothama Rao Tata
Associate Professor, Duke University
David Ornitz
Professor, Washington University
Programme
THURSDAY 19TH MAY 2022 |
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13:30 – 14:30 |
Student & Postdoc Networking Reception |
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14:30 – 15:20 |
Registration & Welcome Reception |
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Keynote and Emerging Topics Session |
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15:20 – 15:30 |
Opening Comments |
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15:30 – 16:05 |
Keynote Presentation Edward Morrisey |
CELLULAR AND MOLECULAR MECHANISMS UNDERLYING LUNG HOMEOSTASIS AND REGENERATION |
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16:05 – 16:30 |
Matthew Thomas |
STRATEGIC APPROACH TO PF-ILD DRUG DISCOVERY: INNOVATION THROUGH ‘DIFFERENTIAL PATIENT BIOLOGY’ |
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16:30 – 16:45 |
Masahiro Yoshida |
EPITHELIAL AND IMMUNE RESPONSES TO SARS-COV-2 DURING POSTNATAL DEVELOPMENT IN CHILDREN VERSUS ADULTS |
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16:45 – 17:15 |
Refreshments & Poster Viewing |
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Emerging topics: Monogenic Lung Diseases |
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17:15 – 17:40 |
Xin Sun |
LUNG INTEROCEPTION: HOW THE LUNG SENSE AND RESPOND TO CUES |
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17:40 – 18:05 |
David Schwartz |
IDIOPATHIC PULMONARY FIBROSIS: A GENETIC AND EPIGENETIC DISEASE INITIATED BY MUC5B |
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18:05– 18:20 |
Aaron Zorn |
THE CLEAR CONSORTIUM: DISCOVERING THE DEVELOPMENTAL BASIS OF TRACHEA-ESOPHAGEAL BIRTH DEFECTS |
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18:20 – 18:45 |
David Ornitz |
FIBROBLAST GROWTH FACTOR 18 (FGF18) REGULATION OF POSTNATAL LUNG DEVELOPMENT |
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18:45 |
Group Dinner |
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FRIDAY 20TH MAY 2022 |
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07:00 – 08:30 |
Buffet Breakfast |
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Mechanotransduction In Lung Development and Fibrosis. |
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08:30 – 08:55 |
Wellington Cardoso |
ONTOGENY AND PLASTICITY OF THE AIRWAY STEM CELL COMPARTMENT IN DEVELOPMENT AND DISEASE |
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08:55 – 09:20 |
Purushothama Rao Tata |
HUMAN DISTAL LUNG CELL DYNAMICS IN HEALTH AND DISEASE |
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09:20 – 09:45 |
Daniel Tschumperlin |
DOPAMINE SIGNALING IN FIBROSIS RESOLUTION |
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09:45 – 10:10 |
Jin-Ah Park |
COLLECTIVE EPITHELIAL CELL MIGRATION BY THE UNJAMMING TRANSITION (UJT) IN THE ABSENCE OF THE EPITHELIAL–MESENCHYMAL TRANSITION (EMT) |
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10:10 – 10:40 |
Refreshments & Poster Viewing |
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10:40 – 11:05 |
Dean Sheppard |
PULMONARY FIBROBLAST HETEROGENEITY IN HEALTH AND DISEASE |
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11:05 – 11:20 |
Rachel Warren |
LUNG STEM CELLS AND THEIR NICHES |
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11:20 – 11:35 |
Robbert Rottier |
DISTINCT ROLES FOR SOX2 AND SOX21 IN DIFFERENTIATION, DISTRIBUTION AND MATURATION OF PULMONARY NEUROENDOCRINE CELLS |
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11:35 – 11:50 |
Katharine Goodwin |
PLASTICITY IN AIRWAY SMOOTH MUSCLE DIFFERENTIATION DURING MOUSE LUNG DEVELOPMENT |
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11:50 - 12:05 |
SeungHye Han |
MITOCHONDRIAL NAD+ REGENERATION CONTROLS ALVEOLAR EPITHELIAL CELL FATE THROUGH THE INTEGRATED STRESS RESPONSE |
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12:05 – 17:00 |
Lunch at Leisure & Free Time |
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Novel Models of IPF |
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17:00 – 17:25 |
Melanie Koenigshoff |
LUNG EPITHELIAL CELLS AND THE FIBROTIC NICHE |
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17:25 – 17:50 |
Timothy Blackwell |
GENETIC LANDSCAPE OF FAMILIAL PULMONARY FIBROSIS |
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17:50 – 18:15 |
Darrell Kotton |
PLURIPOTENT STEM CELLS TO MODEL AND TREAT LUNG DISEASE |
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18:15 – 18:40 |
Susanne Herold |
SINGLE CELL RNA SEQUENCING AND LUNG ORGANOID MODELS REVEAL NOVEL MECHANISMS OF MACROPHAGE-EPITHELIAL INTERACTIONS DURING LUNG REPAIR |
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18:40 – 18:55 |
Cara J. Gottardi |
LUNG INJURY INDUCES ALVEOLAR TYPE 2 CELL HYPERTROPHY AND POLYPLOIDY WITH IMPLICATIONS FOR REPAIR AND REGENERATION |
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18:55 – 19:10 |
Tatiana Kalin |
SINGLE CELL RNA SEQUENCING IDENTIFIES ENDOTHELIAL TRANSCRIPTION FACTORS INHIBITING LUNG FIBROSIS. |
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19:10 – 20:10 |
Poster Session 1 & Refreshments |
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20:10 |
Dinner at Leisure |
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SATURDAY 21ST MAY 2022 |
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07:00 – 08:30 |
Buffet Breakfast |
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Stem Cell Niche Interactions in Lung Health and Disease |
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08:30 – 08:55 |
Tushar Desai |
CARTOGRAPHY OF DYNAMIC WNT SIGNALING IN IPF |
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08:55 - 09:20 |
Ana Pardo-Saganta |
DECIPHERING NOVEL EPITHELIAL-MESENCHYMAL INTERACTIONS INVOLVED IN PULMONARY FIBROSIS |
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09:20 - 09:45 |
Jianwen Que |
RUNX2-CENTERED TRANSCRIPTION PROGRAM PROMOTES MYOFIBROBLAST DIFFERENTIATION OF LEPR+ MESENCHYMAL POPULATION DURING PULMONARY FIBROSIS. |
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09:45 - 10:30 |
Group Photo, Refreshments & Poster Viewing |
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10:30 – 10:55 |
Tien Peng |
FUNCTIONAL CHARACTERIZATION OF SENESCENT CELLS IN THE LUNG STEM CELL NICHE. |
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10:55 – 11:10 |
Yuru Liu |
REGULATION OF ALVEOLAR TYPE II CELLS DURING LUNG HOMEOSTASIS AND REPAIR |
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11:10 – 11:35 |
Barry Stripp |
EPITHELIAL PLASTICITY AND INNATE IMMUNE ACTIVATION PROMOTE LUNG TISSUE REMODELING FOLLOWING RESPIRATORY VIRAL INFECTION |
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11:35 – 11:50 |
Discussion on the future of this Fusion meeting |
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12:25 – 17:10 |
Lunch at Leisure & Free Time |
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Pathways regulating Lung Development |
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| 17:10 - 17:25 |
Jaymin Kathiriya |
HUMAN ALVEOLAR TYPE 2 EPITHELIUM TRANSDIFFERENTIATES INTO METAPLASTIC KRT5+ BASAL CELLS |
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17:25 – 17:50 |
Debora Sinner |
MOLECULAR AND CELLULAR MECHANISMS MEDIATING DIFFERENTIATION OF THE LARGE AIRWAYS |
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17:50 – 18:15 |
Parviz Minoo |
“UNDER CONSTRUCTION, ALVEOLAR EPITHELIAL NICHE”: IMPLICATIONS FOR REGENERATIVE CAPACITY IN IMMATURE LUNGS |
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18:15 – 18:40 |
Jason Spence |
EPITHELIAL-MESENCHYMAL INTERACTIONS GOVERNING PROGENITOR CELL FATE IN THE DEVELOPING HUMAN LUNG |
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18:40 – 18:55 |
Sarah Paramore |
MESENCHYMAL VANGL1/2 DRIVES SACCULATION IN THE EMBRYONIC MOUSE LUNG |
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18:55 – 20:00 |
Poster Session 2 & Refreshments |
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20:00 |
*Gala Dinner & Poster Awards* |
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SUNDAY 22ND MAY 2022 |
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07:00 – 08:30 |
Buffet Breakfast |
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Aging and Lung Fibrosis |
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08:30 – 08:55 |
Gisli Jenkins |
UNDERSTANDING PULMONARY FIBROSIS IN THE POST COVID WORLD |
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08:55 – 09:20 |
Mike O’Reilly |
NEONATAL HYPEROXIA STIMULATES EXPRESSION OF THE PROLIFERATION MARKER KI67 IN ALVEOLAR EPITHELIAL TYPE 1 CELLS. WHAT IS GOING ON HERE? |
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09:20 – 09:45 |
Brent Carter |
THERAPEUTIC TARGETING APOPTOSIS RESISTANCE TO REVERSE ESTABLISHED FIBROSIS. |
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09:45 – 10:15 |
Refreshments |
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10:15 – 10:40 |
Victor Thanncikal |
CELLULAR BIOENERGETICS IN EPITHELIAL MESENCHYMAL INTERACTIONS |
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10:40 – 11:05 |
Tanyalak Parimon |
SYNDECAN-1 ACCELERATES EPITHELIAL CELL SENESCENCE TO PROMOTE LUNG FIBROSIS |
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11:05 – 11:20 |
Cory Wilson |
SINE OCULIS HOMEOBOX HOMOLOG 1 (SIX1) PLAYS A CRITICAL ROLE IN LUNG FIBROSIS |
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11:20 – 11:30 |
Closing Comments |
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Contact usVenue & Location
Fiesta Americana Condesa Cancun All Inclusive
This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
Hotel Facilities
- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
General Information
Venue Rating
★ ★ ★ ★ ★
Currency
US Dollar (USD)
Address
Fiesta Americana Condesa Cancún All Inclusive Blvd. Kukulcan km 16.5 Zona Hotelera 77500 Cancun Q.R. Mexico
Nearest Airport
Cancun International Airport
Location
Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.
Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.
Conference History
If you are interested in this meeting but not yet ready to register, you can sign up for updates here and our team will keep you updated regarding deadline reminders and grant opportunities relating to this meeting only.
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Conference Manager
Amy Johnson
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