Past Conference

2nd Epithelial Mesenchymal Interactions in Lung Development & Fibrosis Conference

#FusionLung22

Date

19 May - 22 May 2022

Location

Cancun, Mexico

Early Bird - Expired  •  Talk Submission - Expired  •  Poster Submission - Expired  •  Registration & Payment Deadline - Expired

Synopsis

Lung development is governed by epithelial-mesenchymal interactions. These pathways are recapitulated during injury and repair. This conference will focus on understanding key processes underlying lung development, injury and repair in the context of age, environment and species, with the hope of better understanding disease development and to discover novel therapeutic approaches.

We will highlight critical issues on lung epithelial biology such as stem cells and regenerative medicine, while expanding sessions to encompass themes such as single cell analytical approaches, cell-cell communication, dissect the biological distinctions mesenchymal proliferation as a repair mechanism and fibrosis; present the impact of new tools in single cell analysis on understanding lung development, repair, and disease; and characterize epithelial-mesenchymal interrelationships that maintain lung homeostasis and orchestrate repair and regeneration. The entire program has been designed to achieve a better understanding of the key clinical research issues and how they relate to basic mechanistic investigation.

Key Sessions

  • Keynote and Emerging Topics
  • Monogenic lung diseases
  • Mechanotransduction in lung development and fibrosis
  • Novel in vivo and in vitro models of IPF
  • Stem cell niche interactions in lung health and disease
  • In vivo and in vitro models of lung development
  • Aging and Lung Fibrosis

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying academics can bring a student for only $785. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 19, 20, 21 May 2022 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Amy Johnson to obtain a special registration link for your student. 

Confirmed Invited Speakers

Timothy Blackwell (Vanderbilt University)
GENETIC LANDSCAPE OF FAMILIAL PULMONARY FIBROSIS
Wellington Cardoso (Columbia University)
ONTOGENY AND PLASTICITY OF THE AIRWAY STEM CELL COMPARTMENT IN DEVELOPMENT AND DISEASE
Brent Carter (University of Alabama at Birmingham)
ARE FIBROBLASTS AN END EFFECTOR OR DRIVER OF FIBROSIS?
Jichao Chen (MD Anderson Cancer Center)
ROLES OF AT1 CELLS DURING ALVEOLOGENESIS AND VIRAL INFECTION
Tushar Desai (Stanford Child Health Research Institute)
CARTOGRAPHY OF DYNAMIC WNT SIGNALING IN IPF
Susanne Herold (Justus Liebig University Giessen)
SINGLE CELL RNA SEQUENCING AND LUNG ORGANOID MODELS REVEAL NOVEL MECHANISMS OF MACROPHAGE-EPITHELIAL INTERACTIONS DURING LUNG REPAIR
Gisli Jenkins (Imperial College London)
Darrell Kotton (Boston University and Boston Medical Center)
PLURIPOTENT STEM CELLS TO MODEL AND TREAT LUNG DISEASE
Melanie Koenigshoff (University of Pittsburgh)
LUNG EPITHELIAL CELLS AND THE FIBROTIC NICHE
Joo-Hyeon Lee (University of Cambridge)
THE NICHES FOR ALVEOLAR REGENERATION AND DISEASE
Yuru Liu (University of Illinois at Chicago)
REGULATION OF ALVEOLAR TYPE II CELLS DURING LUNG HOMEOSTASIS AND REPAIR
Parviz Minoo (University of Southern California)
"UNDER CONSTRUCTION, ALVEOLAR EPITHELIAL NICHE”: IMPLICATIONS FOR REGENERATIVE CAPACITY IN IMMATURE LUNGS
Edward Morrisey (University of Pennsylvania)
CELLULAR AND MOLECULAR MECHANISMS UNDERLYING LUNG HOMEOSTASIS AND REGENERATION
Ana Pardo-Saganta (Institute for Lung Health)
DECIPHERING NOVEL EPITHELIAL-MESENCHYMAL INTERACTIONS INVOLVED IN PULMONARY FIBROSIS
Tanyalak Parimon (Cedars-Sinai Medical Center)
SYNDECAN-1 ACCELERATES EPITHELIAL CELL SENESCENCE TO PROMOTE LUNG FIBROSIS
Jin-Ah Park (Harvard University)
COLLECTIVE EPITHELIAL CELL MIGRATION BY THE UNJAMMING TRANSITION (UJT) IN THE ABSENCE OF THE EPITHELIAL–MESENCHYMAL TRANSITION (EMT)
Tien Peng (University of California, San Francisco)
REGULATION OF ALVEOLAR TYPE II CELLS DURING LUNG HOMEOSTASIS AND REPAIR
Jianwen Que (Columbia University)
FIBROBLAST-TO-MYOFIBROBLAST CONVERSION AT THE SINGLE-CELL LEVEL
David Schwartz (University of Colorado)
IDIOPATHIC PULMONARY FIBROSIS: A GENETIC AND EPIGENETIC DISEASE INITIATED BY MUC5B
Dean Sheppard (University of California, San Francisco)
PULMONARY FIBROBLAST HETEROGENEITY IN HEALTH AND DISEASE
Debora Sinner (Cincinnati Children’s Hospital Medical Center)
MOLECULAR AND CELLULAR MECHANISMS MEDIATING DIFFERENTIATION OF THE LARGE AIRWAYS
Jason Spence (University of Michigan)
EPITHELIAL-MESENCHYMAL INTERACTIONS GOVERNING PROGENITOR CELL FATE IN THE DEVELOPING HUMAN LUNG
Xin Sun (University of California, San Diego)
LUNG INTEROCEPTION: HOW THE LUNG SENSE AND RESPOND TO CUES
Purushothama Rao Tata (Duke University School of Medicine)
HUMAN DISTAL LUNG CELL DYNAMICS IN HEALTH AND DISEASE
Victor Thannickal (Tulane University School of Medicine)
CELLULAR BIOENERGETICS IN EPITHELIAL MESENCHYMAL INTERACTIONS
Daniel Tschumperlin (Mayo Clinic)
DOPAMINE SIGNALING IN FIBROSIS RESOLUTION

Target Audience 

  • Lung developmental biologists
  • Stem cell researchers
  • Fibrosis researchers
  • Pulmonary fibrosis researchers

Educational Need

It is known that lung developmental pathways are reactivated in pulmonary fibrosis, yet few if any meetings bring lung developmental biologists and researchers studying lung fibrosis together. This meeting will provide a unique opportunity to bring these 2 fields together.

Confirmed Speakers

Chairs
Stijn De Langhe

Stijn De Langhe

Professor, Mayo Cinic, Rochester

Barry Stripp

Barry Stripp

Professor, Cedars-Sinai Medical Center

Invited Speakers
Dean Sheppard

Dean Sheppard

Professor, UCSF

Ana Pardo-Saganta

Ana Pardo-Saganta

Professor, Institute for Lung Health (ILH)

Yuru Liu

Yuru Liu

Associate Professor, University of Illinois at Chicago

Tushar Desai

Tushar Desai

Associate Professor, Stanford University School of Medicine

David Schwartz

David Schwartz

Chair, Department of Medicine University of Colorado Anschutz Campus

Xin Sun

Xin Sun

Professor, UCSD

Susanne Herold

Susanne Herold

Chair for pulmonary infections, Justus Liebig University Giessen

Jason Spence

Jason Spence

Professor, University of Michigan

Tien Peng

Tien Peng

Assistant Professor, University of California San Francisco

Daniel Tschumperlin

Daniel Tschumperlin

Professor, Mayo Clinic

Debora Sinner

Debora Sinner

Assistant Professor of Pediatrics, CCHMC

Jin-Ah Park

Jin-Ah Park

Assistant Professor, Harvard University

Edward Morrisey

Edward Morrisey

Professorof Medicine, University of Pennsylvania

Victor Thannickal

Victor Thannickal

Professor and Chair of Medicine, Tulane University School of Medicine

Joo-Hyeon Lee

Joo-Hyeon Lee

Associate Member, Memorial Sloan Kettering Cancer Center

Parviz Minoo

Parviz Minoo

professor of Pediatrics, University of Southern California and Childrens Hospital

Melanie Koenigshoff

Melanie Koenigshoff

Professor of Medicine, University of Pittsburgh

Jianwen Que

Jianwen Que

Professor, Columbia University

Wellington V. Cardoso

Wellington V. Cardoso

Director, Columbia University Medical Center

Gisli Jenkins

Gisli Jenkins

Margaret Turner Warwick Chair of Thoracic Medicine, Imperial College London

A. Brent Carter

A. Brent Carter

Professor, University of Alabama at Birmingham

Darrell Kotton

Darrell Kotton

Professor, Boston University

Tanyalak Parimon

Tanyalak Parimon

Physician Scientist, Cedars-Sinai Medical Center

Timothy Blackwell

Timothy Blackwell

Professor of Medicine, VUMC

Purushothama Rao Tata

Purushothama Rao Tata

Associate Professor, Duke University

David Ornitz

David Ornitz

Professor, Washington University

Programme

THURSDAY 19TH MAY 2022

13:30 – 14:30

Student & Postdoc Networking Reception

14:30 – 15:20

Registration & Welcome Reception

Keynote and Emerging Topics Session
Session Chairs: Stijn De Langhe and Barry Stripp

15:20 – 15:30

Opening Comments

15:30 – 16:05

Keynote Presentation

Edward Morrisey
University of Pennsylvania

CELLULAR AND MOLECULAR MECHANISMS UNDERLYING LUNG HOMEOSTASIS AND REGENERATION

16:05 – 16:30

Matthew Thomas
Boehringer Ingelheim

STRATEGIC APPROACH TO PF-ILD DRUG DISCOVERY: INNOVATION THROUGH ‘DIFFERENTIAL PATIENT BIOLOGY’

16:30 – 16:45

Masahiro Yoshida
University College London

EPITHELIAL AND IMMUNE RESPONSES TO SARS-COV-2 DURING POSTNATAL DEVELOPMENT IN CHILDREN VERSUS ADULTS

16:45 – 17:15

Refreshments & Poster Viewing

Emerging topics: Monogenic Lung Diseases
Session Chairs: Jason Rock and Susanne Herold

17:15 – 17:40

Xin Sun
University of California, San Diego

LUNG INTEROCEPTION: HOW THE LUNG SENSE AND RESPOND TO CUES

17:40 – 18:05

David Schwartz
University of Colorado

IDIOPATHIC PULMONARY FIBROSIS: A GENETIC AND EPIGENETIC DISEASE INITIATED BY MUC5B

18:05– 18:20

Aaron Zorn
Cincinnati Children's Hospital Medical Center

THE CLEAR CONSORTIUM: DISCOVERING THE DEVELOPMENTAL BASIS OF TRACHEA-ESOPHAGEAL BIRTH DEFECTS

18:20 – 18:45

David Ornitz
Washington University

FIBROBLAST GROWTH FACTOR 18 (FGF18) REGULATION OF POSTNATAL LUNG DEVELOPMENT

18:45

Group Dinner

FRIDAY 20TH MAY 2022

07:00 – 08:30

Buffet Breakfast

Mechanotransduction In Lung Development and Fibrosis.
Session Chairs: Xin Sun and Melanie Koenigshoff

08:30 – 08:55

Wellington Cardoso
Columbia University

ONTOGENY AND PLASTICITY OF THE AIRWAY STEM CELL COMPARTMENT IN DEVELOPMENT AND DISEASE

08:55 – 09:20

Purushothama Rao Tata
Duke University School of Medicine

HUMAN DISTAL LUNG CELL DYNAMICS IN HEALTH AND DISEASE

09:20 – 09:45

Daniel Tschumperlin
Mayo Clinic

DOPAMINE SIGNALING IN FIBROSIS RESOLUTION

09:45 – 10:10

Jin-Ah Park
Harvard University

COLLECTIVE EPITHELIAL CELL MIGRATION BY THE UNJAMMING TRANSITION (UJT) IN THE ABSENCE OF THE EPITHELIAL–MESENCHYMAL TRANSITION (EMT)

10:10 – 10:40

Refreshments & Poster Viewing

10:40 – 11:05

Dean Sheppard
University of California, San Francisco

PULMONARY FIBROBLAST HETEROGENEITY IN HEALTH AND DISEASE

11:05 – 11:20

Rachel Warren
Mayo Clinic, Rochester

LUNG STEM CELLS AND THEIR NICHES

11:20 – 11:35

Robbert Rottier
Eramus MC

DISTINCT ROLES FOR SOX2 AND SOX21 IN DIFFERENTIATION, DISTRIBUTION AND MATURATION OF PULMONARY NEUROENDOCRINE CELLS

11:35 – 11:50

Katharine Goodwin
Princeton University

PLASTICITY IN AIRWAY SMOOTH MUSCLE DIFFERENTIATION DURING MOUSE LUNG DEVELOPMENT

11:50 - 12:05

SeungHye Han
Northwestern University

MITOCHONDRIAL NAD+ REGENERATION CONTROLS ALVEOLAR EPITHELIAL CELL FATE THROUGH THE INTEGRATED STRESS RESPONSE

12:05 – 17:00

Lunch at Leisure & Free Time

Novel Models of IPF
Session Chairs: Dan Tschumperlin and Gisli Jenkins

17:00 – 17:25

Melanie Koenigshoff
University of Colorado Denver

LUNG EPITHELIAL CELLS AND THE FIBROTIC NICHE

17:25 – 17:50

Timothy Blackwell
Vanderbilt University

GENETIC LANDSCAPE OF FAMILIAL PULMONARY FIBROSIS

17:50 – 18:15

Darrell Kotton
Boston University

PLURIPOTENT STEM CELLS TO MODEL AND TREAT LUNG DISEASE

18:15 – 18:40

Susanne Herold
Justus Liebig University Giessen

SINGLE CELL RNA SEQUENCING AND LUNG ORGANOID MODELS REVEAL NOVEL MECHANISMS OF MACROPHAGE-EPITHELIAL INTERACTIONS DURING LUNG REPAIR

18:40 – 18:55

Cara J. Gottardi
Northwestern University

LUNG INJURY INDUCES ALVEOLAR TYPE 2 CELL HYPERTROPHY AND POLYPLOIDY WITH IMPLICATIONS FOR REPAIR AND REGENERATION

18:55 – 19:10

Tatiana Kalin
CCHMC

SINGLE CELL RNA SEQUENCING IDENTIFIES ENDOTHELIAL TRANSCRIPTION FACTORS INHIBITING LUNG FIBROSIS.

19:10 – 20:10

Poster Session 1 & Refreshments

20:10

Dinner at Leisure

SATURDAY 21ST MAY 2022

07:00 – 08:30

Buffet Breakfast

Stem Cell Niche Interactions in Lung Health and Disease
Session Chairs: TBC

08:30 – 08:55

Tushar Desai
Stanford Child Health Research Institute

CARTOGRAPHY OF DYNAMIC WNT SIGNALING IN IPF

08:55 - 09:20

Ana Pardo-Saganta
Institute for Lung Health (ILH)

DECIPHERING NOVEL EPITHELIAL-MESENCHYMAL INTERACTIONS INVOLVED IN PULMONARY FIBROSIS

09:20 - 09:45

Jianwen Que
Columbia university

RUNX2-CENTERED TRANSCRIPTION PROGRAM PROMOTES MYOFIBROBLAST DIFFERENTIATION OF LEPR+ MESENCHYMAL POPULATION DURING PULMONARY FIBROSIS.

09:45 - 10:30

Group Photo, Refreshments & Poster Viewing

10:30 – 10:55

Tien Peng
University of California, San Francisco

FUNCTIONAL CHARACTERIZATION OF SENESCENT CELLS IN THE LUNG STEM CELL NICHE.

10:55 – 11:10

Yuru Liu
University of Illinois at Chicago

REGULATION OF ALVEOLAR TYPE II CELLS DURING LUNG HOMEOSTASIS AND REPAIR

11:10 – 11:35

Barry Stripp
Cedars-Sinai Medical Center

EPITHELIAL PLASTICITY AND INNATE IMMUNE ACTIVATION PROMOTE LUNG TISSUE REMODELING FOLLOWING RESPIRATORY VIRAL INFECTION

11:35 – 11:50

Discussion on the future of this Fusion meeting

12:25 – 17:10

Lunch at Leisure & Free Time

Pathways regulating Lung Development
Session Chairs: Wellington Cardoso and Joo-Hyeon Lee

17:10 - 17:25

Jaymin Kathiriya
UCSF

HUMAN ALVEOLAR TYPE 2 EPITHELIUM TRANSDIFFERENTIATES INTO METAPLASTIC KRT5+ BASAL CELLS

17:25 – 17:50

Debora Sinner
Cincinnati Children’s Hospital Medical Center

MOLECULAR AND CELLULAR MECHANISMS MEDIATING DIFFERENTIATION OF THE LARGE AIRWAYS

17:50 – 18:15

Parviz Minoo
University of Southern California

“UNDER CONSTRUCTION, ALVEOLAR EPITHELIAL NICHE”: IMPLICATIONS FOR REGENERATIVE CAPACITY IN IMMATURE LUNGS

18:15 – 18:40

Jason Spence
University of Michigan

EPITHELIAL-MESENCHYMAL INTERACTIONS GOVERNING PROGENITOR CELL FATE IN THE DEVELOPING HUMAN LUNG

18:40 – 18:55

Sarah Paramore
Princeton University

MESENCHYMAL VANGL1/2 DRIVES SACCULATION IN THE EMBRYONIC MOUSE LUNG

18:55 – 20:00

Poster Session 2 & Refreshments

20:00

*Gala Dinner & Poster Awards*

SUNDAY 22ND MAY 2022

07:00 – 08:30

Buffet Breakfast

Aging and Lung Fibrosis
Session Chairs: Dean Sheppard and Ana Pardo- Saganta

08:30 – 08:55

Gisli Jenkins
Imperial College London

UNDERSTANDING PULMONARY FIBROSIS IN THE POST COVID WORLD

08:55 – 09:20

Mike O’Reilly
The University of Rochester

NEONATAL HYPEROXIA STIMULATES EXPRESSION OF THE PROLIFERATION MARKER KI67 IN ALVEOLAR EPITHELIAL TYPE 1 CELLS. WHAT IS GOING ON HERE?

09:20 – 09:45

Brent Carter
University of Alabama at Birmingham

THERAPEUTIC TARGETING APOPTOSIS RESISTANCE TO REVERSE ESTABLISHED FIBROSIS.

09:45 – 10:15

Refreshments

10:15 – 10:40

Victor Thanncikal
Tulane University School of Medicine

CELLULAR BIOENERGETICS IN EPITHELIAL MESENCHYMAL INTERACTIONS

10:40 – 11:05

Tanyalak Parimon
Cedars-Sinai Medical Center

SYNDECAN-1 ACCELERATES EPITHELIAL CELL SENESCENCE TO PROMOTE LUNG FIBROSIS

11:05 – 11:20

Cory Wilson
University of Iowa/UTHealth Houston

SINE OCULIS HOMEOBOX HOMOLOG 1 (SIX1) PLAYS A CRITICAL ROLE IN LUNG FIBROSIS

11:20 – 11:30

Closing Comments

Supported by

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Venue & Location

Fiesta Americana Condesa Cancun All Inclusive

This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment.  We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas

General Information

Venue Rating

★ ★ ★ ★ ★

Currency

US Dollar (USD)

Address

Fiesta Americana Condesa Cancún All Inclusive Blvd. Kukulcan km 16.5 Zona Hotelera 77500 Cancun Q.R. Mexico

Nearest Airport

Cancun International Airport

Location

Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.

Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.

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Conference Manager

Amy Johnson

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