IMPORTANT NOTICE: Effective 28 November 2025, places are now subject to availability, and we cannot guarantee your registration immediately upon payment due to hotel availability. Once full payment has been received, please allow up to 3 working days for Chloe, the Conference Manager, to confirm your registration and hotel room. Please note, all participants must make full payment at the time of registration - the deposit option is no longer available. Registration prices are tied to a specific hotel room category and secured only once your balance is paid in full. As hotel availability decreases, registration prices may increase if reassignment to another room category is required. Please reach out to us if you have any questions.

The conference program covers how RNA and RNA-dependent machineries regulate chromatin landscape, gene expression, and genome architecture during normal development and in disease states. With a focus on high-throughput and systems biology approaches, this conference is a venue to learn about emerging technologies in the field and how they are being used to gain deep mechanistic insights into genome regulation. 

With recent evidence that RNA-protein interactions regulate gene expression, facilitate DNA repair, and play roles in genome organization, we aim to bring together scientists working on these distinct fields and provide a forum for discussion and exchange of scientific ideas and technologies which will advance all these research areas. We will also have opportunities to learn from biotech industry leaders on how RNA biology is making its way into new diagnostics tools and therapeutic applications. The majority of talks will be selected from submitted abstracts.

Key Sessions

• Biogenesis of noncoding RNAs and their role in genome regulation
• Regulatory RNA structures
• RNA-dependent regulation of transcriptional machineries
• Modulating the epigenome
• New genomic technologies  
• Emerging roles of RNA in genome integrity
• Nuclear organization
• Functional implications of RNA modifications
• Transposable elements and gene expression 

Confirmed Invited Speakers

Montserrat Anguera (University of Pennsylvania)
MECHANISMS OF Xist RNA MEDIATED DOSAGE COMPENSATION IN IMMUNE CELLS
Alexei Aravin (Cornell University)
Colin Conine (University of Pennsylvania)
THE TRANSMISSION OF NON- GENETICALLY INHERITED PHENOTYPES TO OFFSPRING BY SPERM miRNAs
Ernesto Guccione (Mount Sinai School of Medicine)
NUCLEAR RNA CATABOLISM AND TRANSPOSABLE ELEMENTS REGULATION IN DEVELOPMENT AND CANCER
Michael Keogh (EpiCypher)
A STANDARDS-DRIVEN GENOMIC MAPPING PLATFORM TO MEASURE ACUTE TRANSCRIPTIONAL RESPONSES
Ashish Lal (National Cancer Institute)
IN VIVO FUNCTIONS OF A MICROPROTEIN FROM A HIGHLY CONSERVED lncRNA
Shannon Lauberth (Northwestern University)
RNA-PROTEIN COMPLEXES AS GUARDIANS OF NUCLEAR FUNCTION
Gaelle Legube (Center of Intergrative Biology)
CHROMATIN AND CHROMOSOME DYNAMICS AT DNA DOUBLE STRAND BREAKS
Rob Martienssen (Cold Spring Harbour Laboratory)
GERMLINE SMALL RNAs AND THE DRIVE FOR GENOME DOMESTICATION
Danny Reinberg (University of Miami)
THE EPIGENETICS OF ESTABLISHING DIFFERENT CELLULAR STATES
Neville Sanjana (New York Genome Center)
TRANSCRIPTOME-SCALE RNA-TARGETING CRISPR SCREENS
Raffaella Santoro (University of Zurich)
GENOME ORGANIZATION AND FUNCTION AROUND NUCLEOLI
Serena Sanulli (Stanford University)
RNA-MEDIATED REGULATION OF HETEROCHROMATIN
Sam Sternberg (Columbia University)
EXAPTATION OF RNA-GUIDED NUCLEASES FOR TRANSCRIPTIONAL CONTROL
Igor Ulitsky (Weizmann Institute)
REGULATION OF GENE EXPRESSION BY LONG NONCODING RNAS
Jeremy Wilusz (Baylor College of Medicine)
DISSECTING HOW THE INTEGRATOR COMPLEX IS CONTROLLED

Target Audience

We target a broad audience, from both academia and industry, with interests in many biological processes including epigenetics, DNA repair, transcription, and genome organization, where there is evidence for RNA playing a key role. To encourage participation from attendees from all career levels, the majority of talks will be chosen from submitted abstracts. 

Educational Need

Scientists interested in genome regulation and RNA-based mechanisms in biology are often partitioned into different sub-fields and lack opportunities to exchange ideas and foster collaborative projects. This conference provides attendees with a unique opportunity to interact with a varied scientific community. We have speakers from both academia and industry which will provide trainees with opportunities to learn how the scientific process occurs in these two distinct settings. In addition, the networking sessions will provide a stage for career discussions.

Please note the programme is still subject to change - the latest version will always be uploaded here, so check in regularly for any updates.