Past Conference

Novel Concepts in the Biology & Treatment of Metastatic Cancer Conference

Date

05 Nov - 08 Nov 2016

Location

Paphos, Cyprus

Early Bird - Expired  •  Talk Submission - Expired  •  Poster Submission - Expired  •  Registration & Payment Deadline - Expired

Synopsis

Metastatic disease, the lethal component of cancer, remains largely intractable to modern medicine. New insights into the biology of metastasis promise fresh insights into how to design therapies that effectively tackle this life-threatening disease process. Recent years have seen the development of novel tools for studying metastasis that continue to provide dramatic advances in our understanding of the cellular and molecular mechanisms that drive metastasis formation. Metastasis is regulated by both tumor cell-intrinisic factors such as genetic defects, epigenetic perturbation and metabolic changes, as well as by a variety of factors in the microenvironment, including cells of the immune system. These tumor cell-intrinsic factors combine with the external microenvironment to regulate tumor dormancy and the development of therapy resistance. This knowledge is starting to be translated into therapies that target not only the metastatic seed but also the microenvironmental soil.

Key Sessions

  1. Therapy-induced metastasis and the patient with metastatic disease
  2. Metabolic changes that drive metastasis
  3. Metastatic dormancy - maintenance and escape
  4. Novel approaches to pharmacology and drug delivery for the  treatment of metastases
  5. Control of metastasis by inflammation and the innate immune system
  6. Targeting the metastatic microenvironment
  7. Novel tools for studying metastasis
  8. Cancer Stem Cells - Do we all mean the same? A controversy session.

Confirmed Keynote Speaker

G. Steven Bova (University of Tampere)
'LEVERAGING THE EVOLUTIONARY HISTORY OF METASTATIC PROSTATE CANCER'

Confirmed Plenary Speakers

Julio Aguirre-Ghiso (Mount Sinai School of Medicine)
'UNDERSTANDING THE BIOLOGY OF DORMANT DISSEMINATED CANCER CELLS: A PATH TO MANAGE LATE CANCER RELAPSE'

Christel Herold-Mende (University of Heidelberg) 
'IMMUNOBIOLOGY OF BRAIN METASTASES'

Tatiana Petrova (Université de Lausanne)
'CROSS-TALK OF COLON CANCER STEM CELLS WITH STROMA'

Confirmed Invited Speakers

Luigi Ombrato (The Francis Crick Institute)
'METASTASIS: A MATTER OF TEAMWORK'

James Lorens (University of Bergen)
'TUMOR PLASTICITY AND DRUG RESISTANCE: THE ROLE OF THE AXL RECEPTOR KINASE'

Yuval Shaked (Technion – Israel Institute of Technology)
'THE CROSS TALK BETWEEN TUMOR AND HOST CELLS FOLLOWING ANTI-CANCER DRUG THERAPY AND ITS CONTRIBUTION TO METASTASIS'

Thordur Oskarsson (German Cancer Research Center - DKFZ)
'EXTRACELLULAR MATRIX PROTEINS OF STEM CELL NICHES: ROLE IN BREAST CANCER METASTASIS'

Triantafyllos Stylianopoulos (University of Cyprus)
'TARGETING TUMOR FIBROSIS TO IMPROVE DRUG DELIVERY AND ENHANCE THERAPY'

Veronique Orian-Rousseau (Karlsruhe Institute of Technology)
'THE CROSSTALK BETWEEN CELL ADHESION MOLECULES AND OTHER CELL SURFACE RECEPTORS DRIVES TUMOR PROGRESSION AND METASTASIS'

Zvika Granot (The Hebrew University of Jerusalem)
'NEUTROPHILS IN CANCER: LOOKING AT THE BRIGHT SIDE'

Dalit Barkan (Haifa University)

Sakari Vanharanta (University of Cambridge)
'EPIGENETIC MECHANISMS OF METASTASIS GENE ACTIVATION'

Dario Marchetti (Houston Methodist Research Institute)
'CIRCULATING TUMOR CELLS: THE FUTURE OF CANCER DIAGNOSTICS'

Rune Linding (University of Copenhagen)
'DECODING OF NETWORK ATTACKING MUTATIONS REWIRING CANCER'

Isaac Witz (Tel Aviv University)
'TUMOR-ASSOCIATED AND MICROENVIRONMENTAL DRIVERS OF METASTASIS'

Vivek Mittal (Weill Cornell Medical College)
'POLYCOMB REPRESSIVE COMPLEX 2 IN BREAST CANCER METASTASIS'

Geoffrey Pilkington (University of Portsmouth)
'MODELLING THE BLOOD BRAIN BARRIER FOR CANCER METASTASIS AND DRUG DELIVERY STUDIES'

Andreas Evdokiou (The University of Adelaide)
'IMMUNOTHERAPEUTIC APPROACHES TARGETING CANCER IN BONE'

Target Audience

Research scientists from both academia and the pharmaceutical industry will benefit from this Novel Concepts in the Biology and Treatment of Metastatic Cancer meeting by updating their knowledge in key areas of this rapidly moving field. Clinicians involved in the treatment and management of cancer patients will obtain new insights into how the modern understanding of metastasis has the potential to translate into the clinic. Graduate students and postdocs in metastatic cancer treatment will gain a cutting-edge overview of the field and will have the unique opportunity to interact with and network intensively with leaders in the field due to the strictly limited number of conference participants.

Confirmed Speakers

Chairs
Jonathan Sleeman

Jonathan Sleeman

Professor, University of Heidelberg

Bruce Zetter

Bruce Zetter

Charles Nowiszewski Professor of Cancer Biology in the Department of Surgery, Boston Children's Hospital

Andreani Odysseos

Andreani Odysseos

Director of Biomedical Research, EPOS-Iasis, R&D

Plenary Speakers
Christel Herold-Mende

Christel Herold-Mende

University Professor, University of Heidelberg, Dpt. Neurosurgery

Julio Aguirre-Ghiso

Julio Aguirre-Ghiso

Professor, Tisch Cancer Institute at Mount Sinai Hospital

George Bova

George Bova

Finnish Distinguished Professor, University of Tampere, BioMediTech

Tatiana Petrova

Tatiana Petrova

Professor, Department of Fundamental Oncology, University of Lausanne

Invited Speakers
Yuval Shaked

Yuval Shaked

PI, Technion

Luigi Ombrato

Luigi Ombrato

Postdoctoral Researcher, The Crick Institute

Triantafyllos Stylianopoulos

Triantafyllos Stylianopoulos

Professor, University of Cyprus

Veronique Orian-Rousseau

Veronique Orian-Rousseau

Group Leader, KIT

Dalit Barkan

Dalit Barkan

Head Laboratory of Tumor Dormancy and Metastasis, University of Haifa

James Lorens

James Lorens

Professor, University of Bergen

Zvi Granot

Zvi Granot

PI, Hebrew University

Sakari Vanharanta

Sakari Vanharanta

group leader, MRC Cancer Unit - University of Cambridge

Dario Marchetti

Dario Marchetti

Director, Center of the Biomarker Research Program, Methodist Hospital Research Institute

Isaac Witz

Isaac Witz

Prof. Lab Chief, Tel Aviv University

Vivek  Mittal

Vivek Mittal

Professor and Director , Weill Medical Center of Cornell University

Thordur Oskarsson

Thordur Oskarsson

Group Leader, HI-STEM gGmbH

Rune Linding

Rune Linding

Principal Investigator, Linding Lab

Geoffrey Pilkington

Geoffrey Pilkington

Professor of Cellular & Molecular Neuro-oncology, Head of Brain Tumour Research Centre, University of Portsmouth

Andreas Evdokiou

Andreas Evdokiou

Head Breast Cancer Research Unit, University of Adelaide

Programme

SATURDAY 05TH NOVEMBER 2016

14:00 – 15:00

Registration & Reception

14:00 – 15:00

Group Welcome Lunch

15:00 – 15:15

Opening Comments

15:15 – 16:15

Steven Bova
University of Tampere, BioMediTech

KEYNOTE TALK: LEVERAGING THE EVOLUTIONARY HISTORY OF METASTATIC PROSTATE CANCER

METASTATIC DORMANCY: MAINTENANCE AND ESCAPE
Session Chair: Julio Aguirre Ghiso

16:15 – 17:00

Julio Aguirre Ghiso
Tisch Cancer Institute at Mount Sinai Hospital

UNDERSTANDING THE BIOLOGY OF DORMANT DISSEMINATED CANCER CELLS: A PATH TO MANAGE LATE CANCER RELAPSE

17:00 – 17:35

Dalit Barkan
University of Haifa

PREVENTING THE RECURRENCE OF BREAST CANCER AT THE METASTATIC NICHE USING RESOLUTION-PHASE MACROPHAGES

17:35 – 18:05

Refreshments

18:05 – 19:05

Panel Discussion with Bruce Zetter, Jonathon Sleeman and Andreani Odysseos
Open Questions from Audience

19:05

Group Dinner

SUNDAY 06TH NOVEMBER 2016

07:00 – 08:30

Group Breakfast

TARGETING THE METASTATIC MICROENVIRONMENT
Session Chair: Jim Lorens

08:30 – 09:15

Jim Lorens
University of Bergen

TUMOR PLASTICITY AND DRUG RESISTANCE: THE ROLE OF THE AXL RECEPTOR KINASE

09:15 – 09:50

Thodur Oskarsson
HI-STEM gGmbH

EXTRACELLULAR MATRIX PROTEINS OF STEM CELL NICHES: ROLE IN BREAST CANCER METASTASIS

09:50 – 10:10

Lena Wullkopf
University of Copenhagen

METASTASIS- A JOURNEY OF FORCE?

10:10 – 10:40

Refreshments

10:40 – 11:15

Isaac Witz
Tel Aviv University

TUMOR-ASSOCIATED AND MICROENVIRONMENTAL DRIVERS OF METASTASIS

11:15 – 11:50

Rune Linding
Biotech Research and Innovation Center (BRIC)

DECODING OF NETWORK ATTACKING MUTATIONS REWIRING CANCER

11:50  – 16:00

Group Lunch & Free Time

13:00 – 16:00

Group Activity: Paphos Tombs of the Kings – Mosaics – Aphrodite’s Rock 

CONTROL OF METASTASIS BY INFLAMMATION AND THE INNATE IMMUNE SYSTEM
Session Chair: Jonathan Sleeman

16:00 – 16:45

Jonathan Sleeman
University of Heidelberg

LYMPHANGIOGENESIS MEETS MDSCS/NEUTROPHILS: A NEW ROLE FOR VEGF-C IN METASTASIS

16:45 – 17:20

Luigi Ombrato
The Crick Institute

METASTASIS: A MATTER OF TEAMWORK

17:20 – 17:55

Andreas Evdokiou
The University of Adelaide

IMMUNOTHERAPEUTIC APPROACHES TARGETING CANCER IN BONE

17:55 – 18:25

Refreshments

18:25 – 19:00

Zvi Granot
Hebrew University

NEUTROPHILS IN CANCER: LOOKING AT THE BRIGHT SIDE

19:00 – 19:35

Veronique Orian-Rousseau
KIT

THE CROSSTALK BETWEEN CELL ADHESION MOLECULES AND OTHER CELL SURFACE RECEPTORS DRIVES TUMOR PROGRESSION AND METASTASIS

19:35

Group Dinner

MONDAY 07TH NOVEMBER 2016

07:00 – 08:30

Group Breakfast

NOVEL TOOLS FOR STUDYING METASTASIS
Session Chair: Dario Marchetti

08:30 – 09:15

Andreani Odysseos
EPOS-Iasis, R&D

THERE IS PLENTY OF ROOM AT THE BOTTOM FOR METASTATIC DISEASE: FROM NANOBIOTECHNOLOGY TO MOLECULAR COMMUNICATIONS AND NANONETWORKS

09:15 – 09:50

Vivek Mittal
Weill Medical Center of Cornell University

POLYCOMB REPRESSIVE COMPLEX 2 IN BREAST CANCER METASTASIS

09:50 – 10:25

Dario Marchetti
Methodist Hospital Research Institute

CIRCULATING TUMOR CELLS: THE FUTURE OF CANCER DIAGNOSTICS

10:25 – 11:00

Refreshments

SPECIAL INVITED TALK ON THERAPY-INDUCED METASTASIS AND THE PATIENT WITH METASTATIC DISEASE
Session Chair: Jonathan Sleeman

11:00 – 11:45

Yuval Shaked               
Technion

THE CROSS TALK BETWEEN TUMOR AND HOST CELLS FOLLOWING ANTI-CANCER DRUG THERAPY AND ITS CONTRIBUTION TO METASTASIS

11:45 – 17:00

Group Lunch & Free Time

13:00 – 16:45

Group Activity: Wine Tasting at Chryssogoriatissa Monasteries – Agios Neophytos

CANCER STEM CELLS – DO WE ALL MEAN THE SAME
Session Chair: Andreani Odysseos

17:00 – 17:45

Christel Herald Mende
University of Heidelberg

IMMUNOBIOLOGY OF BRAIN METASTASES

17:45 – 18:30

Tatiana Petrova
University of Lausanne

CROSS-TALK OF COLON CANCER STEM CELLS WITH STROMA

18:30 – 19:05

Geoffrey Pilkington
University of Portsmouth

MODELLING THE BLOOD BRAIN BARRIER FOR CANCER METASTASIS AND DRUG DELIVERY STUDIES

19:05 – 20:00

Poster Session & Refreshments

20:00 – 23:00

*Gala Dinner, Group Photo & Poster Awards*

TUESDAY 08TH NOVEMBER 2016

07:00 – 08:30

Group Breakfast

NOVEL APPROACHES TO PHARMACOLOGY AND DRUG DELIVERY FOR THE TREATMENT OF METASTASES
Session Chair: Bruce Zetter

08:30 – 09:15

Bruce Zetter
Boston Children's Hospital

SYSTEMIC NANOPARTICLE-MEDIATED DELIVERY OF RNA THERAPEUTICS FOR CANCER THERAPY

09:15 – 09:50

Sakari Vanharanta
MRC Cancer Unit, University of Cambridge

EPIGENETIC MECHANISMS OF METASTASIS GENE ACTIVATION

09:50 - 10:20

Refreshments

10:20 - 10:40

Nancy Dumont
Merrimack Pharmaceuticals

MM-302 EFFECTIVELY TARGETS AND REDUCES METASTATIC BURDEN IN BREAST CANCER MODELS EXPRESSING HER2

10:40 - 11:15

Triantifyllos Stylianopoulos
University of Cyprus

TARGETING TUMOR FIBROSIS TO IMPROVE DRUG DELIVERY AND ENHANCE CANCER THERAPY

11:15 - 11:35

Mathias Dahlmann
Charité University Medicine / ECRC

THERAPEUTIC OPTIONS OF NEW PROLINE-MIMETIC COMPOUNDS IN CRC METASTASIS

11:35 - 11:45

Closing Comments

Supported by

Media Partners

Interested in sponsoring this conference?

Contact us

Venue & Location

Annabelle

The Annabelle is a family-run oasis set within six acres of lush gardens on Paphos’ Mediterranean sea front. 

Cool, peaceful interiors, understated design and warm, caring service combined with 5 star luxury to create a distinct atmosphere of unpretentious elegance.

The Annabelle is the closest hotel to Paphos’ picturesque medieval castle and harbour, yet its seafront gardens, outstanding cuisine and impeccable service have earned it a reputation as one of the town’s best-loved retreats.

Throughout the conference period you will enjoy a delicious buffet breakfast, lunch and dinner. During each meal delegates are entitled to a choice of hot beverages, soft drinks plus one glass of house wine or beer during dinner. The themed Gala Night takes place on the third evening of the conference with a mouth-watering feast exclusively designed by the head chef and a live band. Complimentary drink tickets will be handed out upon arrival. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
 

Hotel Facilities:

  • Fitness Centre with Gym
  • Four Restaurants and Five Bars
  • Complimentary WiFi access in public areas
  • Room Service
  • Floodlit Tennis Court and Squash Court
  • Spa
  • Free Parking
  • Laundry/Valet Service
  • Business Centre with Internet Access
  • Self-Serve Laundry
  • Children Activities ( Kid / Family Friendly )
  • Shuttle Bus Service

General Information

Venue Rating

★ ★ ★ ★ ★

Currency

Great Britain Pound (GBP)

Address

Annabelle 10, Poseidonos Avenue 8042 Paphos

Nearest Airport

Paphos International Airport

Location

Paphos is a coastal city in the southwest of Cyprus and the capital of Paphos District. In antiquity, two locations were called Paphos: Old Paphos and New Paphos. The currently inhabited city, New Paphos, lies on the Mediterranean coast, about 50 km (31.07 mi) west of Limassol (the biggest port on the island). 

Paphos is also the mythical birthplace of Aphrodite and is an open air museum of Byzantine churches and Roman ruins interspersed with al fresco restaurants and café bars.

The Annabelle is the closest hotel to Paphos’s picturesque fishing harbour, ancient port and the UNESCO-listed House of Dionysos, containing Cyprus’s world-renowned Roman mosaics.

Paphos International Airport is the country's second-largest airport and is 16 km away from The Annabelle. The drive time is approximately 20 minutes. 

Media Partners

If you're interested in sponsoring this conference please contact us.

Conference Manager

Laura Trundle

Need some help? Chat to the Fusion team today

As a family run business, our dedication runs deep. We’re committed to each other and, even more so, to every attendee’s experience, delivering a level of care and passion that’s truly unmatched.

Call us

+44 (0) 1638 555057

Looking for forthcoming conferences?