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Novel Concepts in the Biology & Treatment of Metastatic Cancer Conference
05 Nov - 08 Nov 2016
Paphos, Cyprus
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Jonathan Sleeman
University of Heidelberg
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Bruce Zetter
Boston Children's Hospital
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Andreani Odysseos
EPOS-Iasis, R&D
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Synopsis
Metastatic disease, the lethal component of cancer, remains largely intractable to modern medicine. New insights into the biology of metastasis promise fresh insights into how to design therapies that effectively tackle this life-threatening disease process. Recent years have seen the development of novel tools for studying metastasis that continue to provide dramatic advances in our understanding of the cellular and molecular mechanisms that drive metastasis formation. Metastasis is regulated by both tumor cell-intrinisic factors such as genetic defects, epigenetic perturbation and metabolic changes, as well as by a variety of factors in the microenvironment, including cells of the immune system. These tumor cell-intrinsic factors combine with the external microenvironment to regulate tumor dormancy and the development of therapy resistance. This knowledge is starting to be translated into therapies that target not only the metastatic seed but also the microenvironmental soil.
Key Sessions
- Therapy-induced metastasis and the patient with metastatic disease
- Metabolic changes that drive metastasis
- Metastatic dormancy - maintenance and escape
- Novel approaches to pharmacology and drug delivery for the treatment of metastases
- Control of metastasis by inflammation and the innate immune system
- Targeting the metastatic microenvironment
- Novel tools for studying metastasis
- Cancer Stem Cells - Do we all mean the same? A controversy session.
Confirmed Keynote Speaker
G. Steven Bova (University of Tampere)
'LEVERAGING THE EVOLUTIONARY HISTORY OF METASTATIC PROSTATE CANCER'
Confirmed Plenary Speakers
Julio Aguirre-Ghiso (Mount Sinai School of Medicine)
'UNDERSTANDING THE BIOLOGY OF DORMANT DISSEMINATED CANCER CELLS: A PATH TO MANAGE LATE CANCER RELAPSE'
Christel Herold-Mende (University of Heidelberg)
'IMMUNOBIOLOGY OF BRAIN METASTASES'
Tatiana Petrova (Université de Lausanne)
'CROSS-TALK OF COLON CANCER STEM CELLS WITH STROMA'
Confirmed Invited Speakers
Luigi Ombrato (The Francis Crick Institute)
'METASTASIS: A MATTER OF TEAMWORK'
James Lorens (University of Bergen)
'TUMOR PLASTICITY AND DRUG RESISTANCE: THE ROLE OF THE AXL RECEPTOR KINASE'
Yuval Shaked (Technion – Israel Institute of Technology)
'THE CROSS TALK BETWEEN TUMOR AND HOST CELLS FOLLOWING ANTI-CANCER DRUG THERAPY AND ITS CONTRIBUTION TO METASTASIS'
Thordur Oskarsson (German Cancer Research Center - DKFZ)
'EXTRACELLULAR MATRIX PROTEINS OF STEM CELL NICHES: ROLE IN BREAST CANCER METASTASIS'
Triantafyllos Stylianopoulos (University of Cyprus)
'TARGETING TUMOR FIBROSIS TO IMPROVE DRUG DELIVERY AND ENHANCE THERAPY'
Veronique Orian-Rousseau (Karlsruhe Institute of Technology)
'THE CROSSTALK BETWEEN CELL ADHESION MOLECULES AND OTHER CELL SURFACE RECEPTORS DRIVES TUMOR PROGRESSION AND METASTASIS'
Zvika Granot (The Hebrew University of Jerusalem)
'NEUTROPHILS IN CANCER: LOOKING AT THE BRIGHT SIDE'
Dalit Barkan (Haifa University)
Sakari Vanharanta (University of Cambridge)
'EPIGENETIC MECHANISMS OF METASTASIS GENE ACTIVATION'
Dario Marchetti (Houston Methodist Research Institute)
'CIRCULATING TUMOR CELLS: THE FUTURE OF CANCER DIAGNOSTICS'
Rune Linding (University of Copenhagen)
'DECODING OF NETWORK ATTACKING MUTATIONS REWIRING CANCER'
Isaac Witz (Tel Aviv University)
'TUMOR-ASSOCIATED AND MICROENVIRONMENTAL DRIVERS OF METASTASIS'
Vivek Mittal (Weill Cornell Medical College)
'POLYCOMB REPRESSIVE COMPLEX 2 IN BREAST CANCER METASTASIS'
Geoffrey Pilkington (University of Portsmouth)
'MODELLING THE BLOOD BRAIN BARRIER FOR CANCER METASTASIS AND DRUG DELIVERY STUDIES'
Andreas Evdokiou (The University of Adelaide)
'IMMUNOTHERAPEUTIC APPROACHES TARGETING CANCER IN BONE'
Target Audience
Confirmed Speakers
Plenary Speakers
Christel Herold-Mende
University Professor, University of Heidelberg, Dpt. Neurosurgery
Julio Aguirre-Ghiso
Professor, Tisch Cancer Institute at Mount Sinai Hospital
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George Bova
Finnish Distinguished Professor, University of Tampere, BioMediTech
Tatiana Petrova
Professor, Department of Fundamental Oncology, University of Lausanne
Invited Speakers
Yuval Shaked
PI, Technion
Luigi Ombrato
Postdoctoral Researcher, The Crick Institute
Triantafyllos Stylianopoulos
Professor, University of Cyprus
Veronique Orian-Rousseau
Group Leader, KIT
Dalit Barkan
Head Laboratory of Tumor Dormancy and Metastasis, University of Haifa
James Lorens
Professor, University of Bergen
Zvi Granot
PI, Hebrew University
Sakari Vanharanta
group leader, MRC Cancer Unit - University of Cambridge
Dario Marchetti
Director, Center of the Biomarker Research Program, Methodist Hospital Research Institute
Isaac Witz
Prof. Lab Chief, Tel Aviv University
Vivek Mittal
Professor and Director , Weill Medical Center of Cornell University
Thordur Oskarsson
Group Leader, HI-STEM gGmbH
Rune Linding
Principal Investigator, Linding Lab
Geoffrey Pilkington
Professor of Cellular & Molecular Neuro-oncology, Head of Brain Tumour Research Centre, University of Portsmouth
Andreas Evdokiou
Head Breast Cancer Research Unit, University of Adelaide
Programme
SATURDAY 05TH NOVEMBER 2016 |
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14:00 – 15:00 |
Registration & Reception |
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14:00 – 15:00 |
Group Welcome Lunch |
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15:00 – 15:15 |
Opening Comments |
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15:15 – 16:15 |
Steven Bova |
KEYNOTE TALK: LEVERAGING THE EVOLUTIONARY HISTORY OF METASTATIC PROSTATE CANCER |
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METASTATIC DORMANCY: MAINTENANCE AND ESCAPE |
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16:15 – 17:00 |
Julio Aguirre Ghiso |
UNDERSTANDING THE BIOLOGY OF DORMANT DISSEMINATED CANCER CELLS: A PATH TO MANAGE LATE CANCER RELAPSE |
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17:00 – 17:35 |
Dalit Barkan |
PREVENTING THE RECURRENCE OF BREAST CANCER AT THE METASTATIC NICHE USING RESOLUTION-PHASE MACROPHAGES |
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17:35 – 18:05 |
Refreshments |
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18:05 – 19:05 |
Panel Discussion with Bruce Zetter, Jonathon Sleeman and Andreani Odysseos |
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19:05 |
Group Dinner |
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SUNDAY 06TH NOVEMBER 2016 |
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07:00 – 08:30 |
Group Breakfast |
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TARGETING THE METASTATIC MICROENVIRONMENT |
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08:30 – 09:15 |
Jim Lorens |
TUMOR PLASTICITY AND DRUG RESISTANCE: THE ROLE OF THE AXL RECEPTOR KINASE |
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09:15 – 09:50 |
Thodur Oskarsson |
EXTRACELLULAR MATRIX PROTEINS OF STEM CELL NICHES: ROLE IN BREAST CANCER METASTASIS |
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09:50 – 10:10 |
Lena Wullkopf |
METASTASIS- A JOURNEY OF FORCE? |
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10:10 – 10:40 |
Refreshments |
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10:40 – 11:15 |
Isaac Witz |
TUMOR-ASSOCIATED AND MICROENVIRONMENTAL DRIVERS OF METASTASIS |
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11:15 – 11:50 |
Rune Linding |
DECODING OF NETWORK ATTACKING MUTATIONS REWIRING CANCER |
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11:50 – 16:00 |
Group Lunch & Free Time |
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13:00 – 16:00 |
Group Activity: Paphos Tombs of the Kings – Mosaics – Aphrodite’s Rock |
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CONTROL OF METASTASIS BY INFLAMMATION AND THE INNATE IMMUNE SYSTEM |
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16:00 – 16:45 |
Jonathan Sleeman |
LYMPHANGIOGENESIS MEETS MDSCS/NEUTROPHILS: A NEW ROLE FOR VEGF-C IN METASTASIS |
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16:45 – 17:20 |
Luigi Ombrato |
METASTASIS: A MATTER OF TEAMWORK |
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17:20 – 17:55 |
Andreas Evdokiou |
IMMUNOTHERAPEUTIC APPROACHES TARGETING CANCER IN BONE |
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17:55 – 18:25 |
Refreshments |
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18:25 – 19:00 |
Zvi Granot |
NEUTROPHILS IN CANCER: LOOKING AT THE BRIGHT SIDE |
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19:00 – 19:35 |
Veronique Orian-Rousseau |
THE CROSSTALK BETWEEN CELL ADHESION MOLECULES AND OTHER CELL SURFACE RECEPTORS DRIVES TUMOR PROGRESSION AND METASTASIS |
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19:35 |
Group Dinner |
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MONDAY 07TH NOVEMBER 2016 |
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07:00 – 08:30 |
Group Breakfast |
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NOVEL TOOLS FOR STUDYING METASTASIS |
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08:30 – 09:15 |
Andreani Odysseos |
THERE IS PLENTY OF ROOM AT THE BOTTOM FOR METASTATIC DISEASE: FROM NANOBIOTECHNOLOGY TO MOLECULAR COMMUNICATIONS AND NANONETWORKS |
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09:15 – 09:50 |
Vivek Mittal |
POLYCOMB REPRESSIVE COMPLEX 2 IN BREAST CANCER METASTASIS |
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09:50 – 10:25 |
Dario Marchetti |
CIRCULATING TUMOR CELLS: THE FUTURE OF CANCER DIAGNOSTICS |
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10:25 – 11:00 |
Refreshments |
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SPECIAL INVITED TALK ON THERAPY-INDUCED METASTASIS AND THE PATIENT WITH METASTATIC DISEASE |
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11:00 – 11:45 |
Yuval Shaked |
THE CROSS TALK BETWEEN TUMOR AND HOST CELLS FOLLOWING ANTI-CANCER DRUG THERAPY AND ITS CONTRIBUTION TO METASTASIS |
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11:45 – 17:00 |
Group Lunch & Free Time |
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13:00 – 16:45 |
Group Activity: Wine Tasting at Chryssogoriatissa Monasteries – Agios Neophytos |
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CANCER STEM CELLS – DO WE ALL MEAN THE SAME |
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17:00 – 17:45 |
Christel Herald Mende |
IMMUNOBIOLOGY OF BRAIN METASTASES |
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17:45 – 18:30 |
Tatiana Petrova |
CROSS-TALK OF COLON CANCER STEM CELLS WITH STROMA |
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18:30 – 19:05 |
Geoffrey Pilkington |
MODELLING THE BLOOD BRAIN BARRIER FOR CANCER METASTASIS AND DRUG DELIVERY STUDIES |
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19:05 – 20:00 |
Poster Session & Refreshments |
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20:00 – 23:00 |
*Gala Dinner, Group Photo & Poster Awards* |
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TUESDAY 08TH NOVEMBER 2016 |
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07:00 – 08:30 |
Group Breakfast |
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NOVEL APPROACHES TO PHARMACOLOGY AND DRUG DELIVERY FOR THE TREATMENT OF METASTASES |
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08:30 – 09:15 |
Bruce Zetter |
SYSTEMIC NANOPARTICLE-MEDIATED DELIVERY OF RNA THERAPEUTICS FOR CANCER THERAPY |
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09:15 – 09:50 |
Sakari Vanharanta |
EPIGENETIC MECHANISMS OF METASTASIS GENE ACTIVATION |
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09:50 - 10:20 |
Refreshments | |
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10:20 - 10:40 |
Nancy Dumont |
MM-302 EFFECTIVELY TARGETS AND REDUCES METASTATIC BURDEN IN BREAST CANCER MODELS EXPRESSING HER2 |
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10:40 - 11:15 |
Triantifyllos Stylianopoulos |
TARGETING TUMOR FIBROSIS TO IMPROVE DRUG DELIVERY AND ENHANCE CANCER THERAPY |
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11:15 - 11:35 |
Mathias Dahlmann |
THERAPEUTIC OPTIONS OF NEW PROLINE-MIMETIC COMPOUNDS IN CRC METASTASIS |
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11:35 - 11:45 |
Closing Comments |
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Contact usVenue & Location
Annabelle
The Annabelle is a family-run oasis set within six acres of lush gardens on Paphos’ Mediterranean sea front.
Cool, peaceful interiors, understated design and warm, caring service combined with 5 star luxury to create a distinct atmosphere of unpretentious elegance.
The Annabelle is the closest hotel to Paphos’ picturesque medieval castle and harbour, yet its seafront gardens, outstanding cuisine and impeccable service have earned it a reputation as one of the town’s best-loved retreats.
Hotel Facilities:
- Fitness Centre with Gym
- Four Restaurants and Five Bars
- Complimentary WiFi access in public areas
- Room Service
- Floodlit Tennis Court and Squash Court
- Spa
- Free Parking
- Laundry/Valet Service
- Business Centre with Internet Access
- Self-Serve Laundry
- Children Activities ( Kid / Family Friendly )
- Shuttle Bus Service
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General Information
Venue Rating
★ ★ ★ ★ ★
Currency
Great Britain Pound (GBP)
Address
Annabelle 10, Poseidonos Avenue 8042 Paphos
Nearest Airport
Paphos International Airport
Location
Paphos is a coastal city in the southwest of Cyprus and the capital of Paphos District. In antiquity, two locations were called Paphos: Old Paphos and New Paphos. The currently inhabited city, New Paphos, lies on the Mediterranean coast, about 50 km (31.07 mi) west of Limassol (the biggest port on the island).
Paphos is also the mythical birthplace of Aphrodite and is an open air museum of Byzantine churches and Roman ruins interspersed with al fresco restaurants and café bars.
The Annabelle is the closest hotel to Paphos’s picturesque fishing harbour, ancient port and the UNESCO-listed House of Dionysos, containing Cyprus’s world-renowned Roman mosaics.
Paphos International Airport is the country's second-largest airport and is 16 km away from The Annabelle. The drive time is approximately 20 minutes.
Gallery
View on Flickr
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