**Unfortunately, we have had to close the registration deadline early as we have already reached full capacity! We are looking into increasing the number of places, so if you would like to be added to our wait list, please email Chloe Trundle, and we will alert you should any further places become available.**

Much of what we understand about cellular metabolism has come from research by cancer biologists, who have known since the time of Otto Warburg that metabolic alterations go hand in hand with transformation. Building from this knowledge, in more recent years it has come into focus that many different tissues and cell types undergo metabolic changes that directly impact their function and differentiation. As such, correct metabolic re-wiring is beneficial and a requirement for appropriate cellular function, while aberrant metabolic reprogramming can lead to inappropriate function and have implications on a wide variety of disease states. In this meeting we aim to bring together researchers from different areas of biology, that may otherwise have little crossover, but for their common interest in how metabolism impacts cell differentiation and function. 

Topics will span diverse areas such as cancer metabolism, organismal metabolism in disease, metabolic pathway engagement in cell function, metabolites as signaling molecules, mitochondrial biology, nutrient sensing, metabolism in tissue homeostasis and repair, neurometabolism, and metabolism in host-microbe interactions. This interdisciplinary meeting will bring together researchers working on immunity, metabolism, cancer, stem cells, neurobiology, and host-microbe interactions to gain a more integrated understanding of how metabolism impacts health and disease, with the aim of moving research in the field forward.

Key Sessions

• Mitochondria
• Metabolism and Host/Microbe Interactions
• Stem Cell Metabolism
• Neurometabolism
• Nutrient Sensing
• Cancer Metabolism
• Metabolism in Tissue Homeostasis and Repair
• Metabolites as Signaling Molecules
• Cell Metabolism in Disease and Inflammation

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying academics can bring a student for only $785. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 13, 14, 15 May 2022 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Chloe Trundle to obtain a special registration link for your student.

Confirmed Invited Speakers

Edward Chouchani (Harvard Medical School)
A NEWFOUND MECHANISM OF METABOLITE REGULATION OVER CELL CYCLE AND PROLIFERATION
Ralph DeBerardinis (UT Southwestern)
DETECTING AND TREATING METABOLIC ANOMALIES IN PATIENTS
Mark Febbraio (Monash University)
ROLE OF EXTRACELLULAR VESICLES IN DISEASE PROGRESSION AND PREVENTION 
Lydia Finley (Memorial Sloan Kettering Cancer Center)
METABOLIC REGULATION OF CELL FATE DECISIONS
Douglas Green (St. Jude Children's Research Hospital)
PERSISTER ACT: NEAR DEATH EXPERIENCES IN CANCER CELLS
Marcia Haigis (Harvard Medical School)
DISSECTING METABOLISM IN THE TUMOR MICROENVIRONMENT
Tiffany Horng (ShanghaiTech University)
METABOLIC CONTROL OF MACROPHAGE INFLAMMATORY RESPONSES
Shingo Kajimura (Beth Israel Deaconess Medical Center)
BIOENERGETICS MATTERS TO METABOLIC HEALTH – FROM A VIEW OF BROWN FAT
Lydia Lynch (Harvard Medical School)
IMMUNOMETABOLIC BASIS OF SEX DIFFERENCES IN DISEASE
William Mair (Harvard University)
EFFICACY OF LONGEVITY INTERVENTIONS IN C. ELEGANS IS DETERMINED BY EARLY LIFE ACTIVITY OF RNA SPLICING FACTORS
Brendan Manning (Harvard School of Public Health)
METABOLIC EFFECTORS OF mTOR SIGNALING
Christian Metallo (The Salk Institute)
TRACING LINKS IN SERINE AND GLYCINE METABOLISM TO DISEASE STATES
Sean Morrison (UT Southwestern)
THE METABOLIC REGULATION OF MELANOMA METASTASIS
Daniel Nomura (University of California, Berkeley)
REIMAGINING DRUGGABILITY USING CHEMOPROTEOMIC PLATFORMS
Luke O'Neill (Trinity College Dublin)
IMMUNOMETABOLISM IN INFLAMMATION AND COAGULATION
Lena Pernas (Max Planck Institute for Biology and Aging)
MITOCHONDRIAL METABOLISM IN THE DEFENSE AGAINST MICROBES
Richard Possemato (New York University)
TARGETING IRON METABOLISM IN CANCER AND BEYOND
Jared Rutter (University of Utah)
METABOLITE SIGNALING
Reuben Shaw (The Salk Institute)
AMPK REPROGRAMS METABOLISM AND RESTORES MITOCHONDRIAL HOMEOSTASIS
Mara Sherman (Oregan Health and Science University)
METABOLIC FUNCTIONS OF THE PANCREATIC TUMOR MICROENVIRONMENT
Claudio Villanueva (University of California, Los Angeles)
INTER-ORGAN COMMUNICATION AND METABOLIC CONTROL
Ivan Zanoni (Harvard Medical School)
REGULATION OF IMMUNOMETABOLISM BY ENDOGENOUS INFLAMMATORY CUES

Target Audience

We anticipate that the meeting will lead to the adoption of new technologies that will accelerate the rate of discovery in the field, encourage new collaborations between laboratories that may not have had previous interactions, and promote a focus on translational applications.  We expect attendees to emerge from the meeting with a clearer picture of how these different disciplines come together to shape our understanding of how metabolism impacts health and disease. We also expect that this meeting will help illuminate new areas of research in the field, and identify critical gaps in our knowledge that need further study in order to move the field forward. We plan for this meeting to be an exceptional opportunity for students, postdocs, and junior group leaders to meet more senior scientists and foster interactions that will increase their chances of success.

Educational Need

Attendees will leave the meeting with a stronger understanding of how metabolism in a variety of cell types and tissues impacts health and disease. We hope that researchers from diverse biological disciplines, such as those who study cancer and those who study immunology, will as a result of their interactions, forge new collaborations founded in their mutual appreciation that engagement of particular metabolic pathways shapes cell function and fate. Given the resurgence that metabolism has seen in recent years, we think our meeting will appeal broadly to many researchers across a variety of disciplines, many of whom are interested in investigating metabolic changes in their particular systems.