*Registration has now closed for 3rd Metabolism in Health & Disease Conference. However, a few final places remain. If you wish to join us in Malta, please email Amy to enquire about availblity.*

In recent years it has come into focus that many different tissues and cell types undergo metabolic changes that directly impact their function and differentiation. As such, correct metabolic re-wiring is beneficial and a requirement for appropriate cellular responses, while aberrant metabolic reprogramming can lead to inappropriate function and have implications on a wide variety of disease states. In spite of recent advances in the field of metabolism, our understanding of the mechanisms underlying how metabolites signal, how metabolic reprogramming occurs, and how cellular organelles modulate these processes remains limited. In this meeting we aim to bring together researchers from different areas of biology, that may otherwise have little crossover, but for their common interest in how metabolism impacts cell differentiation and function. 

Topics will span diverse areas such as cancer metabolism, organismal metabolism in disease, metabolic pathway engagement in cell function, metabolites as signaling molecules, mitochondrial biology, nutrient sensing, metabolism in tissue homeostasis and repair, neurometabolism, and metabolism in host-microbe interactions. This interdisciplinary meeting will bring together researchers working on immunity, metabolism, cancer, stem cells, neurobiology, and host-microbe interactions to gain a more integrated understanding of how metabolism impacts health and disease, with the aim of moving research in the field forward.

Key Sessions

•    Metabolism and Host/Microbe Interactions
•    Stem Cell Metabolism
•    Systemic metabolism in health and disease
•    Organellar Metabolism
•    Metabolites as Signaling Molecules
•    Emerging Technologies in Metabolism Research
•    Metabolism as a therapeutic target
•    Metabolism and Immune Responses

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying ‘single’ or ‘shared’ registrants can bring a student for only €990. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 01, 02,03 October 2024 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Amy Johnson to obtain a special registration link for your student.

Confirmed Invited Speakers

Theodore Alexandrov (EMBL)
SPATIAL SINGLE-CELL METABOLOMICS REVEALS METABOLIC CELL STATES
Kivanc Birsoy (The Rockefeller University)
NUTRIENT TRANSPORTERS IN HEALTH AND DISEASE
Donita Brady (University of Pennsylvania)
MITOCHONDRIAL COPPER SENSING VIA METABOLISM AND SIGNALING
Carlos Carmona-Fontaine (NYU)
COOPERATIVE NUTRIENT SCAVENGING IS AN EVOLUTIONARY ADVANTAGE IN CANCER
Navdeep S. Chandel (Northwestern Medicine)
MITOCHONDRIA AS SIGNALING ORGANELLES IN PHYSIOLOGY AND DISEASES
Ralph DeBerardinis (UT Southwestern)
HUMAN METABOLIC VARIATION AND ITS IMPACT ON DISEASE
Gina DeNicola  (Moffitt Cancer Center)
CYSTEINE METABOLISM IN CANCER
Mark Febbraio (Monash University)
IS EXERCISE MEDICINE? ROLE OF EXERCISE DERIVED EXTRACELLULAR VESICLES IN PREVENTION OF AGE RELATED DISEASES
Florent Ginhoux (Singapore Immunology Network)
METABOLIC CROSSTALK BETWEEN MACROPHAGES AND THEIR TISSUE OF RESIDENCE
Doug Green (St.Jude Children's Research Hospital)
START ME UP!  PHOSPHATIDYLSERINE CLUSTERING SIGNALS AND ANTI-CANCER IMMUNITY.
David James (The University of Sydney)
GENETIC ANALYSIS OF METABOLIC DIVERSITY
Samantha Lewis (UC Berkeley)
MITOCHONDRIAL STRESS GRANULES SEQUESTER NUCLEIC ACIDS AND CONTRIBUTE TO TRANSLATIONAL CONTROL
Oliver Maddocks (University of Glasgow)
CANCER SPECIFIC AMINO ACID METABOLISM
Brendan Manning (Harvard University)
THE PI3K-MTOR PATHWAY CONTROLS CELLULAR AND SYSTEMIC METABOLISM
Christian Metallo (Salk Institute)
CROSSTALK BETWEEN AMINO ACID AND LIPID METABOLISM IN DIABETES CO-MORBIDITIES
Luke O’Neill (Trinity College Dublin)
A BREAK IN ENDOSYMBIOSIS AS A BASIS FOR INFLAMMATORY DISEASES
Thales Papagiannakopoulos (New York University)
METABOLIC AND PHYSIOLOGIC MECHANISMS OF DISEASE PROGRESSION IN LUNG CANCER
Rushika Perera (UCSF)
IDENTIFYING LYSOSOME DEPENDENT ADAPTIVE PROGRAMS THAT DRIVE PANCREATIC CANCER
Reuben Shaw (Salk Institute)
AMPK CONTROLS THE MITOCHONDRIAL REPLACEMENT PLAN
Karen Vousden (The Francis Crick Institute)
A ROLE FOR ONE CARBON METABOLISM IN CANCER DEVELOPMENT AND PROGRESSION
Eileen White (Rutgers University)
SYSTEMIC CANCER METABOLISM
Omer Yilmaz (MIT)
DIETARY CONTROL OF INTESTINAL STEM CELLS IN PHYSIOLOGY AND DISEASE

Target Audience

We anticipate that the meeting will lead to the adoption of new technologies that will accelerate the rate of discovery in the field, encourage new collaborations between laboratories that may not have had previous interactions, and promote a focus on translational applications.  We expect attendees to emerge from the meeting with a clearer picture of how these different disciplines come together to shape our understanding of how metabolism impacts health and disease. We also expect that this meeting will help illuminate new areas of research in the field, and identify critical gaps in our knowledge that need further study in order to move the field forward. We plan for this meeting to be an exceptional opportunity for students, postdocs, and junior group leaders to meet more senior scientists and foster interactions that will increase their chances of success.