**Unfortunately, we have had to close the poster submission deadline early as we have already reached full capacity for poster presentation! We are looking into increasing the number of poster slots, so if you would like to be added to our reserve list, please email a copy of your abstract to Amy Johnson, and we will keep you updated if additional poster opportunities become available.**

Recent years have witnessed transformative advances in the ability to profile distinct biological features at the resolution of single-cells, which has reverberated across biology and medicine. These breakthroughs encompass new microfluidic techniques, molecular advances in next-generation sequencing approaches, and the development of computational platforms to analyse sequencing information at massive scale. All these gave us the ability to profile the genome (DNA sequencing), transcriptome (RNA-Sequencing), epi-genome (ATAC-Sequencing, DNA methylation sequencing) at single cell resolution leading to a deluge of novel information on the biological make up of a number of cell types, tissues and even whole organisms. The field of human health has used such sequencing and analytic approaches to start profiling normal and disease states, leading to significant breakthroughs in our understanding of how disease looks at the single cell level. Such tools are now applied to human genetics, immunity, infection and the understanding of cancer, to mention just a few areas of intense interest. The main focus of this conference will be to explore of how these methodological advances in single cell biology can impact our understanding of human disease, and lead to the introduction of novel therapies. Our goal is to bring together both single cell biologists and human health leaders, to spark new interactions, collaborations and generate ideas that will lead to future clinical trials and cures. We also aim to highlight new technical breakthroughs in the areas of sequencing and protocol development, sample preparation, and data analysis. As the field is progressing at warp speed it will important to hear from leaders in the field of single cell technology development and understand new directions and future applications. Finally, our objective is to see how such new technical developments can be applied to the study of human disease, opening a window on genomic medicine of tomorrow.

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying academics can bring a student for only $785. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 13, 14, 15 May 2022 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact (Amy Johnson) to obtain a special registration link for your student

Target Audience

This conference will appeal to biologists, computational scientists, physicians and technology developers. Some basic knowledge in these fields will be beneficial.
Graduate Students and postdoctoral fellows focusing on these areas are particularly welcome. 

Confirmed Speakers

Ido Amit (Weizmann Institute of Science)
The power of ONE: Immunology in the age of single cell genomics
Elham Azizi (Columbia University in the City of New York)
MODELING DYNAMICS IN THE TUMOR MICROENVIRONMENT
Omer Bayratkar (Wellcome Sanger Institute)
Ana Cvejic (University of Cambridge)
INVESTIGATING HUMAN FOETAL BLOOD DEVELOPMENT AT THE SINGLE-CELL LEVEL
Lee Grimes (Cincinnati Children's Hospital)
PROGRESSION THROUGH DISCRETE HEMATOPOIETIC CELL STATES
Ben Izar (Columbia University)
CANCER IMMUNE EVASION AND METASTASIS IN MELANOMA
Dan Landau (Weill Cornell Medicine)
SOMATIC EVOLUTION VIEWED THROUGH THE LENS OF SINGLE-CELL MULTI-OMICS.
Ken Lau (Vanderbilt School of Medicine)
HUMAN COLONIC PRE-CANCER ATLAS REVEALS PERSISTENCE OF TUMOR-IMMUNE ASSOCIATIONS IN MALIGNANT TRANSFORMATION
Ashley Laughney (Weill Cornell Medicine)
SYSTEMS ANALYSIS OF TUMOR-MICROENVIRONMENT CROSSTALK INDUCED BY CHROMOSOMAL INSTABILITY
Samantha Morris (Washington University)
NEW GENOMIC TECHNOLOGIES TO DECONSTRUCT CELL IDENTITY
Marta Olah (Columbia University)
MICROGLIA PHENOTYPIC HETEROGENEITY IN HUMAN AGING AND NEURODEGENERATIVE DISEASES
Dana Pe'er (Memorial Sloan Kettering Cancer Center)
PLASTICITY AND TUMOR PROGRESSION 
Arjun Raj (University of Pennsylvania)
Sydney Shaffer (University of Pennsylvania)
UNRAVELING CLONAL DYNAMICS IN CANCER
Alex Shalek (MIT & Harvard)
IDENTIFYING AND RATIONALLY MODULATING CELLULAR DRIVERS OF ENHANCED AND DIMINISHED IMMUNITY.
Meromit Singer (Harvard Medical School)
SINGLE-CELL RNA-SEQ COUPLED WITH CLONAL ANALYSIS REVEALS SYSTEMIC T CELL CHARACTERISTICS IN CANCER AND AUTOIMMUNITY
Mario Suva (Harvard Medical School)
DISSECTING THE BIOLOGY OF HUMAN GLIOMAS BY SINGLE-CELL GENOMICS
David Van Valen (Caltech)
EVERYTHING AS CODE
Itai Yanai (NYU School of Medicine)
CANCER CELL STATES AND THEIR INTERACTIONS WITH THE TUMOR MICROENVIRONMENT

Educational Need

The field of single cell biology has erupted the last five years with the introduction of next generation sequencing technologies that probe the genome, transcriptome, epigenome and even spatial positioning of individual cells. As the tools and number of applications increases, there is a need for a review of the field and an intense look to the future with a focus on human disease and single cell technology applications. 

Learning Objectives

• Understanding of how single cell biology impacts the understanding of human disease 
• To bring together both single cell biologists and human health leaders 
• To spark new interactions, collaborations and generate ideas
• To present new technical breakthroughs

News

• Stephanie Houston; Iannis Aifantis: An accidental scientist. J Exp Med 3 February 2020; 217