Past Conference

Probing Human Disease Using Single-Cell Technologies Conference

#FusionSCT

Date

13 May - 16 May 2022

Location

Cancun, Mexico

Early Bird - Expired  •  Talk Submission - Expired  •  Poster Submission - Expired  •  Registration & Payment Deadline - Expired

Synopsis

**Unfortunately, we have had to close the poster submission deadline early as we have already reached full capacity for poster presentation! We are looking into increasing the number of poster slots, so if you would like to be added to our reserve list, please email a copy of your abstract to Amy Johnson, and we will keep you updated if additional poster opportunities become available.**

Recent years have witnessed transformative advances in the ability to profile distinct biological features at the resolution of single-cells, which has reverberated across biology and medicine. These breakthroughs encompass new microfluidic techniques, molecular advances in next-generation sequencing approaches, and the development of computational platforms to analyse sequencing information at massive scale. All these gave us the ability to profile the genome (DNA sequencing), transcriptome (RNA-Sequencing), epi-genome (ATAC-Sequencing, DNA methylation sequencing) at single cell resolution leading to a deluge of novel information on the biological make up of a number of cell types, tissues and even whole organisms. The field of human health has used such sequencing and analytic approaches to start profiling normal and disease states, leading to significant breakthroughs in our understanding of how disease looks at the single cell level. Such tools are now applied to human genetics, immunity, infection and the understanding of cancer, to mention just a few areas of intense interest. The main focus of this conference will be to explore of how these methodological advances in single cell biology can impact our understanding of human disease, and lead to the introduction of novel therapies. Our goal is to bring together both single cell biologists and human health leaders, to spark new interactions, collaborations and generate ideas that will lead to future clinical trials and cures. We also aim to highlight new technical breakthroughs in the areas of sequencing and protocol development, sample preparation, and data analysis. As the field is progressing at warp speed it will important to hear from leaders in the field of single cell technology development and understand new directions and future applications. Finally, our objective is to see how such new technical developments can be applied to the study of human disease, opening a window on genomic medicine of tomorrow.

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying academics can bring a student for only $785. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 13, 14, 15 May 2022 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact (Amy Johnson) to obtain a special registration link for your student

Target Audience

This conference will appeal to biologists, computational scientists, physicians and technology developers. Some basic knowledge in these fields will be beneficial.
Graduate Students and postdoctoral fellows focusing on these areas are particularly welcome. 

Confirmed Speakers

Ido Amit (Weizmann Institute of Science)
The power of ONE: Immunology in the age of single cell genomics
Elham Azizi (Columbia University in the City of New York)
MODELING DYNAMICS IN THE TUMOR MICROENVIRONMENT
Omer Bayratkar (Wellcome Sanger Institute)
Ana Cvejic (University of Cambridge)
INVESTIGATING HUMAN FOETAL BLOOD DEVELOPMENT AT THE SINGLE-CELL LEVEL
Lee Grimes (Cincinnati Children's Hospital)
PROGRESSION THROUGH DISCRETE HEMATOPOIETIC CELL STATES
Ben Izar (Columbia University)
CANCER IMMUNE EVASION AND METASTASIS IN MELANOMA
Dan Landau (Weill Cornell Medicine)
SOMATIC EVOLUTION VIEWED THROUGH THE LENS OF SINGLE-CELL MULTI-OMICS.
Ken Lau (Vanderbilt School of Medicine)
HUMAN COLONIC PRE-CANCER ATLAS REVEALS PERSISTENCE OF TUMOR-IMMUNE ASSOCIATIONS IN MALIGNANT TRANSFORMATION
Ashley Laughney (Weill Cornell Medicine)
SYSTEMS ANALYSIS OF TUMOR-MICROENVIRONMENT CROSSTALK INDUCED BY CHROMOSOMAL INSTABILITY
Samantha Morris (Washington University)
NEW GENOMIC TECHNOLOGIES TO DECONSTRUCT CELL IDENTITY
Marta Olah (Columbia University)
MICROGLIA PHENOTYPIC HETEROGENEITY IN HUMAN AGING AND NEURODEGENERATIVE DISEASES
Dana Pe'er (Memorial Sloan Kettering Cancer Center)
PLASTICITY AND TUMOR PROGRESSION 
Arjun Raj (University of Pennsylvania)
Sydney Shaffer (University of Pennsylvania)
UNRAVELING CLONAL DYNAMICS IN CANCER
Alex Shalek (MIT & Harvard)
IDENTIFYING AND RATIONALLY MODULATING CELLULAR DRIVERS OF ENHANCED AND DIMINISHED IMMUNITY.
Meromit Singer (Harvard Medical School)
SINGLE-CELL RNA-SEQ COUPLED WITH CLONAL ANALYSIS REVEALS SYSTEMIC T CELL CHARACTERISTICS IN CANCER AND AUTOIMMUNITY
Mario Suva (Harvard Medical School)
DISSECTING THE BIOLOGY OF HUMAN GLIOMAS BY SINGLE-CELL GENOMICS
David Van Valen (Caltech)
EVERYTHING AS CODE
Itai Yanai (NYU School of Medicine)
CANCER CELL STATES AND THEIR INTERACTIONS WITH THE TUMOR MICROENVIRONMENT

Educational Need

The field of single cell biology has erupted the last five years with the introduction of next generation sequencing technologies that probe the genome, transcriptome, epigenome and even spatial positioning of individual cells. As the tools and number of applications increases, there is a need for a review of the field and an intense look to the future with a focus on human disease and single cell technology applications. 

Learning Objectives

  • Understanding of how single cell biology impacts the understanding of human disease 
  • To bring together both single cell biologists and human health leaders 
  • To spark new interactions, collaborations and generate ideas
  • To present new technical breakthroughs

News

Confirmed Speakers

Invited Speakers
Alex Shalek

Alex Shalek

Associate Professor, MIT

Samantha Morris

Samantha Morris

Associate Professor, Washington University in St Louis

Dana Pe'er

Dana Pe'er

Chair Computational & Systems Biology, Memorial Sloan Kettering

Itai Yanai

Itai Yanai

Professor of Biochemistry and Molecular Pharmacology/Director of Institute for Computational Medicine, NYU Langone Health

Ana Cvejic

Ana Cvejic

Principal Investigator, University of Cambridge

Elham Azizi

Elham Azizi

Assistant Professor, Columbia University

Marta Olah

Marta Olah

Assistant Professor, Columbia University Medical Center

Ashley Laughney

Ashley Laughney

Assistant Professor, Weill Cornell Medicine

Ken Lau

Ken Lau

Associate Professor, Vanderbilt University

Dan Landau

Dan Landau

Associate Prof, WCM/NYGC

Mario Suva

Mario Suva

Associate Professor of Pathology, Mass General Hospital/Harvard Medical School

Sydney Shaffer

Sydney Shaffer

Assistant Professor, University of Pennsylvania

Arjun Raj

Arjun Raj

Professor, University of Pennsylvania

Benjamin Izar

Benjamin Izar

Physician, Columbia Universtiy Medical Center

Meromit Singer

Meromit Singer

Associate Director, Guardant Health

Nathan Salomonis

Nathan Salomonis

Associate Professor, CINCINNATI CHILDRENS HOSP MED CTR

Programme

FRIDAY 13TH MAY 2022

13:30 – 14:30

Student Networking Reception

14:00 – 15:00

Registration & Welcome Reception

Session 1

Session chair: Iannis Aifantis

15:00 – 15:10

Opening Comments

15:10 – 15:35

Alex Shalek
MIT & Harvard

IDENTIFYING AND RATIONALLY MODULATING CELLULAR DRIVERS OF ENHANCED AND DIMINISHED IMMUNITY.

15:35 – 16:00

Samantha Morris
Washington University, St. Louis

NEW GENOMIC TECHNOLOGIES TO DECONSTRUCT CELL IDENTITY

16:00 – 16:25

Mario Suva
Harvard Medical School

DISSECTING THE BIOLOGY OF HUMAN GLIOMAS BY SINGLE-CELL GENOMICS

16:25 – 16:50

Marta Olah
Columbia University

MICROGLIA PHENOTYPIC HETEROGENEITY IN HUMAN AGING AND NEURODEGENERATIVE DISEASES

16:50 – 17:35

Refreshments

17:35 – 18:00

Ana Cvejic
University of Cambridge

INVESTIGATING HUMAN FOETAL BLOOD DEVELOPMENT AT THE SINGLE-CELL LEVEL

18:00 – 18:15

Robert Myers
Weill Cornell Medicine

HIGH-THROUGHPUT SINGLE-CELL SIMULTANEOUS GENOTYPING AND CHROMATIN ACCESSIBILITY REVEALS GENOTYPE TO EPIPHENOTYPE RELATIONSHIP IN HUMAN MYELOPROLIFERATION

18:15 – 18:30

Yichi Xu
MSKCC

A SINGLE-CELL TRANSCRIPTOME ATLAS OF HUMAN EARLY EMBRYOGENESIS

18:30 – 18:45

Rafael Arguello
CNRS - CIML

FUNCTIONAL PROFILING METABOLISM WITH SINGLE CELL RESOLUTION IN A FIXATION-COMPATIBLE SYSTEM USING MICRO-SAMPLES OF WHOLE BLOOD

18:45 – 19:00

Vikram Devgan
Nanostring Technologies

CosMx SMI: REVOLUTIONIZING SINGLE-CELL SPATIAL RESEARCH

19:00 – 19:30

Meet the Poster Presenters I

19:30

Dinner at Leisure

SATURDAY 14TH MAY 2022

07:00 – 09:00

Breakfast at Leisure

Session 2

Session Chair: Ana Cvejic

09:00 – 09:25

Dan Landau
Weill Cornell Medicine

SOMATIC EVOLUTION VIEWED THROUGH THE LENS OF SINGLE-CELL MULTI-OMICS.

09:25 – 09:40

Anna Mathioudaki
EMBL Heidelberg

SINGLE CELL PROFILING OF XENOGRAFT MOUSE MODELS UNVEIL THE BONE MARROW MICROENVIRONMENT REMODELLING UPON ACUTE MYELOID LEUKEMIA

09:40 – 10:05

Itai Yanai
NYU School of Medicine

CANCER CELL STATES AND THEIR INTERACTIONS WITH THE TUMOR MICROENVIRONMENT

10:05 – 10:50

Group Photo, Refreshments & Poster Viewing

10:50 – 11:15

Dana Pe’er
Memorial Sloan Kettering Cancer Center

PLASTICITY AND TUMOR PROGRESSION

11:15 – 11:30

Dimitris Skokos
Regeneron

A SINGLE-CELL MAP OF DYNAMIC CHROMATIN LANDSCAPES OF IMMUNE CELLS IN RENAL CELL CARCINOMA

11:30 – 12:00

Meet the Poster Presenters II

12:00 – 16:50

Group Lunch & Free Time

Session 3
Session Chair – Nathan Solomonis

16:50 – 17:15

Iannis Aifantis
NYU

INFLAMMATION REMODELS THE IMMUNE MICROENVIRONMENT IN ACUTE MYELOID LEUKEMIA

17:15 – 17:40

Meromit Singer
Harvard Medical School

SINGLE-CELL RNA-SEQ COUPLED WITH CLONAL ANALYSIS REVEALS SYSTEMIC T CELL CHARACTERISTICS IN CANCER AND AUTOIMMUNITY

17:40 – 17:55

Charlie Rocco
Parse Biosciences

PERFORMING SINGLE CELL SEQUENCING WITH UNPRECEDENTED SCALE AND EASE

17:55 – 19:55

Poster Session & Refreshments

19:55

Parse Biosciences Group Dinner

SUNDAY 15TH MAY 2022

07:00 –09:00

Breakfast at Leisure

Session 4
Session Chair- Ashley Laughney

09:00 –09:25

Rahul Satija
NYU

INTEGRATED ANALYSIS OF SINGLE-CELL DATA ACROSS MODALITIES AND TECHNOLOGIES

09:25 –09:50

Elham Azizi
Columbia University in the City of New York

MODELING DYNAMICS IN THE TUMOR MICROENVIRONMENT

09:50 – 10:05

Costanza Borrelli

ETH Zurich

ACTIVE EOSINOPHILS REGULATE HOST DEFENSE AND IMMUNE RESPONSES DURING INTESTINAL INFLAMMATION

10:05 – 10:50

Refreshments & Poster Viewing

10:50 – 11:15

David Van Valen
Caltech

EVERYTHING AS CODE

11:15 – 11:40

Ben Izar
Columbia University

CANCER IMMUNE EVASION AND METASTASIS IN MELANOMA

11:40 – 11:55

Erin McCaffrey
Stanford University

SPATIAL MAPPING OF SINGLE CELLS AND MICROENVIRONMENTS IN HUMAN TUBERCULOSIS

11:55 – 17:20

Group Lunch & Free Time

Session 5
Session Chair – Rahul Satija

17:20 – 17:35

Caleb Lareau
Stanford University

SINGLE-CELL MULTI-OMICS REVEALS DETERMINANTS OF PURIFYING SELECTION AND METABOLIC VULNERABILITIES OF PATHOGENIC MITOCHONDRIAL DNA

17:35 – 18:00

Sydney Shaffer
University of Pennsylvania

UNRAVELING CLONAL DYNAMICS IN CANCER

18:00 – 18:45

Refreshments & Poster Viewing

18:45 – 19:10

Ashley Laughney
Weill Cornell Medicine

SYSTEMS ANALYSIS OF TUMOR-MICROENVIRONMENT CROSSTALK INDUCED BY CHROMOSOMAL INSTABILITY

19:10 – 19:25

Karen Grimes
EMBL Heidelberg

MEASURING THE IMPACT OF SOMATIC MOSAIC STRUCTURAL VARIATION ON HUMAN BLOOD LINEAGES

19:25 – 19:40

Irene Whitney
Honeycomb Biotechnologies

HIVETM scRNAseq: Expanding Access to Single-Cell Genomics

20:00

Gala Dinner & Poster Awards

MONDAY 16TH MAY 2022

07:00 – 09:00

Breakfast at Leisure

Session 6
Session Chair – Elham Azizi

09:00 – 09:25

Ken Lau
Vanderbilt School of Medicine

HUMAN COLONIC PRE-CANCER ATLAS REVEALS PERSISTENCE OF TUMOR-IMMUNE ASSOCIATIONS IN MALIGNANT TRANSFORMATION

09:25 – 09:50

Nathan Salomonis
Cincinnati Children's Hospital

PROGRESSION THROUGH DISCRETE HEMATOPOIETIC CELL STATES

09:50 – 10:05

Maria Sirenko
Memorial Sloan Kettering Cancer Center

SUBCLONAL PHENOTYPING OF DISEASE-DEFINING MUTATIONS USING INTEGRATIVE SINGLE CELL TECHNOLOGIES

10:05 – 10:30

Arjun Raj
University of Pennsylvania

CELLULAR ADAPTATION IN THERAPY RESISTANCE

10:30 – 11:00

Refreshments

11:00 – 11:15

Sergio Heli Triana Sierra
Massachusetts institute of technology

SINGLE-CELL PROTEO-GENOMIC REFERENCE MAPS OF THE HEMATOPOIETIC SYSTEM ENABLE THE PURIFICATION AND MASSIVE PROFILING OF PRECISELY DEFINED CELL STATES

11:15 – 11:30

Doron Haviv
Memorial Sloan Kettering

SPATIAL CONTEXT OF HETEROGENOUS T CELL RESPONSE TO FUNGAL INFECTION

11:30 – 11:40

Closing Comments

Supported by

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Venue & Location

Fiesta Americana Condesa Cancun All Inclusive

This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment.  We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas

General Information

Venue Rating

★ ★ ★ ★ ★

Currency

US Dollar (USD)

Address

Fiesta Americana Condesa Cancún All Inclusive Blvd. Kukulcan km 16.5 Zona Hotelera 77500 Cancun Q.R. Mexico

Nearest Airport

Cancun International Airport

Location

Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.

Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.

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Conference Manager

Amy Johnson

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