The 3rd Fusion conference on Neuroepigenetics and Neuroepitranscriptomics brought together leaders in the field and junior investigators as well as trainees to discuss many exciting topics from April 28 to 30, 2023 at the beautiful site of Riviera Maya, Mexico. The meeting started with a keynote talk by Eric Nestler, followed by 34 talks by speakers from north America, Asia, Australia and Europe, including many junior investigators, woman scientists, and those from under-represented groups. In addition, there were a total of 40 poster presentations.  The meeting awarded multiple fellowships to support early career investigators with the enthusiastic support of meeting organizers and many invited speakers. The meeting covered topics ranging from epigenetic and epitranscriptomic regulation during brain development, neuronal maturation, plasticity to brain disorders and drug development. Most speakers included their latest and unpublished results in their talks. Moreover, the poster presentations were of extremely high quality.  There were numerous opportunities for discussions and interactions with a meeting size of 85 attendees and in a relaxed beautiful location. The meeting concluded with a gala dinner, where 6 poster awards were presented. The fusion team provided excellent support before and throughout the meeting and sponsors, media partners and exhibitors made this meeting possible. The Fusion conference series on neuroepigenetics amd neuroepitranscriptomics started in 2018 and has become the most favorite meeting for many investigators in this exciting, rapidly advancing and expanding field. We are looking forward to the next meeting in a couple of years. 

If you are interested in this meeting but not yet ready to register, you can sign up for updates here and our team will keep you updated regarding deadline reminders and grant opportunities relating to this meeting only. 

Epigenetic mechanisms - including DNA and histone modifications, as well as regulation by non-coding RNAs - have pivotal roles in the nervous system. Aberrant epigenetic regulation also contributes to pathogenesis in various brain disorders. There are a number of recent ground-breaking discoveries of new features of epigenetic marks and regulation that are enriched in the nervous system, leading to an emerging new field of “neuroepigenetics”. In addition, new discoveries of modification of mRNAs and long non-coding RNAs lead to a new field of “epitranscriptomics”. This meeting will bring together experts and pioneers in studying neuroepigenetics and epitranscriptomics to provide an up-to-date and comprehensive picture of epigenetic and epitranscriptomic mechanisms in neural development, reprogramming and cell identity, plasticity, neuronal function and dysfunction. The meeting will offer opportunity for interdisciplinary interactions and future collaborations.

Key Sessions

• Epigenetic mechanisms regulating brain development and stem cells 
• Transcriptional and translational regulation
• Neuronal specific splicing
• Brain developmental disorders, aging and neurodegeneration
• Single-cell transcriptome and epigenome analysis
• Genome-wide analysis of different DNA and RNA modifications
• 3D epigenome and chromatin topology

Early Career Researcher Grants

The deadline for the Early Career Researchers Grants has now closed. All candidates will be contacted by Fusion in due course once submissions have been reviewed.

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic and bring a student for only $777. Unfortunately, Postdocs are not eligible for this offer. Both registration packages include; accommodation for the 28, 29, 30 April 2023 (on a shared basis for students) and an all-inclusive food and beverage package for the conference period. Once registered, please contact Amy Johnson to obtain a special registration link for your student.

Confirmed Keynote Speaker:

Eric Nestler (Icahn School of Medicine at Mount Sinai)
EPIGENETIC AND TRANSCRIPTIONAL MECHANISMS OF ADDICTION

Confirmed Plenary Speakers:

Angel Barco (Instituto de Neurociencias)
EPIGENETIC ETIOLOGY OF INTELLECTUAL DISABILITY
Shelley Berger  (University of Pennsylvania)
Joe Ecker (Salk Institute)
SINGLE-CELL DNA METHYLOME AND 3D MULTI-OMIC ATLAS OF THE ADULT MOUSE BRAIN
Yukiko Gotoh (University of Tokyo)
REGULATION OF NEOCORTICAL NEURAL STEM CELL FATE AT THE CHROMATIN LEVEL
Manolis Kellis (MIT)
SINGLE-CELL DISSECTION OF BRAIN DISORDERS: GENETICS, EPIGENOMICS, EXPRESSION, CIRCUITRY, FUNCTION
Guo-li Ming  (Perelman School of Medicine)
EPITRANSCRIPTOMIC REGULATION OF NEURAL DEVELOPMENT

Confirmed Invited Speakers:

Tim Bredy (University of Queensland)
LOCALIZED ACTIVITY OF SYNAPSE-ENRICHED LONG NONCODING RNAS SUPPORTS PLASTICITY AND MEMORY
Aleksandra Deczkowska (Institut Pasteur)
IMMUNE ACTIVITIES AT THE CHOROID PLEXUS SHAPE BRAIN FUNCTION THROUGHOUT LIFE.
Harrison Gabel (Washington University in St. Louis)
MECHANISMS OF NEURONAL DNA METHYLATION: ESTABLISHMENT, READ OUT, FUNCTION
Junjie Guo (Yale University School of Medicine)
ALTERNATIVE TRANSLATION OF NEURONAL mRNAs
Farah Lubin (University of Alabama at Birmingham)
THE ROLE OF DNA HYDROXYMETHYLATION IN THE CELLULAR AND MOLECULAR RESPONSE TO EPILEPSY
Ram Madabhushi (UT Southwestern)
DNA TOPOLOGY AND TOPOISOMERASES IN NEURONAL ACTIVITY-DEPENDENT TRANSCRIPTION
Kate Meyer (Duke University School of Medicine)
M6A-MEDIATED RNA REGULATION IN THE BRAIN
Alexi Nott (Imperial College London)
GENE REGULATORY LANDSCAPES OF BRAIN CELL-TYPES AND ASSOCIATIONS WITH DISEASE
Andreas Pfenning (Carnegie Mellon University)
Yin Shen (University of California, San Francisco)
CHARACTERIZE ALZHEIMER'S DISEASE GENETIC ASSOCIATION WITH MOLECULAR AND CELLULAR FUNCTION IN MICROGLIA
Yanhong Shi (City of Hope)
RNA MODIFICATION IN BRAIN DISORDERS.
Anne West (Duke University School of Medicine)
CHROMATIN REGULATION OF NEURONAL MATURATION