The conference will bring together scientists working to better understand nuclear and genome organisation in various organisms, tissues, and cell states.
 
Conference sessions will cover topics related to:

●    Nuclear and subnuclear structure and function
●    Nuclear organisation and chromosome topology in gene expression
●    Nuclear organisation and chromosome topology in DNA replication and repair
●    Crosstalk between transcription and repair
●    Impact of nuclear and genome organisation on genome editing
●    Genome editing technologies in the study of nuclear and genome structure and function
●    Nuclear bodies including the nucleolus, Cajal bodies, speckles, PML bodies
●    Constitutive and induced phase separation in the nucleus
●    Topologically associated domains and transcription in genome control
●    Signalling cues, cellular states and genome organisation
●    Genome organisation in pluripotency and during differentiation
●    Nuclear and genome structures in health, cancer, aging, and age-related diseases
●    Chromatin loops and non-canonical nucleic acids structures in genome expression and stability
●    Spatial genome organisation: from the bench to the bedside

Workshops will cover: Technical advances in the study of nuclear and genome organisation; The next frontiers in spatial genome organisation and its connection to health and disease; How to publish in the era of spatial genome organisation?

Confirmed Plenary Speakers

Ibrahim Cisse (Max Planck)
SUPER-RESOLUTION IMAGING OF TRANSCRIPTION IN LIVING CELLS
Marco Foiani (IFOM)
TOPOLOGICAL ARCHITECTURE OF THE YEAST GENOME
Roger Greenberg (University of Pennsylvania)
MOLECULAR PATTERNS FROM DNA DAMAGE TO IMMUNITY

Confirmed Invited Speakers

Jumana AlHaj Abed (Max Planck Institute)
HOW DO HOMOLOGOUS CHROMOSOMES COMMUNICATE?
Effie Apostolou (Weill Cornell Medicine)
3D REGULATORY HUBS CONTROL ONCOGENIC PROGRAMS
Samuel Bakhoum (Volastra Therapeutics / Geisel School of Medicine at Dartmouth)
THE IMPACT OF CHROMOSOMAL INSTABILITY ON CHROMATIN STRUCTURE AND DYNAMICS
Magda Bienko (Human Technopole/Karolinska Institutet)
CELL TYPE-SPECIFIC INTRONIC RNAs SHAPE GENOME ARCHITECTURE DURING NEURONAL LINEAGE SPECIFICATION
Tony Cesare (Children's Medical Research Institute)
NUCLEAR FILAMENTOUS ACTIN AND GENOME INTEGRITY
Jennifer Cremins (University of Pennsylvania)
LEARNING INDUCES PERSISTENT CHROMATIN LOOPS UNDERLYING ROBUST GENE EXPRESSION DURING MEMORY RECALL
Emmanuelle Fabre (St Louis Research Center (IRSL))
CHROMATIN DYNAMICS, OR HOW TO SHED LIGHT ON THE ROLE OF SMC5/6 
Catherine Freudenreich (Tufts University)
REPOSITIONING OF STRUCTURE-FORMING REPEATS TO THE NUCLEAR PERIPHERY: ROLE IN REPLICATION AND REPAIR
Taekjip Ha (Boston Children's Hospital)
DYNAMIC CTCF CONFORMATIONS CONTROL COHESIN BARRIER.
Razq Hakem (University of Toronto)
UNCOVERING NEW ROLES FOR RING FINGER PROTEINS IN GENOMIC STABILITY AND CANCER
Shane Harding (University of Toronto)
MICRONUCLEAR PROTEOMES AS A GUIDE TO REPLICATION ASSOCIATED DNA DAMAGE VULNERABILITIES
Jop Kind (Hubrecht Institute)
SPATIAL GENOME ORGANIZATION AND GENE REGULATION IN ORGANOGENESIS 
Christina Leslie (MSKCC)
DECODING ENHANCER REWIRING IN PANCREATIC DIFFERENTIATION
Anthony Leung (Johns Hopkins Medicine)
TRANSIENT POLY(ADP-RIBOSE) TRIGGERS FUS CONDENSATION PERSISTENCE
Marina Lusic (University of Heidelberg)
AQUARIUS AT THE CROSSROADS: R-LOOPS, SPLICING, AND HIV INTEGRATION
Peter Ly (UT Southwestern)
CHROMOTHRIPSIS AND GENOMIC INSTABILITY FROM MITOTIC ERRORS
Phillipp Maass (The Hospital for Sick Children)
INTER-CHROMOSOMAL CONTACTS DEMARCATE GENOME TOPOLOGY
Kristijan Ramadan (NTU)
NUCLEOPHAGY IN DNA REPAIR AND GENOME STABILITY
Ofer Rog (University of Utah)
REGULATING SISTER INTERACTIONS DURING MEIOSIS
Evi Soutoglou (University of Sussex)
DNA DAMAGE AT LAMINA ASSOCIATED DOMAINS TRIGGERS NUCLEAR ENVELOPE REORGANIZATION AND CHROMATIN DETACHMENT TO PREVENT NUCLEAR ENVELOPE BLEBBING AND GENOME INSTABILITY
Jessica Tyler (Weill Cornell Medicine)
IMPROVING GENOME STABILITY TO EXTEND LIFESPAN

Target Audience

This conference is of interest to researchers and scientists from academia and industry who are seeking to understand the basic principles of spatial genome organisation and how their disruption impacts health and disease, all within a beautiful and natural setting. Those interested in learning or developing new technologies that help reveal more of the secrets of spatial genome organisation should both benefit from and greatly enrich the conference. Attendees typically have a background in the basics of genetics, nuclear organisation, genome functions, microscopy, and sequencing.

Educational Need

This conference provides a unique opportunity for trainees interested in spatial genome organisation and the latest advances in this rapidly growing area of research from established and emerging leaders in the field. The conference also provides numerous scientific and social networking opportunities for trainees to discuss their research activities and career plans with others in the field.