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Past Conference

Osteoarthritis Therapeutics Conference 2015 - Targeting Metabolic & Oxidative Stress in Osteoarthritis

Date

08 Dec - 11 Dec 2015

Location

Budapest, Hungary

Early Bird - Expired  •  Talk Submission - Expired  •  Poster Submission - Expired  •  Registration & Payment Deadline - Expired

Synopsis

Osteoarthritis (OA) is a leading cause of disability in developed countries.  The World Health Organization estimates that 10% of men and 18% of women over age 60 suffer from this disease.  Presently we have no drugs that stop or even slow its progression.  

The Osteoarthritis Therapeutics Conference will focus on drug discovery for Osteoarthritis (OA).  This objective is responsive to a major societal need given the rapidly increasing impact of OA around the world and the present lack of effective medications to halt progression of this disease. 

In the Osteoarthritis Therapeutics Conference we will focus on a model of OA in which metabolic and oxidative stress is an early event that damages the articular cartilage matrix - rendering it vulnerable to subsequent mechanical stress.   Under these conditions, even the relatively physiological stresses of daily life can lead to degeneration of weakened cartilage and subsequent development of OA, a disease that affects all of the tissues of the joint.  

The metabolic syndrome, diabetes, cigarette smoking, joint trauma, and inflammatory diseases of joints represents conditions in which oxidative modifications of cartilage matrix proteins have been shown to occur. In this conference we will focus on basic oxidative injury mechanisms, the resulting alterations in protein structure and function, the biological mechanisms that protect against oxidative injury, the clinical consequences of oxidative modifications of cartilage matrix proteins, and potential strategies for intervening in these harmful processes through pharmacological means.

Most drug trials of compounds of potential benefit for individuals with OA have been tested in patients in whom collapse of the structural elements of the involved joints has already occurred.  The question will be addressed as to the possibility of designing trials that might intervene in the OA process at early stages of damage to the cartilage matrix.

The conference will bring together basic and translational scientists and drug discovery experts in an effort to explore new approaches to drug discovery in OA.  The goal is to facilitate a dialogue that will reenergize drug discovery in OA.

Key Sessions

  1. The societal impact of OA
  2. An overview of protein oxidative damage
  3. Advanced glycation end-products
  4. New insights into the role of inflammation in OA
  5. Autophagy and Proteostasis
  6. Assessment of oxidative injury in the clinical setting
  7. Therapeutic strategies to ameliorate metabolic and oxidative injury
  8. Regulatory considerations
  9. Mobilizing society to address chronic diseases 

Confirmed Plenary Speakers

Professor Martin Lotz (The Scripps Research Institute)
CELLULAR HOMEOSTASIS MECHANISMS AND PROTEIN AGGREGATION IN JOINT AGING AND OSTEOARTHRITIS

Professor Ali Mobasheri (The University of Surrey)
BIOMARKERS AS TOOLS FOR FACILITATING DRUG DISCOVERY FOR OSTEOARTHRITIS AND SURROGATE ENDPOINTS IN CLINICAL TRIALS

Dr. Gloria Matthews (Genzyme Corporation)

Dr. Rodney Levine (NIH)
OXIDATIVE MODIFICATION OF PROTEINS IN DISEASE AND AGING

Professor Jennifer Elisseeff (Johns Hopkins)
NEW STRATEGIES TO TARGET OA: REDUCING INFLAMMATION AND REBUILDING CARTILAGE.

Professor György Dormán (Szeged University)
HITTING THE RIGHT TARGET IN OESTEOARTHRITIS: ATTEMPTS TO SELECTIVELY INHIBITING MATRIX METALLOPROTEINASES

Dr. George R Dodge (Penn Medicine)
PLATFORMS TO STUDY MECHANISMS INVOLVED IN TRAUMATIC CARTILAGE INJURIES AND DISCOVERY OF POTENTIAL THERAPEUTICS FOR PTOA

Professor Francis Berenbaum (Pierre & Marie Curie University-INSERM)
OSTEOARTHRITIS: THE BRAIN-JOINT AXIS

Professor Sharmila Majumdar (UCSF)
QUANTITATIVE IMAGING BIOMARKERS IN UNDERSTANDING CARTILAGE, BONE AND MENISCUS DEGENERATION IN OSTEOARTHRITIS 

Professor Stefan Lohmander (Lunds University)
HUMAN JOINT INJURY: A MODEL FOR DEVELOPMENT OF OA THERAPY?

Prof. Dr. Christian Lattermann (University of Kentucky)
BIOMARKER CHANGES BEFORE AND AFTER ACL INJURY. A CLINICAL APPROACH TO DECIPHER TIMING OF PTOA ONSET AND TREATMENT 

Dr Ailis Tweed-Kent (Cocoon Biotech Inc)

Professor Alexandrina F Mendes (University of Coimbra)
DIABETES MELLITUS AS A RISK FACTOR FOR OSTEOARTHRITIS: MODULATION OF CHONDROCYTE FUNCTIONS BY HIGH GLUCOSE

Professor Di Chen (Rush University)
THE ROLE OF CARTILAGE Β-CATENIN SIGNALING IN THE PATHOGENESIS OF SPONDYLOARTHRITIS

Dr. Simon Blake (Janssen Research and Development)
THE POTENTIAL ROLE OF ADIPOKINES IN THE PATHOGENESIS OF OA

Dr. C. Kent Kwoh (The University of Arizona)

Confirmed Speakers

Chairs
Laura Santambrogio

Laura Santambrogio

Professor, Albert Einstein College of Medicine

John Hardin

John Hardin

Professor, Albert Einstein College of Medicine

Plenary Speakers
Ali Mobasheri

Ali Mobasheri

Professor of Musculoskeletal Physiology, University of Surrey

Martin Lotz

Martin Lotz

Professor, The Scripps Research Institute

Gloria Matthews

Gloria Matthews

Chief Medical Officer, Histogenics

Jennifer Elisseeff

Jennifer Elisseeff

Professor, Johns Hopkins University School of Medicine

Sharmila Majumdar

Sharmila Majumdar

Professor, University of California, San Francisco

Stefan Lohmander

Stefan Lohmander

Professor, Lund University

George Dodge

George Dodge

Associate Professor and Director, University of Pennsylvania / VA Translational Musculoskeletal Research Center

Rodney Levine

Rodney Levine

Senior Investigator, NIH

Alexandrina F Mendes

Alexandrina F Mendes

Professor, University of Coimbra

Christian Lattermann

Christian Lattermann

Professor, Vice Chair of Clinical Research, University of Kentucky, Dept Orthopaedic Surgery

György Dormán

György Dormán

Honorary Professor of Chemistry, University of Szeged

Di Chen

Di Chen

Professor, Rush University

Simon Blake

Simon Blake

Senior Director Scientific Licensing, Janssen Research and Development

Ailis Tweed-Kent

Ailis Tweed-Kent

CEO, Cocoon Biotech

C. Kent Kwoh

C. Kent Kwoh

Directer, University Arizona Arthritis Center, University of Arizona

Programme

 

Tuesday 8th December 2015

17:30 – 18:30

Registration

17:30 – 18:30

Welcome Drinks and Canapés

Session Chair: John Hardin

18:30 – 18:40

Opening Comments

 

18:40 – 19:10

Dr. John Hardin &
Professor Laura Santambrogio
Albert Einstein College of Medicine

OVERVIEW OF GOALS FOR THE WORKSHOP

19:10 – 19:40

Dr. Rodney Levine
NIH

OXIDATIVE MODIFICATION OF PROTEINS IN DISEASE AND AGING

19:40

Group Dinner (ICON Restaurant)

Wednesday 9th December 2015

07:00 – 09:00

Group Breakfast

Oxidative and Metabolic Stress
Session Chair: Laura Santambrogio

09:00 – 09:30

Professor Laura Santambrogio
Albert Einstein College of Medicine

CONSEQUENCES OF METABOLIC AND OXIDATIVE MODIFICATIONS OF CARTILAGE TISSUE

09:30 – 10:00

Dr. Gloria Matthews
Genzyme Corporation

GENE THERAPEUTIC APPROACHES TO TREATING OXIDATIVE STRESS IN ANIMAL MODELS OF OSTEOARTHRITIS

10:00 – 10:30

Refreshments (Ballroom Foyer)

10:30 – 11:00

Professor Alexandrina F Mendes
University of Coimbra

DIABETES MELLITUS AS A RISK FACTOR FOR OSTEOARTHRITIS: MODULATION OF CHONDROCYTE FUNCTIONS BY HIGH GLUCOSE

11:00 – 11:30

Professor Jennifer Elisseeff Johns Hopkins

NEW STRATEGIES TO TARGET OA: REDUCING INFLAMMATION AND REBUILDING CARTILAGE

11:30 – 13:30

Group Lunch (ICON Restaurant)

Biomarkers
Session Chair: Martin Lotz

13:30 – 14:00

Professor Martin Lotz
The Scripps Research Institute

CELLULAR HOMEOSTASIS MECHANISMS AND PROTEIN AGGREGATION IN JOINT AGING AND OSTEOARTHRITIS

14:00 – 14:30

Professor Sharmila Majumdar

UCSF

 

QUANTITATIVE IMAGING BIOMARKERS IN UNDERSTANDING CARTILAGE, BONE AND MENISCUS DEGENERATION IN OSTEOARTHRITIS

14:30 – 15:00

Professor Ali Mobasheri
The University of Surrey

BIOMARKERS AS TOOLS FOR FACILITATING DRUG DISCOVERY FOR OSTEOARTHRITIS AND SURROGATE ENDPOINTS IN CLINICAL TRIALS

15:00 – 15:20

Refreshments (Ballroom Foyer)

15:20 – 15:50

Professor Di Chen
Rush University

THE ROLE OF CARTILAGE Β-CATENIN SIGNALING IN THE PATHOGENESIS OF SPONDYLOARTHRITIS

15:50 – 16:10

Professor John Kisiday
Colorado State University

 

EFFECTS OF PRE- AND POST-SURIGICAL EQUINE SYNOVIAL FLUID ON THE GENERATION OF REACTIVE OXYGEN SPECIES AND CHONDROGENESIS OF EQUINE BONE MARROW MESENCHYMAL STEM CELLS

16:30 – 19:30

Group Activity to Budapest Christmas Market - Vörösmarty Square

19:30

Group Dinner (ICON Restaurant)

Thursday 10th December 2015

07:00 – 09:00

Group Breakfast

ACL Injury as a Platform for Drug Discovery in OA
Session Chair: Stefan Lohmander

09:00 – 09:30

Professor Stefan Lohmander
Lunds University

HUMAN JOINT INJURY: A MODEL FOR DEVELOPMENT OF OA THERAPY?

09:30 – 10:00

Prof. Dr. Christian Lattermann
University of Kentucky

BIOMARKER CHANGES BEFORE AND AFTER ACL INJURY. A CLINICAL APPROACH TO DECIPHER TIMING OF PTOA ONSET AND TREATMENT

10:00 – 10:30

Refreshments (Ballroom Foyer)

10:30 – 11:00

Professor Sharmila Majumdar
UCSF

CARTILAGE BIOCHEMICAL CHANGES AND ASSOCIATIONS WITH CARTILAGE LESIONS AFTER ACL INJURY: A MULTICENTER STUDY USING QUANTITATIVE MRI

11:00 – 11:30

Dr. C. Kent Kwoh
University of Arizona

IMAGING BIOMARKERS AND THEIR RELATIONSHIP TO KNEE OA DEVELOPMENT AND INCIDENT FREQUENT KNEE PAIN

11:30 – 12:00

Dr. George R Dodge
Penn Medicine

PLATFORMS TO STUDY MECHANISMS INVOLVED IN TRAUMATIC CARTILAGE INJURIES AND DISCOVERY OF POTENTIAL THERAPEUTICS FOR PTOA

12:00 – 16:00

Group Lunch & Free Time (ICON Restaurant)

13:30 – 15:30

Budapest Danube Boat Tour

Drug Discovery and Therapeutics
Session Chair: Ali Mobasheri

16:00 – 16:30

Dr. Simon Blake
Janssen Research and Development

THE POTENTIAL ROLE OF ADIPOKINES IN THE PATHOGENESIS OF OA

16:30 – 17:00

Dr. Ailis Tweed-Kent
Cocoon Biotech Inc

 

17:00 – 17:30

Refreshments (Ballroom Foyer)

17:30 – 18:00

Professor György Dormán Szeged University

HITTING THE RIGHT TARGET IN OESTEOARTHRITIS: ATTEMPTS TO SELECTIVELY INHIBITING MATRIX METALLOPROTEINASES

18:00 – 18:20

Dr. Janine Post
University of Twente

AN ECHO IN BIOLOGY: COMPUTER MODEL SUGGESTS OA THERAPEUTIC TARGETS

18:20 – 18:40

Mr. Pradeep Kumar Sacitharan
University of Oxford

LOSS OF SIRT1 IMPAIRS AUTOPHAGY AND IS ASSOCIATED WITH ACCELERATED EXPERIMENTAL OA

18:40 – 19:00

Miss. Rebecca Jones
The University of Manchester

THE CHONDROPROTECTIVE EFFECT OF UROCORTIN INVOLVES BLOCKADE OF A NON-SELECTIVE CATION CHANNEL THROUGH CRF RECEPTOR 1: NOVEL EXPLOITABLE PATHWAYS FOR THE TREATMENT AND PREVENTION OF OSTEOARTHRITIS?

19:00 – 22:00

*Gala Dinner & Group Photo* (Corvina)

Friday 11th December 2015

DEPARTURE

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Venue & Location

Hilton Budapest

The uniquely designed Hilton Budapest hotel is situated in a 13th Century Dominican Church with the Baroque façade of a 16th century Jesuit College. Set in the heart of the Royal Castle District- a UNESCO World Heritage Site, this Budapest hotel rests on the Buda side of the city, just steps from Matthias Church and Fisherman’s Bastion. The hotel combines world-class facilities and services with spectacular panoramic views towards the River Danube, the Hungarian Parliament and Margaret Island.

Throughout the conference period you will enjoy a delicious buffet breakfast, lunch and dinner. During each meal delegates are entitled to a choice of hot beverages, soft drinks plus one glass of house wine or beer during dinner. The themed Gala Night takes place on the third evening of the conference with a mouth-watering feast exclusively designed by the head chef and a live band. Complimentary drink tickets will be handed out upon arrival. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities:

  • 24-hour fitness center with jogging track, sauna, and masseuse
  • Complimentary WiFi access in public areas
  • Fantastic views over the River Danube and parliament
  • Foreign Currency Exchange
  • Barber Shop
  • Beauty Salon
  • Car Rental Desk
  • Laundry/Valet Service
  • Local Area Transportation
  • Lobby Café and Bar 
  • ATM Machine 
  • Gift Shop 
  • Business Center 

General Information

Venue Rating

★ ★ ★ ★ ★

Currency

Euro (EUR)

Address

Hess A. Ter 1-3, Budapest, H-1014, Hungary

Nearest Airport

Budapest Ferenc Liszt International Airport

Location

Budapest is cited as one of the most beautiful cities in Europe. Budapest's extensive World Heritage Site includes the banks of the Danube, the Buda Castle Quarter, Andrássy Avenue, Heroes' Square and the Millennium Underground Railway, the second-oldest metro line in the world. It has around 80 geothermal springs, the world's largest thermal water cave system, second largest synagogue, and third largest Parliament building. The city attracts about 4.3 million tourists a year, the 25th most popular city in the world, and the 6th in Europe, according to Euromonitor.

The Hotel is set in the heart of the Royal Castle District - a UNESCO World Heritage Site, the hotel rests on the Buda side of the city, just steps from Matthias Church and Fisherman's Bastion.

Budapest Ferenc Liszt International Airport is 24 km away from the Hilton Budapest and the drive time is approximately 40 minutes. 

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Media Partners

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Conference Manager

Laura Trundle

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