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Cancer Metabolism & the Tumour Microenvironment Conference
Importance of Inflammation and Stromal Cells
09 Nov - 12 Nov 2016
Paphos, Cyprus
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Michael Lisanti
University of Salford
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Federica Sotgia
University of Salford
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Synopsis
Cancer cells recruit normal cells such as endothelial cells, immune cells, adipocytes and fibroblasts, to establish a reactive tumour microenvironment. Researchers are rapidly expanding our knowledge of how cancer and stromal cells communicate, via metabolic changes and inflammation, and establish a symbiotic relationship that supports malignant progression and suppresses anti-tumour immunity.
Throughout the Cancer Metabolism and the Tumour Microenvironment meeting there will be an emphasis placed not only on the mechanisms underlying the metabolic crosstalk established between cancer cells and stromal cells, but also on the impact of context-specific metabolism on cancer development and progression, and on how to therapeutically target these metabolic processes in cancer.
This Cancer Metabolism meeting will bring together diverse researchers from the fields of cancer metabolism and stromal cell biology, providing an opportunity to discuss recent developments and new areas of cross-fertilization between those fields.
The main topics will include:
- Tumour microenvironment metabolic pathways and tumour progression
- Metabolism of circulating tumour cells and cancer stem cells
- Inflammation and cancer initiation
- Immune microenvironment and tumour progression
- Targeting metabolism for cancer therapy
Learning Objectives
This Cancer Metabolism conference will cover the major aspects of the metabolic transformation of cancer cells, such as in tumour-initiating cells and circulating tumour cells. The conference will also highlight the role of key stromal cell types, such as cancer-associated fibroblasts and cells of the immune system, emphasising novel therapeutic approaches.
Target Audience
Researchers and clinicians from the following specialty fields will be expected to attend, such as: cancer biology, translational medicine, cell biology, vascular biology, immunology, inflammation, medicinal chemistry, drug discovery, biomarker discovery, tumour microenvironment, metabolism, cancer stem cells and circulating tumour cells, among other fields.
Confirmed Speakers
Prof. Dr. Michael Lisanti (University of Manchester)
CANCER METABOLISM AND TUMOR HETEROGENEITY: MITOCHONDRIA IN CANCER STEM CELLS ARE A THERAPEUTIC TARGET
Dr. Federica Sotgia (University of Manchester)
UNDERSTANDING THE ROLE OF TELOMERASE IN CANCER STEM CELLS
Dr. Ubaldo E. Martinez Outschoorn (Thomas Jefferson University Hospitals)
HUMAN METABOLIC ECOSYSTEMS
Prof. Lluis Fajas (UNIL)
CELL CYCLE REGULATORS ARE MAJOR FACTORS IN ADAPTING THE MATABOLIC RESPONSE TO
Dr. Jacques Pouyssegur (University of Nice)
TARGETING BIOENERGETICS AND NUTRIENT SENSING IN HYPOXIC TUMOURS
Prof. Adrian Harris (Oxford University)
INTRATUMOUR HETEROGENEITY OF THE HYPOXIA RESPONSE, ROLES IN INVASION, METABOLISM, STEM CELL BIOLOGY AND DRUG RESPONSE
Prof. Pierre Sonveaux (Catholic University of Louvain)
POSITIONING AUTOPHAGY IN THE METABOLIC SYMBIOSIS BASED ON THE EXCHANGE OF LACTATE BETWEEN OXIDATIVE AND GLYCOLYTIC CANCER CELLS
Prof. Arne Östman (Karolinska Institute)
CAFS AND PERIVASCULAR CELLS; IMPACT ON PROGNOSIS AND RESPONSE TO TREATMENT
Prof. Isaac Witz (Tel Aviv University)
ASTROCYTES, BRAIN ENDOTHELIAL CELLS AND MICROGLIA RESPOND EQUALLY TO BRAIN-METASTASIZING MELANOMA CELLS AND TO STROKE
Dr. Myriam Fabre (Oncomatryx)
TARGETING TUMOR MICROENVIRONMENT TO TREAT INVASIVE TUMORS: OMTX705, A POWERFUL FAP-SPECIFIC ANTIBODY-DRUG CONJUGATE
Dr. Michelangelo Campanella (The Royal Veterinary College, London)
THE 18KDA PROTEIN TSPO INHIBITS MITOCHONDRIAL AUTOPHAGY AND UNDERPINS METABOLIC REPROGRAMMING OF BREAST CANCER CELLS
Dr. Balázs GyÅ‘rffy (Semmelweis University)
LINKING TP53 MUTATION TO ENERGY METABOLISM AND INCREASED GLYCOLYSIS IN BREAST CANCER
Assist. Prof. Ana Urbano (University of Coimbra)
METABOLIC ALTERATIONS PRODUCED BY HEXAVALENT CHROMIUM: INSIGHTS INTO THE MOLECULAR MECHANISMS UNDERLYING ITS CARCINOGENICITY
Dr. Balamurugan Kuppusamy (NIH/NCI)
THE CEBPD TRANSCRIPTION FACTOR, A MARKER OF GOOD PROGNOSIS IN BREAST CANCER, BECOMES A SIGNALING HUB FOR PROMOTION OF CANCER CELL STEMNESS BY HYPOXIA AND INTERLEUKIN-6
Mark Musters (Lead Pharma)
TARGETING TUMOUR METABOLISM BY INHIBITION OF NUCLEAR RECPTOR ERRα WITH SMALL MOLECULAR COMPOUNDS
Matthew Hirschey (Duke University)
ACTIVATING LIPID METABOLISM AS A CANCER THERAPY
Confirmed Speakers
Chairs
Michael Lisanti
Professor and Chair of Translational Medicine , University of Salford
Federica Sotgia
Senior Lecturer, University of Salford
Invited Speakers
Lluis Fajas
Director Department Physiology, UNIL
Adrian Harris
Professor of Medical Oncology, University of Oxford
Arne Östman
Professor, Karolinska Institutet
Isaac Witz
Prof. Lab Chief, Tel Aviv University
Jacques Pouyssegur
CNRS Research Director, University of Nice
Pierre Sonveaux
Prof., Université catholique de Louvain (UCL)
Ubaldo Martinez Outschoorn
Assistant Professor, Thomas Jefferson University
Myriam Fabre
R&D Director, Oncomatryx Biopharma, S.L.
Michelangelo Campanella
Reader in Pharmacology and Unit Head, The Royal Veterinary College, University of London and UCL Consortium for Mitochondrial Research
Ana Urbano
Assistant Professor, University of Coimbra
Balázs Győrffy
Assistant professor, MTA TTK
Mark Musters
Project leader / Scientist, Lead Pharma
Balamurugan Kuppusamy
Staff Scientist, National Cancer Institute/National Institutes of Health
Matthew Hirschey
Assoc. Professor, Duke University
Programme
THIS IS A PRELIMINARY PROGRAMME AND IS SUBJECT TO CHANGE.
WEDNESDAY 9TH NOVEMBER 2016 |
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14:00 – 15:00 |
Registration & Reception |
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14:00 – 14:45 |
Group Welcome Lunch |
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CANCER METABOLISM |
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14:45 – 15:00 |
Opening Comments |
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15:00 – 15:30 |
Michael Lisanti |
CANCER METABOLISM AND TUMOR HETEROGENEITY: MITOCHONDRIA IN CANCER STEM CELLS ARE A THERAPEUTIC TARGET |
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15:30 – 16:00 |
Adrian Harris |
INTRATUMOUR HETEROGENEITY OF THE HYPOXIA RESPONSE, ROLES IN INVASION, METABOLISM, STEM CELL BIOLOGY AND DRUG RESPONSE |
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16:00 – 16:30 |
Arne Ostman |
CAFS AND PERIVASCULAR CELLS; IMPACT ON PROGNOSIS AND RESPONSE TO TREATMENT |
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16:30 – 17:00 |
Dr. Jacques Pouyssegur |
TARGETING BIOENERGETICS AND NUTRIENT SENSING IN HYPOXIC TUMOURS |
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17:00 – 17:30 |
Refreshments |
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METABOLIC SYMBIOSIS AND REPROGRAMMING |
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17:30 – 18:00 |
Ubaldo E. Martinez Outschoorn |
HUMAN METABOLIC ECOSYSTEMS |
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18:00 – 18:30 |
Pierre Sonveaux |
POSITIONING AUTOPHAGY IN THE METABOLIC SYMBIOSIS BASED ON THE EXCHANGE OF LACTATE BETWEEN OXIDATIVE AND GLYCOLYTIC CANCER CELLS |
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18:30 – 19:00 |
Lluis Fajas |
CELL CYCLE REGULATORS ARE MAJOR FACTORS IN ADAPTING THE METABOLIC RESPONSE TO CANCER |
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19:00 – 19:30 |
Isaac Witz |
ASTROCYTES, BRAIN ENDOTHELIAL CELLS AND MICROGLIA RESPOND EQUALLY TO BRAIN-METASTASIZING MELANOMA CELLS AND TO STROKE |
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19:30 – 20:00 |
PM Panel Discussion |
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20:00 |
Group Dinner |
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THURSDAY 10TH NOVEMBER 2016 |
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07:00 – 08:30 |
Group Breakfast |
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METABOLISM, AUTOPHAGY AND THE TUMOR MICROENVIRONMENT |
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08:30 – 09:00 |
Federica Sotgia |
UNDERSTANDING THE ROLE OF TELOMERASE IN CANCER STEM CELLS |
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09:00 – 09:30 |
Michelangelo Campanella |
THE 18KDA PROTEIN TSPO INHIBITS MITOCHONDRIAL AUTOPHAGY AND UNDERPINS METABOLIC REPROGRAMMING OF BREAST CANCER CELLS |
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09:30 – 10:00 |
Myriam Fabre |
TARGETING TUMOR MICROENVIRONMENT TO TREAT INVASIVE TUMORS: OMTX705, A POWERFUL FAP-SPECIFIC ANTIBODY-DRUG CONJUGATE |
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10:00 – 10:30 |
Refreshments |
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10:30 – 11:00 |
Balázs GyÅ‘rffy |
LINKING TP53 MUTATION TO ENERGY METABOLISM AND INCREASED GLYCOLYSIS IN BREAST CANCER |
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11:00 – 11:30 |
Ana Urbano |
METABOLIC ALTERATIONS PRODUCED BY HEXAVALENT CHROMIUM: INSIGHTS INTO THE MOLECULAR MECHANISMS UNDERLYING ITS CARCINOGENICITY |
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11:30 – 12:00 |
AM Panel Discussion |
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12:00 – 16:30 |
Group Lunch & Free Time |
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13:00 – 16:00 |
Group Activity: Paphos Tombs of the Kings – Mosaics – Aphrodite’s Rock |
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NEW PROMISING TARGETS AND STRATEGIES FOR CANCER THERAPY |
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16:30 – 17:00 |
Mark Musters |
TARGETING TUMOUR METABOLISM BY INHIBITION OF NUCLEAR RECPTOR ERRα WITH SMALL MOLECULAR COMPOUNDS |
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17:00 – 17:30 |
Balamurugan Kuppusamy |
THE CEBPD TRANSCRIPTION FACTOR, A MARKER OF GOOD PROGNOSIS IN BREAST CANCER, BECOMES A SIGNALING HUB FOR PROMOTION OF CANCER CELL STEMNESS BY HYPOXIA AND INTERLEUKIN-6 |
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17:30 – 18:00 |
Matthew Hirschey |
ACTIVATING LIPID METABOLISM AS A CANCER THERAPY |
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18:00 – 18:30 |
Refreshments |
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18:30 – 19:00 |
Derek Radisky |
EPITHELIAL AND STROMAL ALTERATIONS THAT DRIVE BREAST CANCER PROGRESSION FROM BENIGN BREAST DISEASE |
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19:00 – 19:30 |
Paola Marignani |
IS METABOLISM THE INTERCEPT BETWEEN TUMOUR MICROENVIRONMENT AND EPIGENETIC CHANGES THAT SUPPORT CANCER? |
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19:30 – 20:00 |
PM Panel Discussion |
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20:00 |
Group Dinner |
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FRIDAY 11TH NOVEMBER 2016 |
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07:00 – 08:30 |
Group Breakfast |
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INFLAMMATION AND CANCER PROGRESSION |
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08:30 – 09:00 |
Petr Benes |
SUPPRESSION OF BREAST CANCER LUNG METASTASES BY INFLAMMATORY SIGNATURE TARGETED BY c-MYB |
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09:00 – 09:30 |
Adit Ben-Baruch |
INFLAMMATION-DRIVEN TUMOR-STROMA INTERACTIONS IN BREAST CANCER: REGULATION OF METABOLIC AND PRO-TUMORAL TRAITS OF MESENCHYMAL STEM CELLS |
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09:30 – 10:00 |
Si Chen |
INFLAMMATORY NICHE SIGNALLING DRIVES GENOTOXIC STRESS IN HEMATOPOIETIC STEM CELLS AND PREDICTS LEUKEMIC EVOLUTION IN HUMAN LEUKEMIA PREDISPOSITION SYNDROMES |
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10:00 – 10:30 |
AM Panel Discussion |
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10:30 – 11:00 |
Refreshments |
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11:45 – 17:00 |
Group Lunch & Free Time |
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12:45 – 16:30 |
Group Activity: Wine Tasting at Chryssogoriatissa Monasteries – Agios Neophytos |
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MITOCHONDRIA IN CANCER PATHOGENESIS |
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17:00 – 17:30 |
Mike Berridge |
MITOCHONDRIAL TRANSFER FROM THE MICROENVIRONMENT FACILITATES GROWTH AND METASTASIS OF TUMOUR CELLS WITHOUT MITOCHONDRIAL DNA |
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17:30 – 18:00 |
Igal Madar |
18F-FBNTP - A NOVEL BIOMARKER FOR DIFFERENTIAL IMAGING OF OXIDATIVE AND NON-OXIDATIVE MICROREGIONS IN BREAST TUMOR |
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18:00 – 18:30 |
PM Panel Discussion |
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18:30 – 19:30 |
Refreshments |
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20:00 |
*Gala Dinner & Group Photo* |
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SATURDAY 12TH NOVEMBER 2016 |
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07:00 – 08:30 |
Group Breakfast |
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MYC AND INTEGRINS AS THERAPEUTIC TARGETS |
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08:30 – 09:00 |
Juha Klefstrom |
REACTIVATING MYC APOPTOSIS PATHWAY IN BREAST CANCER
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09:00 – 09:30 |
Jai Prakash |
INTEGRIN ALPHA5: A KEY PROGNOSTIC AND THERAPEUTIC TARGET IN PANCREATIC TUMOR STROMA |
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09:30 – 09:45 |
Maria Rosaria Ambrosio |
GLUCOSE IMPAIRS TAMOXIFEN RESPONSIVENESS MODULATING CTGF (Connective Tissue Growth Factor) IN BREAST CANCER CELLS |
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09:45 – 10:00 |
Vadim Pokrovsky |
ANTICANCER ACTIVITY OF L-LYSINE ALPHA-OXIDASE FROM TRICHODERMA CF. AUREOVIRIDE RIFAI |
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10:00 – 10:30 |
AM Panel Discussion |
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10:30 – 10:45 |
Closing Comments |
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10:45 – 11:45 |
Refreshments |
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Venue & Location
Annabelle
The Annabelle is a family-run oasis set within six acres of lush gardens on Paphos’ Mediterranean sea front.
Cool, peaceful interiors, understated design and warm, caring service combined with 5 star luxury to create a distinct atmosphere of unpretentious elegance.
The Annabelle is the closest hotel to Paphos’ picturesque medieval castle and harbour, yet its seafront gardens, outstanding cuisine and impeccable service have earned it a reputation as one of the town’s best-loved retreats.
Hotel Facilities:
- Fitness Centre with Gym
- Four Restaurants and Five Bars
- Complimentary WiFi access in public areas
- Room Service
- Floodlit Tennis Court and Squash Court
- Spa
- Free Parking
- Laundry/Valet Service
- Business Centre with Internet Access
- Self-Serve Laundry
- Children Activities ( Kid / Family Friendly )
- Shuttle Bus Service
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General Information
Venue Rating
★ ★ ★ ★ ★
Currency
Great Britain Pound (GBP)
Address
Annabelle 10, Poseidonos Avenue 8042 Paphos
Nearest Airport
Paphos International Airport
Location
Paphos is a coastal city in the southwest of Cyprus and the capital of Paphos District. In antiquity, two locations were called Paphos: Old Paphos and New Paphos. The currently inhabited city, New Paphos, lies on the Mediterranean coast, about 50 km (31.07 mi) west of Limassol (the biggest port on the island).
Paphos is also the mythical birthplace of Aphrodite and is an open air museum of Byzantine churches and Roman ruins interspersed with al fresco restaurants and café bars.
The Annabelle is the closest hotel to Paphos’s picturesque fishing harbour, ancient port and the UNESCO-listed House of Dionysos, containing Cyprus’s world-renowned Roman mosaics.
Paphos International Airport is the country's second-largest airport and is 16 km away from The Annabelle. The drive time is approximately 20 minutes.
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