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Cell Death, Cell Stress & Metabolism Conference
From Basic Mechanisms to Novel Treatment Options
14 Mar - 17 Mar 2017
Cancun, Mexico
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Synopsis
The interplay between cell death, cell stress and metabolism plays a crucial role in shaping normal turnover of tissues, in sensing of danger posed by pathogens or other damage and the immunological response that is mounted to response to them.
At this conference we will discuss the basic biological principles that govern cell death, cell stress and metabolism. We will also cover how cellular stress and alterations in metabolism influence the cellular death programs such as apoptosis, necroptosis, ferroptosis and others.
Importantly, this conference aims to become the go-to forum at which the most current and up-to-date therapeutic avenues in the fields of cell death, cell stress and metabolism will be presented and discussed.
Target Audience
We anticipate representation from researchers interested in cell death, cell stress and metabolism in both academia and the biotech/pharma industries who want to be on top of these interconnected fields and participate in an international meeting serving as platform for presentation and discussion of the most up-to-date preclinical and clinical work emerging from them.
Learning Objectives
- To be on top of the field with the diversity of new mechanisms of cell death induction, in addition to apoptosis, which recently entered this field of research
- To understand the interplay between cell death, cell stress and metabolism
- To develop an understanding for where the treatment options are currently seen in these fields
- To learn what is presently being developed preclinically and what is already in clinical trials
- To develop a good sense for where the opportunities for the future lie, both with respect of mechanistic insight and treatment options for the various diseases affected by dysregulated cell death, cell stress and metabolism
Invited Speakers
Henning Walczak (UCL Cancer Institute)
"LINEAR UBIQUITIN IN CELL DEATH, INFLAMMATION AND IMMUNITY"
Poul Sorensen (BC Cancer Research Centre)
"STRESS-MEDIATED TRANSLATIONAL CONTROL OF TUMOR METASTASIS”
Vishva Dixit (Genentech)
"WHY SO MANY WAYS TO DIE? THE NON-CANONICAL INFLAMMASOME PATHWAY"
Douglas Green (St. Jude Children's Research Hospital)
"CELL DEATH AND RESUSCITATION: TO THE EDGE OF NECROPTOSIS AND BACK"
Karen Vousden (CRUK, Glasgow)
"A ROLE FOR p53 IN RESPONSE TO METABOLIC STRESS"
Manolis Pasparakis (University of Cologne)
"RIPK1 IN CELL DEATH AND INFLAMMATION"
Michael Karin (UCSD)
"METABOLISM, INFLAMMATION AND IMMUNITY IN LIVER CANCER"
Celeste Simon (University of Pennsylvania)
"STRIKING A BALANCE BETWEEN CELLULAR GROWTH AND HOMEOSTASIS"
Scott Lowe (MSKCC)
"TUMOR SUPPRESSOR AND TUMOR MAINTENANCE GENES"
Jiri Bartek (Danish Cancer Society)
"REPLICATION STRESS: MECHANISMS AND RELEVANCE FOR CANCER DEVELOPMENT AND TREATMENT"
Navdeep Chandel (Northwestern University)
"WHY MAMMALIAN CELLS RESPIRE?"
Ralph Deberardinis (UT Southwestern)
"METABOLIC PHENOTYPES AND VULNERABILITIES IN CANCER CELLS"
Gerry Melino (MRC Toxicology Unit Leicester, University of Rome – Tor Vergata Italy)
"THE p53 FAMILY IN CANCER BIOLOGY"
Andreas Linkermann (Universitätsklinikum Carl Gustav Carus)
"HUMAN pMLKL AND ESCRT-EXPRESSION IN ACUTE KIDNEY INJURY AND KIDNEY TRANSPLANTATION"
Brent Derry (University of Toronto)
"YOUR NEIGHBOURS MATTER! NON-AUTONOMOUS CONTROL OF CELL DEATH IN C. elegans”
Atan Gross (Weizmann Institute of Science)
"THE MANY FACES OF MITOCHONDRIA"
William Kaiser (University of Texas Health Science Center San Antonio)
"DAI’ING TO FIGHT HERPESVIRUSES"
Pascal Meier (the Institute of Cancer Research)
'UBIQUITIN-MEDIATED REGULATION OF CELL DEATH AND INFLAMMATION'
Ana J. García-Sáez (University of Tübingen)
"NECROPTOSIS EXECUTION IS MEDIATED BY PLASMA MEMBRANE NANOPORES INDEPENDENT OF CALCIUM"
Mads Daugaard (University of British Columbia)
"GLYCOSAMINOGLYCANS IN CANCER"
Claudio Mauro (William Harvey Research Institute)
“LOCAL AND SYSTEMIC METABOLIC CONTROL OF THE ADAPTIVE IMMUNE RESPONSE”
Will Wood (University of Bristol)
‘DETECTING DEATH AND DAMAGE; MACROPHAGE MIGRATION IN DROSOPHILA’
Ivan Topisirovic (McGill University)
EXPLOITING CROSS-TALK BETWEEN THE TRANSLATION APPARATUS AND THE METABOLOME IN CANCER
Mike Overholtzer (MSKCC)
"CELL POPULATION EFFECTS OF FERROPTOSIS AND ENTOSIS"
Scott Dixon (Stanford University)
"FERROPTOSIS: AN UNUSUAL FORM OF METABOLIC STRESS-INDUCED CELL DEATH"
Lars Jønson (Roche Innovation Center Copenhagen)
"RNA THERAPEUTICS - DEVELOPING A NEW CLASS OF DRUGS"
Michael Pollak (McGill University)
"A NEW METFORMIN – P53 LINK"
Confirmed Speakers
Chairs
Invited Speakers
Manolis Pasparakis
Professor, University of Cologne
Karen Vousden
Senior Group Leader, The Francis Crick Institute
Celeste Simon
Scientific Director and Professor, University of Pennsylvania Perelman School of Medicine
Navdeep Chandel
Professor of Medicine, Feinberg School of Medicine, Northwestern University
Jiri Bartek
Department Head, Danish Cancer Society
Michael Karin
Distinguished Professor of Pharmacology, UC San Diego
Ralph DeBerardinis
Associate Professor, UT Southwestern Medical Center
Douglas Green
Member and Chair, St Jude Children's Research Hospital
Scott Lowe
Chair, Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center
Atan Gross
Associate Professor, Weizmann Institute
Brent Derry
Senior Scientist, The Hospital for Sick Children
Mads Daugaard
Senior Research Scientist, Vancouver Prostate Centre
Will Wood
Professor, University of Bristol
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Ivan Topisirovic
Investigator/Associate Professor, Lady Davis Institute/McGill University
Scott Dixon
Associate Professor, Stanford University
Lars Joenson
Principal Scientist, Roche Pharma Research & Early Development, Roche Innovation Center Copenhagen
Ana J. Garcia Saez
Professor, University of Tuebingen
Andreas Linkermann
Deputy Director - Department of Nephrology, UKD Dresden
Claudio Mauro
Professor of Metabolism and Inflammation (Professorial Fellow), Univ of Birmingham
Pascal Meier
Professor, Institute of Cancer Research
Michael Overholtzer
Associate Professor, Memorial Sloan Kettering Cancer Center
Michael Pollak
Oncologist, Jewish General Hospital
Gerry Melino
Head of 'Apoptosis & Cancer' Section, MRC Toxicology Unit Leicester, University of Rome – Tor Vergata Italy
Programme
TUESDAY 14TH MARCH 2017 |
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14:00 – 14:45 |
Registration & Reception |
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14:00 – 14:45 |
Group Welcome Lunch |
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CELL DEATH, CELL STRESS & METABOLISM I |
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14:45 – 15:00 |
Opening Comments by Henning Walczak & Poul Sorensen |
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15:00 – 15:30 |
Will Wood |
DETECTING DEATH AND DAMAGE: MACROPHAGE MIGRATION IN DROSOPHILA |
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15:30 – 16:00 |
Manolis Pasparakis |
RIPK1 IN CELL DEATH AND INFLAMMATION |
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16:00 – 16:30 |
Michelle Kelliher |
ENDOTHELIAL RIPK1 IN TNF-INDUCED ENDOTOXIC SHOCK |
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16:30 – 17:00 |
Pascal Meier |
UBIQUITIN-MEDIATED REGULATION OF CELL DEATH AND INFLAMMATION |
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17:00 – 17:30 |
Refreshments |
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17:30 – 18:00 |
Henning Walczak |
DEATH RECEPTORS AND UBIQUITIN IN INFLAMMATION, IMMUNITY AND CANCER |
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18:00 – 18:15 |
Maurice Darding |
DEFICIENCY IN THE DIFFERENT LUBAC COMPONENTS: A SURPRISE IN THREE ACTS |
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18:15 – 18:30 |
Beiyun Liu |
HOST-INTRINSIC IFN DRIVES TWO FORMS OF LPS-INDUCED NECROTIC CELL DEATH |
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18:30 – 19:00 |
Ralph Deberardinis |
METABOLIC PHENOTYPES AND VULNERABILITIES IN CANCER |
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19:00 – 19:15 |
Erik Norberg |
PHGDH DEFINES A METABOLIC SUBTYPE IN LUNG CANCER ADENOCARCINOMAS WITH POOR PROGNOSIS DISPLAYING UNIQUE METABOLIC DEPENDENCIES |
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19:15 – 19:45 |
Atan Gross |
THE MANY FACES OF MITOCHONDRIA |
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19:45 – 20:15 |
Michael Karin |
METABOLISM, INFLAMMATION AND IMMUNITY IN LIVER CANCER |
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20:15 |
Drinks at the Lobby Bar followed by Dinner at Leisure & Free Time |
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WEDNESDAY 15TH MARCH 2017 |
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07:00 – 09:00 |
Breakfast |
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CELL DEATH, CELL STRESS & METABOLISM II |
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09:00 – 09:30 |
Robin Aglietti |
WHY SO MANY WAYS TO DIE? THE NON-CANONICAL INFLAMMASOME PATHWAY |
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09:30 – 10:00 |
Poul Sorensen |
STRESS-MEDIATED TRANSLATIONAL CONTROL OF TUMOR METASTASIS |
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10:00 – 10:15 |
Bo Rafn |
ETV6-NTRK3 REGULATION OF OXIDATIVE STRESS IN BREAST CANCER |
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10:15 – 10:45 |
Refreshments & Group Photo |
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10:45 – 11:15 |
Ana Garcia Saez |
NECROPTOSIS EXECUTION IS MEDIATED BY PLASMA MEMBRANE NANOPORES INDEPENDENT OF CALCIUM |
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11:15 – 11:30 |
Sam Katz |
BOK CONTROLS CALCIUM TRANSFER THROUGH ER-MITOCHONDRIAL CONTACT SITES |
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11:30 – 11:45 |
Reuven Stein |
TARGETING CD38 IN THE TUMOR MICROENVIRONMENT INHIBITS GLIOMA AND MELANOMA PROGRESSION |
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11:45 – 12:15 |
Navdeep Chandel |
WHY MAMMALIAN CELL RESPIRE |
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12:15 – 16:30 |
Lunch at Leisure & Free Time |
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16:30 – 17:00 |
Michael Pollack |
A NEW METFORMIN-P53 LINK |
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17:00 – 17:15 |
Iñigo San-Millán |
REEXAMINING CANCER METABOLISM: LACTATE PRODUCTION FOR CARCINOGENESIS AS THE PURPOSE AND EXPLANATION OF THE WARBURG EFFECT |
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17:15 – 17:45 |
Ivan Topisirovic |
EXPLOITING CROSSTALK BETWEEN THE TRANSLATION APPARATUS AND THE METABOLOME IN CANCER |
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17:45 – 18:00 |
Laura Hulea |
EIF4F LINKS TRANSLATION TO ENERGY STRESS RESPONSE IN CANCER |
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18:00 – 18:30 |
Claudio Mauro |
LOCAL AND SYSTEMIC METABOLIC CONTROL OF THE ADAPTIVE IMMUNE RESPONSE |
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18:30 – 19:00 |
Refreshments |
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19:00 – 19:30 |
Brent Derry |
YOUR NEIGHBORS MATTER! NON-AUTONOMOUS CONTROL OF CELL DEATH IN C. ELEGANS |
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19:30 – 20:00 |
Jiri Bartek |
REPLICATION STRESS: MECHANISMS AND RELEVANCE FOR CANCER DEVELOPMENT AND TREAT |
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20:00 – 20:15 |
Denise Montell |
ANASTASIS: RECOVERY FROM THE BRINK OF DEATH |
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20:15 – 20:45 |
Doug Green |
CELL DEATH AND RESUSCITATION: TO THE EDGE OF NECROPTOSIS AND BACK |
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20:45 |
Dinner at Leisure & Free Time |
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THURSDAY 16TH MARCH 2017 |
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07:00 – 09:00 |
Breakfast |
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CELL DEATH, CELL STRESS & METABOLISM III |
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09.00 – 09:30 |
Karen Vousden |
A ROLE FOR P53 IN RESPONSE TO METABOLIC STRESS |
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09:30 – 10:00 |
Gerry Melino |
THE P53 FAMILY IN CANCER BIOLOGY |
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10:00 – 10:30 |
Mads Daugaard |
GLYCOSAMINOGLYCANS IN CANCER |
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10:30 – 10:45 |
Davide Tortora |
AN ONCOFETAL GLYCOSAMINOGLYCAN MODIFICATION PROVIDES THERAPEUTIC ACCESS TO MESOTHELIOMA |
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10:45 – 11:15 |
Refreshments |
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11:15 – 11:45 |
Mike Overholtzer |
CELL POPULATION EFFECTS OF FERROPTOSIS AND ENTOSIS |
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11:45 – 12:00 |
Shefali Krishna |
METABOLIC CONSEQUENCES OF ENTOTIC AND APOPTOTIC CELL CLEARANCE |
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12:00 – 12:30 |
Scott Dixon |
FERROPTOSIS: AN UNUSUAL FORM OF METABOLIC STRESS-INDUCED CELL DEATH |
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12:30 – 12:45 |
Amy Tarangelo |
INVESTIGATING THE ROLE OF P53 IN NON-APOPTOTIC CELL DEATH |
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12:45 – 16:30 |
Lunch at Leisure & Free Time |
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16:30 – 17:00 |
Andreas Linkermann |
HUMAN PMLKL AND ECRT EXPRESSION IN ACUTE KIDNEY INJURY AND KIDNEY TRANSPLANTATION |
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17:00 – 17:15 |
Corey Rogers |
CLEAVAGE OF DFNA5 BY CASPASE-3 MEDIATES PROGRESSION FROM APOPTOSIS TO SECONDARY NECROSIS |
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17:15 – 17:30 |
Kirill Rosen |
THE AUTOPHAGY MEDIATOR ATG12 AS A KILLER OF ONCOGENIC RAS-CARRYING CANCER CELLS |
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17:30 – 17:50 |
Lars Joenson |
RNA THERAPEUTICS – DEVELOPING A NEW CLASS OF DRUGS |
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17:50 – 18:20 |
Scott Lowe |
TUMOR SUPPRESSOR AND TUMOR MAINTENANCE GENES |
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18:20 – 18:50 |
Celeste Simon |
STRIKING A BALANCE BETWEEN CELLULAR GROWTH AND METABOLISM |
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18:50 – 20:00 |
Poster Session & Refreshments |
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20:00 |
*Gala Dinner & Poster Awards* |
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Supported by
Venue & Location
Fiesta Americana Condesa
This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
Hotel Facilities
- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
The Fiesta Americana Condesa, Cancun is the 2015 Winner of the Trip Advisor Certificate of Excellence and also received the Travellers Choice Award in 2014.
The remains of ancient Mayan cities are scattered throughout the Yucatan Peninsula and no trip to Cancun would be complete without a visit to these majestic temples and pyramids set amongst lush tropical vegetation. We will be working very closely with a reputable tour company who will be organising trips to Tulum, Chichen Itza, Coba and Xcaret to name a few, some of which may require a full day. Full day excursions will be arranged pre or post conference and may be on an individual or group booking so we would recommend booking extra nights to extend your stay as early as possible to avoid disappointment should these excursions be of interest to you and/or your party. For further information please contact us.
General Information
Venue Rating
★ ★ ★ ★ ★
Currency
US Dollar (USD)
Address
Fiesta Americana Condesa, Blvd.Kukulkán km 16.5 Zona Hotelera, Cancun, 77500 Mexico
Nearest Airport
Cancun International Airport
Location
Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.
Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.
Gallery
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Conference Manager
Emily Meen
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