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2nd Cell Death, Cell Stress & Metabolism Conference
From Basic Mechanisms to Novel Treatment Options
27 May - 30 May 2019
Puerto Vallarta, Mexico
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Synopsis
The interplay between cell death, cell stress and metabolism plays a crucial role in shaping normal turnover of tissues, in sensing of danger posed by pathogens or other damage and the immunological response that is mounted to response to them. At this conference we will discuss the basic biological principles that govern cell death, cell stress and metabolism. We will also cover how cellular stress and alterations in metabolism influence the cellular death programs such as apoptosis, necroptosis, ferroptosis and others. Importantly, this conference aims to become the go-to forum at which the most current and up-to-date therapeutic avenues in the fields of cell death, cell stress and metabolism will be presented and discussed.
For those interested, this meeting follows the Metabolism in Health and Disease Conference, taking place from 24 - 27 May 2019 at the same venue.
Student Offer
Take advantage of this fantastic opportunity for students! Register an academic at the standard rate of $1,775 and bring a student for only $700. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 27, 28 and 29 May 2019 (on a shared basis for students) and food and beverage package for the conference period. Academic registrations must be completed by 10th May 2019. Once registered, please contact Chloe Trundle to obtain a special registration link for your student.
Confirmed Invited Speakers:
Martin Aichinger (Boehringer Ingelheim)
TARGETING IAP IN CANCER: FROM CELL DEATH INDUCTION TO IMMUNE CELL ACTIVATION
Matthew Albert (Insitro)
CHEMOTHERAPY INDUCED DNA DAMAGE ENHANCES THE IMMUNOGENICITY OF DYING CELLS
Alessandro Annibaldi (Queen Mary University of London)
CHECKPOINTS IN TNF-INDUCED CELL DEATH
Petr Broz (University of Lausanne)
GBPS AND CASPASE-4 ASSEMBLE THE NON-CANONICAL INFLAMMASOME AT THE OUTER MEMBRANE OF CYTOSOLIC BACTERIA
Mathieu Bertrand (Ghent University)
REGULATION OF RIPK1-DEPENDENT CELL DEATH IN MODELS OF INFECTION AND INFLAMMATION
Francis Chan (Duke University)
PARADOXICAL ROLES OF RIP KINASES IN INJURY-INDUCED INFLAMMATION
Ralph Deberardinis (UT Southwestern Medical Center)
METABOLIC REPROGRAMMING IN HUMAN DISEASES
Shoukat Dedhar (BC Cancer Agency)
HYPOXIA AND ACIDOSIS MEDIATED STRESS SIGNALING: TARGETING CARBONIC ANHYDRASE IX/XII
Vishva Dixit (Genentech)
NON - CANONICAL INFLAMMASOME PATHWAY
Scott Dixon (University of Stanford)
A NOVEL MECHANISM OF NON-APOPTOTIC LIPOTOXICITY
Gerard Evan (University of Cambridge)
BUILDING AND KILLING CANCERS
Ana García-Sáez (University of Tübingen)
STRUCTURAL REARRANGEMENTS DURING MLKL ACTIVATION
Kairbaan Hodivala-Dilke (Barts Cancer Institute)
SURPRISES FROM TARGETING THE TUMOUR MICROENVIRONMENT
Philipp Jost (Technical University of Munich)
XIAP PROTECTS AGAINST TNF RECEPTOR-DEPENDENT INFLAMMATION IN INTESTINAL HOMEOSTASIS
Andreas Linkermann (University Hospital Dresden)
REGULATED NECROSIS IN ISCHEMIC TISSUES
Scott Lowe (Memorial Sloan Kettering Cancer Center)
RESTORING TUMOR SUPPRESSION IN ADVANCED CANCERS
Najoua Lalaoui (Walter and Eliza Hall Institute of Medical Research)
MUTATIONS THAT PREVENT CASPASE-8 CLEAVAGE OF RIPK1 CAUSE INFLAMMATION IN HUMANS AND MOUSE
Claudio Mauro (University of Birmingham)
METABOLITE-MEDIATED REGULATION OF INFLAMMATION
Cristina Muñoz Pinedo (IDIBELL)
CELL-CELL RESPONSES TO STARVATION
Lynne-Marie Postovit (University of Alberta)
TRANSLATIONAL CONTROL OF BREAST CANCER PLASTICITY
Shigekazu Nagata (Osaka University)
PHOSPHOLIPID FLIPPASE AND SCRAMBLASE
Andrew Oberst (University of Washington)
NECROPTOSIS WITHOUT CELL DEATH: HOW THE RIP KINASES CONTROL VIRAL INFECTION IN THE BRAIN
Davide Ruggero (University of California, San Francisco)
TRANSLATING THE CANCER GENOME ONE CODON AT A TIME AND ITS THERAPEUTIC IMPLICATIONS.
Massimo Santoro (University of Padua)
REDOX METABOLISM IN ANGIOGENESIS AND CANCER PROGRESSION
Nahum Sonenberg (McGill University)
TRANSLATIONAL CONTROL OF CANCER BY EIF4E VIA THE PI3K/MTOR AND RAS/MAPK PATHWAYS
Stephen Tait (University of Glasgow)
FIRST AMONG EQUALS - MITOCHONDRIAL HETEROGENEITY, CELL DEATH AND CANCER
Ivan Topirisovic (McGill University)
TRANSLATIONAL REGULATION OF METABOLIC PLASTICITY
Domagoj Vucic (Genentech)
REGULATION OF INFLAMMATORY CELL DEATH SIGNALING BY RIP KINASES
Tom Vanden Berghe (Universiteit Antwerpen)
FERROPTOSIS AND INFLAMMATION RESEARCH IN CRITICAL ILLNESS
Christine Watson (University of Cambridge)
CELL DEATH INITIATES DYNAMIC ARCHITECTURAL CHANGES IN THE EPITHELIUM AND ASSOCIATED IMMUNE CELLS AND VASCULATURE DURING MAMMARY GLAND INVOLUTION
Target Audience
From basic researchers interested in cell death all the way to people in the biotech and pharma industries who would like to be on top of these fields and want to form part of a meeting which is specifically geared towards providing a platform for the presentation and discussion of the most up-to-date preclinical and clinical work in these fields.
Confirmed Speakers
Chairs
Invited Speakers
Andrew Oberst
Associate Professor, University of Washington, Department of Immunology
Stephen Tait
Group Leader, Cancer Research UK Beatson Institute
Nahum Sonenberg
Gilman Cheney Chair in Biochemistry, McGill University
Gerard Evan
Head of Department, University of Cambridge, Department of Biochemistry
Shoukat Dedhar
Distinguished Scientist, BC Cancer Research Centre
Lynne-Marie Postovit
Associate professor, University of Alberta
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Ivan Topisirovic
Investigator/Associate Professor, Lady Davis Institute/McGill University
Vishva Dixit
Vice President, Research, Genentech Inc
Claudio Mauro
Professor of Metabolism and Inflammation (Professorial Fellow), Univ of Birmingham
Scott Dixon
Associate Professor, Stanford University
Francis Chan
Professor, Duke University
Petr Broz
Professor, Univeristy of Lausanne
Davide Ruggero
Professor, UCSF
Ralph DeBerardinis
Associate Professor, UT Southwestern Medical Center
Christine Watson
Professor of Cell and Cancer Biology, University of Cambridge
Alessandro Annibaldi
Junior Research Group Leader, Center for Molecular Medicine Cologne
Tom Vanden Berghe
Assistant Professor, University of Antwerp
Massimo Santoro
Full Professor, University of Padua
Ana J. Garcia Saez
Professor, University of Tuebingen
Kairbaan Hodivala-Dilke
Deputy Director,, Barts Cancer Institute (Centre for Tumour Biology)
Martin Aichinger
Principal Scientist, Boehringer Ingelheim RCV GmbH & Co KG
Shigekazu Nagata
Distinguished Professor, Immunology Frontier Research Center, Osaka University
Domagoj Vucic
Senior Fellow, Genentech
Cristina Muñoz-Pinedo
Group leader, IDIBELL
Andreas Linkermann
Deputy Director - Department of Nephrology, UKD Dresden
Philipp Jost
Consultant, Technical University of Munich
Mathieu Bertrand
Associate Professor, VIB Center for Inflammation Research / Ghent university
Scott Lowe
Chair, Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center
Matthew Albert
VP, Immunology and Infectious Diseases, insitro
Najoua Lalaoui
Senior Postdoc, The Walter and Eliza Hall Institute of Medical Research
Programme
MONDAY 27TH MAY 2019 |
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14:00 – 15:00 |
Registration & Welcome Reception |
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Tumor Metabolism and Cell Intrinsic Pathways |
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15:00 – 15:10 |
Opening Comments |
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15:10 – 15:35 |
Ralph Deberardinis |
METABOLIC REPROGRAMMING IN HUMAN DISEASES |
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15:35 – 16:00 |
Cristina Muñoz Pinedo |
CELL-CELL RESPONSES TO STARVATION: INFLAMMATION |
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16:00 – 16:25 |
Claudio Mauro |
METABOLITE-MEDIATED REGULATION OF INFLAMMATION |
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16:25 – 16:50 |
Shigekazu Nagata |
PHOSPHOLIPID FLIPPASE AND SCRAMBLASE |
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16:50 – 17:35 |
Refreshments |
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17:35 – 18:10 |
Poster Presenter Short Teaser Talks |
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18:10 – 18:35 |
Vishva Dixit |
NON - CANONICAL INFLAMMASOME PATHWAY |
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18:35 – 19:00 |
Scott Lowe |
RESTORING TUMOR SUPPRESSION IN ADVANCED CANCERS |
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19:00 – 19:15 |
Rute Ferreira |
CD9 IDENTIFIES PANCREATIC CANCER STEM CELLS AND MODULATES GLUTAMINE METABOLISM TO FUEL TUMOUR GROWTH |
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19:15 – 19:40 |
Gerard Evan |
BUILDING AND KILLING CANCERS |
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19:40 |
Group Dinner |
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TUESDAY 28TH MAY 2019 |
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07:00 – 08:45 |
Buffet Breakfast at Chulavista |
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Cancer Biology and the Tumor Microenvironment |
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08:45 – 09:10 |
Matthew Albert |
CHEMOTHERAPY INDUCED DNA DAMAGE ENHANCES THE IMMUNOGENICITY OF DYING CELLS |
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09:10 – 09:25 |
Tania Løve Aaes |
NECROPTOSIS UNLIKE APOPTOSIS INDUCES IMMUNOGENICITY AGAINST NEO-EPITOPES IN A TUMOR VACCINATION SETTING |
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09:25 – 09:50 |
Stephen Tait |
FIRST AMONG EQUALS - MITOCHONDRIAL HETEROGENEITY, CELL DEATH AND CANCER |
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09:50 – 10:15 |
Kairbaan Hodivala-Dilke |
SURPRISES FROM TARGETING THE TUMOUR MICROENVIRONMENT |
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10:15 – 10:45 |
Refreshments & Poster Viewing |
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10:45 – 11:10 |
Massimo Santoro |
METABOLIC SIGNALING IN ANGIOGENESIS AND CANCER PROGRESSION |
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11:10 – 11:35 |
Shoukat Dedhar |
HYPOXIA AND ACIDOSIS MEDIATED STRESS SIGNALING: TARGETING CARBONIC ANHYDRASE IX/XII |
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11:35 – 17:30 |
Lunch at Leisure & Free Time |
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12:00 – 17:00 |
Group Snorkeling Trip (sign-ups required in advance) |
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Translational Control Mechanisms and Oncogenesis |
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17:30 – 17:55 |
Nahum Sonenberg |
TRANSLATIONAL CONTROL OF CANCER BY EIF4E VIA THE PI3K/MTOR AND RAS/MAPK PATHWAYS |
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17:55 – 18:20 |
Davide Ruggero |
TRANSLATING THE CANCER GENOME ONE CODON AT A TIME AND ITS THERAPEUTIC IMPLICATIONS |
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18:20 – 18:45 |
Poul Sorensen |
TUMOR CELLS EXPLOIT THE MICROENVIRONMENTAL STRESS RESPONSE TO ENHANCE METASTATIC CAPACITY |
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18:45 – 19:30 |
Refreshments & Poster Viewing |
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19:30 – 19:55 |
Lynne-Marie Postovit |
TRANSLATIONAL CONTROL OF BREAST CANCER PLASTICITY |
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19:55 – 20:20 |
Ivan Topirisovic |
TRANSLATIONAL REGULATION OF METABOLIC PLASTICITY |
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20:20 |
Dinner at Leisure |
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WEDNESDAY 29TH MAY 2019 |
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07:00 – 09:00 |
Buffet Breakfast at Chulavista |
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Cell Death and Inflammation Signaling I |
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09:00 – 09:25 |
Francis Chan |
PARADOXICAL ROLES OF RIP KINASES IN INJURY-INDUCED INFLAMMATION |
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09:25 – 09:50 |
Alessandro Annibaldi |
CHECKPOINTS IN TNF-INDUCED CELL DEATH |
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09:50 – 10:15 |
Philipp Jost |
TNF SIGNALING CONTROLS RIP KINASE-DEPENDENT CELL DEATH IN LEUKEMIA |
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10:15 – 10:40 |
Mathieu Bertrand |
REGULATION OF RIPK1-DEPENDENT CELL DEATH IN MODELS OF INFECTION AND INFLAMMATION |
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10:40 – 11:25 |
Group Photo, Refreshments & Poster Viewing |
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Cell Death and Inflammation Signaling II |
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11:25 – 11:50 |
Henning Walczak |
CELL DEATH-INDUCED INFLAMMATION – TNF AND BEYOND |
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11:50 – 12:05 |
Diego de Miguel |
A NEW KINASE-MEDIATED CHECKPOINT IN TNFR1 SIGNALLING |
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12:05 – 12:30 |
Andrew Oberst |
NECROPTOSIS WITHOUT CELL DEATH: HOW THE RIP KINASES CONTROL VIRAL INFECTION IN THE BRAIN |
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12:30 – 12:35 |
Ronny Schmidt |
USP11 KNOCK OUT, IN-DEPTH UBIQUITINATION AND PROTEIN EXPRESSION LEVEL PROFILING |
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12:35 – 16:30 |
Lunch at Leisure & Free Time |
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Cell Death and Inflammation Signaling II - Continued |
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16:30 – 16:55 |
Najoua Lalaoui |
MUTATIONS THAT PREVENT CASPASE-8 CLEAVAGE OF RIPK1 CAUSE INFLAMMATION IN HUMANS AND MOUSE |
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Necroptosis, Ferroptosis and Beyond I |
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16:55 – 17:20 |
Scott Dixon |
A NOVEL MECHANISM OF NON-APOPTOTIC LIPOTOXICITY |
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17:20 – 17:45 |
EMBO YOUNG INVESTIGATOR LECTURE Ana García-Sáez |
STRUCTURAL REARRANGEMENTS DURING MLKL ACTIVATION |
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17:45 – 18:00 |
David Armenta |
INVESTIGATING MACROPINOCYTOSIS AS A MEANS TO PREVENT FERROPTOSIS |
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18:00 – 18:45 |
Refreshments & Poster Viewing |
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18:45 – 19:10 |
Tom Vanden Berghe |
FERROPTOSIS AND INFLAMMATION RESEARCH IN CRITICAL ILLNESS |
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19:10 – 19:25 |
Marcos Perez Washington State University |
DIETARY FATTY ACIDS INDUCE FERROPTOSIS IN THE C. ELEGANS GERM LINE |
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19:25 – 19:40 |
Samya Van Coillie |
NOVEL THIRD-GENERATION FERROSTATINS PROTECT AGAINST ACUTE IRON POISONING-INDUCED ORGAN INJURY |
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20:00 |
Gala Dinner |
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THURSDAY 30TH MAY 2019 |
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07:00 – 09:30 |
Buffet Breakfast at Chulavista |
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Necroptosis, Ferroptosis and Beyond II |
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09:30 – 09:55 |
Petr Broz |
GBPS AND CASPASE-4 ASSEMBLE THE NON-CANONICAL INFLAMMASOME AT THE OUTER MEMBRANE OF CYTOSOLIC BACTERIA |
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09:55 – 10:20 |
Christine Watson |
CELL DEATH INITIATES DYNAMIC ARCHITECTURAL CHANGES IN THE EPITHELIUM AND ASSOCIATED IMMUNE CELLS AND VASCULATURE DURING MAMMARY GLAND INVOLUTION |
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10:20 – 10:45 |
Andreas Linkermann |
REGULATED NECROSIS IN ISCHEMIC TISSUES |
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10:45 – 11:10 |
Mahvash Tavassoli |
TUMOUR-DERIVED EGFR-CONTAINING EXOSOMES MODULATE TUMOUR HYPOXIA TO INFLUENCE RADIATION-INDUCED CELL DEATH IN HEAD AND NECK CANCERS |
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11:10 – 11:25 |
Martin Aichinger |
TARGETING IAP IN CANCER: FROM CELL DEATH INDUCTION TO IMMUNE CELL ACTIVATION |
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11:25 – 11:35 |
Closing Comments |
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11:35 |
Refreshments |
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Supported by
Venue & Location
Fiesta Americana Puerto Vallarta All Inclusive
The Fiesta Americana Puerto Vallarta All Inclusive is in the beautiful Bahía de Banderas on the Pacific Coast of Mexico. With a mix of contemporary Mexican architecture and the more traditional Mexican styles of Jalisco, the buildings blend perfectly with the surrounding landscape of the Western Sierra Madre Mountains.
Located just 13km from Licenciado Gustavo Díaz Ordaz International Airport and within easy reach of the town of Puerto Vallarta with its array of boutique shops and set alongside one of the most beautiful beaches in the area, this provides the perfect setting for a conference.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the wonderful selection of restaurants such as Chulavista, a contemporary buffet restaurant overlooking the beach offering Mexican and International cuisine, Rosato, offering mediterranean cuisine with an Italian twist, El Mexicano, serving traditional Mexican fare, Tiatang, adults-only restaurant serving Asian cuisine nightly for dinner and L'Isola, a sophisticated restaurant serving lobster and fine meat cuts in a poolside setting - there is a surchage for dining at this venue. There are also several other dining opportunities such as the Cevichería, Fajita House and Grill as well as the Terrace and Pool Bars. The Café / Deli Express is also open daily for coffee, teas, cakes and pastries.
The themed Gala Night takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
Hotel facilities include;
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
- Lagoon Pool
- Spa
- Fitness Center
- 8 Restaurants
- Kids Club
- Private Beach
General Information
Venue Rating
★ ★ ★ ★
Currency
US Dollar (USD)
Address
Blvd Francisco Medina Ascencio Km 2.5, Puerto Vallarta 48300, Mexico
Nearest Airport
Licenciado Gustavo Diaz Ordaz International Airport (PVR)
Location
Originally a bustling mining town known as the ‘Las Peñas’ in the 19th century, Puerto Vallarta is framed by the stunning mountains of the Sierra Madre Occidental of Jalisco and the immense Mexican Pacific. This fascinating destination with red roofs, golden sunsets, cobbled streets and beautiful beaches possesses everything that makes for an incredible place to visit.
Puerto Vallarta’s art offering is amazing, from crafts found in the flea market to the fleeting creations made by artists with the sand on the beach. Its art galleries, boardwalk, calm Banderas Bay waters - loved by scuba diving enthusiasts and bustling nightlife bare some of the contrasts that Vallarta holds.
There are many activities you can enjoy during your fee time such as visiting the El Salado estuary, going on horseback up the Quimixto waterfall or taking a tour of Banderas Bay. You may also like to explore the Jardín Botánico de Vallarta where you will find orchids, bromeliads, agaves, wild palms and fern grottos along the paths of this gorgeous nature park.
If you are interested in this meeting but not yet ready to register, you can sign up for updates here and our team will keep you updated regarding deadline reminders and grant opportunities relating to this meeting only.
Bronze Sponsors
Exhibitors
Media Partners
If you're interested in sponsoring this conference please contact us.
Conference Manager
Meredith Willmott
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