Nuclear Receptors Conference

Report

New Roles for Nuclear Receptors in Health, Development & Disease

Cancun, Feb 27th - March 02nd 2018

This new major meeting, focussing on recent breakthroughs and insights in Nuclear Receptor Biology, took place in Cancun, Mexico from Feb 27^th to March 2^nd 2018. It had a broad remit, to cover how nuclear receptors shape development and contribute to health as well as how their dysfunction and dysregulation can cause disease - and importantly how we can exploit them therapeutically. The attendance reflected this breadth, with scientists and clinicians whose research areas included fertility, oncology, cardiology, endocrinology, ageing, neuroscience, reproduction and metabolism. The meeting was chaired by an international panel consisting of Charlotte Bevan and Simak Ali (Imperial College, London, UK), Karen Knudsen (Sidney Kimmel Cancer Center and University of Philadelphia, USA) and Wayne Tilley (University of Adelaide, Australia).

As the inaugural Fusion Nuclear Receptor meeting, a keynote address, sponsored by Cancer Research UK, was given by the “Father of molecular endocrinology”, Bert O’Malley (Baylor College of Medicine). He gave an overview of the history of the field, encompassing the first work on steroid hormones, the cloning of their receptors, right up to his current exciting work on nuclear receptor cofactors in disease and therapy.

The rest of the meeting divided into relevant subject areas, although inevitably there was a lot of cross-talk and cross-fertilisation between sessions. Day 1 began with a wide-ranging session on “NR in Development, Metabolism and Reproduction”. The first speaker, David Moore (Baylor) gave an authoritative and thought-provoking plenary on how the receptors PPARalpha and FXR act and compete in the liver to regulate liver energy, and later in the session these receptors came up again in Catherine Williamson’s (King’s College, London) talk on metabolic adaptations in gestation and David Volle’s (Clermont) on NR networks in male fertility. Carlie de Vries (Denmark) described how the orphan receptor Nurr77 links inflammatory response and mitochondrial metabolism in macrophages. Ying Zhou (Baylor) discussed Vitamin D receptor regulation of macrophages in the liver and Kendall Nettles (Scripps) described systems biology discovery of new roles for GR in skeletal muscle. Exciting data was also presented on roles of “sex steroid” receptors, AR and ER, in non-reproductive tissue (Muscle and brain) in talks by Frank Claessens (Leuven) and Charlotte Cornil (Liege). The session closed with a fast-paced panel discussion, led ably by the session chairs and involving all the speakers and many of the audience. This set the tone for these panel discussions which were a well-received and a stimulating feature of the meeting as a whole.

Day 2 began with the hot topic of nuclear receptor crosstalk. Three of the talks (Karen Knudsen (Philadelphia), Dan Gioeli (Virginia) and Claire Fletcher (Imperial College discussed the issue of NR crosstalk with DNA damage repair pathways, while Theresa Hickey (Adelaide), Suzanne Conzen (Chicago) and Wilbert Zwart (NKI) dealt with NR-NR crosstalk. Both of these have enormous implications for cancer therapy, and the question of synthetic lethality and how this translates to patients was hotly debated in the panel discussion. The afternoon session went on to Epigenetics & Chromatin Regulation – by and of NRs – and it covered enhancer RNAs (Lee Kraus (UTSW) and Luca Magnani (Imperial)), transfer RNAs (Jessica Finley-Schultz (Colorado)), microRNAs (Charlotte Bevan (Imperial)) and the importance of genomic 3D structure on transcriptional regulation (Yijun Ruan, Jackson Laboratory). The latter topic was picked up again on Day 3 in the session on Structure and Regulation, by Sebastiaan Meijsing (Max Planck Inst). This session also included several speakers on NR structure, (Eric Ortlund (Emory), Eva Estebanez-Perpina (Barcelona) Isabelle Billas (IGBMC), Eric Kalkhoven (Utrecht) and John Schwabe (Leicester). This is a controversial subject on which some disagreements are evident in the field, providing a great deal of discussion. We also heard how mutations alter NR structure and functional, from Geoff Greene (Chicago) and Steffi Osterreich (Pittsburgh).

Session 4, on NR in Non-Malignant Disorders, was kicked off by Philippa Saunders (Edinburgh), an authority on steroids in the female reproductive system, who talks about androgens in the endometrium; endometriosis was also discussed by Sang Jun Han (Baylor) in the context of ERbeta. Toshiya Tanaka (Tokyo) presented interesting work on PPARalpha ligands for non-alcoholic fatty liver disease. Fascinating talks were given by David Ray (Manchester) on nongenomic actions of GR, with implications in development, Susanne Mandrup (Southern Denmark) on differentiation of mesenchymal stem cells, Ines Pineda-Torra (UCL) on Liver X Receptor in metabolic disease and Pamela England with her work on Nurr1 as a potential drug target in Parkinson’s disease

The final session on NR in cancer picked up on some of the themes from previous talks, with Amy Mandigo (Jefferson) discussing AR interactions with Rb and E2F1 signalling in prostate cancer, while Gordon Hager showed his fascinating work concerning tracking transcriptional regulation in real time. Scott Dehm (Minnesota) talked about truncated AR variants and their significance in prostate cancer, while Ganesh Raj (UTSW) described new ways to target a so-called “orphan” receptor in breast cancer and Amina Zoubeidi (Vancouver) described less specific ways of inhibiting androgen signalling in prostate cancer to prevent cell plasticity.

Two poster viewings were held (days 1 and 3) and poster judges were drawn from the speakers: the awards went to 3 early-career researchers who were also well represented in the oral presentations. The attendance at all sessions was close to 100%, typical of the collaborative and collegiate atmosphere at the meeting. Panel discussions were frank and inclusive, and indeed were continued into he social aspects of the meeting, which again illustrated the friendly and inclusive atmosphere. The feeling was overwhelmingly that this was a hugely useful and timely meeting which should be revisited in 2020. The breadth of the programme and speakers was acknowledged to be unique and a positive reason why so many would enthusiastically return, in additional to the opportunities for networking with so many key researchers in an intimate meeting. The venue and professional, friendly and effective organisation by Fusion Conferences were also felt to be major contributing factors to the meeting’s success. The free time in the afternoons, whether with colleagues on arranged tours, or informal activities at the resort, enhanced networking and were greatly appreciated by all attendees.

The meeting was made possible by generous support from Gold sponsors Janssen, Bronze sponsors the Society for reproduction & Fertility and Cancer Research UK, and endorsing partners Society for Endocrinology and Journal of Molecular Endocrinology.

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Synopsis

Nuclear Receptors are, physiologically and pharmacologically, a critical superfamily of transcription factors. They drive key processes at every stage from development and reproduction to ageing and cancer. They are critical determinants of everyday health via their roles in metabolism and circadian rhythms. Nuclear receptors allow external factors to influence cellular pathways and the fact that many bind and are activated by small molecules means they represent highly druggable targets; currently, 13% of FDA-approved drugs target nuclear receptors.

This meeting will address the new roles and novel crosstalk mechanisms that are emerging for many of the 48 human nuclear receptors, in health and disease. For example, it has long been known that the estrogen receptor drives progression of breast cancer, and patients with estrogen receptor-positive disease are treated using antiestrogens or aromatase inhibitors to inhibit estrogen signalling. Now however, it is apparent that the androgen receptor can in some cases drive breast cancer progression and is a therapeutic target, resulting in clinical trials for androgen receptor-targeting therapies in advanced breast cancer. The androgen receptor, itself long the main therapeutic target in prostate cancer, is emerging as a key player in metabolic disease, while conversely other nuclear receptor including the glucocorticoid receptor and several orphan nuclear receptors are implicated in prostate cancer progression. Meanwhile, given the impact of many nuclear receptors on the central nervous system, it is unsurprising that they are being explored in the context of neurological disorders and depression. Thus there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases.

Crosstalk between nuclear receptors and other fundamental processes is another exciting expanding area that will also be covered. DNA damage repair pathways are inextricably linked to steroid signalling via transcriptional processes, with implications for drug combinations in several diseases. Hitherto unsuspected roles of nuclear receptors in epigenetic control and the processing and function of non-coding RNAs opens up to capacity of this superfamily to further means of impacting on development and normal functioning, but also on disease development.

This unique meeting will bring together many of the leading figures in nuclear receptor research from across the globe, to discuss emerging roles and their implications for health and disease – and both human and drug development – in an intimate meeting that will generate meaningful idea exchange and interaction that will help to further shape this influential field.

Join the conference LinkedIn group to keep up to date with announcements and latest news concerning the conference.

Key Sessions

Further emerging roles for nuclear receptors in cancer
Structural insights into nuclear receptor function and crosstalk
Nuclear receptors’ role in epigenetic regulation and non coding RNA
Nuclear receptors and DNA damage
Nuclear receptors and cell cycle
Nuclear receptors in metabolism/metabolic disease
Nuclear receptors in the CNS

Target Audience

Scientists and Clinician Scientists at a range of levels from postdoctoral and up: Principal Investigators, Junior Team Leaders, Research Fellows. Ambitious postgraduate students in the field will also be encouraged to attend.

Relevant specialties are wide-ranging, reflecting the importance of nuclear receptors in many aspects of health and disease. These include Endocrinology, Oncology, Paediatrics, Urology, Gynaecology, Obstetric Medicine, Neuroscience, Cardiology.

Learning Objectives

Introduce the newest advances, in discovery and methodology in the field of Nuclear Receptor research to a wide audience, through oral and poster presentation with both formal and informal discussion.
Develop a deeper understanding of the latest advances in our knowledge of nuclear receptor biology at all levels (structural, transcriptional, cross-talk with each other and with different pathways) and the subsequent effects on development, reproduction and disease.
Consider and possibly extend the evidence base for re-purposing of nuclear receptor-targeting therapies
Provide an environment for cross-talk and cross-fertilisation between all Nuclear Receptor-related disciplines (reproduction, fertility, neuroscience, oncology, structural biology, transcription) allowing the different disciplines to learn from each other and forge new collaborations
Celebrate over 30 years of Nuclear Receptor research while discussing the next challenges in the field and how we can address them.

Student Grants

We currently have 3 x $800 student grants available for the conference to help offset the cost of registration. If this is of interest to you, please send the following to Meredith@fusion-conferences.com by 15th January 2018:

Name and brief description of your current research
Why you would benefit from attend
An abstract for poster consideration

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the standard rate of $1,798.00 and bring a student for only $745. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 27th February, 28th February and 1st March 2018 (on a shared basis for students, note guest rooms are open plan) and a 24hour all-inclusive food and beverage package for the conference period. Once you have registered and paid in full, please contact Meredith Willmott (Meredith@fusion-conferences.com) to obtain a special registration link for your student.

Publishing Opportunity

We are delighted to be working with Bioscientifica publishing house to publish abstracts from the Nuclear Receptors Conference, 27^th February – 02nd March 2018 in Cancun, Mexico. Bioscientifica publishes many of the leading journals and online products in endocrinology on behalf of, and in collaboration with, key endocrine societies worldwide. They provide permanent, citable, free-to-read records of meeting abstracts, ensuring the content from an event remains discoverable and available in perpetuity, prolonging the life of the event.

If consent is given abstracts from speakers, oral presenters and poster presenters will be published. Please see the Bioscientifica website for more information about them.

If you would like your abstract to be published, please provide consent by confirming via email (meredith@fusion-conferences.com). Please note this opportunity is not mandatory we will only publish abstracts if consent has been given.

Confirmed Plenary Speakers

Geoffrey Greene (The University of Chicago)
UNDERSTANDING AND EXPLOITING STEROID RECEPTOR CROSS TALK IN HORMONE SENSITIVE CANCERS

Bert O'Malley (Baylor College of Medicine)
NUCLEAR RECEPTORS AND THEIR COACTIVATORS: AN ENTRE TO UNDERSTANDING HUMAN DISEASES

David Moore (Baylor College of Medicine)

Confirmed Invited Speakers

Suzanne Conzen (The University of Chicago)
MODULATING GLUCOCORTICOID RECEPTOR FUNCTION IN BREAST AND PROSTATE CANCER

Frank Claessens (University of Leuven)
DIRECT AND INDIRECT EFFECTS OF ANDROGENS ON THE MUSCULOSKELETAL SYSTEM

Scott Dehm (University of Minnesota)
CLINICALLY-RELEVANT CONTEXTS FOR AR VARIANTS IN PROSTATE CANCER

Theresa Hickey (The University of Adelaide)

Lee Kraus (The University of Texas Southwestern Medical Center)
NUCLEAR RECEPTORS, TRANSCRIPTIONAL ENHANCERS, AND GENE REGULATION

Luca Magnani (Imperial College London)
MAPPING THE EPIGENOME OF BREAST CANCER PATIENTS TO EXPOSE NEW MECHANISMS OF ENDOCRINE THERAPY RESISTANCE

Susanne Mandrup (University of Southern Denmark)
TRANSCRIPTIONAL NETWORKS REGULATING MSC DIFFERENTIATION

Sebastiaan Meijsing (Max Planck Institute for Molecular Genetics)
TRANSCRIPTIONAL REGULATION BY THE GLUCOCORTICOID RECEPTOR: ROLE OF DNA SHAPE AND SEQUENCE IN MODULATING OUTPUT AND NOISE

Eric Ortlund (Emory University)
TARGETING LRH-1 WITH SMALL MOLECULE MODULATORS

Steffi Oesterreich (Women's Cancer Research Institute)

Eva Estébanez-Perpiñá (University of Barcelona)
ANDROGEN RECEPTOR DIMERIZATION

David Ray (The University of Manchester)
RAPID, CYTOPLASMIC ACTIONS OF THE GLUCOCORTICOID RECEPTOR IMPACT ON CELL MOVEMENT

Ganesh Raj (University of Texas Southwestern Medical Center)

Yijun Ruan (The Jackson Laboratory)

Philippa Saunders (University of Edinburgh)
ANDROGENS AND ENDOMETRIAL FUNCTION: REPLICATION, REPAIR AND REGENERATION

Carol Sartorius (University of Colorado)
PROGESTERONE RECEPTOR REGULATION OF CANCER CELL TRANSLATION

John Schwabe (University of Leicester)

Carlie de Vries (University of Amsterdam)
NUR77 GOES METABOLIC IN MACROPHAGES

Catherine Williamson (King's College London)
GESTATIONAL METABOLIC ADAPTATIONS SIGNALLED THROUGH NUCLEAR RECEPTORS

Wilbert Zwart (Netherlands Cancer Institute)
ESTROGEN RECEPTOR CISTROMICS IN BREAST TUMORS: FROM BIOMARKERS TO NOVEL DRUG TARGETS

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Speakers

Plenary Speakers

Geoffrey Greene

Professor and Chair, University of Chicago

David Moore

Professor, Baylor College of Medicine

Bert O'Malley

Professor and Chair, Baylor College of Medicine

Invited Speakers

Sebastiaan Meijsing

Group leader, Max Planck Institute for Molecular Genetics

Carlie de Vries

Professor, Chair, Amsterdam UMC, location AMC, Uni of Amsterdam

Theresa Hickey

Senior Research Fellow, University of Adelaide

W. Lee Kraus

Professor and Director, UT Southwestern Medical Center

Luca Magnani

Chair in Cancer Adaptation and Evolution, Imperial College London

Philippa Saunders

Professor, The University of Edinburgh

Susanne Mandrup

Professor, University of Southern Denmark

Frank Claessens

Prof., KU Leuven

David Ray

Professor of Medicine, University of Manchester

Steffi Oesterreich

Professor and Vice Chair, Department of Pharmacology& Chemical Biology, Women's Cancer Research Institute

Jessica Finlay-Schultz

Associate Professor, University of Colorado Anschutz Medical Campus

Wilbert Zwart

Senior groupleader, Netherlands Cancer Institute

Eric Ortlund

Associate Professor, Emory University

Ganesh Raj

Professor, UT Southwestern Medical Center

Gordon Hager

Lab Chief, National Cancer Inst, NIH

Scott Dehm

Associate Professor, Masonic Cancer Center, University of Minnesota

Charlotte Cornil

F.R.S.-FNRS Senor Research Associate, Univeristy of Liege

Yijun Ruan

Professor & Director, JAX Genomic Sciences, The Jackson Laboratory

Suzanne Conzen

Professor, The University of Chicago

David Volle

PI, team leader, CNRS UMR 6293, Inserm U1103, UCA

Catherine Williamson

Professor, King's College London

Eva Estebanez-Perpina

Professor, University of Barcelona

John Schwabe

Director of Leicester Institute of Structural and Chemical Biology, University of Leicester

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Programme

TUESDAY 27^th FEBRUARY 2018
14:00 – 14:45	Registration & Reception
14:00 – 14:45	Group Welcome Lunch Kalmia Buffet Restaurant
14:45 – 15:00	Opening Comments
NR in Development, Metabolism and Reproduction Session Chairs: Wayne Tilley and Isabelle Billas
15:00 – 15:45	David Moore Baylor College of Medicine	REGULATION OF LIVER ENERGY BALANCE BY PPARALPHA AND FXR
15:45 – 16:15	Carlie de Vries University of Amsterdam	NUR77 GOES METABOLIC IN MACROPHAGES
16:15 – 16:45	Frank Claessens University of Leuven	DIRECT AND INDIRECT EFFECTS OF ANDROGENS ON THE MUSCULOSKELETAL SYSTEM
16:45 – 17:15	Charlotte Cornil University of Liege	ESTROGEN NUCLEAR- AND MEMBRANE-INITIATED SIGNALING COOPERATE TO REGULATE BEHAVIOR
17:15 – 17:45	Refreshment Break
17:45 – 18:15	Catherine Williamson Kings College London	GESTATIONAL METABOLIC ADAPTATIONS SIGNALLED THROUGH NUCLEAR RECEPTORS
18:15 – 18:30	Kendall Nettles The Scripps Research Institute	CHEMICAL SYSTEMS BIOLOGY ANALYSES REVEAL DISSOCIATED GLUCOCORTICOID SIGNALING NETWORKS IN SKELETAL MUSCLE
18:30 – 18:45	Ying Zhou Baylor College of Medicine	VITAMIN D RECEPTOR REGULATES TISSUE MACROPHAGE ACTIVITY IN PRESPONSE TO HEPATIC ENDOPLASMIC RETICULUM STRESS
18:45 – 19:15	David Volle Université Clermont Auvergne	NUCLEAR RECEPTOR NETWORKS IN MALE FERTILITY
19:15 – 19:45	PM Panel Discussion
19:45 – 20:15	Poster Viewing & Drinks
20:15	Group Dinner

WEDNESDAY 28^th FEBRUARY 2018
07:00 – 08:30	Breakfast *Kalmia Buffet Restaurant*
NR Crosstalk Session Chairs: Sylvie Mader and Eric Kalkhoven
08:30 – 09:15	Karen Knudsen Thomas Jefferson University	TARGETING DNA REPAIR-AR CROSSTALK DYSFUNCTION IN ADVANCED PROSTATE CANCER
09:15 – 09:30	Daniel Gioeli University of Virginia	CHECKPOINT KINASE 2 AND ANDROGEN RECEPTOR CROSS-TALK REGULATE THE DDR AND PROSTATE CANCER GROWTH
09:30 – 10:00	Theresa Hickey The University of Adelaide	ANDROGEN AND ESTROGEN RECEPTORS IN BREAST TISSUES: OPPONENTS OR TEAMMATES?
10:00 – 10:30	Refreshment Break
10:30 – 11:00	Wilbert Zwart Netherlands Cancer Institute	ESTROGEN RECEPTOR CISTROMICS IN BREAST TUMORS: FROM BIOMARKERS TO NOVEL DRUG TARGETS
11:00 – 11:30	Suzanne Conzen The University of Chicago	MODULATING GLUCOCORTICOID RECEPTOR FUNCTION IN BREAST AND PROSTATE CANCER
11:30 – 11:45	Claire Fletcher Imperial College London	MIR-346 INTERACTION WITH A LONG NON-CODING RNA LINKS AR ACTIVITY AND DNA DAMAGE REPAIR.
11:45 – 12:15	AM Panel Discussion
12:15 – 16:15	Lunch at Leisure & Free Time
12:30 – 15:45	Group Trip: Snorkeling (signups required in advance)
Epigenetics & Chromatin Regulation Session Chairs: Claire Fletcher and Daniel Gioeli
16:15 – 16:45	Lee Kraus University of Texas Southwestern Medical Center	NUCLEAR RECEPTORS, TRANSCRIPTIONAL ENHANCERS, AND GENE REGULATION
16:45 – 17:15	Luca Magnani Imperial College London	ENHANCERS MAPPING UNCOVERS PHENOTYPIC HETEROGENEITY AND EVOLUTION IN PATIENTS WITH LUMINAL BREAST CANCER
17:15 – 17:45	Charlotte Bevan Imperial College London	MICRORNA REGULATION OF ANDROGEN SIGNALLING
17:45 – 18:15	Yijun Ruan The Jackson Laboratory	PROTEIN FACTORS INVOLVED IN 3D GENOME ORGANIZATION & TRANSCRIPTION REGULATION
18:15 – 18:45	Jessica Finlay-Schultz University of Colorado	PROGESTERONE RECEPTOR REGULATION OF CANCER CELL TRANSLATION
18:45 – 19:15	PM Panel Discussion
19:15 – 19:45	Refreshment Break
19:45 – 20:45	Bert O’Malley: Cancer Research UK plenary speaker Baylor College of Medicine	NUCLEAR RECEPTORS AND THEIR COACTIVATORS: AN ENTRE TO UNDERSTANDING HUMAN DISEASES
20:45	Dinner at Leisure

THURSDAY 1^st MARCH 2018
07:00 – 08:30	Breakfast *Kalmia Buffet Restaurant*
NR structure & regulation Session Chairs: Moray Campbell and Pamela England
08:30 – 09:15	Geoffrey Greene The University of Chicago	EXPLOITING MULTIPLE NUCLEAR RECEPTORS IN BREAST CANCER
09:15 – 09:45	Steffi Oesterreich University of Pittsburgh	ER MUTATIONS IN ENDOCRINE RESISTANT BREAST CANCER
09:45 – 10:15	Eric Ortlund Emory University	TARGETING LRH-1 WITH SMALL MOLECULE MODULATORS
10:15 – 10:45	Sebastiaan Meijsing Max Planck Institute for Molecular Genetics	TRANSCRIPTIONAL REGULATION BY THE GLUCOCORTICOID RECEPTOR: ROLE OF DNA SHAPE AND SEQUENCE IN MODULATING OUTPUT AND NOISE
10:45 – 11:15	Refreshment Break
11:15 – 11:45	Eva Estébanez-Perpiñá University of Barcelona	ANDROGEN RECEPTOR DIMERIZATION
11:45 – 12:00	Eric Kalkhoven Utrecht University	NATURAL PPARγ MUTANTS: A MODEL FOR ALLOSTERIC SIGNALING BETWEEN NUCLEAR RECEPTORS AND DNA
12:00 – 12:15	Isabelle Billas IGBMC	STRUCTURAL BASIS OF SPECIFIC DNA RECOGNITION BY THE ESTROGEN-RELATED RECEPTOR ERR
12:15 – 12:45	John Schwabe University of Leicester	STRUCTURAL BIOLOGY TO UNDERSTAND CO-REGULATOR MECHANISMS, NUCLEAR RECEPTOR DISEASE AND TO DEVELOP NOVEL THERAPEUTIC APPROACHES
12:45 – 13:15	AM Panel Discussion
13:15 – 15:30	Lunch at Leisure & Free Time
NR in non-malignant disorders Session Chairs: Amina Zoubeidi and Douglas Gibson
15:30 – 16:00	Philippa Saunders The University of Edinburgh	ANDROGENS AND ENDOMETRIAL FUNCTION: REPLICATION, REPAIR AND REGENERATION
16:00 – 16:15	Pamela England University of California, San Francisco	DE-ORPHANING AND DRUGGING NURR1 – A THERAPEUTIC TARGET FOR PARKINSON’S DISESASE
16:15 – 16:45	David Ray The University of Manchester	RAPID, CYTOPLASMIC ACTIONS OF THE GLUCOCORTICOID RECEPTOR IMPACT ON CELL MOVEMENT
16:45 – 17:00	Sang Jun Han Baylor College of Medicine	THE PATHOGENIC ROLE OF ESTROGEN RECEPTOR ΒETA DRIVES IN ENDOMETRIOSIS
17:00 – 17:30	Refreshment Break
17:30 – 18:00	Susanne Mandrup University of Southern Denmark	TRANSCRIPTIONAL NETWORKS REGULATING MSC DIFFERENTIATION
18:00 – 18:15	Toshiya Tanaka The University of Tokyo	PEMAFIBRATE, A SELECTIVE PPARΑ MODULATOR (SPPARMΑ), PREVENTS INTRAHEPATIC MACROPHAGE ACCUMULATION AND ACTIVATION OF NON-ALCOHOLIC STEATOHEPATITIS
18:15 – 18:30	Ines Pineda-Torra University College London	BEYOND LIGAND ACTIVATION: DISRUPTING LXRΑ PHOSPHORYLATION TO REPROGRAM DIETINDUCEDTRANSCRIPTOMES AND MODULATE PROGRESSION OF METABOLIC DISEASES
18:30 – 19:00	PM Panel Discussion
19:00 – 20:00	Poster Session & Refreshments
20:00	*Gala Dinner & Poster Awards*

FRIDAY 2^nd MARCH 2018
07:00 – 08:30	Breakfast *Kalmia Buffet Restaurant*
NR in cancer Session Chairs: Ines Pineda-Torra and Wilbert Zwart
08:30 – 09:00	Gordon Hager National Cancer Institute	THE STRUCTURAL BASIS OF CHROMATIN REPROGRAMMING BY STEROID RECEPTORS
09:00 – 09:15	Moray Campbell The Ohio State University	STAGE-SPECIFIC AND GLOBAL FUNCTIONS OF NCOR2 IN PROSTATE CANCER PROGRESSION
09:15 – 09:45	Scott Dehm University of Minnesota	CLINICALLY-RELEVANT CONTEXTS FOR AR VARIANTS IN PROSTATE CANCER
09:45 – 10:15	Refreshment Break
10:15 – 10:45	Ganesh Raj University of Texas Southwestern Medical Center	TARGETING THE INTERACTOME OF AN ORPHAN NUCLEAR RECEPTOR IN TRIPLE NEGATIVE BREAST CANCER
10:45 – 11:00	Amina Zoubeidi University of British Columbia	RATIONALE TARGETING CELL PLASTICITY IN TREATMENT RESISTANT PROSTATE CANCER
11:00 – 11:15	Sylvie Mader Université de Montréal	ROLE OF CHROMATIN REMODELING IN THE SUPPRESSION OF ESTROGEN-INDUCED TRANSCRIPTION BY PURE ANTIESTROGENS
11:15 – 11:30	Amy Mandigo Thomas Jefferson University	RB LOSS REPROGRAMS AR AND E2F1 SIGNALING IN MODELS OF PROSTATE CANCER PROGRESSION
11:30 – 12:00	AM Panel Discussion
12:00 – 12:15	Closing Comments
13:00 – 19:50	Group Trip: Tulum (signups required in advance)

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Prices

Ticket Type	Early Bird	Full Price
Single Choose this option if you will be attending the conference alone, or if you will bring accompanying guests that will not attend the meeting.	$1748	$1798
Shared Choose this option if you wish to share with a colleague who is also attending the conference, or if you wish to be paired with another attendee of the same sex.	$1748	$1798
Student Choose this option if you are a student. Please note all students will be paired with another attendee of the same sex if a room sharer is not specified. If you wish to have your own room, please register under the Single option.	$1490	$1540

Additional Person

This is the cost for an additional adult or child to join you in the same room, for the entire conference period. Accompanying persons are not permitted access to the conference. If you wish to extend your stay, please see our 'Extra night' prices.

Adult

$626

Child

$284

Extra nights

Prices are per person.

Adult

$292

Child

$71

All registration fees include 3 nights accommodation and meals during the conference period. Exact inclusions are detailed below.

Accompanying child fees and extra night child fees are applicable for children aged 5-12 years of age. Children aged 13 years and older are classified as an adult at this venue (Fiesta Americana Condesa).

What's Included in our Registration Fees?

The Fiesta Americana Condesa, Cancun offers a 24hour all inclusive service. Our registration and additional adult/child fees are inclusive of the following;

- Accommodation for 3 Nights (27th February, 28th February and 1st March 2018).
- Breakfast, Lunch and Dinner – available at all restaurants according to operational hours or programmed events.
- International Bar available by the glass in restaurants and bars according to operational hours.
- Pool snacks and International Bar available by the glass at Pool Area.
- Minibar including: soft drinks, domestic beer, bottled water and coffee. Refreshed daily.
- 24 Hour Room Service.
- In Room amenity – Bottle of wine, per room, per stay.
- Gala Night Entry (includes an open bar).
- Complimentary WI-FI throughout the hotel.

Additional nights (per person) are inclusive of the following;

- Accommodation for 1 Night
- Lunch on day of arrival
- Dinner on day of arrival
- Breakfast on day of departure
- International bar available by the glass in restaurants and bars from lunch on day of arrival until breakfast on day of departure

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Grants

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Venue

Fiesta Americana Condesa

This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

Lagoon Pool
Extensive Health Club and Spa
Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas

The Fiesta Americana Condesa, Cancun is the 2015 Winner of the Trip Advisor Certificate of Excellence and also received the Travellers Choice Award in 2014.

The remains of ancient Mayan cities are scattered throughout the Yucatan Peninsula and no trip to Cancun would be complete without a visit to these majestic temples and pyramids set amongst lush tropical vegetation. We will be working very closely with a reputable tour company who will be organising trips to Tulum, Chichen Itza, Coba and Xcaret to name a few, some of which may require a full day. Full day excursions will be arranged pre or post conference and may be on an individual or group booking so we would recommend booking extra nights to extend your stay as early as possible to avoid disappointment should these excursions be of interest to you and/or your party. For further information please contact us.

Venue Rating

Currency

US Dollar (USD)

Address

Fiesta Americana Condesa, Blvd.KukulkÃ¡n km 16.5 Zona Hotelera, Cancun, 77500 Mexico

Nearest Airport

Cancun International Airport

Location

Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.

Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Transportation

Cancun International airport is just a short 20-minute journey from the Fiesta Americana Condesa and is easily accessible from almost every country in the world with many major international airlines providing direct or interconnecting flights on a daily basis.

Amstar are a reputable and trustworthy DMC based in Cancun. The Amstar team will be on hand to provide a seamless transfer service to and from Cancun International Airport. Amstar will manage and confirm all transportation bookings, therefore please contact them directly with any questions (see contact info below). To book a transfer, please do so via the online booking facility here.

Contact Name: Daniela Jiménez
Contact Telephone: +52 (998) 881 9587 Ext. 4245
Contact Email: dajimene@amstardmc.com

Private Airport Transfers

Private Transportation prices to and from Cancun International Airport and to and from the Fiesta Americana Condesa hotel are as follows:

Number of Passengers	Price (One Way, Per Vehicle)	Price (Return Trip, Per Vehicle)
1 - 3 Passengers plus luggage	$39.00 USD	$77.00 USD
4 - 7 Passenger plus luggage	$44.00 USD	$85.00 USD
8 - 10 Passengers plus luggage	$53.00 USD	$103.00 USD

Note: Prices do not include gratuity.

Includes:
- Private van with bilingual driver.
- Amenities on arrival (bottled water per person).

If your flight is delayed or your wait at immigration is more than 45 minutes, please contact Amstar as soon as you can to keep them updated with your situation. It’s important Amstar are informed of any delays as soon as you are made aware so the transfer can be rescheduled. Note: If you wish to cancel your transfer, please inform Amstar at least 72 hours in advance otherwise full cancellation charges will apply. If you fail to inform Amstar of any amendments to your travel schedule and consequently do not turn up at the date and time booked, full cancellation charges will apply for no shows.

Upon arrival at the airport, please exit the terminal building and look for ‘Fusion Conferences’ signage where a member of the Amstar team will greet you and escort you to the vehicle. For departures, please wait in the hotel lobby at your requested pick-up time where your driver will meet you.

For arrival transfers and round-trip transfers, payment has to be made online at the time of booking. For return transfers, payment can be made online at the time of booking or at the Amstar Transfers desk during the conference via card or cash (USD or MXN).

For frequently asked questions please take a look at the FAQ section on the Amstar website.

To make a booking with Amstar Transfers, please follow this link to access the online booking facility. If you have any questions for Amstar Transfers, please contact them directly.

Contact Name: Daniela Jiménez
Contact Telephone: +52 (998) 881 9587 Ext. 4245
Contact Email: dajimene@amstardmc.com

IMPORTANT: PLEASE PRINT YOUR CONFIRMATION OR CONFIRMATION NUMBER AND BRING IT WITH YOU.

** Please note Fusion Conferences accept no responsibility for any bookings made with Amstar Transfers or any other transportation supplier **

Shared Shuttle Service

The Amstar Shuttle is a shared service with other Amstar guests and may include 3-4 stops before reaching the Fiesta Americana Condesa. This service operates for flights arriving at Cancun Airport between 7:00am - 17:00pm EST and for flights departing Cancun Airport between 7:00am - 18:00pm EST from the 07^th February until 08^th March 2018.

Shared Transportation prices to and from Cancun International Airport and to and from the Fiesta Americana Condesa hotel are as follows:

Price (One Way, Per Person)	Price (Return Trip, Per Person)
$10.00 USD	$20.00 USD

Note: Prices do not include gratuity.

Includes:
- Shared transfer with non-group participants from nearby resorts.
- Just a few stops en route to the Fiesta Americana Condesa.
- Comfortable, fully air-conditioned vehicle.

Please note that the shared shuttle operates for flights arriving at Cancun Airport between 7:00am - 17:00pm EST and for flights departing Cancun Airport between 7:00am - 18:00pm EST. If your flight times fall outside of the shuttle schedule, you will need to opt for a private transfer.

Amstar will monitor your flight arrival information and adjust your pick-up time accordingly in the event of a delay. Should you change your inbound or outbound flight for any reason, please ensure you inform Amstar of the changes so they monitor the correct flight. Note: If you wish to cancel your place on the shuttle, please inform Amstar at least 72 hours in advance otherwise full cancellation charges will apply. Full cancellation charges will apply for no shows.

Upon arrival at the airport, please exit the terminal building and look for ‘Amstar’ signage where a member of the Amstar team will greet you and escort you to the vehicle. For departures, please wait in the hotel lobby at your requested pick-up time where your driver will meet you.

For arrival transfers and round-trip transfers, payment has to be made online at the time of booking. For return transfers, payment can be made online at the time of booking or at the Amstar Transfers desk during the conference via card or cash (USD or MXN).

For frequently asked questions please take a look at the FAQ section on the Amstar website.

To make a booking with Amstar Transfers, please follow this link to access the online booking facility. If you have any questions for Amstar Transfers, please contact them directly.

Contact Name: Daniela Jiménez
Contact Telephone: +52 (998) 881 9587 Ext. 4245
Contact Email: dajimene@amstardmc.com

IMPORTANT: PLEASE PRINT YOUR CONFIRMATION OR CONFIRMATION NUMBER AND BRING IT WITH YOU.

** Please note Fusion Conferences accept no responsibility for any bookings made with Amstar Transfers or any other transportation supplier **

Taxis

If you do not wish to make a reservation in advance and would prefer to take a taxi upon arrival at the airport, or from the hotel, please check that the vehicle and driver are licensed and be vigilant at all times. If you are unsure about the driver or if the vehicle is unmarked, wait until another taxi becomes available or telephone Amstar to see if they can immediately send a car.

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Local Activities

Details will be available at a later date.

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Group Activities

We have arranged three exciting group activities for the 2018 Nuclear Receptors participants. This is a great opportunity to socialise with fellow colleagues outside of the conference whilst taking in the beautiful natural sights of Mexico. Please find details, timings and prices for the activities below. The activities are either scheduled pre or post conference, or during free time between sessions. Please carefully check the date and timings of each activity before signing up.

Snorkel Trip- Wednesday 28th February 2018

Departing from Aquaworld marina we take you on a motor boat to Punta Nizuc reef area where you disembark to the floating platform. Here you adorn your snorkel gear and you’re ready to take the plunge and snorkel as long as you like in the crystal clear turquoise waters.

Price: $57.00 per person
Price: $36.00 per person (child 4-10 years)
*please note prices do not include gratuity.

Includes:

-Travel through the lagoon and mangrove channels
-Snorkel guided tours
-Full snorkel equipment with a new tube as a gift
-Beer, sodas and bottled water
-Docking fee

Itinerary for Wednesday 28th February 2018:

Walk to Aquaworld from hotel- 10/15 minutes (across the road from the hotel)
12:30 Walk to Aquaworld Marina from hotel
13:00 Boat trip from Aquaworld Marina
13:45 Snorkelling
15:00 Return boat trip from Snorkelling
15:45 Walk from Aquaworld Marina to hotel

*Minimum of 10 people required*

Please note that sign-ups are required by 15^th January 2018, please contact Meredith@fusion-conferences.com if you’d like to participate. Payment for the trip is required pre- conference, more details will be provided after completing the signing up.

This is a non-refundable fee should you later change your mind and decide not to participate in the trip.

Tulum Trip – Friday 2nd March 2018

Tulum is located 78 miles South of Cancun, about a 1:45 minute drive. It was discovered by John Stephens in 1842. Perched on top of a cliff facing the Caribbean Sea, it is the only entirely walled-in group of Mayan ruins ever discovered. Under the advice of an official English speaking tour guide, the group will go around the structures getting the history and spirit of the Mayan.

Price: $63.00
*please note prices do not include gratuity.

Includes:
-Air-conditioned vehicle
-Beverages on board: Soft drinks, bottled water (Estimated: 3 drinks per person)
-Individual bags of dry snacks on board
-Official Tourism Guides English/Spanish
-Admission fee in Tulum
-Round train transportation from Tulum parking lot to the archaeological zone.
-T.I. Escorts
-Tax

Itinerary for Friday 2nd March 2018:

13:00 Depart from hotel
14:50 Estimated arrival to Tulum
15:00 – 17:00 Guided Tour / Free Time
17:00 Depart from Tulum
19:50 Estimated arrival to Hotel.

*Minimum of 10 people required*

Please note that sign-ups are required by Monday 15^th January, please contact Meredith@fusion-conferences.com if you’d like to participate. Payment for the trip is required pre-conference, more details will be provided after signing up. Note this is a non-refundable fee should you later change your mind and decide not to participate.

Chichen Itzá Group Tour – Saturday 3rd March 2018

Chichén Itzá, recently nominated one of the new 7^th Wonders of the World. Chichén Itzá is located 125 miles West of Cancun about 2:15 hrs. It is the most visited archaeological site on the Peninsula, famed for its extraordinary architecture beauty.

Price: $140 per person

*please note prices do not include gratuity.

Includes:

-Air-conditioned vehicles
-Beverages on board: Soft drinks, water (Estimated: 5 drinks per person)
-Individual bags of dry snacks on board
-Official Tourism Guides English/Spanish
-Admission fee at Chichen Itza
-Reserved Area at the restaurant
-Buffet lunch (includes 2 beverages)
-Typical Regional dances during lunch (by local people – not professional at no additional cost)
-Signs for the vehicles
-T.I. Escorts
-Federal Tax

Note: All food and beverages a la carte is subject to 10% TI Administrative Fee

Itinerary for Saturday 3rd March 2018:

Schedule Activity

8.20 am Participants ready at the lobby of the hotel
8.30 am Depart from Hotel
11:00 am Estimated arrival to Chichen Itza Parking Lot
11:15-1:00 pm Guided visit to the Archaeological Site
1:15 pm Depart for Restaurant
1:30 -2:30 pm Lunch
2:45 pm Board the vehicle
5:30 pm Estimated return to Hotel

*Minimum of 5 people required*

Please note that sign-ups are required by 15^th January 2018 please contact Meredith@fusion-conferences.com if you’d like to participate. Payment for the trip is required pre- conference, more details will be provided after completing the signing up.

This is a non-refundable fee should you later change your mind and decide not to participate in the trip.

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Childcare

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Oral Presenters

We have a number of oral opportunities available at this meeting. To be considered for a talk, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Please take note of the oral submission deadline:
6th Nov 2017

Please check the conference programme carefully to note your presentation time (inclusive of Q&A) should you be accepted for an oral presentation. We recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference page.

Your Presentation on the Day

If you have prepared some slides to accompany your talk please ensure you bring these with you on a USB or portable file saving device.

For those presenting on the first day, please email your slides to us so we can have everything prepared and ready for the first session. Please email your slides to: admin@fusion-conferences.com

On the day of your presentation please make yourself known to the AV team who will be available in the conference room. If you have any animations or videos we do advise to run through the presentation with the AV tech to make sure everything is compatible. We also advise that all speakers make themselves known to the AV tech in the conference room immediately before your session beings. The AV tech will apply your microphone and provide a laser pointer should you have an accompanying presentation. We prefer speakers to use our master laptop to run presentations from, however, if you prefer to use your own laptop, please notify us in advance.

It is important that all speakers adhere to their presentation time and respect their fellow presenters. A visual traffic light aide will be available to warn presenters and the audience as your time decreases.

If you have any questions, please don’t hesitate to approach our AV tech or a member of the Fusion team.

Helpful Tips for Presentation Slides

Aspect Ratio:On Screen Show (16:9) and in Landscape Orientation.
Font Size: Minimum font size used should be 24pt.
File Type: Please save your presentation in PPT or PPTS format.
Video Clips: Please save these separately and do not build them into the PowerPoint. Videos will be played via the AV control desk using the master laptop.

Download Abstract Template

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Posters

We have a number of poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Please take note of the poster submission deadline: 15th Jan 2018

Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.

Displaying & Presenting Your Poster

During conference registration if you are presenting a poster please request a poster number from the registration desk. Please do not put up your poster without notifying a member of the Fusion team. Certain adhesive agents are not permitted at some venues therefore; Fusion will be the sole provider of all poster fixings.

You can display your poster from registration. Your poster can remain on display for the entire duration of the conference and we ask that posters are taken down on the final day of the meeting. The poster session is usually scheduled on Day 3, but please check the official programme for exact timings. Refreshments will be provided and the poster prizes will be awarded during the conference Gala Night that evening.

2018 Nuclear Receptors Poster Prize

The conference chairs will be awarding 3 poster prizes for the best poster display and presentation. To be in with a chance of winning, submit your poster by 15 Jan 2017. The winners will be selected shortly after the Poster Session and the following prizes will be awarded: 1st Place $350, 2nd Place $250, 3rd Place $150.

Download Abstract Template

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs

Conference History

27 Feb 2018, 02 Mar 2018

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

Fiesta Americana Condesa, Cancun, Mexico

Nuclear Receptors are, physiologically and pharmacologically, a critical superfamily of transcription factors. They drive key processes at every stage from development and reproduction to ageing and cancer. They are critical determinants of everyd...

More Information

24 Feb 2020, 27 Feb 2020

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

Melia Nassau Beach All Inclusive, Nassau, Bahamas

Nuclear Receptors are, physiologically and pharmacologically, a critical superfamily of transcription factors. They drive key processes at every stage from development and reproduction to ageing and cancer. They are critical determinants of everyd...

More Information

04 May 2022, 07 May 2022

3^rd Nuclear Receptors Conference

#NR2022

Fiesta Americana Condesa Cancun All Inclusive, Cancun, Mexico

Nuclear Receptors are, physiologically and pharmacologically, a critical superfamily of transcription factors. They drive key processes at every stage from development and reproduction to ageing and cancer. They are critical determinants of everyd...

More Information

Supported By

Gold

Bronze

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Nuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease

27 Feb 2018 - 02 Mar 2018

Cancun, Mexico

Chairs