Past Conference

3rd Nuclear Receptors Conference

 #NR2022

Date

04 May - 07 May 2022

Location

Cancun, Mexico

Early Bird - Expired  •  Talk Submission - Expired  •  Poster Submission - Expired  •  Registration & Payment Deadline - Expired

Synopsis

Nuclear Receptors are, physiologically and pharmacologically, a critical superfamily of transcription factors. They drive key processes at every stage from development and reproduction to ageing and cancer. They are critical determinants of everyday health via their roles in metabolism and circadian rhythms. Nuclear receptors allow external factors to influence cellular pathways and the fact that many bind and are activated by small molecules means they represent highly druggable targets; currently, 13% of FDA-approved drugs target nuclear receptors.

This meeting will address the new roles and novel crosstalk mechanisms that are emerging for many of the 48 human nuclear receptors, in health and disease. For example, it has long been known that the estrogen receptor drives progression of the majority of breast cancers, and patients with estrogen receptor-positive disease are treated using antiestrogens or aromatase inhibitors to inhibit estrogen signalling. Now however, it is apparent that activation of other nuclear receptors (e.g. progesterone and androgen receptors) can inhibit breast cancer progression, resulting in clinical trials of drugs that activate these receptors and studies to elucidate cross talk between these critical regulatory signalling pathways. The androgen receptor, itself long the main therapeutic driver and target in prostate cancer, is emerging as a key player in metabolic disease, while conversely other nuclear receptors including the glucocorticoid receptor and several orphan nuclear receptors are implicated in prostate cancer progression. Meanwhile, given the impact of many nuclear receptors on the central nervous system, it is unsurprising that they are being explored in the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases.

Crosstalk between nuclear receptors and other fundamental processes is another exciting expanding area that will also be covered. DNA damage repair pathways are inextricably linked to steroid signalling via transcriptional processes, with implications for drug combinations in several diseases. Hitherto unsuspected roles of nuclear receptors in epigenetic control and the processing and function of non-coding RNAs opens up the capacity of this superfamily to further means of impacting on development and normal functioning, but also on disease development.

This unique meeting will bring together many of the leading figures in nuclear receptor research from across the globe, to discuss emerging roles and their implications for health and disease – and both human and drug development – in an intimate meeting that will generate meaningful idea exchange and interaction that will help to further shape this influential field.

Key Sessions

  • Nuclear receptors and cancer
  • Nuclear receptors in reproduction, development and metabolism
  • Nuclear receptors in central systems
  • Translating nuclear receptors to the clinic
  • Nuclear receptors in non-malignant disorders
  • Nuclear receptors, the genome and epigenome

Student & Postdoc Offer

Take advantage of this fantastic opportunity! Fully paying academics can bring a student or junior post doc (early career) for only $765. Both registration packages include; accommodation for the 04, 05, 06 May 2022 (on a shared basis for students and junior postdocs) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact Amy Johnson to obtain a special registration link for your student or junior postdoc.

Early Career Grants

We have 3 x $500 registration grants available for early career candidates. Please submit an abstract for consideration via email to Amy, along with a short message outlining why you would benefit from attending this conference. Please submit your abstracts in line with the appropriate deadlines.

Talk Deadline: 4 March 2022 
Poster Deadline: 31 March 2022

Confirmed Keynote Speaker

Peter Nelson (Fred Hutch)

Confirmed Invited Speakers

Moray Campbell (The Ohio State University)
EPIGENETIC CONTROL OF TYPE II NUCLEAR RECEPTOR BOOKMARKING FUNCTIONS DETERMINES TYPE I NUCLEAR RECEPTOR ENHANCER INTERACTIONS
Jason Carroll (University of Cambridge)
NEW INSIGHT INTO THE ROLE OF HNF4 IN PANCREATIC CANCER
Frank Claessens (KU Leven)
WHICH OF THREE AR DIMERIZATION MODES IS THE BETTER THERAPEUTIC TARGET?
Karolien De Bosscher (Ugent University)
CROSS-TALK MECHANISMS TO RE-WIRE THE GLUCOCORTICOID RECEPTOR FOR ENHANCED THERAPEUTIC BENEFIT IN CANCER AND INFLAMMATION 
Geoffrey Greene (University of Chicago)
CHOOSING AN OPTIMAL ER-TARGETED THERAPY FOR MUTANT ER+ METASTATIC BREAST CANCER
Theresa Hickey (University of Adelaide)
Carol Lange (University of Minnesota Masonic Cancer Center)
TO SLEEP PERCHANCE TO DREAM: PR REGULATION OF CELL CYCLE EXIT/ENTRY IN FALLOPIAN TUBE MODELS OF HIGH GRADE SEROUS OVARIAN CANCER
Mathieu Lupien (University of Toronto)
FINDING CANCER DRIVERS FROM THE NON-CODING PROSTATE CANCER GENOME
Sreejith Nair (Georgetown University)
NUCLEAR HORMONE CONDENSATES IN LIGAND-ACTIVATED GENE PROGRAMS AND CHROMATIN DYNAMICS.
Ines Pineda-Torra (University College London)
TRANSCRIPTIONAL CONTROL OF MEMBRANE LIPID BY THE NUCLEAR RECEPTOR LXR: NOVEL MECHANISM OF T CELL MODULATION
Ganesh Raj (UT Southwestern Medical Center)
David Ray (University of Oxford)
HNF4A IS REQUIRED TO SPECIFY GLUCOCORTICOID ACTION IN THE LIVER
Inez Rogatsky (Weill Cornell Medicine)
TRANSCRIPTIONAL AND EPIGENOMIC PROGRAMMING OF HOMEOSTATIC MACROPHAGES
Henriette Uhlenhaut (Technische Universität München)
LOCUS-SPECIFIC TRANSCRIPTIONAL COMPLEX ASSEMBLY BY THE GLUCOCORTICOID RECEPTOR
Cecilia Williams (KTH Royal Institute of Technology / Karolinska Institute)
ERβ - BIOMARKER AND FUNCTION IN GRANULOSA CELL TUMORS
Catherine Williamson (King's College London)
AETIOLOGY OF GESTATIONAL METABOLIC DISEASE
Leonie Young (Royal College of Surgeons in Ireland)
ER/CDK12/MED1, A FUNCTIONAL TRANSCRIPTIONAL COMPLEX IN ADVANCED BREAST CANCER.
Amina Zoubeidi (Vancouver Prostate Centre)
ROLE OF AR IN LINEAGE PLASTICITY
Wilbert Zwart (Netherlands Cancer Institute)
CISTROMIC PLASTICITY IN CLINICAL TRIALS: HOW DOES PROSTATE CANCER EVADE AR INHIBITION?

Target Audience

Scientists and Clinician Scientists at a range of levels from postdoctoral and up: Principal Investigators, Junior Team Leaders, Research Fellows. Ambitious postgraduate students in the field will also be encouraged to attend.
Relevant specialties are wide-ranging, reflecting the importance of nuclear receptors in many aspects of health and disease. These include Endocrinology, Oncology, Paediatrics, Urology, Gynaecology, Obstetric Medicine, Neuroscience, Cardiology.
 

Confirmed Speakers

Invited Speakers
Henriette Uhlenhaut

Henriette Uhlenhaut

Professor, Helmholtz Zentrum München GmbH

Karolien De Bosscher

Karolien De Bosscher

Full Professor, VIB

Carol Lange

Carol Lange

Professor of Medicine and Pharmacology, University of Minnesota Masonic Cancer Center

Mathieu Lupien

Mathieu Lupien

Senior Scientist/Professor, Princess Margaret Cancer Centre/UHN

Cecilia Williams

Cecilia Williams

Professor, KTH Royal Institute of Technology / Karolinska Institute

Jason Carroll

Jason Carroll

Professor, University of Cambridge

Wilbert Zwart

Wilbert Zwart

Senior groupleader, Netherlands Cancer Institute

Geoffrey Greene

Geoffrey Greene

Professor and Chair, University of Chicago

David Ray

David Ray

professor of endocrinology, university of oxford

Moray Campbell

Moray Campbell

Professor, The Ohio State Univeristy

Inez Rogatsky

Inez Rogatsky

Professor, Senior Scientist, Hospital for Special Surgery and Weill Cornell Medical College

Catherine Williamson

Catherine Williamson

Professor, King's College London

Amina Zoubeidi

Amina Zoubeidi

Assistant Professor, The Vancouver Prostate Centre/UBC

Leonie Young

Leonie Young

Research Scientist, Royal College of Surgeons in Ireland

Frank Claessens

Frank Claessens

Prof., KU Leuven

Ines Pineda-Torra

Ines Pineda-Torra

Associate Professor, University College London

Theresa Hickey

Theresa Hickey

Senior Research Fellow, University of Adelaide

Programme

Wednesday 4th May 2022

14:00 – 15:00

Registration

NRs in the female reproductive tract
Session chairs - Jessica-Finlay Schultz & Geof Greene

15:00 – 15:15

Opening Comments

15:15 – 15:45

Carol Lange
University of Minnesota Masonic Cancer Center

TO SLEEP PERCHANCE TO DREAM: PR REGULATION OF CELL CYCLE EXIT/ENTRY IN FALLOPIAN TUBE MODELS OF HIGH GRADE SEROUS OVARIAN CANCER

15:45 – 16:15

Cecilia Williams
KTH Royal Institute of Technology / Karolinska Institute

ERβ - BIOMARKER AND FUNCTION IN GRANULOSA CELL TUMORS

16:15 – 16:30

Thao Dinh
University of Adelaide

PROGESTERONE RECEPTOR COOPERATES WITH RUNX1 AND PROMOTES CHROMATIN ACCESSIBILITY TO ACTIVATE GENE EXPRESSION IN OVARIAN GRANULOSA CELLS DURING OVULATION

16:30 – 17:00

Catherine Williamson
Kings College London

AETIOLOGY OF GESTATIONAL METABOLIC DISEASE

17:00 – 17:30

Refreshments & Poster Viewing

New insight into the diversity of NR functions
Session Chairs - Charlotte Bevan & Wayne Tilley

17:30 – 18:00

Jason Carroll
University of Cambridge

NEW INSIGHT INTO THE ROLE OF HNF4 IN PANCREATIC CANCER

18:00 – 18:30

Inez Rogatsky
Weill Cornell Medicine

TRANSCRIPTIONAL AND EPIGENOMIC PROGRAMMING OF HOMEOSTATIC MACROPHAGES

18:30 – 18:45

Hui Xia
McGill University

TRANSCRIPTIONAL REGULATION OF INSULIN ACTION AND SENSITIVITY VIA THE GSK3β-FBXW7-ERRα AXIS

18:45 – 19:25

Peter Nelson
Fred Hutch

TEACHING AR NEW TRICKS IN PROSTATE CANCER

19:25 – 19:55

Panel Discussion

19:55

Group Dinner

Thursday 5th May 2022

07:00– 08:30

Buffet Breakfast

Transcriptional Regulation & Function
Session Chairs - Scott Dehm & Amy Dwyer

08:30 – 09:00

Ines Pineda Torra
University College London

TRANSCRIPTIONAL CONTROL OF MEMBRANE LIPID BY THE NUCLEAR RECEPTOR LXR: NOVEL MECHANISM OF T CELL MODULATION

09:00 – 09:30

Frank Claessens
KU Leven

WHICH OF THREE AR DIMERIZATION MODES IS THE BETTER THERAPEUTIC TARGET?

09:30 – 09:45

Jessica Finlay-Schultz
University of Colorado

PROGESTERONE RECEPTOR REGULATION OF RNA POLYMERASE III GENES

09:45 – 10:15

Refreshments & Poster Viewing

10:15 – 10:45

Moray Campbell
The Ohio State University

EPIGENETIC CONTROL OF TYPE II NUCLEAR RECEPTOR BOOKMARKING FUNCTIONS DETERMINES TYPE I NUCLEAR RECEPTOR ENHANCER INTERACTIONS

10:45 – 11:00

Damien Leach
Imperial College London

ANDROGEN RECEPTOR ACTION IN THE MESENCHYME: ANDROGENS REGULATE MESENCHYMAL CELLS AND THEIR EXTRACELLULAR MATRIX IN PRIMARY AND METASTATIC SITES TO INFUENCE CANCER CELL TRANSCRIPTION AND BEHAVIOUR

11:00 – 11:15

Kiel Tietz
University of Minnesota

ALTERNATIVE POLYADENYLATION AS A THERAPEUTIC VULNERABILITY IN PROSTATE CANCER

11:15 – 11:45

Amina Zoubeidi
Vancouver Prostate Centre

ROLE OF AR IN LINEAGE PLASTICITY

11:45 – 12:15

Panel Discussion

12:15

Lunch at Leisure & Afternoon Free Time

12:45 – 19:00

Group Activity

 

Dinner at Leisure

Friday 6th May 2022

07:00 – 08:30

Buffet Breakfast

NR-Cofactor Interactions and Implications
Session chairs - Carol Sartorius & Pete Nelson

08:30 – 09:00

Leonie Young
Royal College of Surgeons in Ireland

ER/CDK12/MED1, A FUNCTIONAL TRANSCRIPTIONAL COMPLEX IN ADVANCED BREAST CANCER

09:00 – 09:30

Henriette Uhlenhaute
Technische Universität München

LOCUS-SPECIFIC TRANSCRIPTIONAL COMPLEX ASSEMBLY BY THE GLUCOCORTICOID RECEPTOR

09:30 – 10:00

David Ray
University of Oxford

HNF4A IS REQUIRED TO SPECIFY GLUCOCORTICOID ACTION IN THE LIVER

10:00 – 10:30

Refreshments & Poster Viewing

10:30 – 11:00

Wilbert Zwart
Netherlands Cancer Institute

CISTROMIC PLASTICITY IN CLINICAL TRIALS: HOW DOES PROSTATE CANCER EVADE AR INHIBITION?

11:00 – 11:15

Zong Wei
Mayo Clinic Arizona

CHROMATIN REMODELLING COMPLEXES DEFINE NUCLEAR RECEPTOR FUNCTION IN METABOLISM AND INFLAMMATION

11:15 – 11:45

Karolien de Bosscher
Ugent University

CROSS-TALK MECHANISMS TO RE-WIRE THE GLUCOCORTICOID RECEPTOR FOR ENHANCED THERAPEUTIC BENEFIT IN CANCER AND INFLAMMATION

11:45 – 12:00

Amy Dwyer
University of Adelaide

REPROGRAMMING NUCLEAR RECEPTOR SIGNALLING IN BREAST AND PROSTATE CANCER

12:00 – 12:30

Matthieu Lupien
University of Toronto

FINDING CANCER DRIVERS FROM THE NON-CODING PROSTATE CANCER GENOME

12:30 – 13:00

Panel Discussion

13:00 – 16:15

Group Photo, Lunch at Leisure & Free Time

New approaches to ER targeting
Session Chairs - Leonie Young & Jason Carroll

16:15 – 16:45

Geof Greene
University of Chicago

CHOOSING AN OPTIMAL ER-TARGETED THERAPY FOR MUTANT ER+ METASTATIC BREAST CANCER

16:45 – 17:15

Ganesh Raj
UT Southwestern Medical Center

A NOVEL STRATEGY TO TARGET MUTANT ER

17:15 – 17:45

Theresa Hickey
University of Adelaide

COMING IN SIDEWAYS TO TARGET ERα

17:45 – 18:15

Panel Discussion

18:15 – 19:45

Poster Session & Refreshments

20:00

Gala Dinner, Poster Awards

Saturday 7th May 2022

07:00 – 09:00

Buffet Breakfast

Round table discussion
Session Chairs - Carol Sartorius & Scott Dehm

09:00 – 10:00

The future of NRs: biology to therapeutic target

10:00 – 10:15

Reprograming the NR meeting; what would you like to see?

10:15 – 10:30

Closing Comments & Departure

 

Supported by

Endorsing Partners
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Venue & Location

Fiesta Americana Condesa Cancun All Inclusive

This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment.  We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas

General Information

Venue Rating

★ ★ ★ ★ ★

Currency

US Dollar (USD)

Address

Fiesta Americana Condesa Cancún All Inclusive Blvd. Kukulcan km 16.5 Zona Hotelera 77500 Cancun Q.R. Mexico

Nearest Airport

Cancun International Airport

Location

Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.

Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.

Endorsing Partners

Media Partners

If you're interested in sponsoring this conference please contact us.

Conference Manager

Amy Johnson

Need some help? Chat to the Fusion team today

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+44 (0) 1638 555057

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