Programme
Wednesday 4th May 2022 |
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14:00 – 15:00 |
Registration |
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NRs in the female reproductive tract |
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15:00 – 15:15 |
Opening Comments |
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15:15 – 15:45 |
Carol Lange |
TO SLEEP PERCHANCE TO DREAM: PR REGULATION OF CELL CYCLE EXIT/ENTRY IN FALLOPIAN TUBE MODELS OF HIGH GRADE SEROUS OVARIAN CANCER |
15:45 – 16:15 |
Cecilia Williams |
ERβ - BIOMARKER AND FUNCTION IN GRANULOSA CELL TUMORS |
16:15 – 16:30 |
Thao Dinh |
PROGESTERONE RECEPTOR COOPERATES WITH RUNX1 AND PROMOTES CHROMATIN ACCESSIBILITY TO ACTIVATE GENE EXPRESSION IN OVARIAN GRANULOSA CELLS DURING OVULATION |
16:30 – 17:00 |
Catherine Williamson |
AETIOLOGY OF GESTATIONAL METABOLIC DISEASE |
17:00 – 17:30 |
Refreshments & Poster Viewing |
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New insight into the diversity of NR functions |
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17:30 – 18:00 |
Jason Carroll |
NEW INSIGHT INTO THE ROLE OF HNF4 IN PANCREATIC CANCER |
18:00 – 18:30 |
Inez Rogatsky |
TRANSCRIPTIONAL AND EPIGENOMIC PROGRAMMING OF HOMEOSTATIC MACROPHAGES |
18:30 – 18:45 |
Hui Xia |
TRANSCRIPTIONAL REGULATION OF INSULIN ACTION AND SENSITIVITY VIA THE GSK3β-FBXW7-ERRα AXIS |
18:45 – 19:25 |
Peter Nelson |
TEACHING AR NEW TRICKS IN PROSTATE CANCER |
19:25 – 19:55 |
Panel Discussion |
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19:55 |
Group Dinner |
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Thursday 5th May 2022 |
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07:00– 08:30 |
Buffet Breakfast |
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Transcriptional Regulation & Function |
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08:30 – 09:00 |
Ines Pineda Torra |
TRANSCRIPTIONAL CONTROL OF MEMBRANE LIPID BY THE NUCLEAR RECEPTOR LXR: NOVEL MECHANISM OF T CELL MODULATION |
09:00 – 09:30 |
Frank Claessens |
WHICH OF THREE AR DIMERIZATION MODES IS THE BETTER THERAPEUTIC TARGET? |
09:30 – 09:45 |
Jessica Finlay-Schultz |
PROGESTERONE RECEPTOR REGULATION OF RNA POLYMERASE III GENES |
09:45 – 10:15 |
Refreshments & Poster Viewing |
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10:15 – 10:45 |
Moray Campbell |
EPIGENETIC CONTROL OF TYPE II NUCLEAR RECEPTOR BOOKMARKING FUNCTIONS DETERMINES TYPE I NUCLEAR RECEPTOR ENHANCER INTERACTIONS |
10:45 – 11:00 |
Damien Leach |
ANDROGEN RECEPTOR ACTION IN THE MESENCHYME: ANDROGENS REGULATE MESENCHYMAL CELLS AND THEIR EXTRACELLULAR MATRIX IN PRIMARY AND METASTATIC SITES TO INFUENCE CANCER CELL TRANSCRIPTION AND BEHAVIOUR |
11:00 – 11:15 |
Kiel Tietz |
ALTERNATIVE POLYADENYLATION AS A THERAPEUTIC VULNERABILITY IN PROSTATE CANCER |
11:15 – 11:45 |
Amina Zoubeidi |
ROLE OF AR IN LINEAGE PLASTICITY |
11:45 – 12:15 |
Panel Discussion |
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12:15 |
Lunch at Leisure & Afternoon Free Time |
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12:45 – 19:00 |
Group Activity |
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Dinner at Leisure |
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Friday 6th May 2022 |
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07:00 – 08:30 |
Buffet Breakfast |
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NR-Cofactor Interactions and Implications |
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08:30 – 09:00 |
Leonie Young |
ER/CDK12/MED1, A FUNCTIONAL TRANSCRIPTIONAL COMPLEX IN ADVANCED BREAST CANCER |
09:00 – 09:30 |
Henriette Uhlenhaute |
LOCUS-SPECIFIC TRANSCRIPTIONAL COMPLEX ASSEMBLY BY THE GLUCOCORTICOID RECEPTOR |
09:30 – 10:00 |
David Ray |
HNF4A IS REQUIRED TO SPECIFY GLUCOCORTICOID ACTION IN THE LIVER |
10:00 – 10:30 |
Refreshments & Poster Viewing |
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10:30 – 11:00 |
Wilbert Zwart |
CISTROMIC PLASTICITY IN CLINICAL TRIALS: HOW DOES PROSTATE CANCER EVADE AR INHIBITION? |
11:00 – 11:15 |
Zong Wei |
CHROMATIN REMODELLING COMPLEXES DEFINE NUCLEAR RECEPTOR FUNCTION IN METABOLISM AND INFLAMMATION |
11:15 – 11:45 |
Karolien de Bosscher |
CROSS-TALK MECHANISMS TO RE-WIRE THE GLUCOCORTICOID RECEPTOR FOR ENHANCED THERAPEUTIC BENEFIT IN CANCER AND INFLAMMATION |
11:45 – 12:00 |
Amy Dwyer |
REPROGRAMMING NUCLEAR RECEPTOR SIGNALLING IN BREAST AND PROSTATE CANCER |
12:00 – 12:30 |
Matthieu Lupien |
FINDING CANCER DRIVERS FROM THE NON-CODING PROSTATE CANCER GENOME |
12:30 – 13:00 |
Panel Discussion |
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13:00 – 16:15 |
Group Photo, Lunch at Leisure & Free Time |
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New approaches to ER targeting |
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16:15 – 16:45 |
Geof Greene |
CHOOSING AN OPTIMAL ER-TARGETED THERAPY FOR MUTANT ER+ METASTATIC BREAST CANCER |
16:45 – 17:15 |
Ganesh Raj |
A NOVEL STRATEGY TO TARGET MUTANT ER |
17:15 – 17:45 |
Theresa Hickey |
COMING IN SIDEWAYS TO TARGET ERα |
17:45 – 18:15 |
Panel Discussion |
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18:15 – 19:45 |
Poster Session & Refreshments |
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20:00 |
Gala Dinner, Poster Awards |
Saturday 7th May 2022 |
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07:00 – 09:00 |
Buffet Breakfast |
Round table discussion |
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09:00 – 10:00 |
The future of NRs: biology to therapeutic target |
10:00 – 10:15 |
Reprograming the NR meeting; what would you like to see? |
10:15 – 10:30 |
Closing Comments & Departure |