5th Interventions in Aging Conference

#FusionAging25

Date

04 Oct - 07 Oct 2025

Location

St. Julian's, Malta

  • Heinrich Jasper

    Genentech, Inc.

  • Linda Partridge

    University College London

  • William Mair

    Harvard University

Early Bird - Expired  •  Talk Submission - Expired  •  Poster Submission - Expired  •  Registration & Payment Deadline - Expired

Synopsis

Molecular and cellular mechanisms of aging are the main contributors to age-related decline, frailty, diseases and multimorbidity. The contributions of these aging mechanisms vary between different types of organisms, cell types and tissues, but they are conserved over large evolutionary distances and genetic, lifestyle and pharmacological interventions can ameliorate their effects. These findings have led to the geroscience approach, which aims to develop broad-spectrum preventative defences against age-related impairments, by targeting their main risk factor, aging. Important current challenges in the field are (1) to assess the roles of somatic mutation and impaired genes expression, (2) to understand the origins of the highly damaging age-related increase in inflammation, (3) to specify the multiple interactions between organs that combine to produce age-related impairments, (4) to better understand interactions within cells that lead to decline in their function, (5) to evaluate the promise and challenges of regenerative interventions and cellular reprogramming.  

This fifth meeting will explore these topics, with particular emphasis on new knowledge and its potential for translation into benefits to human health during aging.

Confirmed Plenary Speakers

Rozalyn Anderson (University of Wisconsin-Madison)
AGING METABOLIC SIGNATURES
Helen Blau (Stanford University)
ENHANCING MUSCLE STRENGTH IN AGING BY TARGETING THE GEROZYME 15-PGDH
Anne Brunet (Stanford University)
QUANTIFYING THE DYNAMICS OF AGING
Vishwa Deep Dixit (Yale School of Medicine)
ENANTIOSTATIC CHECKPOINTS OF INFLAMMAGING
Andrew Dillin (University of California, Berkeley)
THE ANTAGONISTIC EFFECTS OF AUTOPHAGY ON QUIESCENT CELLS
Juan Carlos Izpisua Belmonte (Altos Labs)
RESTORING CELL HEALTH AND REVERSING DISEASE BY CELLULAR REJUVENATION
Saul Villeda (University of California, San Francisco)
SYSTEMIC MECHANISMS OF BRAIN AGING AND REJUVENATION

Confirmed Invited Speakers

Andrea Ablasser (EPFL)
Darren Baker (Mayo Clinic)
THE AGE-OLD ENEMY WITHIN: TARGETING SENESCENCE TO IMPROVE HEALTH
Constanza Cortes (University of Southern California)
EXERCISE-MEDIATED TRANSCRIPTIONAL REMODELING OF THE ALZHEIMER'S DISEASE HIPPOCAMPUS
Costas Demetriades (Max Planck Institute for Biology of Ageing)
CELL BIOLOGICAL PRINCIPLES OF NUTRIENT SIGNALING TO mTORC1
Oliver Hahn (Calico Labs)
DECODING HOTSPOTS OF BRAIN AGING
Adam Hughes (University of Utah)
UNTANGLING THE ROLE OF AMINO ACID TOXICITY IN AGE-RELATED ORGANELLE DECLINE
Leanne Jones (University of California, San Francisco)
MECHANISMS DRIVING AGING AND REJUVENATION OF THE INTESTINE
Jason Karpac (Texas A&M University)
EXPLOITING DROSOPHILA TO EXPLORE INTER-ORGAN COORDINATION OF IMMUNO-METABOLIC RESPONSES
Heidi McBride (McGill University)
MITOCHONDRIAL REGULATION OF ADAPTIVE IMMUNITY IN AGE-RELATED DISEASE
Martin Picard (Columbia University)
THE ENERGETIC COST OF STRESS RESPONSES AND BODY-TO-BRAIN SIGNALING IN AGING
Luca Scorrano (University of Padua)
Amy Wagers (Harvard University)
REVERSING AGING-ASSOCIATED DYSFUNCTION BY MANIPULATING BLOOD-BORNE FACTORS
David Walker (University of California, Los Angeles)
INTESTINAL BARRIER DYSFUNCTION DRIVES BRAIN AGING
Ashley Webb (Buck Institute for Research on Aging)
TRANSCRIPTIONAL AND EPIGENETIC MECHANISMS OF BRAIN AGING AND NEURODEGENERATION
Matthew Yousefzadeh (Columbia University)
THE IMPACT OF IMMUNE SENESCENCE ON THE INTERORGAN COMMUNICATION OF AGING

Key Sessions

•    Somatic mutation 
•    Origins of age-related inflammation
•    Metabolism and physiology
•    Inter-organ communication
•    Inter-organelle communication
•    Cellular reprogramming

Target Audience

Scientists at all career stages and working in contexts across academia and industry who are doing or may in the future do work to understand the aging process and ways in which its effects on health at later ages can be ameliorated.

Educational Need

The meeting will present and discuss cutting edge work on several mechanisms of aging and the promise and challenges of translating them into interventions to improve human health during aging.

Confirmed Speakers

Chairs
Heinrich Jasper

Heinrich Jasper

Genentech, Inc.

Linda Partridge

Linda Partridge

University College London

William Mair

William Mair

Harvard University

Plenary Speakers
Roz Anderson

Roz Anderson

University of Wisconsin-Madison

Helen Blau

Helen Blau

Stanford University

Anne Brunet

Anne Brunet

Stanford University

Vishwa Deep Dixit

Vishwa Deep Dixit

Yale School of Medicine

Andrew Dillin

Andrew Dillin

University of California, Berkeley

Juan Carlos Izpisua Belmonte

Juan Carlos Izpisua Belmonte

Altos Labs

Saul Villeda

Saul Villeda

University of California, San Francisco

Invited Speakers
Darren Baker

Darren Baker

Mayo Clinic

Constanza Cortes

Constanza Cortes

University of Southern California

Costas Demetriades

Costas Demetriades

Max Planck Institute for Biology of Ageing

Oliver Hahn

Oliver Hahn

Calico Labs

Adam Hughes

Adam Hughes

University of Utah

Leanne Jones

Leanne Jones

University of California, San Francisco

Jason Karpac

Jason Karpac

Texas A&M University

Heidi McBride

Heidi McBride

McGill University

Martin Picard

Martin Picard

Columbia University

Luca Scorrano

Luca Scorrano

University of Padua

Amy Wagers

Amy Wagers

Harvard University

David Walker

David Walker

University of California, Los Angeles

Ashley Webb

Ashley Webb

Buck Institute for Research on Aging

Matthew Yousefzadeh

Matthew Yousefzadeh

Columbia University

Programme

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Venue & Location

Hilton Malta

We are excited to be heading back to St. Julian’s as our Mediterranean destination for October 2025! 

Located only 15 minutes from the ancient capital city of Valletta, a UNESCO World Heritage Site, Hilton Malta is an oceanfront resort overlooking the stunning Portomaso Marina in St. Julian’s. With modern amenities, scenic views, and a tranquil atmosphere, it offers the perfect balance between professional functionality and easy access to local culture and history. 

This is not an all-inclusive property, but our registration packages include a full food and beverage package during the conference period. Breakfast remains at leisure, however, the more intimate hotel setting allows us to host group lunches and dinners, providing an ideal environment for focused discussions, so attendees can continue to network and brainstorm outside of planned sessions. 

For those who wish to stay extra nights either side of the conference, rates will be bed and breakfast only, so attendees have the freedom to explore local dining experiences and authentic cuisine. 

Hotel facilities include;
•    Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
•    4 Seasonal Outdoor Pools
•    Spa with Indoor Swimming Pool
•    Fitness Center and Tennis Court
•    3 Restaurants
•    2 Bars

General Information

Venue Rating

★ ★ ★ ★ ★

Currency

Euro (EUR)

Address

Vjal Portomaso St Julian's PTM, 01, Malta

Nearest Airport

Malta International Airport

Location

The Hilton Malta overlooks the stunning Portomaso Marina in St. Julian’s. This beautiful hotel is located only 15 minutes from the ancient capital city of Valletta, a UNESCO World Heritage Site. 

Bronze Sponsors

Media Partners

If you're interested in sponsoring this conference please contact us.

Conference Manager

Rosie Johnson

Need some help? Chat to the Fusion team today

As a family run business, our dedication runs deep. We’re committed to each other and, even more so, to every attendee’s experience, delivering a level of care and passion that’s truly unmatched.

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+44 (0) 1638 555057

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