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3rd Interventions in Aging Conference
03 Mar - 06 Mar 2019
Nassau, Bahamas
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Linda Partridge
University College London
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Brian Kennedy
Yong Loo Lin School of Medicine, National University Singapore
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Synopsis
A plethora of genetic, dietary and pharmacological interventions can extend healthy lifespan in laboratory animals, and can delay or ameliorate diverse aging-related diseases. Many of the signalling pathways involved are evolutionarily conserved, and are starting to be implicated in human aging. This raises the intriguing possibility of performing preventative medicine against the chronic diseases of our time by targeting the main risk factor for all of them, namely aging. Two important current challenges in the field are (1) to understand the downstream pathways by which longevity interventions combat age-related loss of function and pathology, and (2) to translate the findings into the extension of human healthspan.
This third meeting will continue to explore these topics, with particular emphasis on the systemic environment, mitochondria, biomarkers and frailty, immune aging and the protective effects of natural products.
For those interested, this meeting follows the Mitochondria: From Basic Biology to Mechanisms of Disease Conference, taking place from 27 February - 02 March 2019 at the same venue.
Student Offer
Take advantage of this fantastic opportunity for students! Register an academic at the standard rate of $1,922 and bring a student for only $850. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 03, 04, 05 March 2019 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 14 December 2018. Once registered, please contact Meredith Willmott to obtain a special registration link for your student.
Confirmed Plenary Speakers:
Darren Baker (Mayo Clinic)
IMPLICATING SENESCENT CELLS TO NEURODEGENERATIVE PATHOLOGIES
Shin-ichiro Imai (Washington University in St. Louis)
Thomas Langer (Max Planck Institute)
PROTEOLYTIC CONTROL OF MITOCHONDRIAL PLASTICITY
Janet Lord (University of Birmingham)
PREVENTING AND OVERCOMING IMMUNESENESCENCE
Joan Mannick (resTORbio)
TORC1 INHIBITION AS AN IMMUNOTHERAPY TO DECREASE INFECTIONS IN THE ELDERLY
Dennis Villareal (Baylor College of Medicine)
LIFESTYLE INTERVENTIONS TO REVERSE FRAILTY IN OLDER ADULTS WITH OBESITY
Confirmed Invited Speakers:
Thiruma Arumugam (National University of Singapore)
INTERMITTENT METABOLIC SWITCHING AND BRAIN HEALTH
Bonnie Blomberg (University of Miami)
PROGRESS IN AGING AND IMMUNITY
Steven Braithwaite (Alkahest)
MULTIMODAL THERAPEUTICS FROM THE PLASMA PROTEOME FOR AGE-RELATED DISORDERS
Katrin Chua (Stanford University)
CHROMATIN REGULATION AND GENOME MAINTENANCE BY HUMAN SIRTUINS SIRT6 AND SIRT7
Kaare Christensen (University of Southern Denmark)
LONGEVITY ENRICHED FAMILIES. HOW DID THEY SUCCEED?
Peter Fedichev (GERO)
Vadim Gladyshev (Harvard Medical School)
Jan Gruber (Yale NUS College)
LEVERAGING PATHWAY SYNERGY FOR PHARMACOLOGICAL INTERVENTIONS TO EXTEND HEALHTY LIFESPAN
Vera Gorbunova (University of Rochester)
FROM COMPARATIVE BIOLOGY TO ANTI-AGING INTERVENTIONS
Jesús Gil (MRC London Institute of Medical Sciences)
Marcia Haigis (Harvard Medical School)
MITOCHONDRIAL METABOLISM AND AGING
Jackie Han (PICB Shanghai)
Gerald de Haan (European Research Institiute for the Biology of Ageing)
NEW GENES INVOLVED IN HEMATOPOIETIC STEM CELL AGING
Heinrich Jasper (Genentech)
AGE RELATED STEM CELL DYSFUNCTION IN BARRIER EPITHELIA - STRATEGIES FOR INTERVENTION
Dudley Lamming (University of Wisconsin)
THE REGULATION OF METABOLIC HEALTH AND LONGEVITY BY SPECIFIC DIETARY MACRONUTRIENTS
William Mair (Harvard T.H. Chan)
RNA SPLICING AND LONGEVITY
Darcie Moore (University of Wisconsin)
Richard Miller (University of Michigan)
THE MOUSE ITP: CURRENT PROGRESS AND PROJECTS or CAP-INDEPENDENT TRANSLATION OF SELECTIVE MRNAS IN LONG-LIVED MUTANT MICE
Nicolas Musi (UT Health, San Antionio)
Thomas Nystrom (University of Gothenburg)
HUNTING FOR GENES GENERATING CELLULAR AGE ASYMMETRY
Arlan Richardson (University of Oklahoma Health Science Center)
IS REDUCING NECROPTOSIS AN POTENTIAL INTERVENTION IN AGING?
Dave Schubert (Salk Institute)
GERONEUROPROTECTORS: EFFECTIVE GEROPROTECTORS FOR THE BRAIN
Thomas Weldon (Ponce de Leon Health, Inc)
PONCE DE LEON HEALTH
Kai Zhou (Buck Institute)
Target Audience
- Basic scientists in the field of aging research using animal models.
- Human researchers interested in biomarkers of aging
- Clinical trials specialists in aging and associated diseases.
- Scientists and other professionals developing aging interventions.
- Investors looking to enter this new space
- Educated public
Educational Need
The aging field encompasses a wide range of biology, involving many model organisms and, with respect to mammals, the involvement of many tissues. In addition, translational strategies to modify the rate of aging range from lifestyle change to drugs and, more recently stem cell-based therapeutics. As such, there is an abiding need to bring together scientists across diverse fields with the purpose of providing a clear overview of the state of basic research in aging and the development of translational strategies. The goal is to create cross-fertilization between scientists in different areas, accelerating the development of interventions that extend human healthspan.
Confirmed Speakers
Plenary Speakers
Janet Lord
Director of the Institute of Inlammation and Ageing, Birmingham University
Darren Baker
Senior Associate Consultant I, Mayo Clinic
Dennis Villareal
Professor, Baylor College of Medicine
Thomas Langer
Director, Max-Planck-Institute for Biology of Ageing
Joan Mannick
Chief Medical Officer, resTORbio
Shin-ichiro Imai
Professor, Washington University School of Medicine
Invited Speakers
Dudley Lamming
Assistant Professor, University of Wisconsin-Madison
Kaare Christensen
Professor, University of Southern Denmark
Darcie Moore
Associate Professor, University of Wisconsin-Madison
David Schubert
professor, Salk Institute
William Mair
Associate Professor, Harvard University
Steven Braithwaite
CSO, Alkahest
Heinrich Jasper
Staff Scientist, Genentech, Inc.
Thiruma Arumugam
Associate Professor, National University of Singapore
Richard Miller
Professor, University of Michigan
Bonnie Blomberg
Professor, U Miami Miller School of Medicine
Gerald de Haan
Scientific Director, European Research Institute for the Biology of Ageing
Chuankai (Kai) Zhou
Fellow, Buck Institute for Research on Agin
Arlan Richardson
Professor, University of Oklahoma Health Sciences Center
Vadim Gladyshev
Principal Investigator, Harvard Medical School
Vera Gorbunova
Professor, University of Rochester
Thomas Weldon
Chairman & CEO, Ponce de Leon Health, Inc
Marcia Haigis
Associate Professor, Harvard Medical School
Peter Fedichev
Founder & Chief Science Officer, Gero LLC
Nicolas Musi, MD
Professor of Medicine, Director of the Barshop Institute, UT Health Science SA
Jan Gruber
Assistant Professor, Yale-NUS
Matt Kaeberlein
Chief Science Officer, Optispan
Jesus Gil
Professor, MRC London Institute of Medical Sciences
Programme
SUNDAY 03RD MARCH 2019 |
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14:00 – 15:00 |
Registration & Welcome Reception |
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Translational Gerontology |
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15:00 – 15:10 |
Opening Comments |
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15:10 – 15:45 |
Joan Mannick |
TORC1 INHIBITION AS AN IMMUNOTHERAPY TO DECREASE INFECTIONS IN THE ELDERLY |
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15:45 – 16:10 |
Steven Braithwaite |
MULTIMODAL THERAPEUTICS FROM THE PLASMA PROTEOME FOR AGE-RELATED DISORDERS |
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16:10 – 16:35 |
Matt Kaeberlein |
TARGETING HALLMARKS OF AGING WITH RAPAMYCIN: NEW INSIGHTS INTO MECHANISM AND OPPORTUNITIES FOR CLINICAL INTERVENTION |
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16:35 – 17:00 |
Jan Gruber |
LEVERAGING PATHWAY SYNERGY FOR PHARMACOLOGICAL INTERVENTIONS TO EXTEND HEALHTY LIFESPAN |
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17:00 – 17:45 |
Refreshments |
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Immunity and Aging |
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17:45 – 18:10 |
Thomas Weldon |
PONCE DE LEON HEALTH |
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18:10 – 18:35 |
Bonnie Blomberg |
PROGRESS IN AGING AND IMMUNITY |
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18:35 – 19:10 |
Janet Lord |
PREVENTING AND OVERCOMING IMMUNESENESCENCE |
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19:10 – 19:35 |
Vera Gorbunova |
FROM COMPARATIVE BIOLOGY TO ANTI-AGING INTERVENTIONS |
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19:35 – 20:00 |
Meet the Poster Presenters I |
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19:35 – 20:00 |
Accompanying Guests Pre-Dinner Welcome Drinks |
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20:00 |
Dinner |
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MONDAY 04TH MARCH 2019 |
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07:00 – 09:00 |
Buffet Breakfast at The Market Place |
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Human Aging |
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09:00 – 09:35 |
Dennis Villareal |
LIFESTYLE INTERVENTIONS TO REVERSE FRAILTY IN OLDER ADULTS WITH OBESITY |
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09:35 – 10:00 |
David Schubert |
GERONEUROPROTECTORS: EFFECTIVE GEROPROTECTORS FOR THE BRAIN |
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10:00 – 10:25 |
Peter Fedichev |
LONGITUDINAL ANALYSIS OF AGING TRAJECTORIES REVEALS INTERPLAY BETWEEN AGING, FRAILTY AND RESILIENCE, PROVIDES EVIDENCE OF THE LIMITING LIFESPAN |
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10:25 – 11:10 |
Group Photo, Refreshments & Poster Viewing |
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11:10 – 11:35 |
Kaare Christensen |
LONGEVITY ENRICHED FAMILIES. HOW DID THEY SUCCEED? |
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11:35 – 12:00 |
Nicolas Musi |
ACARBOSE AS A LIFESPAN AND HEALTHSPAN-EXTENDING DRUG |
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12:00 – 16:30 |
Lunch at Leisure & Free Time |
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12:45 – 16:00 |
Group Activity: Snorkel Trip (sign-ups required in advance) |
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Aging in Mice |
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16:30 – 17:05 |
Shin-ichiro Imai |
NAD WORLD 3.0: THE IMPORTANCE OF ENAMPT AND THE NMN TRANSPORTER IN MAMMALIAN AGING/LONGEVITY CONTROL |
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17:05 – 17:30 |
Arlan Richardson |
IS REDUCING NECROPTOSIS AN POTENTIAL INTERVENTION IN AGING? |
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17:30 – 17:55 |
Richard Miller |
THE NIA ITP: PROGRESS AND PLANS |
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17:55 – 18:10 |
Tobias Nespital |
TESTING THE EFFECT OF TRAMETINIB ON MOUSE LIFESPAN AND HEALTHSPAN |
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18:10 – 18:25 |
Paul Fox |
A NOVEL S6K1 PHOSPHO-FORM TARGETS EPRS AND INFLUENCES ADIPOSITY AND LIFESPAN IN MICE |
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18:25 – 18:50 |
Marcia Haigis |
MITOCHONDRIAL METABOLISM AND AGING |
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18:50 – 20:00 |
Poster Session & Refreshments |
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20:00 |
Dinner |
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TUESDAY 05TH MARCH 2019 |
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07:00 – 09:00 |
Buffet Breakfast at The Market Place |
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09:00 – 09:15 |
Keshav Singh |
REVERSING WRINKLED SKIN AND LOST HAIR IN MICE BY RESTORING MITOCHONDRIAL FUNCTION |
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09:15 – 09:30 |
Pamela Maher |
A NOVEL ANTI-AGING COMPOUND FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
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09:30 – 09:55 |
Kai Zhou |
MITOCHONDRIAL FACTORS REGULATE THE FORMATION AND DISSOLUTION OF PROTEIN AGGREGATES |
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09:55 – 10:30 |
Thomas Langer |
PROTEOLYTIC CONTROL OF MITOCHONDRIAL PLASTICITY |
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10:30 – 11:15 |
Refreshments & Poster Viewing |
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11:15 – 11:30 |
Martin Denzel |
INHIBITION OF THE INTEGRATED STRESS RESPONSE EXTENDS LIFESPAN |
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11:30 – 11:45 |
Franziska Ottens |
OLFACTION REGULATES ORGANISMAL PROTEOSTASIS AND LONGEVITY VIA MICRORNA-DEPENDENT SIGNALING |
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11:45 – 17:00 |
Lunch at Leisure & Free Time |
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Cellular Senescence |
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17:00 – 17:25 |
Darren Baker |
IMPLICATING SENESCENT CELLS TO NEURODEGENERATIVE PATHOLOGIES |
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17:25 – 17:50 |
Jesús Gil |
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17:50 – 18:15 |
Gerald de Haan |
NEOGENIN-1: IDENTIFICATION OF A NOVEL RECEPTOR ASSOCIATED WITH HEMATOPOIETIC STEM CELL AGING |
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18:15 – 19:00 |
Refreshments & Poster Viewing |
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19:00 – 19:25 |
Darcie Moore |
THE INTERMEDIATE FILAMENT VIMENTIN MEDIATES RECOVERY FROM A LOSS OF PROTEOSTASIS IN NEURAL STEM CELLS |
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19:25 – 19:40 |
Emma Bolderson |
THE ROLE OF BANF1 IN THE REPAIR OF OXIDATIVE DNA DAMAGE |
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19:40 – 19:55 |
Alyona Keder |
DECIPHERING AUDITORY AGEING: LESSONS FROM DROSOPHILA |
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20:00 |
Gala Dinner & Poster Awards |
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WEDNESDAY 06TH MARCH 2019 |
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07:00 – 09:00 |
Buffet Breakfast at The Market Place |
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Metabolism and Aging |
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09:00 – 09:25 |
Dudley Lamming |
THE REGULATION OF METABOLIC HEALTH AND LONGEVITY BY SPECIFIC DIETARY MACRONUTRIENTS |
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09:25 – 09:50 |
Gavin Ng |
DISSECTING EPIGENETIC MECHANISM OF INTERMITTENT FASTING |
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09:50 – 10:20 |
Refreshments |
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Longevity Pathways |
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10:20 – 10:45 |
Heinrich Jasper |
AGE RELATED STEM CELL DYSFUNCTION IN BARRIER EPITHELIA - STRATEGIES FOR INTERVENTION |
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10:45 – 11:10 |
Vadim Gladyshev |
COMPARATIVE GENOMICS OF LIFESPAN CONTROL |
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11:10 – 11:35 |
Katrin Chua |
CHROMATIN REGULATION AND GENOME MAINTENANCE BY HUMAN SIRTUINS SIRT6 AND SIRT7 |
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11:35 – 12:00 |
William Mair |
NOVEL MOLECULAR MECHANISMS LINKING RNA SPLICING AND LONGEVITY |
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12:00 – 12:15 |
Closing Comments |
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Supported by
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Contact usVenue & Location
Melia Nassau Beach All Inclusive
Overlooking one of the finest beaches in the world the Meliá Nassau Beach is surrounded by crystal blue waters and white sandy beaches. Located on the stunning Cable Beach, you are just a few minutes walk from the center, shops and restaurants. The beautiful Nassau Botanical Gardens are within easy reach (7km) and Lynden Pindling International Airport is situated only 9km away.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from Cilantro where you can experience the natural textures, aromas and flavors of Mexico, Nikkei, celebrated for its exquisite fusion of Japanese, Cantonese and Peruvian cuisine featuring a sushi bar and Teppanyaki tables, Estavida, an upbeat tapas lounge located in the hotel lobby serving innovative tapas and a wide selection of cocktails, Aqua, an A la carte restaurant specializing in exquisite, rustic Italian cuisine, The Market Place, where you will find an International buffet serving an array of exquisite dishes, O'Grille, an open air restaurant with fabulous views of the sea and pool serving casual beach fare and light bites and finally The Black Angus, a steakhouse featuring hip, contemporary jazz and modern decor, offering guests the finest quality prime cuts and the freshest ingredients.(This restaurant is not included in the all inclusive package, additional charges apply). The Gala Night takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
Hotel Facilities
- 24 hour reception
- Room service
- 3 heated outdoor pools
- Complimentary resort wide Wi-Fi (guest rooms, throughout hotel, beach and conference areas)
- 24-hour Fitness Center
- 7 dining venues
- 4 bars.
- non-motorised water sports
The Bahamas is formed by over 700 islands, keys and islets located in the Atlantic Ocean and renowned for its warm sunshine, mild climate, fine, white sandy beaches, turquoise, crystal clear water and friendly people, making this the perfect environment to relax and unwind in your free time during the conference.
General Information
Venue Rating
★ ★ ★ ★
Currency
US Dollar (USD)
Address
Nassau W Bay St. Nassau Bahamas
Nearest Airport
Lynden Pindling International Airport
Location
The Melia Nassau Beach All-Inclusive is located right on the stunning Cable Beach just a few minutes away from the airport and city center; Nearby in Downtown Nassau you can experience the flavours of new foods at local restaurants, shop 'til you drop at Straw market or take a trip through time at the Pirates Museum. The beautiful Nassau Botanical Gardens are close by and water enthusiasts can enjoy non-motorized water sports right on property.
Nassau is the capital of the Bahamas. It lies on the island of New Providence, with neighboring Paradise Island accessible via Nassau Harbor bridges. The city has a hilly landscape and is known for it's fabulous beaches as well as its offshore coral reefs, popular for diving and snorkeling. It retains many of its typical pastel-colored British colonial buildings, like the pink-hued Government House.
Conference History
If you are interested in this meeting but not yet ready to register, you can sign up for updates here and our team will keep you updated regarding deadline reminders and grant opportunities relating to this meeting only.
Media Partners
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Conference Manager
Meredith Willmott
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