Past Conference

3rd Interventions in Aging Conference

Date

03 Mar - 06 Mar 2019

Location

Nassau, Bahamas

Early Bird - Expired  •  Talk Submission - Expired  •  Poster Submission - Expired  •  Registration & Payment Deadline - Expired

Synopsis

A plethora of genetic, dietary and pharmacological interventions can extend healthy lifespan in laboratory animals, and can delay or ameliorate diverse aging-related diseases. Many of the signalling pathways involved are evolutionarily conserved, and are starting to be implicated in human aging. This raises the intriguing possibility of performing preventative medicine against the chronic diseases of our time by targeting the main risk factor for all of them, namely aging. Two important current challenges in the field are (1) to understand the downstream pathways by which longevity interventions combat age-related loss of function and pathology, and (2) to translate the findings into the extension of human healthspan.

This third meeting will continue to explore these topics, with particular emphasis on the systemic environment, mitochondria, biomarkers and frailty, immune aging and the protective effects of natural products.

For those interested, this meeting follows the Mitochondria: From Basic Biology to Mechanisms of Disease Conference, taking place from 27 February - 02 March 2019 at the same venue.

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the standard rate of $1,922 and bring a student for only $850. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 03, 04, 05 March 2019 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 14 December 2018. Once registered, please contact Meredith Willmott to obtain a special registration link for your student.

Confirmed Plenary Speakers:


Darren Baker (Mayo Clinic)
IMPLICATING SENESCENT CELLS TO NEURODEGENERATIVE PATHOLOGIES
Shin-ichiro Imai (Washington University in St. Louis)
Thomas Langer (Max Planck Institute)
PROTEOLYTIC CONTROL OF MITOCHONDRIAL PLASTICITY
Janet Lord (University of Birmingham)
PREVENTING AND OVERCOMING IMMUNESENESCENCE
Joan Mannick (resTORbio)
TORC1 INHIBITION AS AN IMMUNOTHERAPY TO DECREASE INFECTIONS IN THE ELDERLY
Dennis Villareal (Baylor College of Medicine)
LIFESTYLE INTERVENTIONS TO REVERSE FRAILTY IN OLDER ADULTS WITH OBESITY

Confirmed Invited Speakers: 

Thiruma Arumugam (National University of Singapore)
INTERMITTENT METABOLIC SWITCHING AND BRAIN HEALTH 
Bonnie Blomberg (University of Miami)
PROGRESS IN AGING AND IMMUNITY
Steven Braithwaite (Alkahest)
MULTIMODAL THERAPEUTICS FROM THE PLASMA PROTEOME FOR AGE-RELATED DISORDERS
Katrin Chua (Stanford University)
CHROMATIN REGULATION AND GENOME MAINTENANCE BY HUMAN SIRTUINS SIRT6 AND SIRT7
Kaare Christensen (University of Southern Denmark)
LONGEVITY ENRICHED FAMILIES. HOW DID THEY SUCCEED?
Peter Fedichev (GERO)
Vadim Gladyshev (Harvard Medical School)
Jan Gruber (Yale NUS College)
LEVERAGING PATHWAY SYNERGY FOR PHARMACOLOGICAL INTERVENTIONS TO EXTEND HEALHTY LIFESPAN
Vera Gorbunova (University of Rochester)
FROM COMPARATIVE BIOLOGY TO ANTI-AGING INTERVENTIONS
Jesús Gil (MRC London Institute of Medical Sciences)
Marcia Haigis (Harvard Medical School)
MITOCHONDRIAL METABOLISM AND AGING
Jackie Han (PICB Shanghai)
Gerald de Haan (European Research Institiute for the Biology of Ageing)
NEW GENES INVOLVED IN HEMATOPOIETIC STEM CELL AGING
Heinrich Jasper (Genentech)
AGE RELATED STEM CELL DYSFUNCTION IN BARRIER EPITHELIA - STRATEGIES FOR INTERVENTION
Dudley Lamming (University of Wisconsin)
THE REGULATION OF METABOLIC HEALTH AND LONGEVITY BY SPECIFIC DIETARY MACRONUTRIENTS
William Mair (Harvard T.H. Chan)
RNA SPLICING AND LONGEVITY
Darcie Moore (University of Wisconsin)
Richard Miller (University of Michigan)
THE MOUSE ITP: CURRENT PROGRESS AND PROJECTS or CAP-INDEPENDENT TRANSLATION OF SELECTIVE MRNAS IN LONG-LIVED MUTANT MICE
Nicolas Musi (UT Health, San Antionio)
Thomas Nystrom (University of Gothenburg)
HUNTING FOR GENES GENERATING CELLULAR AGE ASYMMETRY
Arlan Richardson (University of Oklahoma Health Science Center)
IS REDUCING NECROPTOSIS AN POTENTIAL INTERVENTION IN AGING?
Dave Schubert (Salk Institute)
GERONEUROPROTECTORS: EFFECTIVE GEROPROTECTORS FOR THE BRAIN
Thomas Weldon (Ponce de Leon Health, Inc)
PONCE DE LEON HEALTH
Kai Zhou (Buck Institute)

Target Audience

  • Basic scientists in the field of aging research using animal models.
  • Human researchers interested in biomarkers of aging
  • Clinical trials specialists in aging and associated diseases.
  • Scientists and other professionals developing aging interventions.
  • Investors looking to enter this new space
  • Educated public

Educational Need

The aging field encompasses a wide range of biology, involving many model organisms and, with respect to mammals, the involvement of many tissues. In addition, translational strategies to modify the rate of aging range from lifestyle change to drugs and, more recently stem cell-based therapeutics. As such, there is an abiding need to bring together scientists across diverse fields with the purpose of providing a clear overview of the state of basic research in aging and the development of translational strategies. The goal is to create cross-fertilization between scientists in different areas, accelerating the development of interventions that extend human healthspan.

 

 

Confirmed Speakers

Plenary Speakers
Janet Lord

Janet Lord

Director of the Institute of Inlammation and Ageing, Birmingham University

Darren Baker

Darren Baker

Senior Associate Consultant I, Mayo Clinic

Dennis Villareal

Dennis Villareal

Professor, Baylor College of Medicine

Thomas Langer

Thomas Langer

Director, Max-Planck-Institute for Biology of Ageing

Joan Mannick

Joan Mannick

Chief Medical Officer, resTORbio

Shin-ichiro Imai

Shin-ichiro Imai

Professor, Washington University School of Medicine

Invited Speakers
Dudley Lamming

Dudley Lamming

Assistant Professor, University of Wisconsin-Madison

Kaare Christensen

Kaare Christensen

Professor, University of Southern Denmark

Darcie Moore

Darcie Moore

Associate Professor, University of Wisconsin-Madison

David Schubert

David Schubert

professor, Salk Institute

William Mair

William Mair

Associate Professor, Harvard University

Steven Braithwaite

Steven Braithwaite

CSO, Alkahest

Heinrich Jasper

Heinrich Jasper

Staff Scientist, Genentech, Inc.

Thiruma Arumugam

Thiruma Arumugam

Associate Professor, National University of Singapore

Richard Miller

Richard Miller

Professor, University of Michigan

Bonnie Blomberg

Bonnie Blomberg

Professor, U Miami Miller School of Medicine

Gerald de Haan

Gerald de Haan

Scientific Director, European Research Institute for the Biology of Ageing

Chuankai (Kai) Zhou

Chuankai (Kai) Zhou

Fellow, Buck Institute for Research on Agin

Arlan Richardson

Arlan Richardson

Professor, University of Oklahoma Health Sciences Center

Vadim  Gladyshev

Vadim Gladyshev

Principal Investigator, Harvard Medical School

Vera Gorbunova

Vera Gorbunova

Professor, University of Rochester

Thomas Weldon

Thomas Weldon

Chairman & CEO, Ponce de Leon Health, Inc

Marcia Haigis

Marcia Haigis

Associate Professor, Harvard Medical School

Peter Fedichev

Peter Fedichev

Founder & Chief Science Officer, Gero LLC

Nicolas Musi, MD

Nicolas Musi, MD

Professor of Medicine, Director of the Barshop Institute, UT Health Science SA

Jan Gruber

Jan Gruber

Assistant Professor, Yale-NUS

Matt Kaeberlein

Matt Kaeberlein

Chief Science Officer, Optispan

Jesus Gil

Jesus Gil

Professor, MRC London Institute of Medical Sciences

Programme

SUNDAY 03RD MARCH 2019

14:00 – 15:00

Registration & Welcome Reception

Translational Gerontology 
Session Chair: Linda Partridge

15:00 – 15:10

Opening Comments

15:10 – 15:45

Joan Mannick 
resTORbio

TORC1 INHIBITION AS AN IMMUNOTHERAPY TO DECREASE INFECTIONS IN THE ELDERLY

15:45 – 16:10

Steven Braithwaite 
Alkahest

MULTIMODAL THERAPEUTICS FROM THE PLASMA PROTEOME FOR AGE-RELATED DISORDERS

16:10 – 16:35

Matt Kaeberlein 
University of Washington

TARGETING HALLMARKS OF AGING WITH RAPAMYCIN: NEW INSIGHTS INTO MECHANISM AND OPPORTUNITIES FOR CLINICAL INTERVENTION

16:35 – 17:00

Jan Gruber 
Yale NUS College

LEVERAGING PATHWAY SYNERGY FOR PHARMACOLOGICAL INTERVENTIONS TO EXTEND HEALHTY LIFESPAN

17:00 – 17:45

Refreshments

Immunity and Aging 
Session Chair: Joan Mannick

17:45 – 18:10

Thomas Weldon 
Ponce de Leon Health, Inc

PONCE DE LEON HEALTH

18:10 – 18:35

Bonnie Blomberg 
University of Miami

PROGRESS IN AGING AND IMMUNITY

18:35 – 19:10

Janet Lord 
University of Birmingham

PREVENTING AND OVERCOMING IMMUNESENESCENCE

19:10 – 19:35

Vera Gorbunova 
University of Rochester

FROM COMPARATIVE BIOLOGY TO ANTI-AGING INTERVENTIONS

19:35 – 20:00

Meet the Poster Presenters I 
Moderators: Linda Partridge & Brian Kennedy

19:35 – 20:00

Accompanying Guests Pre-Dinner Welcome Drinks

20:00

Dinner

MONDAY 04TH MARCH 2019

07:00 – 09:00

Buffet Breakfast at The Market Place

Human Aging 
Session Chair: Arlan Richardson

09:00 – 09:35

Dennis Villareal 
Baylor College of Medicine

LIFESTYLE INTERVENTIONS TO REVERSE FRAILTY IN OLDER ADULTS WITH OBESITY

09:35 – 10:00

David Schubert 
Salk Institute

GERONEUROPROTECTORS: EFFECTIVE GEROPROTECTORS FOR THE BRAIN

10:00 – 10:25

Peter Fedichev 
GERO LLC

LONGITUDINAL ANALYSIS OF AGING TRAJECTORIES REVEALS INTERPLAY BETWEEN AGING, FRAILTY AND RESILIENCE, PROVIDES EVIDENCE OF THE LIMITING LIFESPAN

10:25 – 11:10

Group Photo, Refreshments & Poster Viewing

11:10 – 11:35

Kaare Christensen 
University of Southern Denmark

LONGEVITY ENRICHED FAMILIES. HOW DID THEY SUCCEED?

11:35 – 12:00

Nicolas Musi 
UT Health Science, San Antonio

ACARBOSE AS A LIFESPAN AND HEALTHSPAN-EXTENDING DRUG

12:00 – 16:30

Lunch at Leisure & Free Time

12:45 – 16:00

Group Activity: Snorkel Trip (sign-ups required in advance)

Aging in Mice 
Session Chair: Janet Lord

16:30 – 17:05

Shin-ichiro Imai 
Washington University School of Medicine

NAD WORLD 3.0: THE IMPORTANCE OF ENAMPT AND THE NMN TRANSPORTER IN MAMMALIAN AGING/LONGEVITY CONTROL

17:05 – 17:30

Arlan Richardson 
University of Oklahoma Health Science Center

IS REDUCING NECROPTOSIS AN POTENTIAL INTERVENTION IN AGING?

17:30 – 17:55

Richard Miller 
University of Michigan

THE NIA ITP: PROGRESS AND PLANS

17:55 – 18:10

Tobias Nespital 
Max Planck Institute for Biology of Ageing

TESTING THE EFFECT OF TRAMETINIB ON MOUSE LIFESPAN AND HEALTHSPAN

18:10 – 18:25

Paul Fox 
Cleveland Clinic

A NOVEL S6K1 PHOSPHO-FORM TARGETS EPRS AND INFLUENCES ADIPOSITY AND LIFESPAN IN MICE

18:25 – 18:50

Marcia Haigis 
Harvard Medical School

MITOCHONDRIAL METABOLISM AND AGING

18:50 – 20:00

Poster Session & Refreshments

20:00

Dinner

TUESDAY 05TH MARCH 2019

07:00 – 09:00

Buffet Breakfast at The Market Place

Mitochondri a and Aging 
Session Chair: Gerald de Haan

09:00 – 09:15

Keshav Singh 
The University of Alabama at Birmingham

REVERSING WRINKLED SKIN AND LOST HAIR IN MICE BY RESTORING MITOCHONDRIAL FUNCTION

09:15 – 09:30

Pamela Maher 
Salk Institute for Biological Studies

A NOVEL ANTI-AGING COMPOUND FOR THE TREATMENT OF ALZHEIMER'S DISEASE

09:30 – 09:55

Kai Zhou 
Buck Institute for Research on Aging

MITOCHONDRIAL FACTORS REGULATE THE FORMATION AND DISSOLUTION OF PROTEIN AGGREGATES

09:55 – 10:30

Thomas Langer 
Max Planck Institute

PROTEOLYTIC CONTROL OF MITOCHONDRIAL PLASTICITY

10:30 – 11:15

Refreshments & Poster Viewing

11:15 – 11:30

Martin Denzel 
Max Planck Institute for Biology of Ageing

INHIBITION OF THE INTEGRATED STRESS RESPONSE EXTENDS LIFESPAN

11:30 – 11:45

Franziska Ottens 
University of Cologne, CECAD Research Center

OLFACTION REGULATES ORGANISMAL PROTEOSTASIS AND LONGEVITY VIA MICRORNA-DEPENDENT SIGNALING

11:45 – 17:00

Lunch at Leisure & Free Time

Cellular Senescence 
Session Chair: Shin-ichiro Imai

17:00 – 17:25

Darren Baker 
Mayo Clinic

IMPLICATING SENESCENT CELLS TO NEURODEGENERATIVE PATHOLOGIES

17:25 – 17:50

Jesús Gil 
MRC London Institute of Medical Sciences

 

17:50 – 18:15

Gerald de Haan 
European Research Institute for the Biology of Ageing

NEOGENIN-1: IDENTIFICATION OF A NOVEL RECEPTOR ASSOCIATED WITH HEMATOPOIETIC STEM CELL AGING

18:15 – 19:00

Refreshments & Poster Viewing

19:00 – 19:25

Darcie Moore 
University of Wisconsin-Madison

THE INTERMEDIATE FILAMENT VIMENTIN MEDIATES RECOVERY FROM A LOSS OF PROTEOSTASIS IN NEURAL STEM CELLS

19:25 – 19:40

Emma Bolderson 
Queensland University of Technology

THE ROLE OF BANF1 IN THE REPAIR OF OXIDATIVE DNA DAMAGE

19:40 – 19:55

Alyona Keder 
University College London

DECIPHERING AUDITORY AGEING: LESSONS FROM DROSOPHILA

20:00

Gala Dinner & Poster Awards

WEDNESDAY 06TH MARCH 2019

07:00 – 09:00

Buffet Breakfast at The Market Place

Metabolism and Aging 
Session Chair: Heinrich Jasper

09:00 – 09:25

Dudley Lamming 
University of Wisconsin-Madison

THE REGULATION OF METABOLIC HEALTH AND LONGEVITY BY SPECIFIC DIETARY MACRONUTRIENTS

09:25 – 09:50

Gavin Ng 
National University of Singapore

DISSECTING EPIGENETIC MECHANISM OF INTERMITTENT FASTING

09:50 – 10:20

Refreshments

Longevity Pathways 
Session Chair: Brian Kennedy

10:20 – 10:45

Heinrich Jasper 
Genentech

AGE RELATED STEM CELL DYSFUNCTION IN BARRIER EPITHELIA - STRATEGIES FOR INTERVENTION

10:45 – 11:10

Vadim Gladyshev 
Harvard Medical School

COMPARATIVE GENOMICS OF LIFESPAN CONTROL

11:10 – 11:35

Katrin Chua 
Stanford University

CHROMATIN REGULATION AND GENOME MAINTENANCE BY HUMAN SIRTUINS SIRT6 AND SIRT7

11:35 – 12:00

William Mair 
Harvard University

NOVEL MOLECULAR MECHANISMS LINKING RNA SPLICING AND LONGEVITY

12:00 – 12:15

Closing Comments

 

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Venue & Location

Melia Nassau Beach All Inclusive

Overlooking one of the finest beaches in the world the Meliá Nassau Beach is surrounded by crystal blue waters and white sandy beaches. Located on the stunning Cable Beach, you are just a few minutes walk from the center, shops and restaurants. The beautiful Nassau Botanical Gardens are within easy reach (7km) and Lynden Pindling International Airport is situated only 9km away.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from Cilantro where you can experience the natural textures, aromas and flavors of Mexico, Nikkei, celebrated for its exquisite fusion of Japanese, Cantonese and Peruvian cuisine featuring a sushi bar and Teppanyaki tables, Estavida, an upbeat tapas lounge located in the hotel lobby serving innovative tapas and a wide selection of cocktails, Aqua, an A la carte restaurant specializing in exquisite, rustic Italian cuisine, The Market Place, where you will find an International buffet serving an array of exquisite dishes, O'Grille, an open air restaurant with fabulous views of the sea and pool serving casual beach fare and light bites and finally The Black Angus, a steakhouse featuring hip, contemporary jazz and modern decor, offering guests the finest quality prime cuts and the freshest ingredients.(This restaurant is not included in the all inclusive package, additional charges apply). The Gala Night takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment.  We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

  • 24 hour reception
  • Room service
  • 3 heated outdoor pools
  • Complimentary resort wide Wi-Fi (guest rooms, throughout hotel, beach and conference areas)   
  • 24-hour Fitness Center
  • 7 dining venues
  • 4 bars.
  • non-motorised water sports

The Bahamas is formed by over 700 islands, keys and islets located in the Atlantic Ocean and renowned for its warm sunshine, mild climate, fine, white sandy beaches, turquoise, crystal clear water and friendly people, making this the perfect environment to relax and unwind in your free time during the conference.

General Information

Venue Rating

★ ★ ★ ★

Currency

US Dollar (USD)

Address

Nassau W Bay St. Nassau Bahamas

Nearest Airport

Lynden Pindling International Airport

Location

The Melia Nassau Beach All-Inclusive is located right on the stunning Cable Beach just a few minutes away from the airport and city center; Nearby in Downtown Nassau you can experience the flavours of new foods at local restaurants, shop 'til you drop at Straw market or take a trip through time at the Pirates Museum. The beautiful Nassau Botanical Gardens are close by and water enthusiasts can enjoy non-motorized water sports right on property.

Nassau is the capital of the Bahamas. It lies on the island of New Providence, with neighboring Paradise Island accessible via Nassau Harbor bridges. The city has a hilly landscape and is known for it's fabulous beaches as well as its offshore coral reefs, popular for diving and snorkeling. It retains many of its typical pastel-colored British colonial buildings, like the pink-hued Government House.

 

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Conference Manager

Meredith Willmott

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