2 nd Interventions in Aging Conference

Brian Kennedy

Buck Institute for Research on Aging

Report

In March 2017, the Second Interventions in Aging Conference was held in Cancun, Mexico and organized by Fusion Conferences, Ltd. As meeting organizers, we would like to provide a brief overview of the meeting proceedings, which reflect larger views in the aging research field about the future directions critical for continued progress.

The meeting, similar to the earlier event in 2015, was focused on interventional strategies. One notable difference was that this year’s meeting was much more directed toward potential interventions to target human aging. The field has been very successful over the last decade in identifying interventions that extend lifespan and healthspan in animal models such as yeast, flies, worms, mice and, to some extent, primates. However, the primary goal is to employ knowledge from basic aging research to develop novel medical strategies aimed at extending human healthspan. Aging is the biggest risk factor for a wide range of chronic diseases that, to date, medical strategies have treated as separate entities, and as they arise. Yet, aging is driven by a limited number of coordinated pathways that can be modulated, and evidence suggests that interventions delaying aging will protect against multiple age-related diseases simultaneously. Discoveries in basic aging research thus point towards a broad-spectrum, preventative, medical strategy for aging-related disease.

There were seven research topics each addressed thematically at the meeting. All were chosen because they embody different strategies to target human aging. Each session combined talks from Platform speakers with those chosen from submitted abstracts. The first and largest theme was targeted toward Organismal Aging, or understanding the intrinsic pathways that govern aging of the entire organism. Platform presentations were provided by Rozalyn Anderson (University of Wisconsin-Madison), Adam Antebi (Max Planck Institute, Köln), Holly Brown-Borg (University of North Dakota), Yuki Ikeno and Nicolas Musi (University of Texas Health Sciences Center), Laura Niedernhofer (Scripps Florida), Scott Pletcher (University of Michigan), Eline Slagboom (Leiden University Medical Center). The interesting aspect of these presentations is that they address strategies to modify aging that touch back to research from the early days of aging research while simultaneously pointing to novel strategies for future interventions. Dr. Brown-Borg defined new mechanisms linking growth hormone signaling to aging, Dr. Ikeno, using mammalian models, re-evaluated the role of reactive oxygen species; Dr. Niedernhofer presented new evidence for links between progeria and normal aging, interpreting these strategies in the context of possible interventions that may affect both normal and “premature” aging; Dr. Musi linked NFkB signaling to sarcopenia, a major driver of frailty in aging; Dr. Pletcher described fly studies to examine the impacts of psychological stress on aging using flies; Dr. Antebi discussed novel strategies linking nuclear structure to aging using the classic model organism – C. elegans; Dr. Anderson elaborated mechanisms linking calorie restriction to lifespan extension in primates; and Dr. Slagboom described strategies to examine the impact of aging pathways in elderly human populations.

The second theme was focused on using Stem Cells to target aging, with exciting presentations by Heinrich Jasper (Buck Institute for Research on Aging) on aging of epithelial stem cells in flies and mice, Emmanuelle Passague (Columbia University) on links between metabolism, autophagy and aging in the hematopoietic system and Sara Wickstrom (Max Planck Institute, Köln), who discussed focused on how adult stem cells self-organize into functional configurations. The third theme, addressing Cellular Mechanisms of Longevity Assurance, focused on pathways suspected to modulate aging, including autophagy by Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute), mitochondrial function and aging with emphasis on the role of small mitochondrial peptides by David Lee (University of Southern California), and the hypoxia pathway by Dana Miller (University of Washington).

Theme 4 centered on Epigenetics, which is not only becoming a target for intervention in aging, but is rapidly becoming a leading candidate for providing biomarkers of biological age. Weiwei Dang (Baylor College of Medicine) studied mesenchymal stems cells and adipocyte differentiation, elucidating mechanisms leading to activation of the protein deacetylase, SIRT1; Dr. Eric Greer (Harvard Medical School/Boston Children’s Hospital) evaluated mechanisms leading to transgenerational inheritance of epigenetic marks that impact lifespan, John Sedivy (Brown University) described links between the epigenome and activation of somatic retrotransposons, and how this activation may drive senescence and aging; and Steve Horvath (UCLA) detailed a number of studies further promoting the epigenetic clock as a marker of accelerated and delayed aging.

Theme 5 was designed to take a Systems Aging viewpoint. Such a holistic understanding of the aging process is in a sense the ultimate goal of the research. Is it possible to understand such a complex process as aging not just one gene and pathway at a time but in totality? Anne Brunet (Stanford University) discussed strategies to model aging using worms and killifish (a short-live vertebrate gaining popularity in the aging research field); Paul Robbins (Sripps Florida) described studies to target mammalian aging and Christiaan Leeuwenburgh (University of Florida) described the multi-fold connections between iron metabolism/transport and aging. The final theme centered on Signaling and Metabolism, hitting the major metabolic pathways that are linked to aging and that can be targeted with interventional strategies. These include the mTOR pathway and rapalogs, discussed by Matt Kaeberlein (University of Washington); dietary restriction and links through mTOR to regulation of mRNA splicing, discussed by William Mair (Harvard University), dietary restriction in primates discussed by Julie Mattison (National Institute on Aging/NIH), NAD metabolism and Sirtuins, discussed by David Sinclair (Harvard Medical School) and mitochondrial roles in regulating aging and metabolism, discussed by Pinchas Cohen (USC Leonard Davis School of Gerontology).

As we move closer to interventions targeting human aging, it is critical to get together and discuss the best strategies and the ideal path forward. The meeting in Cancun provided a low stress atmosphere where scientists in the aging field could not only share data but take the time to think creatively and discuss issues in depth. We as organizers thank the session chairs, speakers, poster presenters and attendees, as well as the staff of Fusion Conferences, Ltd. for enabling a fascinating meeting. We also look forward to the 3^rd Interventions in Conference to be held in approximately two years.

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Synopsis

A plethora of genetic, dietary and pharmacological interventions can extend healthy lifespan in laboratory animals, and can delay or ameliorate diverse aging-related diseases. Many of the signalling pathways involved are evolutionarily conserved, and are starting to be implicated in human aging. This raises the intriguing possibility of performing preventative medicine against the chronic diseases of our time by targeting the main risk factor for all of them, namely aging. Two important current challenges in the field are (1) to understand the downstream pathways by which longevity interventions combat age-related loss of function and pathology, and (2) to translate the findings into the extension of human healthspan.

Student / Post-doc Grants

We have $1,000 grants available for students and post-docs to help offset the cost of registration. We would be delighted to hear from you should you wish to put forward a student or postdoc to be considered for this opportunity. Applications must contain a full name, brief description of current research, a short explanation as to why they would benefit from attending and lastly an abstract must be attached for consideration for either a talk or poster presentation.

Key Sessions

Epigenetics
Stem Cells
Cell Signalling
Translating Research to Benefit Aging Humans

Confirmed Plenary Speakers

Steve Horvath (UCLA David Geffen School of Medicine)
'ANTI-AGING INTERVENTIONS AND THE EPIGENETIC CLOCK'

Sara Wickström (Max Planck Institute for Biology of Ageing, Cologne)
'POPULATION-LEVEL CONTROL OF STEM CELL FATE DURING HOMEOSTASIS AND AGING'

Matt Kaeberlein (University of Washington)
'TARGETING mTOR SIGNALING TO PROMOTE HEALTHY LONGEVITY'

Eline Slagboom (Leids Universitair Medisch Centrum)
'LIFESTYLE INTERVENTIONS IN ELDERLY: THE RESPONSE OF MUSCLE, FAT AND THE METABOLOME'

Adam Antebi (Max Planck Institute for Biology of Ageing)
'CONVERGENT MECHANISMS OF LONGEVITY'

Pinchas Cohen (USC Leonard Davis School of Gerontology)
'NEW ROLES OF THE MITOCHONDRIA IN AGING'

Anne Brunet (Stanford School of Medicine)
'UNDERSTANDING AND MODELING AGING'

Heinrich Jasper (Buck Institute for Research on Aging)
'STEM CELL REGULATION AND MAINTENANCE IN AGING EPITHELIA'

Confirmed Invited Speakers

Rozalyn Anderson (Memorial Veterans Hospital)
'MECHANISMS OF CR IN RHESUS MONKEYS'

Changhan David Lee (University of Southern California)
'THE MITOCHONDRIAL-DERIVED PEPTIDE MOTS-c AND MITONUCLEAR COMMUNICATION'

Weiwei Dang (Huffington Center On Aging)
'ACTIVATION OF OXIDATIVE STRESS RESPONSE VIA SIRT1 IS REQUIRED FOR SUCCESSFUL ADIPOGENIC DIFFERENTIATION IN MESENCHYMAL STEM CELLS'

Eric Greer (Boston Children's Hospital)
'TOWARDS A MECHANISM OF TRANSGENERATIONAL INHERITANCE OF LONGEVITY'

Holly Brown-Borg (University of North Dakota)
'SOMATOTROPIC SIGNALING AND METABOLISM IN LONG-LIVING MICE'

Julie Mattison (Translational Gerontology Branch)
'RHESUS MONKEYS: CALORIE RESTRICTION, AGING, AND BEYOND'

Emmanuelle Passegué (Columbia University)
'HEMATOPOIETIC STEM CELL AGING, AUTOPHAGY, METABOLISM AND FATE DECISIONS'

Malene Hansen (Sanford Burnham Prebys Medical)
'CELLULAR RECYCLING: ROLE OF AUTOPHAGY IN AGING AND DISEASE'

Susana Gonzalo (Saint Louis University School of Medicine)
'ROLE FOR VITAMIN D RECEPTOR PRESERVING GENOME STABILITY DURING AGING'

William Mair (Harvard University)
'DIETARY RESTRICTION AND TORC1 PROMOTE LONGEVITY VIA SPLICING FACTOR 1 MODULATION OF Pre-mRNA SPLICING HOMEOSTASIS'

Scott Pletcher (University of Michigan)
'MODELING THE EFFECTS OF PSYCHOLOGICAL STRESS ON HEALTHY AGING'

David Sinclair (Harvard Medical School)
'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF AGING IN MAMMALS'

Dana Miller (University of Washington)
'ACTIVATION OF SKN-1 PROMOTES SURVIVAL INDEPENDENT OF HIF-1'

Nick Musi (University of Texas Health Science Center)
'ROLE OF NFkB ON AGING-RELATED SARCOPENIA'

Christiaan Leeuwenburgh (University of Florida)
'IRON TRANSPORT DEREGULATION WITH AGING'

Yuji Ikeno (University of Texas Health Science Center at San Antonio)
'MECHANISMS THAT EXTEND LIFESPAN AND HEALTHSPAN IN SPRAGUE-DAWLEY RATS OVEREXPRESSING Cu/ZnSOD'

Laura Niedernhofer (The Scripps Research Institute)
'NOVEL MOUSE MODELS OF ACCELERATED AGING FOR RAPID DRUG TESTING'

Paul Robbins (The Scripps Research Institute)
'DEVELOPMENT OF THERAPEUTIC APPROACHES TO EXTEND HEALTH SPAN'

Target Audience

This interdisciplinary meeting will address the above two challenges in depth, with participation from basic scientists, physicians and pharmacology experts.

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Speakers

Plenary Speakers

Steve Horvath

Professor, University of California, Los Angeles

Matt Kaeberlein

Chief Science Officer, Optispan

P. Eline Slagboom

Head of section of Molecular Epidemiology, Leiden University Medical Center

Pinchas Cohen

Dean, USC Leonard Davis School of Gerontology

Heinrich Jasper

Professor, Buck Institute for Research on Aging

Sara WickstrÃ¶m

Group Leader, Max Planck Institute for Biology of Ageing

Adam Antebi

Director, Max Planck Institute for Biology of Ageing

Anne Brunet

Michele and Timothy Barakett Professor of Genetics, Stanford University

Invited Speakers

Rozalyn Anderson

Professor, University of Wisconsin Madison

Holly Brown-Borg

Professor, University of North Dakota

Julie Mattison

Staff Scientist, National Institute on Aging/NIH

Malene Hansen

Associate Professor, Sanford Burnham Prebys Medical Discovery Institute

Weiwei Dang

Assistant Professor, Baylor College of Medicine

William Mair

Associate Professor, Harvard University

Eric Greer

Assistant Professor, Harvard Medical School/Boston Children's Hospital

Dana Miller

Assistant Professor, University of Washington

Christiaan Leeuwenburgh

Chief Division Biology of Aging , University of Florida

Nicolas Musi, MD

Professor of Medicine, Director of the Barshop Institute, UT Health Science SA

Changhan Lee

Assistant Professor, University of Southern California

David Sinclair

Professor, Harvard Medical School

Susana Gonzalo

Associate Professor, Saint Louis University School of Medicine

Scott Pletcher

Professor, University of Michigan

Emmanuelle PasseguÃ©

Director, Columbia Stem Cell Initiative, Columbia University

Laura Niedernhofer

Associate Professor, Scripps Florida

Paul Robbins

Professor, Scripps Florida

Yuji Ikeno

Professor, Barshop Institute/UTHSCSA

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Programme

THURSDAY 02^ND MARCH 2017
14:00 – 14:45	Registration & Reception
14:00 – 14:45	Group Welcome Lunch Kalmia Buffet Restaurant
ORGANISMAL AGING Session Chair: Brian Kennedy
14:45 – 15:00	Opening Comments by Linda Partridge and Brian Kennedy
15:00 – 15:45	Adam Antebi Max Planck Institute for Biology of Ageing	CONVERGENT MECHANISMS OF LONGEVITY
15:45 – 16:15	Laura Niedernhofer Scripps Florida	NOVEL MOUSE MODELS OF ACCELERATED AGING FOR RAPID DRUG TESTING
16:15 – 16:30	Andrew Samuelson University of Rochester Medical Center	THE HOMEODOMAIN-INTERACTING PROTEIN KINASE HPK-1 PRESERVES PROTEIN HOMEOSTASIS AND LONGEVITY THROUGH THE HSF-1 CHAPERONE NETWORK AND TORC1-RESTRICTED AUTOPHAGY
16:30 – 16:45	William Balch The Scripps Research Institute	IDENTIFYING THE LUNG AGING SIGNATURE RESPONSIVE TO PROTEOSTATIC INTERVENTION
16:45 – 17:15	Yuji Ikeno University of Texas Health Science Center at San Antonio	MECHANISMS THAT EXTEND LIFESPAN AND HEALTHSPAN IN SPRAGUE-DAWLEY RATS OVEREXPRESSING Cu/ZnSOD
17:15 – 17:45	Refreshments
STEM CELLS Session Chair: Linda Partridge
17:45 – 18:30	Sara Wickström Max Planck Institute for Biology of Ageing	POPULATION-LEVEL CONTROL OF STEM CELL FATE DURING HOMEOSTASIS AND AGING
18:30 – 19:00	Emmanuelle Passegué Columbia University	HEMATOPOIETIC STEM CELL AGING, AUTOPHAGY, METABOLISM AND FATE DECISIONS
19:00 – 19:45	Heinrich Jasper Buck Institute for Research on Aging	STEM CELL REGULATION AND MAINTENANCE IN AGING EPITHELIA
19:45	Dinner at Leisure

FRIDAY 03^RD MARCH 2017
07:00 – 08:30	Breakfast
CELLULAR MECHANISMS OF LONGEVITY ASSURANCE Session Chair: Heinrich Jasper
08:30 – 09:00	Malene Hansen Sanford Burnham Prebys Medical Discovery Institute	CELLULAR RECYCLING: ROLE OF AUTOPHAGY IN AGING AND DISEASE
09:00 – 09:15	Lindsay Wu UNSW Australia	SIRT2 ACTIVITY AND NAD+ RESTORATION TREAT LATE LIFE INFERTILITY
09:15 – 09:30	Arjumand Ghazi University of Pittsburgh School of Medicine	PROMOTION OF LONGEVITY BY COORDINATION OF LIPID PRODUCTION AND BREAKDOWN PATHWAYS
09:30 – 09:45	Allon Canaan Yale University	FAT10 SILENCING SLOWS AGING THROUGH SEVERAL NETWORKS AT THE INTERSECT OF INFLAMMATION METABOLISM AND INNATE IMMUNITY
09:45 – 10:00	Vyacheslav Labunskyy Boston University School of Medicine	ER STRESS RESISTANCE CONFERRED BY ADAPTIVE ANEUPLOIDY AND CONSTITUTIVE INDUCTION OF THE UNFOLDED PROTEIN RESPONSE IS ASSOCIATED WITH DECREASED YEAST REPLICATIVE LIFESPAN
10:00 – 10:30	Changhan David Lee University of Southern California	THE MITOCHONDRIAL-DERIVED PEPTIDE MOTS-c AND MITONUCLEAR COMMUNICATION
10:30 – 11:00	Refreshments & Group Photo
11:00 – 11:30	Dana Miller University of Washington	ACTIVATION OF SKN-1 PROMOTES SURVIVAL INDEPENDENT OF HIF-1
11:30 – 11:45	Karima Djabali Technical University of Munich	SULFORAPHANE, AN Nrf2 ACTIVATOR, ENHANCES PROGERIN CLEARANCE IN HUTCHINSON-GILFORD PROGERIA FIBROBLASTS
11:45 – 12:00	Adam de Graff Stony Brook University	CHAPERONES CONTROL SENSITIVITY TO STRESS AND OXIDATION BY DEPLETING DAMAGE-PRONE STATES
12:00 – 16:00	Lunch at Leisure & Free Time
13:30 – 15:35	Group Snorkel Trip (to be confirmed)
ORGANISMAL AGING Session Chair: Steve Horvath
16:00 – 16:45	Eline Slagboom Leiden University Medical Center	LIFESTYLE INTERVENTIONS IN ELDERLY: THE RESPONSE OF MUSCLE, FAT AND THE METABOLOME
16:45 – 17:15	Nicolas Musi UT Health Science SA	ROLE OF NFkB ON AGING-RELATED SARCOPENIA
17:15 – 17:45	Scott Pletcher University of Michigan	MODELING THE EFFECTS OF PSYCHOLOGICAL STRESS ON HEALTHY AGING
17:45 – 18:15	Holly Brown-Borg University of North Dakota	SOMATOTROPIC SIGNALING AND METABOLISM IN LONG-LIVING MICE
18:15 – 18:45	Rozalyn Anderson University of Wisconsin Madison	MECHANISMS OF CR IN RHESUS MONKEYS
18:45 – 19:15	Refreshments
19:15 – 19:30	Doron Melamed Technion Faculty of Medicine	MOLECULAR MECHANISMS CONTROLLING B-CELL HEMATOPOIESIS AND SURVIVAL IN AGING
19:30 – 19:45	Ann-Charlotte Granholm-Bentley University of Denver	AGING AND ALZHEIMER’S DISEASE IN DOWN SYNDROME
19:45 – 20:00	Cheryl Conover Mayo Clinic	PAPP-A: A PROMISING THERAPEUTIC TARGET FOR HEALTHY LONGEVITY
20:00	Dinner at Leisure

SATURDAY 04^TH MARCH 2017
07:00 – 08:30	Breakfast
EPIGENETICS Session Chair: Adam Antebi
08:30 – 09:15	Steve Horvath University of California, Los Angeles	ANTI-AGING INTERVENTIONS AND THE EPIGENETIC CLOCK
09:15 – 09:45	Weiwei Dang Baylor College of Medicine	ACTIVATION OF OXIDATIVE STRESS RESPONSE VIA SIRT1 IS REQUIRED FOR SUCCESSFUL ADIPOGENIC DIFFERENTIATION IN MESENCHYMAL STEM CELLS
09:45 – 10:15	Refreshments
10:15 – 10:45	Eric Greer Harvard Medical School/Boston Childrens Hospital	TOWARDS A MECHANISM OF TRANSGENERATIONAL INHERITANCE OF LONGEVITY
10:45 – 11:15	Susana Gonzalo Saint Louis University School of Medicine	ROLE FOR VITAMIN D RECEPTOR PRESERVING GENOME STABILITY DURING AGING
11:15 – 11:30	John Sedivy Brown University	EPIGENETIC CHANGES AND SOMATIC RETROTRANSPOSITION IN CELLULAR SENESCENCE AND AGING
11:30 – 16:00	Lunch at Leisure & Free Time
SYSTEMS AGING Session Chair: Sara Wickström
16:00 – 16:45	Anne Brunet Stanford University	UNDERSTANDING AND MODELING AGING
16:45 – 17:00	Martin Denzel Max Planck Institute for Biology of Ageing	THE HEXOSAMINE PATHWAY MODULATES PROTEIN QUALITY CONTROL IN MAMMALS
17:00 – 17:30	Paul Robbins Scripps Florida	DEVELOPMENT OF THERAPEUTIC APPROACHES TO EXTEND HEALTH SPAN
17:30 – 17:45	David Melzer University of Exeter Medical School	IDEAL VASCULAR RISKS AND RADICAL HEALTHY LIFE EXTENSION
17:45 – 18:15	Christiaan Leeuwenburgh University of Florida	IRON TRANSPORT DEREGULATION WITH AGING
18:15 – 20:00	Poster Session & Refreshments
20:00	*Gala Dinner & Poster Awards*

SUNDAY 05^TH MARCH 2017
07:00 – 08:30	Breakfast
SIGNALING AND METABOLISM Session Chair: Pinchas Cohen
08:30 – 09:15	Matt Kaeberlein University of Washington	TARGETING mTOR SIGNALING TO PROMOTE HEALTHY LONGEVITY
09:15 – 09:45	William Mair Harvard University	DIETARY RESTRICTION AND TORC1 PROMOTE LONGEVITY VIA SPLICING FACTOR 1 MODULATION OF Pre-mRNA SPLICING HOMEOSTASIS
09:45 – 10:15	Julie Mattison National Institute on Aging/NIH	RHESUS MONKEYS: CALORIE RESTRICTION, AGING, AND BEYOND
10:15 – 10:45	David Sinclair Harvard Medical School	IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF AGING IN MAMMALS
10:45 – 11:15	Refreshments
TBC Session Chair: Brian Kennedy
11:15 – 11:30	Louis Lapierre Brown University	BLOCKING LIPID SECRETION PROMOTES LIPOPHAGY AND LONGEVITY
11:30 – 12:15	Pinchas Cohen USC Leonard Davis School of Gerontology	NEW ROLES OF THE MITOCHONDRIA IN AGING
12:15 – 12:30	Closing Comments by Linda Partridge and Brian Kennedy

MONDAY 06^TH MARCH 2017
07:00 – 19:40	Group Chichen Itzá Trip (to be confirmed)

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Prices

Ticket Type	Early Bird	Full Price
Single Choose this option if you will be attending the conference alone, or if you will bring accompanying guests that will not attend the meeting.	$1739	$1839
Shared Choose this option if you wish to share with a colleague who is also attending the conference, or if you wish to be paired with another attendee of the same sex.	$1739	$1839
Student Choose this option if you are a student. Please note all students will be paired with another attendee of the same sex if a room sharer is not specified. If you wish to have your own room, please register under the Single option.	$1236	$1336

Additional Person

This is the cost for an additional adult or child to join you in the same room, for the entire conference period. Accompanying persons are not permitted access to the conference. If you wish to extend your stay, please see our 'Extra night' prices.

Adult

$666

Child

$284

Extra nights

Prices are per person.

Adult

$278

Child

$71

All registration fees include 3 nights accommodation and meals during the conference period. Exact inclusions are detailed below.

Accompanying child fees and extra night child fees are applicable for children aged 5-12 years of age. Children aged 13 years and older are classified as an adult at this venue (Fiesta Americana Condesa).

What's Included in our Registration Fees?

The Fiesta Americana Condesa, Cancun offers a 24hour all inclusive service. Our registration and additional adult/child fees are inclusive of the following;

- Accommodation for 3 Nights (02, 03, 04 March 2017).
- Breakfast, Lunch and Dinner – available at all restaurants according to operational hours or programmed events.
- International Bar available by the glass in restaurants and bars according to operational hours.
- Pool snacks and International Bar available by the glass at Pool Area.
- Minibar including: soft drinks, domestic beer, bottled water and coffee. Refreshed daily.
- 24 Hour Room Service.
- In Room amenity – Bottle of wine, per room, per stay.
- Gala Night Entry (includes an open bar).
- Complimentary WI-FI throughout the hotel.

Additional nights (per person) are inclusive of the following;

- Accommodation for 1 Night
- Lunch on day of arrival
- Dinner on day of arrival
- Breakfast on day of departure
- International bar available by the glass in restaurants and bars from lunch on day of arrival until breakfast on day of departure

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Grants

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Venue

Fiesta Americana Condesa

This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

Lagoon Pool
Extensive Health Club and Spa
Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas

The Fiesta Americana Condesa, Cancun is the 2015 Winner of the Trip Advisor Certificate of Excellence and also received the Travellers Choice Award in 2014.

The remains of ancient Mayan cities are scattered throughout the Yucatan Peninsula and no trip to Cancun would be complete without a visit to these majestic temples and pyramids set amongst lush tropical vegetation. We will be working very closely with a reputable tour company who will be organising trips to Tulum, Chichen Itza, Coba and Xcaret to name a few, some of which may require a full day. Full day excursions will be arranged pre or post conference and may be on an individual or group booking so we would recommend booking extra nights to extend your stay as early as possible to avoid disappointment should these excursions be of interest to you and/or your party. For further information please contact us.

Venue Rating

Currency

US Dollar (USD)

Address

Fiesta Americana Condesa, Blvd.KukulkÃ¡n km 16.5 Zona Hotelera, Cancun, 77500 Mexico

Nearest Airport

Cancun International Airport

Location

Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.

Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Transportation

Cancun International airport is just a short 20 minute journey from the Fiesta Americana Condesa and is easily accessible from almost every country in the world with many major international airlines providing direct or interconnecting flights on a daily basis.

Airport Transfers

Mayan Sky are a reputable and trustworthy DMC based in Cancun. The Mayan Sky team will be on hand to provide a seamless transfer service to and from Cancun International Airport. Mayan Sky will manage and confirm all transportation bookings. To arrange transportation please contact Mayan Sky directly via email, phone or the online booking facility (see links below).

Shuttle Transportation Reservations: http://www.mayansky.com/index.php?fusionconferences2

Private Transportation Reservations: http://www.mayansky.com/index.php?fusionconferences

Conference Shuttle Service

Mayan Sky have arranged a conference shuttle service which will run at scheduled times surrounding our conferences. The conference shuttle schedule can be found below.

Arrivals (Cancun Airport to the Fiesta Americana Condesa)
12:00, 14:00, 15:00, 18:00 and 19:00 hours.

Feb: 20th, 21st, 23rd, 24th, 26th, 27th
Mar: 1st, 2nd, 4th, 5th, 7th, 8th, 10th, 11th, 13th, 14th, 16th, 17th, 19th, 20th

Departures (Fiesta Americana Condesa to Cancun Airport)
12:00, 13:00, 14:00, 15:00 and 18:00 hours.

Feb: 24th, 27th
Mar: 2nd, 5th, 8th, 11th, 14th, 17th, 20th, 23rd

$25 per person, each way (includes taxes)

Please allow at least 45minutes from your flight landing time to the shuttle departure time. In the event of any delays or cancellations, please ensure you contact Mayan Sky at least 24hours in advance; if Mayan Sky are not informed within 24hours full cancellation charges will apply (Not notified of flight cancellation: 100% penalty charge, No-Shows: 100% penalty charge).

Upon arrival at the airport, please exit the terminal building and look for ‘Fusion Conferences’ signage where a member of the Mayan Sky team will greet you and escort you to the group transportation.

Please contact Mayan Sky directly to enquire or make a booking. Please direct enquiries to:

David Garcia (Sales, Groups & Marketing Manager)
Telephone: 521 (998) 301 51 58
Email: gventas@mayanskydmc.com

Shuttle Transportation Reservations: http://www.mayansky.com/index.php?fusionconferences2

Private Transportation

Mayan Sky also offer a private transfer service for those travelling outside of the available shuttle dates/times mentioned above. The private transfer service vehicles can accommodate a maximum of 10 persons, plus luggage.

Private Transportation prices to and from Cancun International Airport and to and from the Fiesta Americana Condesa hotel are as follows:

Unit for 1 or 2 Passengers $40 (one way) / $68 (round trip)
Unit for 3 Passengers $45 (one way) / $75 (round trip)
Unit for 4 Passengers $52 (one way) / $79 (round trip)
Unit for 5 to 10 Passengers $58 (one way) / $90 (round trip)

In the event of any delays or cancellations, please ensure you contact Mayan Sky at least 24hours in advance; if Mayan Sky are not informed within 24hours full cancellation charges will apply (Not notified of flight cancellation: 100% penalty charge, No-Shows: 100% penalty charge).

Upon arrival at the airport, please exit the terminal building and look for ‘Fusion Conferences’ signage where a member of the Mayan Sky team will greet you and escort you to the group transportation.

Please contact Mayan Sky directly to enquire or make a booking. Please direct enquiries to:

David Garcia (Sales, Groups & Marketing Manager)
Telephone: 521 (998) 301 51 58
Email: gventas@mayanskydmc.com

Private Transportation Reservations: http://www.mayansky.com/index.php?fusionconferences

** Please note that Fusion Conferences is not responsible for any bookings made with Mayan Sky as transportation is not included within the registration package **

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Local Activities

Half Day Activities

Mayan Sky are a reputable and reliable company offering a variety of fascinating trips and excursions. If you wish to make a booking prior to your arrival, please contact David Garcia at Mayan Sky. If you wish to make a booking onsite at the hotel, please approach the Mayan Sky hospitality desk which will be located alongside the Fusion registration desk.

Please direct enquiries to:
David Garcia (Sales, Groups & Marketing Manager)
Telephone: 521 (998) 301 51 58
Email: gventas@mayanskydmc.com

Our half day tours can be booked during the conference period between the available free times scheduled in the programme. The half day tours are available to both individual and group bookings.

The following activities are available at Aquaworld which is based in the Marina directly opposite the Fiesta Americana Condesa hotel and on the beach, therefore no transportation is necessary.

Aquatwister

Experience Aquaworld’s ultimate tour adventure on board a high speed jet boat ride, Aquatwister. This is a roller coaster of manoeuvres orchestrated by a highly skilled captain and drivers on board and provides an amazing combination of nature, emotion, fun and adrenaline in one adventure.
Duration: 30 minutes

Sky Rider

Live this exciting experience flying in couples above the Caribbean Sea and experience an amazing aerial view.
Duration: 30-40 minutes includes 10 minute flying time at an altitude of 100mtrs

Jungle Tour

The Jungle Tour is considered one of the most popular tours in Cancun. You will enjoy speeding through the dense mangrove channels of the Nichupte Lagoon before snorkelling in the second largest reef barrier in the World.
Duration: 2:15 hrs

Wave Runner

Drive and Speed on board a Yamaha VX 1100 across the Caribbean Sea.
Duration: 30 minutes or 1 hr

Sub See

An extraordinary way to admire the marine life and the reef’s ecosystem without getting wet! Be part of this unique adventure on board The Sub See Explorer, a glass bottom boat from where you will be able to watch the multi-coloured species of the Scorpion´s coral reef.
Duration: 2 hrs.

Fly Board

The Flyboard is the latest craze in water sports sweeping the world, and now you can try it for yourself. Using water jet propulsion from specially designed boot pads, the personal water craft forces water out under extreme pressure sending you soaring into the air to heights of about 5-7 metres.

Full Day Activities

If you wish to make a booking prior to your arrival, please contact David Garcia at Mayan Sky. If you wish to make a booking onsite at the hotel, please approach the Mayan Sky hospitality desk which will be located alongside the Fusion registration desk.

Please direct enquiries to:
David Garcia (Sales, Groups & Marketing Manager)
Telephone: 521 (998) 301 51 58
Email: gventas@mayanskydmc.com

Our full day tours are offered pre and post conference dates. If you require any additional nights at the Fiesta Americana Condesa due to a full day excursion, please ensure you book these in advance to avoid disappointment (through Fusion). The full days tours are available to both individual and group bookings.

Selvatica Extreme Canopy Tour

Over 250 acres of Tropical Jungle, in Selvatica you will be able to experience a unique adventure on the longest zip-line circuit in North America, recognized by Travel & Leisure magazine as one of the 35 great adventures in the World, divided into 12 zip lines varying in lengths and heights from 270 ft. to over 2,000 ft, it will make you fly over the jungle. Then take a ride on a military vehicle through the jungle to get to the natural cenote. With crystal and pristine waters you will be able to swim choosing between a water zip line or the diving platform. Live this unique and exciting adventure and feel the emotion and adrenaline running through your body.

Chichen Itza

Chichen Itza which means “at the mouth of the well of Itza “, is the 2nd most visited archeological site of Mexico today. The Kukulkan Pyramid in Chichen-Itza which known as “El Castillo” (the castle), is one of the new seven wonders of the world elected in 07.07.2007.

Rio Secreto

Rio Secreto is an incredible underground nature reserve on Mexico’s Yucatan Peninsula. Located in the Riviera Maya 3 miles southwest of Playa del Carmen, Rio Secreto is a system of caves carved out over the course of several centuries by an underground river. Stretching approximately 8 miles, with 15 natural outlets, it’s the longest partially flooded cave on Mexico’s Yucatan Peninsula. But what makes Rio Secreto unique is the fact that it’s semi-sunken, which means that you can hike or float through most of it.

Xcaret

Your admission to Xcaret Park allows you to enjoy a natural paradise in Cancun and Riviera Maya, with access to over 40 attractions and activities. We invite you to enjoy a whole day of fun and to assist to cultural events such as the Ritual Ceremony of the Voladores de Papantla, the Mayan Ball Game and the show Xcaret Mexico Espectacular. Dare to live Mexico in Xcaret!

Sail & Snorkel

Enjoy a spectacular day on the crystal clear waters. Sailing from Cancun to Isla Mujeres on board a sailboat. Explore the breath-taking sites of Isla Mujeres one of the wonderful reef in the Caribbean. Join us for a full day of adventure in the most beautiful sea around the world.

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Group Activities

We have arranged two exciting group activities for the 2^nd Interventions in Aging participants. Please find the details, timings and prices for the activities below. The Snorkel Trip is scheduled during free time and the Chichen Itzá Trip is organised for the day immediately following the conference.

This is a great opportunity to socialise with fellow colleagues outside of the conference whilst taking in the beautiful natural sights of Cancun.

Snorkel Trip - Friday 03^rd March 2017

Departing from Aquaworld marina we take you on a motor boat to "El Meco" marine park. Here you adorn your snorkel gear and you’re ready to take the plunge and snorkel in the crystal clear turquoise waters.

The price per person is $42 USD.
+ $10 USD Marine park/dock fee (to be paid to Aquaworld)

Includes; private boat, snorkel equipment, snorkel guide, 45 minutes for snorkel tour in "El Meco" marine park, water, soda and beers.

Itinerary for Friday 03^rd March 2017:
Walk to Aquaworld from hotel - 10/15 minutes (across the road from the hotel)
13:30 – 14:10 Private boat to "El Meco" marine park
14:10 – 14:55 Snorkel tour (45 minutes)
14:55 – 15:35 Private boat return to Aquaworld

*Minimum of 10 people required*

Please note that sign-ups and payment for the trip will need to be made during conference registration at the Mayan Sky Hospitality desk. We will be booking the trip immediately after conference registration.

Mayan Sky will accept both cash and card payments. Please note a surcharge will be added for payments made using card (5% for VISA or Master Card and 6% for AMEX). This is a non-refundable fee should you later change your mind and decide not to participate in the trip.

Chichen Itzá Trip - Monday 06^th March 2017

Discover the essence of the Mayan culture by visiting one of the 7 New Wonders of the World. The visit of Chichen Itza includes a guided tour of 3 hours with time to take pictures. At the end of the tour we go to the restaurant for buffet lunch, followed by the visit of a cenote where people have the possibility to go for a swim.
In addition, when returning to Cancun, we can enjoy a panoramic visit to Valladolid, an ancient Colonial City.

Price: $150 per person

Includes; an air conditioned vehicle, parking, highway fee and tips, entrance/guided tour in the Chichen Itzá archaeological site, entrance and swimming in the Cenote, visit to Valladolid Colonial City, water, buffet lunch (not including drinks) and a certified Federal Guide.

Itinerary for Monday 06^th March 2017:
07:00 – 09:30 Trip to Chichen Itzá.
09:40 – 12:40 Tour in Chichen Itzá.
12:50 – 13:00 Trip to Cenote.
13:00 – 14:00 Time in Cenote.
14:10 – 14:20 Transfer to Restaurant.
14:20 – 15:20 Buffet lunch.
15:30 – 16:10 Trip to Valladolid.
16:10 – 17:00 Time in Valladolid.
17:10 – 19:40 Trip to Cancun Hotel Zone.

*Minimum of 8 people required*

Please note that sign-ups and payment for the trip will need to be made during conference registration at the Mayan Sky Hospitality desk. We will be booking the trip immediately after conference registration.

Mayan Sky will accept both cash and card payments. Please note a surcharge will be added for payments made using card (5% for VISA or Master Card and 6% for AMEX). This is a non-refundable fee should you later change your mind and decide not to participate in the tour.

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Childcare

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Oral Presenters

We have a number of oral opportunities available at this meeting. To be considered for a talk, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Please take note of the oral submission deadline: 01 December 2016.

Please check the conference programme carefully to note your presentation time (inclusive of Q&A) should you be accepted for an oral presentation. We recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference page.

Your Presentation on the Day

If you have prepared some slides to accompanying your talk please ensure you bring these with you on a USB or portable file saving device.

For those presenting on the first day, please email your slides to us so we can have everything prepared and ready for the first session. Please email your slides to: admin@fusion-conferences.com

On the day of your presentation please make yourself known to the AV team who will be available in the conference room. If you have any animations or videos we do advise to run through the presentation with the AV tech to make sure everything is compatible. We also advise that all speakers make themselves known to the AV tech in the conference room immediately before your session beings. The AV tech will apply your microphone and provide a laser pointer should you have an accompanying presentation. We prefer speakers to use our master laptop to run presentations from, however, if you prefer to use your own laptop, please notify us in advance.

It is important that all speakers adhere to their presentation time and respect their fellow presenters. A visual traffic light aide will be available to warn presenters and the audience as your time decreases.

If you have any questions, please don’t hesitate to approach our AV tech or a member of the Fusion team.

Helpful Tips for Presentation Slides

Aspect Ratio: On Screen Show (16:9) and in Landscape Orientation.
Font Size: Minimum font size used should be 24pt.
File Type: Please safe your presentation in PPT or PPTS format.
Video Clips: Please save these separately and do not build them into the PowerPoint. Videos will be played via the AV control desk using the master laptop.

Download Abstract Template

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Posters

We have a number of poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Please take note of the poster submission deadline: 19 January 2017

Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.

Displaying & Presenting Your Poster

During conference registration if you are presenting a poster please request a poster number from the registration desk. Please do not put up your poster without notifying a member of the Fusion team. Certain adhesive agents are not permitted at some venues therefore; Fusion will be the sole provider of all poster fixings.

You can display your poster from registration. Your poster can remain on display for the entire duration of the conference and we ask that posters are taken down on the final day of the meeting. The poster session is usually scheduled on Day 3, but please check the official programme for exact timings. Refreshments will be provided and the poster prizes will be awarded during the conference Gala Night that evening.

2017 Aging Poster Prize

The conference chairs will be awarding 3 poster prizes for the best poster display and presentation. To be in with a chance of winning, submit your poster by 19 January 2017. The winners will receive the following prizes at the Gala dinner: 1st Place $350, 2nd Place $250, 3rd Place $150.

Download Abstract Template

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs

Brian Kennedy

Buck Institute for Research on Aging

Conference History

02 Feb 2015, 05 Feb 2015

Interventions in Aging

Understanding mechanisms and the promise of extending human healthspan

Fiesta Americana Condesa, Cancun, Mexico

The first in the series of the Intervention in Aging Fusion conferences. A plethora of genetic, dietary and pharmacological interventions can extend healthy lifespan in laboratory animals, and can delay or ameliorate diverse aging-relate...

02 Mar 2017, 05 Mar 2017

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

Fiesta Americana Condesa, Cancun, Mexico

A plethora of genetic, dietary and pharmacological interventions can extend healthy lifespan in laboratory animals, and can delay or ameliorate diverse aging-related diseases. Many of the signa...

03 Mar 2019, 06 Mar 2019

3^rd Interventions in Aging Conference

Melia Nassau Beach All Inclusive, Nassau, Bahamas

A plethora of genetic, dietary and pharmacological interventions can extend healthy lifespan in laboratory animals, and can delay or ameliorate diverse aging-related diseases. Many of the signalling pathways involved are evolutionarily conserved, ...

11 Oct 2023, 14 Oct 2023

4^th Interventions in Aging Conference

#Fusionaging23

Sun Gardens Dubrovnik, Dubrovnik, Croatia

A plethora of genetic, dietary and pharmacological interventions can extend healthy lifespan in laboratory animals, and can delay or ameliorate diverse aging-related diseases. Mechanisms of aging are conserved in evolution, and discoveries made in...

04 Oct 2025, 07 Oct 2025

5^th Interventions in Aging Conference

#FusionAging25

Hilton Malta, St. Julians, Malta

Molecular and cellular mechanisms of aging are the main contributors to age-related decline, frailty, diseases and multimorbidity. The contributions of these aging mechanisms vary between different types of organisms, cell types and tissues, but t...

Supported By

Silver

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Interventions in Aging Conference

Understanding Mechanisms & Compressing Morbidity in Aging Humans

02 Mar 2017 - 05 Mar 2017

Cancun, Mexico

Chairs