- Home
- Past Conferences
- Niche-epithelial Stem Cell Interactions in Lung Health & Disease Conference
Niche-epithelial Stem Cell Interactions in Lung Health & Disease Conference
#Fusionlung19
20 Jul - 23 Jul 2019
Lisbon, Portugal
-
Emma Rawlins
University of Cambridge
-
Saverio Bellusci
Justus-Liebig-Universitaet Giessen, ECCPS
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Synopsis
The different epithelial stem/progenitor cells identified so far in the different regions of the lung interact with specific stromal, and physical/mechanical, niches. Some of these niches have recently been characterized. These niches dictate the quiescence of the epithelial stem/progenitor cells, as well as their re-entry into the cell cycle and subsequent differentiation. The mesenchyme, which gives rise to different stromal cell niches has so far been understudied during development, homeostasis, injury/repair and disease development. Similarly, the effects on stem cells of the physical/mechanical properties of their local environment are just beginning to be explored.
Key Sessions
- Stem cell niches in lung development
- Stem cell niches in lung homeostasis and repair
- Breaking niche regulation in lung cancer
- Characterisation of epithelial and mesenchymal progenitor cell populations
Student Offer
Take advantage of this fantastic opportunity for students! Register an academic at the earlybird rate of €1,500 and bring a student for only €750. Unfortunately, Postdocs are not eligible for this offer. Both registration packages include; accommodation for the 20, 21, 22 July 2019 (on a shared basis for students) and a food & beverage package for the conference period. Once registered, please contact Jack Peters to obtain a special registration link for your student.
Confirmed Invited Speakers
Denise Al Alam (Children's Hospital Los Angeles)
Miguel Alejandre Alcazar (Uniklinik Köln)
Thomas Braun (Max Planck Institute)
Chengshui Chen (The First Affiliated Hospital of Wenzhou Medical University)
Stijn De Langhe (University of Alabama at Birmingham)
Carla Kim (Children's Hospital Boston)
Joo-Hyeon Lee (MRC Cambridge Stem Cell Institute)
Yuru Liu (University of Illinois at Chicago)
Isaac Almendros Lopez (University of Barcelona)
Parviz Minoo (University of Southern California & Childrens Hospital)
Mitsuru Morimoto (RIKEN Center for Developmental Biology)
Martin Nawijn (University of Groningen)
Michael O'Reilly (University of Rochester Medican Center)
Ana Pardo-Saganta (Center for Applied Medical Research)
Robbert Rottier (Erasmus MC)
Jakub Sedzinski (Danish Stem Cell Center)
Hai Song (Life Sciences Institute Zhejiang University)
Alexandros Sountoulidis (Stockholm University)
Barry Stripp (Cedars-Sinai Medical Center)
Xin Sun (University of California, San Diego)
Nan Tang (National Institute of Biological Sciences)
Emmy Verschuren (FIMM)
Roxana Wasnick (Justus Liebig University Giessen)
Educational Need
The objective of this meeting is to bring together the scientific community interested in niche-epithelial stem/progenitor interaction during lung development, homeostasis and disease. It is proposed that developmental mechanisms are redeployed in the repair process and during disease progression.
The identification of the critical pathways and understanding their function will open the way to their manipulation to enhance the repair process. In particular we propose to bring the audience up to date on:
1) the characterization of the different stromal niches along the proximal-distal axis of the lung during development, homeostasis, injury/repair;
2) the characterization of in vitro assays to test/validate the quality of the stromal cell niches in supporting epithelial stem/progenitor cells (3D organoid-based models involving co-culture of stromal cell niches and epithelial/stem progenitor cells);
3) the identification of drugs affecting the niche-epithelial stem/progenitor cell interaction
Confirmed Speakers
Chairs
Emma Rawlins
Group Leader, University of Cambridge
Saverio Bellusci
Chair for Lung Matrix Remodeling, Justus-Liebig-Universitaet Giessen, ECCPS
Invited Speakers
Nan Tang
Assistant Investigator, National Institute of Biological Sciences, Beijing
Hai Song
Professor, Zhejiang University
Ana Pardo-Saganta
Professor, Institute for Lung Health (ILH)
_copy.jpg)
Carla Kim
Principal Investigator, Boston Children's Hospital
Joo-Hyeon Lee
Associate Member, Memorial Sloan Kettering Cancer Center
Xin Sun
Professor, UCSD
Thomas Braun
Managing Director, Max Planck Institute
Jakub Sedzinski
group leader, Novo Nordisk Foundation Center for Stem Cell Biology (DanStem)
Parviz Minoo
professor of Pediatrics, University of Southern California and Childrens Hospital
Robbert Rottier
Professor, Erasmus MC
Alexandros Sountoulidis
Postdoctoral researcher, Stockholm University
Denise Al Alam
Associate Professor, The Lundquist Institute
Yuru Liu
Associate Professor, University of Illinois at Chicago
Mitsuru Morimoto
Team Leader, RIKEN
Stijn De Langhe
Professor, Mayo Cinic, Rochester
Michael O'Reilly
Professor, The University of Rochester
Roxana Wasnick
Postdoc, University of Giessen
Pieter Hiemstra
Professsor, Leiden University Medical Center
Isaac Almendros
Assistant professor, University of Barcelona, Spain
Martijn Nawijn
Associate Professor, University Medical Center Groningen
Chengshui Chen
professor, The first affiliated hospital of Wenzhou Medical University
Andreas Guenther
Professor, Justus-Liebig-Universität
Barry Stripp
Professor, Cedars-Sinai Medical Center
Miguel Angel Alejandre Alcazar
Professor, Institute for Lung Health (ILH)
Programme
SATURDAY 20TH JULY |
|||
|
15:00 – 16:00 |
Registration |
||
|
Immune Cell Niche |
|||
|
16:00 – 16:10 |
Opening Comments |
||
|
16:10 – 16:35 |
Xin Sun |
THE NEURAL-IMMUNE NICHE IN LUNG |
|
|
16:35 – 17:00 |
Barry Stripp |
DEFINING AND MODELING PROGENITOR CELL DYSFUNCTION IN CHRONIC LUNG DISEASE |
|
|
17:00 – 17:25 |
Martijn Nawijn |
A CELLULAR ATLAS OF EPITHELIAL AND MESENCHYMAL CELLS IN HEALTHY AND ASTHMATIC AIRWAY WALL |
|
|
17:25 – 18:10 |
Refreshments |
||
|
18:10 – 18:35 |
Joo-Hyeon Lee |
INFLAMMATION SHAPES LUNG REGENERATION |
|
|
18:35 – 19:00 |
Ana Pardo-Saganta |
NOTCH IN THE NICHE: MAINTAINING TISSUE BALANCE |
|
|
19:00 – 19:35 |
Meet the Poster Presenters |
||
|
19:35 |
Group Dinner at Manjapão Restaurant |
||
SUNDAY 21ST JULY |
||
|
07:00 – 08:30 |
Buffet Breakfast at Manjapão Restaurant |
|
|
Stem Cells in Neonatal Lung Development |
||
|
08:30 – 08:55 |
Parviz Minoo |
NURSING AT2 STEM CELLS DURING ALVEOLOGENESIS |
|
08:55 – 09:10 |
Chengshui Chen / JinSan Zhang |
SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 CONTROLS ENDOTHELIAL CELLS PERMEABILITY AND FUNCTION THROUGH THE BONE MORPHOGENETIC 9/ENDOGLIN SIGNALING PATHWAY |
|
09:10 – 09:35 |
Miguel Alejandre Alcazar |
IDENTIFYING A NOVEL BALANCER OF DIFFERENTIATION AND STEMNESS OF ALVEOLAR EPITHELIAL CELLS TYPE II IN THE DEVELOPING LUNG |
|
09:35 – 09:50 |
Ana Vazquez ArmendarizJustus Liebig University Giessen |
LUNG ORGANOIDS: MODELLING MACROPHAGE-EPITHELIAL STEM CELL NICHE INTERACTIONS |
|
09:50 – 10:35 |
Group Photo, Refreshments & Poster Viewing |
|
|
10:35 – 11:00 |
Michael O’Reilly |
ADAPTING TO OXYGEN AT BIRTH SETS THE NUMBER OF ADULT ALVEOLAR EPITHELIAL TYPE 2 CELLS |
|
11:00 – 11:25 |
Robbert Rottier |
THE (POTENTIAL) ROLE OF PERICYTES IN PULMONARY VASCULAR DEVELOPMENT |
|
11:25 – 12:25 |
Poster Session I (Odd Numbers Only) |
|
|
12:25 – 16:45 |
Group Lunch & Free Time |
|
|
Mechanical Niche |
||
|
16:45 – 17:10 |
Nan Tang |
THE ROLES OF MECHANICAL FORCE IN THE FIRST BREATH |
|
17:10 – 17:35 |
Isaac Almendros Lopez |
MECHANICAL STIMULI ON STEM CELLS: AN IMPORTANT FACTOR IN LUNG REGENERATION AND REPAIR |
|
17:35 – 18:00 |
Jakub Sedzinski |
HOW TO FIT IN? THE MOLECULAR AND MECHANICAL LOGIC OF AN EPITHELIAL CELL RENEWAL IN VIVO |
|
18:00 – 19:00 |
Poster Session II (Even Numbers Only) |
|
|
19:00 – 20:00 |
Poster Session III (All Posters) |
|
|
20:00 |
Group Dinner at Grande Escolha Restaurant |
|
MONDAY 22ND JULY |
||
|
07:00 – 08:30 |
Buffet Breakfast at Manjapão Restaurant |
|
|
Airway Stem Cell Niche |
||
|
08:30 – 08:55 |
Stijn de Langhe |
AIRWAY STEM CELL NICHE INTERACTIONS IN PULMONARY FIBROSIS |
|
08:55 – 09:10 |
Cody Aros |
A DYNAMIC WNT-SECRETING NICHE REGULATES PROXIMAL AIRWAY REGENERATION |
|
09:10 – 09:35 |
Katherine McCauley |
HIGH-RESOLUTION MAPPING OF SIGNALING PATHWAY CONTROL IN AIRWAY EPITHELIAL FATE |
|
09:35 – 10:00 |
Rachel Warren |
ATAXIA-TELANGIECTASIA MUTATED IS REQUIRED TO REPAIR THE AIRWAY EPITHELIUM FOLLOWING AN INFLUENZA A VIRUS INFECTION |
|
10:00 – 10:45 |
Refreshments & Poster Viewing |
|
|
10:45 – 11:10 |
Alexandros Sountoulidis |
DEVELOPMENTAL TRAJECTORIES AND SPATIAL HETEROGENEITY OF ADULT AIRWAY PROGENITORS AT SINGLE CELL RESOLUTION |
|
11:10 – 11:35 |
Pieter Hiemstra |
STUDYING AIRWAY EPITHELIAL WOUND REPAIR USING CULTURE MODELS |
|
11:35 – 11:50 |
Angela Zhang |
IN VITRO AIRWAY CELL CULTURE FOR CYSTIC FIBROSIS RESEARCH |
|
12:00 – 16:30 |
Group Lunch & Free Time |
|
|
Embryonic Lung Development and Adult Disease |
||
|
16:30 – 16:55 |
Denise Al Alam |
MESENCHYMAL CELL DIVERSITY IN THE DEVELOPING HUMAN LUNG |
|
16:55 – 17:10 |
Eva Schruf |
UTILIZING HUMAN IPSC-DERIVED ALVEOLAR EPITHELIAL PROGENITOR CELLS TO MODEL IPF-RELATED EPITHELIAL DYSFUNCTION |
|
17:10 – 17:35 |
Mitsuru Morimoto |
TRACHEA DEVELOPMENT AND REGENERATION |
|
17:35 – 17:50 |
Antonella Dost |
MODELING LUNG TUMOR PROGRESSION WITH ORGANOIDS |
|
17:50 – 18:30 |
Refreshments & Poster Viewing |
|
|
18:30 – 18:55 |
Killian Hurley |
SINGLE-CELL TIME-SERIES MAPPING OF CELL FATE TRAJECTORIES REVEALS AN EXPANDED DEVELOPMENTAL POTENTIAL FOR HUMAN PSC-DERIVED DISTAL LUNG PROGENITORS |
|
18:55 – 19:20 |
Hai Song |
REGULATION OF PULMONARY NEUROENDOCRINE CELLS IN LUNG INJURY AND TUMORIGENESIS |
|
19:20 – 19:45 |
Carla Kim |
REGULATION OF LUNG PROGENITORS AND THEIR MICROENVIRONMENT |
|
19:45 – 20:00 |
James Ji |
FIBRINOLYTIC NICHE FOR RE-EPITHELIALIZATION BY AT2 CELLS |
|
20:00 |
Gala Dinner & Poster Awards |
|
TUESDAY 23RD JULY |
||
|
07:00 – 08:30 |
Buffet Breakfast at Manjapão Restaurant |
|
|
Alveolar Stem Cell Niche |
||
|
08:30 – 08:55 |
Yuru Liu |
REGULATION OF ALVEOLAR TYPE II CELLS IN THE REPAIR OF LUNG INJURY |
|
08:55 – 09:20 |
Andreas Günther |
NOTCH1-INDUCED DE-DIFFERENTIATION AND HYPERPROLIFERATION OF ALVEOLAR EPITHELIAL TYPE II CELLS IN HUMAN AND EXPERIMENTAL LUNG FIBROSIS |
|
09:20 – 09:35 |
Vahid Kheirollahi |
METFORMIN INDUCES LIPOGENIC DIFFERENTIATION IN MYOFIBROBLASTS TO REVERSE LUNG FIBROSIS |
|
09:35 – 09:50 |
Negah Ahmadvand |
LINEAGE TRACING OF SFTPC-POSITIVE CELLS REVEALS ALVEOLAR TYPE 2 CELLS HETEROGENETIY |
|
09:50 – 10:35 |
Refreshments |
|
|
10:35 – 11:00 |
Roxana Wasnick |
PRECISION CUT LUNG SLICES AND ORGANOIDS TO DISSECT THE HUMAN ALVEOLAR STEM CELL NICHE IN LUNG FIBROSIS |
|
11:00 – 11:15 |
Xinhui Wu |
WNT5A/5B SIGNALING REPRESSES FUNCTIONAL RESPONSES IN LUNG EPITHELIAL PROGENITORS |
|
11:15 – 11:40 |
Thomas Braun |
HETEROGENEITY AND PLASTICITY OF THE BRONCHOALVEOLAR EPITHELIUM |
|
11:40 – 11:50 |
Closing Comments |
|
Supported by
Platinum Sponsors
Silver Sponsors
Media Partners
Interested in sponsoring this conference?
Contact usVenue & Location
Dolce CampoReal Lisboa
Located in Torres Vedras, just a 30-minute drive from Lisbon, Dolce CampoReal Lisboa offers unique tranquillity, as a result of its idyllic environment. The hotel offers stunning views over the golf course, vineyards and the extraordinary landscape of Socorro and Archeira Mountains.
The hotel has three restaurants provide a variety of gastronomic choices, and there are two bars including one beside the outdoor pool.
Hotel Facilities
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
- Indoor heated swimming pool
- Outdoor swimming pool with Jacuzzi
- Spa
- Gym
- Golf course
- 2 Tennis courts
General Information
Venue Rating
★ ★ ★ ★ ★
Currency
Euro (EUR)
Address
R. do Campo (Campo Real ), 2565-770, Portugal
Nearest Airport
Lisbon Portela Airport
Location
The Dolce CampoReal Lisboa is nestled between the vineyards and the extraordinary landscape of the Socorro and Archeira Mountains.
Lisbon is only a short 30-minute drive away. The Portuguese capital is constantly recognised as one of the greatest cities in the world, a claim confirmed by the “Lonely Planet Guides", who named Lisbon one of the world’s top 10 cities. Lisbon in one of the world’s oldest cities, predating the likes of London, Rome and Paris by hundreds of years. Hillsides covered in tumbledown houses and a mix of baroque and neoclassical buildings, including cathedrals and palaces, make up Lisbon’s skyline. The city is a combination of old and new, with beautiful modern buildings constructed near renovated historical landmarks and ruins.
If you are interested in this meeting but not yet ready to register, you can sign up for updates here and our team will keep you updated regarding deadline reminders and grant opportunities relating to this meeting only.
Platinum Sponsors
Silver Sponsors
Media Partners
If you're interested in sponsoring this conference please contact us.
Conference Manager
Jack Peters
Need some help? Chat to the Fusion team today
As a family run business, our dedication runs deep. We’re committed to each other and, even more so, to every attendee’s experience, delivering a level of care and passion that’s truly unmatched.
