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2nd Epigenetics Conference
From Mechanisms to Disease #Epigen20
28 Feb - 02 Mar 2020
Nassau, Bahamas
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Report
Blog: A students perspective | Flora Paldi (Institute of Human Genetics/CNRS)
Read Flora's insights into the 2nd Epigenetics Conference. A great student perspective on the meeting.
Synopsis
Registration is now closed for this event, however, we are still accepting abstracts for the Epigenetic Pathways and Human Disease conference taking place from 30th April - 3rd May 2020 in Chania, Crete.
The DNA of eukaryotic cells is organized into chromatin fibres, where the nucleosome is the basic repeating unit. Chromatin is thus at the core of fundamental processes such as gene regulation, stem cell fate determination and cancer. By and large, these topics have traditionally been covered by separated meetings. However, recent literature indicates that the boundaries among these various disciplines are becoming less clear. This meeting on "Epigenetics: from mechanisms to disease" will bring together scientists studying chromatin architecture, epigenetics, stem cell biology and cancer. The talks will cover a broad range of topics, including chromosome organisation, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms, transcription regulation, DNA methylation and hydroxymethylation.
Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches, including single-cell omics and imaging, chromatin and 3D genome analysis. Young scientists will be able to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. The program has also allocated ample time for exchanging ideas and discussing novel hypotheses at the end of each session, as well as time for informal interactions and networking.
Student Offer
Take advantage of this fantastic opportunity for students! Register an academic at the full rate and bring a student for only $850. Unfortunately, Postdocs are not eligible for this offer. Both registration packages include; accommodation for the 28, 29 February and 01 March 2020 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact Emily Meen to obtain a special registration link for your student.
Confirmed Invited Speakers
Karen Adelman (Harvard Medical School)
CONTROLLING TRANSCRIPTION AT CODING AND NON-CODING RNA LOCI
Salvador Aznar Benitah (IRB Bracelona)
IMPACT OF HETEROCHROMATIN REGULATION IN ADULT STEM CELL FUNCTION AND MUTATIONAL BURDEN IN CANCER STEM CELLS
Roberto Bonasio (University of Pennsylvania)
REGULATION OF CHROMATIN COMPLEXES BY RNA
Adrian Bracken (Trinity College Dublin)
PRC2 COMPLEXES IN DEVELOPMENT AND DISEASE
Anne Brunet (Stanford University)
CHANGES IN CHROMATIN STATES IN AGING NEURAL STEM CELLS
Irene Chiolo (University of Southern California, Los Angeles)
WHEN SILENCE IS LOUD: HETEROCHROMATIN REPAIR MECHANISMS FOR GENOME STABILITY
Victor Corces (Emory University)
MECHANISMS OF TRANSGENERATIONAL INHERITANCE OF OBESITY EPIPHENOTYPES
Yael David (Memorial Sloan Kettering Cancer Center)
NON-ENZYMATIC MODIFICATIONS ON HISTONES DRIVE CHANGES IN CHROMATIN STRUCTURE AND FUNCTION
Amanda Fisher (London Institute of Medical Sciences)
EPIGENETICS AND INHERITANCE
François Fuks (University of Brussels)
TRANSCRIPTOME-WIDE DISTRIBUTION AND FUNCTION OF RNA MODIFICATIONS
Yad Ghavi-Helm (Institute of Functional Genomics of Lyon - IGFL)
REGULATING GENE EXPRESSION IN 3D DURING EMBRYONIC DEVELOPMENT
Robert Kingston (Mass. General Hospital)
NUCLEOSOME COMPACTION, PHASE SEPARATION, AND POLYCOMB-GROUP MAINTENANCE OF REPRESSION
Tony Kouzarides (The Gurdon Institute)
MODIFICATIONS OF RNA AND THEIR ROLE IN CANCER
Jeannie Lee (Massachusetts General Hospital)
THE MANY FACES OF XIST RNA IN 3D
Geeta Narlikar (University of California, San Francisco)
THE ROLE OF PHASE-SEPARATION IN GENOME ORGANIZATION
Diego Pasini (University of Milan)
Rab Prinjha (GlaxoSmithKline)
DRUGGING TRANSCRIPTION: PROGRESS AND POTENTIAL FOR TREATING HUMAN DISEASES
Danny Reinberg (Howard Hughes Medical Institute)
THE EPIGENETIC STATUS OF SOME HISTONE POST-TRANSLATIONAL MODIFICATIONS
Anthony Schmitt (Arima Genomics)
DISCOVERY OF GENOMIC INTERACTIONS AND GENE REGULATORY MECHANISMS USING THE ARIMA-HIC PLATFORM
Ramin Shiekhattar (University of Miami)
REGULATION OF THE CODING AND NONCODING GENOME BY INTEGRATOR
Ali Shilatifard (Northwestern University)
PRINCIPLES OF EPIGENETICS AND CHROMATIN IN DEVELOPMENT AND HUMAN DISEASE
Ting (C.-ting) Wu (Harvard Medical School)
SUCH A LOT OF GENOME TO SEE…
Target Audience
This conference will appeal to PhD students, post-doc and group leaders working in the field of chromatin architecture, epigenetics, stem cell biology and cancer. Scientists active in R&D of small, medium and big pharma or biotech companies.
Educational Need
The primary purpose of workshops is to enhance communication between junior and senior investigators. As mentioned in the executive summary, “Young scientists will have the opportunities to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. The program has also allocated ample time for exchanging ideas and discussing novel hypothesis at the end of each session, as well as time for informal interactions and networking.
Confirmed Speakers
Chairs
Invited Speakers
Rab Prinjha
Head of Immunology Research Unit, R&D, GlaxoSmithKline
Robert Kingston
Chief, Molecular Biology, Mass. General Hospital / Harvard Medical School
Ting (C.-ting) Wu
Professor, Harvard Medical School
Tony Kouzarides
Deputy Director, University of Cambridge
Ali Shilatifard
Chairman, Northwestern University
Salvador Aznar-Benitah
Group Leader, Fundació Institut de Recerca Biomèdica (IRB BARCELONA)
Adrian Bracken
Associate Professor, Trinity College Dublin
Anthony Schmitt
Vice President, Research and Development, Arima Genomics, Inc.
Francois Fuks
Professor, University of Brussels
Karen Adelman
Professor, Harvard Medical School
Geeta Narlikar
Professor, University of California, San Francisco
Ramin Shiekhattar
Professor, Human Genetics, University of Miami - Sylvester Comprehensive Cancer Center
Roberto Bonasio
Assistant Professor, University of Pennsylvania
Yad Ghavi-Helm
Group Leader, Functional Genomics Institute of Lyon, Centre National de la Recherche Scientifique, Ecole Normale Supérieure of Lyon
Jeannie Lee
Professor of Genetics, Massachusetts General Hospital
Amanda Fisher
Director, MRC London Institute of Medical Sciences
Yael David
Assistant Member, Memorial Sloan Kettering Cancer Center
Victor Corces
Professor, Emory University School of Medicine
Irene Chiolo
Assistant Professor, University of Southern California, Los Angeles
Programme
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FRIDAY 28TH FEBRUARY |
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13:00 – 14:00 |
Student Networking Lunch |
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15:00 – 16:00 |
Registration & Welcome Reception |
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Chromatin Complexes in Development and Diseases |
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16:00 – 16:10 |
Opening Comments |
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16:10 – 16:35 |
Luciano Di Croce |
MOLECULAR MECHANISMS GOVERNING CELL IDENTITY, DIFFERENTIATION AND CANCER PROCESSES |
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16:35 – 17:00 |
Adrian Bracken |
PRC2 COMPLEXES IN DEVELOPMENT AND DISEASE |
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17:00 – 17:25 |
Robert Kingston |
NUCLEOSOME COMPACTION, PHASE SEPARATION, AND POLYCOMB-GROUP MAINTENANCE OF REPRESSION |
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17:25 – 17:40 |
Chen Davidovich |
MECHANISM FOR THE REGULATION OF PRC2 BY PALI1 |
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17:40 – 18:25 |
Refreshments |
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18:25 – 18:40 |
Uhnsoo Cho |
CRYO-EM STRUCTURE OF THE HUMAN MIXED LINEAGE LEUKEMIA-1 COMPLEX BOUND TO THE NUCLEOSOME |
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18:40 – 18:55 |
Alea Mills |
EPIGENETIC VULNERABILITIES OF HUMAN GLIOBLASTOMA |
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18:55 – 19:10 |
Shigeki Iwase |
AMELIORATION OF BRAIN HISTONE METHYLOPATHIES BY BALANCING A WRITER-ERASER DUO KMT2A-KDM5C |
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19:10 – 19:30 |
Esther Schnapp |
REVIEW COMMONS AND PUBLISHING WITH EMBO PRESS |
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19:30 – 20:00 |
Meet the Poster Presenters |
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20:00 |
Group Dinner |
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SATURDAY 29TH FEBRUARY |
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07:00 – 08:55 |
Breakfast at Leisure |
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Mechanistic Insight into Multi-Protein Chromatin Complexes Regulation |
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08.55 – 09:10 |
Alfredo Valencia |
RECURRENT C-TERMINAL SMARCB1 MUTATIONS REVEAL A NUCLEOSOME ACIDIC PATCH INTERACTION THAT POTENTIATES mSWI/SNF CHROMATIN REMODELING |
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09:10 – 09:35 |
Ali Shilatifard |
PRINCIPLES OF EPIGENETICS AND CHROMATIN IN DEVELOPMENT AND HUMAN DISEASE |
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09:35 – 10:00 |
Amanda Fisher |
EPIGENETICS AND INHERITANCE |
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10:00 – 10:25 |
Karen Adelman |
CONTROLLING TRANSCRIPTION AT CODING AND NON-CODING RNA LOCI |
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10:25 – 12:15 |
Poster Session |
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12:15 – 16:55 |
Lunch at Leisure & Free Time |
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From Gene Regulation to Chromatin Architecture |
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16:55 – 17:20 |
Rab Prinjha |
DRUGGING TRANSCRIPTION: PROGRESS AND POTENTIAL FOR TREATING HUMAN DISEASES |
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17:20 – 17:45 |
Giacomo Cavalli |
3D GENOME ORGANIZATION AND POLYCOMB PROTEINS IN DEVELOPMENT AND CELL DIFFERENTIATION |
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17:45 – 18:00 |
Meelad Dawlaty |
NON-ENZYMATIC FUNCTIONS OF TET1 REGULATE BIVALENCY AT LINEAGE SPECIFIC GENES IN EMBRYONIC STEM CELLS TO ENSURE PROPER DIFFERENTIATION AND DEVELOPMENT |
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18:00 – 18:45 |
Refreshments & Poster Viewing |
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Ting (C.-ting) Wu |
SUCH A LOT OF GENOME TO SEE… |
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Victor Corces |
MECHANISMS OF TRANSGENERATIONAL INHERITANCE OF OBESITY EPIPHENOTYPES |
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19:35 – 20:00 |
Anthony Schmitt |
DISCOVERY OF GENOMIC INTERACTIONS AND GENE REGULATORY MECHANISMS USING THE ARIMA-HIC PLATFORM |
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20:00 |
Group Dinner |
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SUNDAY 1ST MARCH |
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07:00 – 08:30 |
Breakfast at Leisure |
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Chromatin Alterations in Human Diseases |
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08:30 – 08:55 |
Salvador Aznar Benitah |
IMPACT OF HETEROCHROMATIN REGULATION IN ADULT STEM CELL FUNCTION AND MUTATIONAL BURDEN IN CANCER STEM CELLS |
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08:55 – 09:20 |
Irene Chiolo |
WHEN SILENCE IS LOUD: HETEROCHROMATIN REPAIR MECHANISMS FOR GENOME STABILITY |
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09:20 – 09:35 |
Nicole Vander Schaaf |
THE DNA METHYLATION LANDSCAPE OF INTESTINAL CELLS INFLUENCES THE TUMORIGENICITY OF A GENETIC DRIVER MUTATION |
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09:35 – 10:00 |
Yad Ghavi-Helm |
REGULATING GENE EXPRESSION IN 3D DURING EMBRYONIC DEVELOPMENT |
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10:00 – 10:45 |
Group Photo, Refreshments & Poster Viewing |
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10:45 – 11:00 |
Sundeep Kalantry |
KDM5C AND THE EVOLUTIONARY ORIGINS OF X-CHROMOSOME INACTIVATION |
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11:00 – 11:25 |
Tony Kouzarides |
MODIFICATIONS OF RNA AND THEIR ROLE IN CANCER |
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Yael David |
NON-ENZYMATIC MODIFICATIONS ON HISTONES DRIVE CHANGES IN CHROMATIN STRUCTURE AND FUNCTION |
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11:50 – 12:15 |
Jeannie Lee |
THE MANY FACES OF XIST RNA IN 3D |
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12:15 – 16:45 |
Lunch at Leisure & Free Time |
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RNA and Chromatin Organization |
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16:45 – 17:10 |
Geeta Narlikar |
CAN PHASE-SEPARATION EXPLAIN HETEROCHROMATIN PROPERTIES? |
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17:10 – 17:25 |
Jane Skok |
CTCFL AND ITS IMPACT ON GENE REGULATION AND INTERPLAY WITH CTCF FUNCTION |
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17:25 – 17:50 |
Ramin Shiekhattar |
REGULATION OF THE CODING AND NONCODING GENOME BY INTEGRATOR |
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17:50 – 18:05 |
Marissa Cloutier |
MATERNAL CONTROL OF PATERNAL X-INACTIVATION |
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18:05 – 18:50 |
Refreshments & Poster Viewing |
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18:50 – 19:15 |
Roberto Bonasio |
REGULATION OF CHROMATIN COMPLEXES BY RNA |
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19:15 – 19:40 |
François Fuks |
TRANSCRIPTOME-WIDE DISTRIBUTION AND FUNCTION OF RNA MODIFICATIONS |
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19:40 – 19:55 |
Elizabeth Kahney |
INVESTIGATING HISTONE INHERITANCE PATTERNS AT SPECIFIC GENOMIC LOCI |
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20:00 |
Gala Dinner & Poster Awards |
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MONDAY 2ND MARCH |
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07:00 – 09:00 |
Breakfast at Leisure |
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Neuroepigenetics |
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09:00 – 09:25 |
Hans van Bokhoven |
IMPACT: IDENTIFICATION OF CONVERGING MOLECULAR PATHWAYS ACROSS CHROMATINOPATHIES AS TARGETS FOR THERAPY |
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09:25 – 09:40 |
Gaia Novarino |
EPIGENETIC DEFECTS IN NEURODEVELOPMENTAL DISORDERS |
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09:40 – 09:55 |
Michele Gabriele |
ONE BY ONE: CONVERGENCE, MULTIPLEXING AND SINGLE-CELL RESOLUTION IN THE STUDY OF NEURODEVELOPMENTAL DISORDERS THROUGH BRAIN ORGANOIDS |
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09:55 – 10:10 |
Refreshments |
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10:10 – 10:25 |
Frank Kooy |
ON A COMPLEX NEURODEVELOPMENTAL DISORDER COUSED BY MUTATIONS IN ADNP IN MAN AND MOUSE |
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10:25 – 10:40 |
James Ellis |
ALTERED TRANSLATION AND PROTEIN STABILITY DURING NEURODEVELOPMENT AFFECT DRUGGABLE PATHWAYS IN RETT SYNDROME |
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10:40 – 10:55 |
Ann Boija |
DIFFERENTIAL PARTITIONING OF CANCER THERAPEUTICS IN NUCLEAR CONDENSATES |
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10:55 – 11:00 |
Closing Comments |
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Supported by
Venue & Location
Melia Nassau Beach All Inclusive
Overlooking one of the finest beaches in the world the Meliá Nassau Beach is surrounded by crystal blue waters and white sandy beaches. Located on the stunning Cable Beach, you are just a few minutes walk from the center, shops and restaurants. The beautiful Nassau Botanical Gardens are within easy reach (7km) and Lynden Pindling International Airport is situated only 9km away.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from Cilantro where you can experience the natural textures, aromas and flavors of Mexico, Nikkei, celebrated for its exquisite fusion of Japanese, Cantonese and Peruvian cuisine featuring a sushi bar and Teppanyaki tables, Estavida, an upbeat tapas lounge located in the hotel lobby serving innovative tapas and a wide selection of cocktails, Aqua, an A la carte restaurant specializing in exquisite, rustic Italian cuisine, The Market Place, where you will find an International buffet serving an array of exquisite dishes, O'Grille, an open air restaurant with fabulous views of the sea and pool serving casual beach fare and light bites and finally The Black Angus, a steakhouse featuring hip, contemporary jazz and modern decor, offering guests the finest quality prime cuts and the freshest ingredients.(This restaurant is not included in the all inclusive package, additional charges apply). The Gala Night takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
Hotel Facilities
- 24 hour reception
- Room service
- 3 heated outdoor pools
- Complimentary resort wide Wi-Fi (guest rooms, throughout hotel, beach and conference areas)
- 24-hour Fitness Center
- 7 dining venues
- 4 bars.
- non-motorised water sports
The Bahamas is formed by over 700 islands, keys and islets located in the Atlantic Ocean and renowned for its warm sunshine, mild climate, fine, white sandy beaches, turquoise, crystal clear water and friendly people, making this the perfect environment to relax and unwind in your free time during the conference.
General Information
Venue Rating
★ ★ ★ ★
Currency
US Dollar (USD)
Address
Nassau W Bay St. Nassau Bahamas
Nearest Airport
Lynden Pindling International Airport
Location
The Melia Nassau Beach All-Inclusive is located right on the stunning Cable Beach just a few minutes away from the airport and city center; Nearby in Downtown Nassau you can experience the flavours of new foods at local restaurants, shop 'til you drop at Straw market or take a trip through time at the Pirates Museum. The beautiful Nassau Botanical Gardens are close by and water enthusiasts can enjoy non-motorized water sports right on property.
Nassau is the capital of the Bahamas. It lies on the island of New Providence, with neighboring Paradise Island accessible via Nassau Harbor bridges. The city has a hilly landscape and is known for it's fabulous beaches as well as its offshore coral reefs, popular for diving and snorkeling. It retains many of its typical pastel-colored British colonial buildings, like the pink-hued Government House.
If you are interested in this meeting but not yet ready to register, you can sign up for updates here and our team will keep you updated regarding deadline reminders and grant opportunities relating to this meeting only.
Bronze Sponsors
Media Partners
If you're interested in sponsoring this conference please contact us.
Conference Manager
Emily Meen
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