From Mechanisms to Disease #3EPI22
19 May - 22 May 2022
Cancun, Mexico
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
The DNA of eukaryotic cells is organized into chromatin. Chromatin is the template of life. It is the vector of genetic information and it is at the core of fundamental processes such as gene regulation, stem cell fate determination and cancer. The study of chromatin structure and function and the study of mechanisms of disease and their diagnostic and therapeutic approaches are mostly covered by separate meetings. However, the boundaries among these various disciplines are disappearing and now, the meeting on "Epigenetics: from mechanisms to disease" will bring together scientists studying chromatin architecture, epigenetics, stem cell biology cancer and other diseases. The talks will cover a broad range of topics, including chromosome organisation, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms, transcription regulation, DNA methylation and hydroxymethylation, as well as the use of genome engineering technologies, single-cell approaches and cutting edge epigenomics and imaging approaches.
Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches. Young scientists will be able to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. The program has also allocated ample time for exchanging ideas and discussing novel hypotheses at the end of each session, as well as time for informal interactions and networking.
Take advantage of this fantastic opportunity for students! Fully paying academics can bring a student for only $785. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 19, 20, 21 May 2022 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact Chloe Trundle to obtain a special registration link for your student.
Karen Adelman (Harvard Medical School)
CONTROLLING TRANSCRIPTION AT CODING AND NON-CODING LOCI
Genevieve Almouzni (Research center at the Institut Curie)
HISTONE VARIANTS AND CHAPERONES IN CANCER
Salvador Aznar-Benitah (IRB Barcelona)
DIETARY METABOLITES ESTABLISH AN EPIGENETIC MEMORY IN METASTASIS-INITIATING CELLS, MECHANISMS AND POTENTIAL THERAPIES.
Shelley Berger (University of Pennsylvania)
EPIGENETIC PATHWAYS AS TARGETS IN HUMAN DISEASE
Anne Brunet (Stanford University)
EPIGENETIC REGULATION OF AGING STEM CELLS
Irene Chiolo (University of Southern California)
Elena Ezhkova (Icahn School of Medicine at Mount Sinai)
EPIGENETIC REGULATION OF SKIN STEM CELLS
Francois Fuks (University of Brussels)
RNA MODIFICATIONS IN HEALTH AND DISEASE
Tony Kouzarides (University of Cambridge)
RNA MODIFICATIONS: THEIR FUNCTION AND ROLE IN CANCER
Mounia Lagha (CNRS)
TRANSCRIPTION DYNAMICS AND MEMORY DURING ZYGOTIC GENOME ACTIVATION
Lluis Morey (University of Miami)
EPIGENETIC MECHANISMS IN BREAST CANCER
Diego Pasini (European Institute of Oncology)
Rab Prinjha (GlaxoSmithKline)
CHALLENGES AND OPPORTUNITIES IN PROGRESSING EPIGENETIC THERAPEUTICS
Danny Reinberg (HHMI/NYU Langone School of Medicine)
POLYCOMB, INHERITANCE AND DISEASE
Robert Schneider (Institute of Functional Epigenetics, HMGU)
NOVEL PLAYERS IN CHROMATIN
Ramin Shiekhattar (University of Miami)
Ali Shilatifard (Northwestern University)
PRINCIPLES OF EPIGENETICS AND CHROMATIN IN DEVELOPMENT AND HUMAN DISEASE
Jane Skok (NYU Langone Health)
THE IMPACT OF CANCER ASSOCIATED CTCF MUTATIONS ON CHROMATIN STRUCTURE AND GENE REGULATION
Maria-Elena Torres-Padilla (Helmholtz Zentrum München)
EPIGENETIC MECHANISMS OF CELLULAR PLASTICITY AND REPROGRAMMING TO TOTIPOTENCY
This conference will appeal to PhD students, post-doc and group leaders working in the field of chromatin architecture, epigenetics, stem cell biology and cancer. Scientists active in R&D of small, medium and big pharma or biotech companies.
The primary purpose of workshops is to enhance communication between junior and senior investigators. As mentioned in the executive summary, “Young scientists will have the opportunities to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. The program has also allocated ample time for exchanging ideas and discussing novel hypothesis at the end of each session, as well as time for informal interactions and networking”.
Tony Kouzarides
Deputy Director, University of Cambridge
Robert Schneider
PI, Institute of Functional Epigenetics, HMGU
Genevieve Almouzni
Head of the Chromatin Dynamics team, Research center at the Institut Curie
Danny Reinberg
Principal Investigator, HHMI/NYU Langone School of Medicine
Ali Shilatifard
Chairman, Northwestern University
Maria-Elena Torres-Padilla
Director, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Mounia Lagha
Principal Investigator, CNRS
Karen Adelman
Professor, Harvard Medical School
Anne Brunet
Michele and Timothy Barakett Professor of Genetics, Stanford University
Rab Prinjha
Head of Immunology Research Unit, R&D, GlaxoSmithKline
Jane Skok
PI, NYU School of Medicine
Ramin Shiekhattar
Co-Leader, Cancer Epigenetics Research Program Chief, Division of Cancer Genomics & Epigenetics Professor, Department of Human Genetics, University of Miami
Francois Fuks
Professor, University of Brussels
Elena Ezhkova
Professor, Icahn School of Medicine at Mount Sinai
Diego Pasini
Group Leader, European Institute of Oncology
Irene Chiolo
Assistant Professor, University of Southern California, Los Angeles
THURSDAY 19TH MAY 2022 |
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13:30 – 14:30 |
Student Networking Reception |
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14:00 – 15:00 |
Registration |
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Histone Modifications in Gene Regulation I |
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15:00 – 15:10 |
Opening Comments |
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15:10 – 15:35 |
Luciano Di Croce |
THE DISTINCT ROLE OF POLYCOMB AND MLL PROTEINS IN STEM CELL BIOLOGY AND CANCER |
15:35 – 16:00 |
Diego Pasini |
POLYCOMB REPRESSIVE MECHANISMS IN THE EPIGENETIC CONTROL OF TRANSCRIPTIONAL IDENTITY |
16:00 – 16:25 |
Danny Reinberg |
POLYCOMB, INHERITANCE AND DISEASE |
16:25 – 16:40 |
Christine Brainson |
DIVERSE ROLES OF POLYCOMB REPRESSIVE COMPLEX 2 IN LUNG CANCER AND LUNG DISEASE |
16:40 – 17:25 |
Refreshments |
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17:25 – 17:40 |
Andres Blanco |
CRISPR SCREEN IDENTIFIES KAT6A AND ENL AS AN EPIGENETIC TRANSCRIPTIONAL CONTROL MODULE IN ACUTE MYELOID LEUKEMIA |
Histone Modifications in Gene Regulation II |
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17:40 – 18:05 |
Maria-Elena Torres-Padilla |
EPIGENETIC MECHANISMS OF CELLULAR PLASTICITY AND REPROGRAMMING TO TOTIPOTENCY |
18:05 – 18:20 |
Valerie Sponyoe |
EXAMINING DOSAGE COMPENSATION IN THE ABSENCE OF XIST |
18:20 – 18:55 |
Meet the Poster Presenters |
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18:55 |
Dinner at Leisure |
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FRIDAY 20TH MAY 2022 |
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07:00 – 09:00 |
Buffet Breakfast at Kalmia Buffet |
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Multilayered Regulation of Chromatin & Cellular Memory I |
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09:00 – 09:25 |
Jane Skok |
THE IMPACT OF CANCER ASSOCIATED CTCF MUTATIONS ON CHROMATIN STRUCTURE AND GENE REGULATION |
09:25 – 09:40 |
Michele Gabriele |
DYNAMICS OF CTCF AND COHESIN MEDIATED CHROMATIN LOOPING REVEALED BY LIVE-CELL IMAGING |
09:40 – 10:05 |
Giacomo Cavalli |
3D GENOME ORGANIZATION AND POLYCOMB PROTEINS IN GENE REGULATION AND DEVELOPMENT |
10:05 – 10:50 |
Group Photo, Refreshments & Poster Viewing |
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10:50 – 11:15 |
Irene Chiolo |
HIGH RESOLUTION PROFILING OF DOUBLE STRAND BREAK RESPONSES IN HETEROCHROMATIN |
11:15 – 17:00 |
Group Lunch & Free Time |
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Multilayered Regulation of Chromatin & Cellular Memory II |
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17:00 – 17:25 |
Ramin Shiekhattar |
INTEGRATOR COMPLEX IN HEALTH AND DISEASE |
17:25 – 17:50 |
Karen Adelman |
CONTROLLING TRANSCRIPTION AT CODING AND NON-CODING LOCI |
17:50 – 18:15 |
Mounia Lagha |
PROMOTER CONTROL OF TRANSCRIPTIONAL BURSTING DURING ZYGOTIC GENOME ACTIVATION |
18:15 – 18:30 |
Hans van Bokhoven |
IDENTIFICATION OF CONVERGING MOLECULAR PATHWAYS ACROSS CHROMATINOPATHIES AS TARGETS FOR THERAPY |
18:30 – 18:45 |
Y. George Zheng |
NEW HISTONE LYSINE ACYLATIONS AND THEIR EFFECTS IN EPIGENETIC REGULATION |
18:45 – 20:00 |
Poster Session & Refreshments |
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20:00 |
Group Dinner |
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SATURDAY 21ST MAY 2022 |
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07:00 – 09:00 |
Buffet Breakfast at Kalmia Buffet |
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Chromatin & Disease I |
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09:00 – 09:25 |
Tony Kouzarides |
RNA MODIFICATIONS: THEIR FUNCTION AND ROLE IN CANCER |
09:25 – 09:50 |
Francois Fuks |
RNA MODIFICATIONS IN HEALTH AND DISEASE |
09:50 – 10:05 |
Liliane Broye |
FUSION PROTEIN ISOFORMS ESTABLISH AN ONCOGENIC GENE EXPRESSION PROGRAM IN DSRCT |
10:05 – 10:20 |
Capucine Van Rechem |
CHROMATIN REMODELERS LOST IN TRANSLATION |
10:20 – 11:05 |
Refreshments & Poster Viewing |
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Chromatin & Disease II |
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11:05 – 11:30 |
Rab Prinjha |
CHALLENGES AND OPPORTUNITIES IN PROGRESSING EPIGENETIC THERAPEUTICS |
11:30 – 11:55 |
Genevieve Almouzni |
HISTONE VARIANTS AND CHAPERONES IN CANCER |
11:55 – 12:10 |
Ruslan Sadreyev |
COLLECTIVE REGULATION OF CHROMATIN MODIFICATIONS PREDICTS REPLICATION TIMING DURING CELL CYCLE |
12:10 – 17:00 |
Group Lunch & Free Time |
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Stem Cells & Epigenetics |
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17:00 – 17:25 |
Anne Brunet |
EPIGENETIC REGULATION OF AGING STEM CELLS |
17:25 – 17:40 |
Marissa Cloutier |
PREVENTING EROSION OF X-CHROMOSOME INACTIVATION IN HUMAN EMBRYONIC STEM CELLS |
17:40 – 18:05 |
Robert Schneider |
NOVEL PLAYERS IN CHROMATIN |
18:05 – 18:30 |
Elena Ezhkova |
EPIGENETIC REGULATION OF SKIN STEM CELLS |
18:30 – 18:45 |
Meelad Dawlaty |
TET-MEDIATED DNA DEMETHYLATION IN REGULATION OF HEMATOPOIETIC AND NEURAL ENHANCERS IN STEM CELLS AND DEVELOPMENT |
18:45 – 20:00 |
Refreshments & Poster Viewing |
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20:00 |
Gala Dinner & Poster Awards |
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SUNDAY 22ND MAY 2022 |
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07:00 – 09:00 |
Buffet Breakfast at Kalmia Buffet |
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Chromatin & Disease III |
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09:00 – 09:25 |
Ali Shilatifard |
PRINCIPLES OF EPIGENETICS AND CHROMATIN IN DEVELOPMENT AND HUMAN DISEASE |
09:25 – 09:40 |
Ajinkya Patil (Kadoch Lab) |
STRUCTURE AND FUNCTION OF MAMMALIAN SWI/SNF CHROMATIN REMODELING COMPLEXES IN HUMAN DISEASE |
09:40 – 09:55 |
Frank Kooy |
A NOVEL MUTANT MOUSE MODEL OF THE CHROMATIN REMEDELER ADNP DISPLAYS A COGNITIVE AND BEHAVIORAL PHENOTYPE AS WELL AS MOLECULAR ABNORMALITIES RELEVANT TO THE HELSMOORTEL – VAN DER AA SYNDROME. |
09:55 – 10:10 |
Clair Harris |
ACTIVATION OF XIST BY AN EVOLUTIONARILY CONSERVED FUNCTION OF THE KDM5C DEMETHYLASE |
10:10 – 10:20 |
Closing Comments |
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10:20 |
Refreshments |
Fiesta Americana Condesa Cancun All Inclusive
This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
Venue Rating
★ ★ ★ ★ ★
Currency
US Dollar (USD)
Address
Fiesta Americana Condesa Cancún All Inclusive Blvd. Kukulcan km 16.5 Zona Hotelera 77500 Cancun Q.R. Mexico
Nearest Airport
Cancun International Airport
Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.
Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.
If you are interested in this meeting but not yet ready to register, you can sign up for updates here and our team will keep you updated regarding deadline reminders and grant opportunities relating to this meeting only.
If you're interested in sponsoring this conference please contact us.
Conference Manager
Chloe Trundle
As a family run business, our dedication runs deep. We’re committed to each other and, even more so, to every attendee’s experience, delivering a level of care and passion that’s truly unmatched.