Past Conference

3rd Epigenetics Conference

From Mechanisms to Disease #3EPI22

Date

19 May - 22 May 2022

Location

Cancun, Mexico

Early Bird - Expired  •  Talk Submission - Expired  •  Poster Submission - Expired  •  Registration & Payment Deadline - Expired

Synopsis

The DNA of eukaryotic cells is organized into chromatin. Chromatin is the template of life. It is the vector of genetic information and it is at the core of fundamental processes such as gene regulation, stem cell fate determination and cancer. The study of chromatin structure and function and the study of mechanisms of disease and their diagnostic and therapeutic approaches are mostly covered by separate meetings. However, the boundaries among these various disciplines are disappearing and now, the meeting on "Epigenetics: from mechanisms to disease" will bring together scientists studying chromatin architecture, epigenetics, stem cell biology cancer and other diseases. The talks will cover a broad range of topics, including chromosome organisation, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms, transcription regulation, DNA methylation and hydroxymethylation, as well as the use of genome engineering technologies, single-cell approaches and cutting edge epigenomics and imaging approaches.

Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches. Young scientists will be able to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. The program has also allocated ample time for exchanging ideas and discussing novel hypotheses at the end of each session, as well as time for informal interactions and networking.

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying academics can bring a student for only $785. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 19, 20, 21 May 2022 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact Chloe Trundle to obtain a special registration link for your student. 

Confirmed Invited Speakers

Karen Adelman (Harvard Medical School)
CONTROLLING TRANSCRIPTION AT CODING AND NON-CODING LOCI
Genevieve Almouzni (Research center at the Institut Curie)
HISTONE VARIANTS AND CHAPERONES IN CANCER
Salvador Aznar-Benitah (IRB Barcelona)
DIETARY METABOLITES ESTABLISH AN EPIGENETIC MEMORY IN METASTASIS-INITIATING CELLS, MECHANISMS AND POTENTIAL THERAPIES.
Shelley Berger (University of Pennsylvania)
EPIGENETIC PATHWAYS AS TARGETS IN HUMAN DISEASE
Anne Brunet (Stanford University)
EPIGENETIC REGULATION OF AGING STEM CELLS
Irene Chiolo (University of Southern California)
Elena Ezhkova (Icahn School of Medicine at Mount Sinai)
EPIGENETIC REGULATION OF SKIN STEM CELLS
Francois Fuks (University of Brussels)
RNA MODIFICATIONS IN HEALTH AND DISEASE
Tony Kouzarides (University of Cambridge)
RNA MODIFICATIONS: THEIR FUNCTION AND ROLE IN CANCER
Mounia Lagha (CNRS)
TRANSCRIPTION DYNAMICS AND MEMORY DURING ZYGOTIC GENOME ACTIVATION
Lluis Morey (University of Miami)
EPIGENETIC MECHANISMS IN BREAST CANCER
Diego Pasini (European Institute of Oncology)
Rab Prinjha (GlaxoSmithKline)
CHALLENGES AND OPPORTUNITIES IN PROGRESSING EPIGENETIC THERAPEUTICS
Danny Reinberg (HHMI/NYU Langone School of Medicine)
POLYCOMB, INHERITANCE AND DISEASE
Robert Schneider (Institute of Functional Epigenetics, HMGU)
NOVEL PLAYERS IN CHROMATIN
Ramin Shiekhattar (University of Miami)
Ali Shilatifard (Northwestern University)
PRINCIPLES OF EPIGENETICS AND CHROMATIN IN DEVELOPMENT AND HUMAN DISEASE
Jane Skok (NYU Langone Health)
THE IMPACT OF CANCER ASSOCIATED CTCF MUTATIONS ON CHROMATIN STRUCTURE AND GENE REGULATION
Maria-Elena Torres-Padilla (Helmholtz Zentrum München)
EPIGENETIC MECHANISMS OF CELLULAR PLASTICITY AND REPROGRAMMING TO TOTIPOTENCY

Target Audience

This conference will appeal to PhD students, post-doc and group leaders working in the field of chromatin architecture, epigenetics, stem cell biology and cancer. Scientists active in R&D of small, medium and big pharma or biotech companies.

Educational Need

The primary purpose of workshops is to enhance communication between junior and senior investigators. As mentioned in the executive summary, “Young scientists will have the opportunities to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. The program has also allocated ample time for exchanging ideas and discussing novel hypothesis at the end of each session, as well as time for informal interactions and networking”.

Programme

THURSDAY 19TH MAY 2022

13:30 – 14:30

Student Networking Reception

14:00 – 15:00

Registration

Histone Modifications in Gene Regulation I
Session Chair: Giacomo Cavalli

15:00 – 15:10

Opening Comments

15:10 – 15:35

Luciano Di Croce
Centre for Genomic Regulation

THE DISTINCT ROLE OF POLYCOMB AND MLL PROTEINS IN STEM CELL BIOLOGY AND CANCER

15:35 – 16:00

Diego Pasini
European Institute of Oncology

POLYCOMB REPRESSIVE MECHANISMS IN THE EPIGENETIC CONTROL OF TRANSCRIPTIONAL IDENTITY

16:00 – 16:25

Danny Reinberg
HHMI / NYU Langone School of Medicine

POLYCOMB, INHERITANCE AND DISEASE

16:25 – 16:40

Christine Brainson
University of Kentucky

DIVERSE ROLES OF POLYCOMB REPRESSIVE COMPLEX 2 IN LUNG CANCER AND LUNG DISEASE

16:40 – 17:25

Refreshments

17:25 – 17:40

Andres Blanco
University of Pennsylvania

CRISPR SCREEN IDENTIFIES KAT6A AND ENL AS AN EPIGENETIC TRANSCRIPTIONAL CONTROL MODULE IN ACUTE MYELOID LEUKEMIA

Histone Modifications in Gene Regulation II
Session Chair: Karen Adelman

17:40 – 18:05

Maria-Elena Torres-Padilla
Helmholtz Zentrum München

EPIGENETIC MECHANISMS OF CELLULAR PLASTICITY AND REPROGRAMMING TO TOTIPOTENCY

18:05 – 18:20

Valerie Sponyoe
University of Michigan

EXAMINING DOSAGE COMPENSATION IN THE ABSENCE OF XIST

18:20 – 18:55

Meet the Poster Presenters

18:55

Dinner at Leisure

FRIDAY 20TH MAY 2022

07:00 – 09:00

Buffet Breakfast at Kalmia Buffet

Multilayered Regulation of Chromatin & Cellular Memory I
Session Chair: Luciano Di Croce

09:00 – 09:25

Jane Skok
NYU Langone Health

THE IMPACT OF CANCER ASSOCIATED CTCF MUTATIONS ON CHROMATIN STRUCTURE AND GENE REGULATION

09:25 – 09:40

Michele Gabriele
Massachusetts Institute of Technology

DYNAMICS OF CTCF AND COHESIN MEDIATED CHROMATIN LOOPING REVEALED BY LIVE-CELL IMAGING

09:40 – 10:05

Giacomo Cavalli
Institute of Human Genetics

3D GENOME ORGANIZATION AND POLYCOMB PROTEINS IN GENE REGULATION AND DEVELOPMENT

10:05 – 10:50

Group Photo, Refreshments & Poster Viewing

10:50 – 11:15

Irene Chiolo
University of Southern California

HIGH RESOLUTION PROFILING OF DOUBLE STRAND BREAK RESPONSES IN HETEROCHROMATIN

11:15 – 17:00

Group Lunch & Free Time

Multilayered Regulation of Chromatin & Cellular Memory II
Session Chair: Jane Skok

17:00 – 17:25

Ramin Shiekhattar
University of Miami

INTEGRATOR COMPLEX IN HEALTH AND DISEASE

17:25 – 17:50

Karen Adelman
Harvard Medical School

CONTROLLING TRANSCRIPTION AT CODING AND NON-CODING LOCI

17:50 – 18:15

Mounia Lagha
CNRS

PROMOTER CONTROL OF TRANSCRIPTIONAL BURSTING DURING ZYGOTIC GENOME ACTIVATION

18:15 – 18:30

Hans van Bokhoven
Radboud University Medical Center

IDENTIFICATION OF CONVERGING MOLECULAR PATHWAYS ACROSS CHROMATINOPATHIES AS TARGETS FOR THERAPY

18:30 – 18:45

Y. George Zheng
University of Georgia

NEW HISTONE LYSINE ACYLATIONS AND THEIR EFFECTS IN EPIGENETIC REGULATION

18:45 – 20:00

Poster Session & Refreshments

20:00

Group Dinner

SATURDAY 21ST MAY 2022

07:00 – 09:00

Buffet Breakfast at Kalmia Buffet

Chromatin & Disease I
Session Chair: Maria-Elena Torres-Padilla

09:00 – 09:25

Tony Kouzarides
University of Cambridge

RNA MODIFICATIONS: THEIR FUNCTION AND ROLE IN CANCER

09:25 – 09:50

Francois Fuks
University of Brussels

RNA MODIFICATIONS IN HEALTH AND DISEASE

09:50 – 10:05

Liliane Broye
University of Lausanne

FUSION PROTEIN ISOFORMS ESTABLISH AN ONCOGENIC GENE EXPRESSION PROGRAM IN DSRCT

10:05 – 10:20

Capucine Van Rechem
Stanford University

CHROMATIN REMODELERS LOST IN TRANSLATION

10:20 – 11:05

Refreshments & Poster Viewing

Chromatin & Disease II
Session Chair: Giacomo Cavalli & Luciano Di Croce

11:05 – 11:30

Rab Prinjha
GlaxoSmithKline

CHALLENGES AND OPPORTUNITIES IN PROGRESSING EPIGENETIC THERAPEUTICS

11:30 – 11:55

Genevieve Almouzni
Institut Curie

HISTONE VARIANTS AND CHAPERONES IN CANCER

11:55 – 12:10

Ruslan Sadreyev
Massachusetts General Hospital / Harvard Medical School

COLLECTIVE REGULATION OF CHROMATIN MODIFICATIONS PREDICTS REPLICATION TIMING DURING CELL CYCLE

12:10 – 17:00

Group Lunch & Free Time

Stem Cells & Epigenetics
Session Chair: Genevieve Almounzi

17:00 – 17:25

Anne Brunet
Stanford University

EPIGENETIC REGULATION OF AGING STEM CELLS

17:25 – 17:40

Marissa Cloutier
University of Michigan

PREVENTING EROSION OF X-CHROMOSOME INACTIVATION IN HUMAN EMBRYONIC STEM CELLS

17:40 – 18:05

Robert Schneider
Institute of Functional Epigenetics, HMGU

NOVEL PLAYERS IN CHROMATIN

18:05 – 18:30

Elena Ezhkova
Icahn School of Medicine at Mount Sinai

EPIGENETIC REGULATION OF SKIN STEM CELLS

18:30 – 18:45

Meelad Dawlaty
Albert Einstein College of Medicine

TET-MEDIATED DNA DEMETHYLATION IN REGULATION OF HEMATOPOIETIC AND NEURAL ENHANCERS IN STEM CELLS AND DEVELOPMENT

18:45 – 20:00

Refreshments & Poster Viewing

20:00

Gala Dinner & Poster Awards

SUNDAY 22ND MAY 2022

07:00 – 09:00

Buffet Breakfast at Kalmia Buffet

Chromatin & Disease III
Session Chair: Robert Schneider

09:00 – 09:25

Ali Shilatifard
Northwestern University

PRINCIPLES OF EPIGENETICS AND CHROMATIN IN DEVELOPMENT AND HUMAN DISEASE

09:25 – 09:40

Ajinkya Patil (Kadoch Lab)
Dana-Farber Cancer Institute

STRUCTURE AND FUNCTION OF MAMMALIAN SWI/SNF CHROMATIN REMODELING COMPLEXES IN HUMAN DISEASE

09:40 – 09:55

Frank Kooy
University of Antwerp

A NOVEL MUTANT MOUSE MODEL OF THE CHROMATIN REMEDELER ADNP DISPLAYS A COGNITIVE AND BEHAVIORAL PHENOTYPE AS WELL AS MOLECULAR ABNORMALITIES RELEVANT TO THE HELSMOORTEL – VAN DER AA SYNDROME.

09:55 – 10:10

Clair Harris
University of Michigan

ACTIVATION OF XIST BY AN EVOLUTIONARILY CONSERVED FUNCTION OF THE KDM5C DEMETHYLASE

10:10 – 10:20

Closing Comments

10:20

Refreshments

Supported by

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Venue & Location

Fiesta Americana Condesa Cancun All Inclusive

This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment.  We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas

General Information

Venue Rating

★ ★ ★ ★ ★

Currency

US Dollar (USD)

Address

Fiesta Americana Condesa Cancún All Inclusive Blvd. Kukulcan km 16.5 Zona Hotelera 77500 Cancun Q.R. Mexico

Nearest Airport

Cancun International Airport

Location

Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.

Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.

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Conference Manager

Chloe Trundle

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