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Intestinal Stem Cell - Niche Interactions in Health & Disease Conference
#ISC22
22 May - 25 May 2022
Cancun, Mexico
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Synopsis
The past ten years have seen an explosion of information regarding intestinal stem cells (ISCs), due to an improved ability to identify ISCs, follow their fates, and manipulate ISCs in vitro. The next frontier in the ISC field is understanding the role that dysregulated ISC behavior plays in the etiology of disease, and conversely, the impact of intestinal disease on proper ISC function. This meeting will bring together a diverse group of investigators to discuss topics such as how the environment of the small intestine and colon impacts ISC behavior in healthy and diseased states, how ISC behavior and the niche differ along the proximal-distal axis of the intestine, and the strengths of various models for investigating the relationship between ISCs, the niche, and the onset and propagation of disease states.
Key Sessions
- Inflammation: causes and consequence
- Microbiome
- Metabolism and Aging
- Modeling the intestine in vitro
- Intestinal diseases and ISCs
- Plasticity in the intestine
- Regulation of ISC behavior
Student Offer
Take advantage of this fantastic opportunity for students! Fully paying academics can bring a student for only $785. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 22, 23, 24 May 2022 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact Jack Peters to obtain a special registration link for your student
Confirmed Plenary Speakers
Fred de Sauvage (Genentech)
MICROENVIRONMENT REGULATION OF STEM CELLS IN INTESTINAL REGENERATION AND CANCER
James Wells (Cincinnati Children's Hospital)
ENGINEERING COMPLEXITY INTO PSC-DERIVED GASTROINTESTINAL ORGANOIDS
Confirmed Invited Speakers
Helen Abud (Monash Biomedicine Discovery Institute)
ROLE OF THE EGF FAMILY OF LIGANDS IN MEDIATING STEM CELL IDENTITY AND REGENERATION
Sarah Elizabeth Blutt (Baylor College of Medicine)
GENERATION OF SMALL INTESTINAL TISSUE STEM CELL DERIVED ORGANOID CULTURES FROM CRONKHITE CANADA SYNDROME PATIENTS REVEALS NEW INSIGHTS INTO A RARE DISEASE
Nicolas Buchon (Cornell College)
FROM HOMEOSTASIS TO PLASTICITY: HOW THE DIALOGUE BETWEEN ISCS, NUTRIENTS AND MICROBES SHAPES GUT STRUCTURE AND FUNCTION
Julia Cordero (University of Glasgow)
RECIPROCAL STEM CELL/NICHE INTERACTIONS INFLUENCING INTESTINAL AND MICROENVIRONMENT PLASTICITY DURING REGENERATION
Heinrich Jasper (Genentech)
INTRINSIC AND EXTRINSIC CAUSES OF INTESTINAL STEM CELL AGING
Pekka Katajisto (University of Helsinki)
STEM CELL NICHE INTERACTIONS DURING AGING
Kara McKinley (Harvard Stem Cell Institute)
ACUTE AND CHRONIC RESPONSES TO STEM CELL ABLATION
Maria Mihaylova (Ohio State University)
NUTRIENT SENSING AND UTILIZATION IN THE INTESTINAL CRYPT
Jason Mills (Baylor College of Medicine)
PALIGENOSIS: A CONSERVED CELLULAR PROGRAM FOR RECRUITING STEM CELLS IN REGENERATION AND CANCER
Alessandro Ori (Leibniz Institute on Aging- Fritz Lipmann Institute)
REGION-SPECIFIC EFFECTS OF AGING AND DIETARY RESTRICTION ON THE INTESTINAL EPITHELIUM
Michal Shoshkes (The Hebrew University of Jerusalem-Hadassah Medical School)
SINGLE- CELL TRANSCRIPTOMICS OF TELOCYTES DEFINES THE MOLECULAR BASIS OF INTESTINAL HOMEOSTASIS
Jason Spence (University of Michigan)
DISSECTING THE ROLE OF EGF FAMILY MEMBERS IN THE HUMAN INTESTINAL STEM CELL NICHE
Shervin Rabizadeh (Cedars-Sinai Medical Center)
Jeff Wrana (Lunenfeld-Tanenbaum Research Institute)
Kelley Yan (Columbia University Medical Center)
A TOP-DOWN APPROACH TO UNDERSTANDING INTESTINAL CRYPTS AND REGENERATION
Ömer Yilmaz (Koch Institute for Integrative Cancer Research)
DIETARY CONTROL OF INTESTINAL STEM CELLS IN PHYSIOLOGY AND DISEASE
Target Audience
Scientists and physicians from the fields of stem cell biology, gastrointestinal disease, metabolic disorders, or immunology who are interested in integrating concepts across these areas to improve understanding of mechanisms underlying intestinal homeostasis, disease, and disease treatment.
Educational Need
There does not appear to be any other conference which focuses entirely on intestinal stem cell biology in the context of multiple disease states and in a variety of organisms. In the conference, we will discuss topics such as:
- Novel methods for assessing stem cell growth and differentiation capabilities from along the intestinal tract
- Discussing the extent to which mouse studies can faithfully model human disease, and what are the limits
- The impact of inflammation (disease, infection) on ISC proliferation and differentiation capacity
- The impact of diet and metabolism on ISC behaviour from different regions of the small and large intestine
- The impact of aging on ISCs from different regions of the small and large intestine
Confirmed Speakers
Chairs
Plenary Speakers
Frederic de Sauvage
Vice President Molecular Oncology, Genentech
James Wells
Professor, Cincinnati Childrens Research Founcation
Invited Speakers
Pekka Katajisto
Associate Professor, University of Helsinki
Alessandro Ori
Scientist / Research Group Leader, Leibniz-Institute on Aging
Michal Shoshkes Carmel
Principal Investigator, The Hebrew University
Jason Spence
Professor of Internal Medicine, University of Michigan
Helen Abud
Professor, Monash University
Jason Mills
Professor, Baylor College of Medicine
Julia Cordero
Senior Research Fellow, University of Glasgow and Beatson Institute
Jeff Wrana
Senior Investigator, Lunenfeld-Tanenbaum Research Institute
Omer Yilmaz
Associate Professor, MIT
Maria Mihaylova
Assistant Professor, The Ohio State University
Heinrich Jasper
Staff Scientist, Genentech, Inc.
Sarah Blutt
Associate Professor, Baylor College of Medicine
Kelley Yan
Assistant Professor, Columbia University
Shervin Rabizadeh
Chair, Dept of Peds; Director, Peds GI/IBD, Cedars-Sinai - Los Angeles, CA
Nicolas Buchon
Associate Professor, Cornell University
Karuna Ganesh
Medical Oncologist, Sloan Kettering Institute
Programme
SUNDAY 22ND MAY |
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14:30 – 15:30 |
Student Networking Reception |
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15:00 – 16:00 |
Registration & Refreshments |
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ISC Self-renewal and Regulation I |
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16:00 – 16:10 |
Opening Comments |
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16:10 – 16:40 |
Helen Abud |
ROLE OF THE EGF FAMILY OF LIGANDS IN MEDIATING STEM CELL IDENTITY AND REGENERATION |
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16:40 – 17:10 |
Jason Spence |
DISSECTING THE ROLE OF EGF FAMILY MEMBERS IN THE HUMAN INTESTINAL STEM CELL NICHE |
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17:10 – 17:30 |
Kathleen Cunningham |
ROLE OF NEUROGLIAN/L1CAM IN INTESTINAL HOMEOSTASIS AND AGING |
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17:30 – 18:15 |
Refreshments |
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18:15 – 18:35 |
Kaelyn Sumigray |
ROLES FOR MOUSE INTESTINAL STEM CELL NICHE MORPHOGENESIS IN PATTERN FORMATION |
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18:35 – 18:55 |
Rachel Zwick |
INTRINSIC CONTROL OF SMALL INTESTINAL ZONATION AT MULTIPLE LEVELS OF THE EPITHELIAL HIERARCHY |
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ISC Self-renewal and Regulation II |
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18:55 – 19:15 |
Koen Oost |
ELUCIDATING HUMAN INTESTINAL REGENERATION USING PATIENT-DERIVED ORGANOIDS |
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19:15 – 20:00 |
Fred De Sauvage |
MICROENVIRONMENT REGULATION OF STEM CELLS IN INTESTINAL REGENERATION AND CANCER |
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20:00 |
Dinner at Leisure |
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MONDAY 23RD MAY |
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07:00 – 09:00 |
Breakfast at Leisure |
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Aging, Stress and ISCs |
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09:00 – 09:30 |
Julia Cordero |
RECIPROCAL STEM CELL/NICHE INTERACTIONS INFLUENCING INTESTINAL AND MICROENVIRONMENT PLASTICITY DURING REGENERATION |
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09:30 – 10:00 |
Heinrich Jasper |
INTRINSIC AND EXTRINSIC CAUSES OF INTESTINAL STEM CELL AGING |
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10:00 – 10:30 |
Pekka Katajisto |
STEM CELL NICHE INTERACTIONS DURING AGING |
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10:30 – 11:15 |
Group Photo, Refreshments & Poster Viewing |
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11:15 – 11:45 |
Alessandro Ori |
REGION-SPECIFIC EFFECTS OF AGING AND DIETARY RESTRICTION ON THE INTESTINAL EPITHELIUM |
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11:45 – 12:15 |
Meet the Poster Presenters |
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12:15 – 16:30 |
Lunch at Leisure & Free Time |
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The Microenvironment and the Microbiome |
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16:30 – 17:00 |
Sarah Elizabeth Blutt |
GENERATION OF SMALL INTESTINAL TISSUE STEM CELL DERIVED ORGANOID CULTURES FROM CRONKHITE CANADA SYNDROME PATIENTS REVEALS NEW INSIGHTS INTO A RARE DISEASE |
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17:00 – 17:20 |
Avital Swisa |
EPITHELIAL FOXA TRANSCRIPTION FACTORS DETERMINE THE GUT MICROBIOME VIA CONTROL OF THE GLYCOSYLATION PROGRAM |
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17:20 – 17:50 |
Nicolas Buchon |
FROM HOMEOSTASIS TO PLASTICITY: HOW THE DIALOGUE BETWEEN ISCS, NUTRIENTS AND MICROBES SHAPES GUT STRUCTURE AND FUNCTION |
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17:50 – 18:10 |
Phillip Karpowicz |
THE CIRCADIAN CLOCK GENE, BMAL1, REGULATES INTESTINAL STEM CELL SIGNALING AND REPRESSES TUMOR INITIATION |
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18:10 – 20:00 |
Poster Session & Refreshments |
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20:00 |
Group Dinner |
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TUESDAY 24TH MAY |
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07:00 –09:00 |
Breakfast at Leisure |
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Metabolism and ISCs |
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09:00 –09:30 |
Michal Shoskes The Hebrew University of Jerusalem-Hadassah Medical School |
SINGLE- CELL TRANSCRIPTOMICS OF TELOCYTES DEFINES THE MOLECULAR BASIS OF INTESTINAL HOMEOSTASIS |
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09:30 – 10:00 |
Maria Mihaylova |
NUTRIENT SENSING AND UTILIZATION IN THE INTESTINAL CRYPT |
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10:00 – 10:20 |
Shing Hu |
THE LEFT-RIGHT SYMMETRY-BREAKING TRANSCRIPTION FACTOR PITX2 REGULATES INTESTINAL MESENCHYMAL HOMEOSTASIS AND SYSTEMIC LIPID METABOLISM |
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10:20 – 11:05 |
Refreshments & Poster Viewing |
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11:05 – 11:25 |
Tobias Reiff |
microRNA miR-277 CONTROLS PHYSIOLOGY AND PATHOLOGY OF THE ADULT DROSOPHILA MIDGUT |
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11:25 – 12:05 |
Shervin Rabizadeh |
BRINGING THE BEDSIDE PERSPECTIVE TO THE BENCH – IBD RIPE FOR STEM CELL TECHNOLOGY |
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12:05 – 16:30 |
Lunch at Leisure & Free Time |
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Damage, Repair and Disease I |
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| 16:30 – 17:00 | Ömer Yilmaz Koch Institute for Integrative Cancer Research |
DIETARY CONTROL OF INTESTINAL STEM CELLS IN PHYSIOLOGY AND DISEASE |
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17:00 – 17:20 |
Ophir Klein |
LYMPHANGIOCRINE SIGNALS ARE REQUIRED FOR PROPER INTESTINAL REPAIR AFTER CYTOTOXIC INJURY |
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17:20 – 17:50 |
Jason Mills |
PALIGENOSIS: A CONSERVED CELLULAR PROGRAM FOR RECRUITING STEM CELLS IN REGENERATION AND CANCER |
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17:50 – 18:35 |
Refreshments & Poster Viewing |
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18:35 – 18:55 |
Sanne van Neerven |
APC-MUTANT CELLS ACT AS SUPERCOMPETITORS IN INTESTINAL TUMOUR INITIATION |
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18:55 – 19:15 |
Yi Liu |
INTRACELLULAR PH DYNAMICS REGULATES INTESTINAL STEM CELL LINEAGE SPECIFICATION |
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19:15 – 20:00 |
James Wells |
ENGINEERING COMPLEXITY INTO PSC-DERIVED GASTROINTESTINAL ORGANOIDS |
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20:00 |
Gala Dinner & Poster Awards |
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WEDNESDAY 25TH MAY |
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07:00 –09:00 |
Breakfast at Leisure |
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Damage, Repair and Disease II |
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09:00 –09:30 |
Jeff Wrana |
REVIVAL STEM CELLS IN INTESTINAL REGENERATION AND INFLAMMATORY BOWEL DISEASE |
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09:30 – 10:00 |
Kelley Yan |
A TOP-DOWN APPROACH TO UNDERSTANDING INTESTINAL CRYPTS AND REGENERATION |
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10:00 – 10:30 |
Refreshments |
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10:30 – 11:00 |
David Castillo Azofeifa |
MESENCHYMAL TELOCYTES ARE MECHANOSENSITIVE REGULATORS OF CRYPT FISSION |
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11:00 – 11:30 |
Karuna Ganesh |
PROGRESSIVE PLASTICITY OF INTESTINAL STEM CELLS DURING COLORECTAL CANCER METASTASIS |
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11:30 – 11:40 |
Closing Comments |
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Supported by
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Contact usVenue & Location
Fiesta Americana Condesa Cancun All Inclusive
This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
Hotel Facilities
- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
General Information
Venue Rating
★ ★ ★ ★ ★
Currency
US Dollar (USD)
Address
Fiesta Americana Condesa Cancún All Inclusive Blvd. Kukulcan km 16.5 Zona Hotelera 77500 Cancun Q.R. Mexico
Nearest Airport
Cancun International Airport
Location
Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.
Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.
If you are interested in this meeting but not yet ready to register, you can sign up for updates here and our team will keep you updated regarding deadline reminders and grant opportunities relating to this meeting only.
Media Partners
If you're interested in sponsoring this conference please contact us.
Conference Manager
Amy Johnson
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