In recent years, significant advancements have revolutionized the ability to study distinct biological features at the level of individual cells, resulting in profound implications for biology and medicine. These breakthroughs encompass novel microfluidic techniques, molecular advancements in next-generation sequencing, spatial technologies, and the development of computational platforms capable of analyzing large-scale sequencing data. As a result, we can now profile the genome (through DNA sequencing), transcriptome (using RNA sequencing), and epigenome (via ATAC sequencing and DNA methylation sequencing) at the resolution of single cells. This wealth of information has provided unprecedented insights into the biological composition of various cell types, tissues, and even whole organisms.
Within the realm of human health, these sequencing and analytic approaches have been employed to profile both normal and diseased states, leading to remarkable breakthroughs in our understanding of diseases at the single-cell level. Such tools have been applied to the fields of human genetics, immunity, infection, cancer, development, and neurosciences among others, generating tremendous interest and advancements. The primary focus of this conference is to explore the potential impact of these methodological advances in single-cell biology on our understanding of human diseases and their treatment. By bringing together experts in single-cell biology and leaders in human health, we aim to facilitate new interactions, foster collaborations, and generate innovative ideas that can pave the way for future clinical trials and the development of novel therapies. Additionally, we seek to showcase recent technical breakthroughs in sequencing and protocol development, sample preparation techniques, and data analysis methodologies. Given the rapid progress in this field, it is crucial to hear from leaders in single-cell technology development to gain insights into emerging trends and future applications. Ultimately, our objective is to investigate how these technical advancements can be effectively applied to the study of human diseases, providing a glimpse into the future of genomic medicine.

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying ‘single’ or ‘shared’ registrants can bring a student for only $960. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 11, 12, 13 Feb 24 (on a shared basis for students) and an all-inclusive food and beverage package for the conference period. Once registered, please contact Amy Johnson to obtain a special registration link for your student.

Confirmed Invited Speakers

Elham Azizi (Columbia University)
MACHINE LEARNING CELL DYNAMICS IN THE TUMOR MICROENVIRONMENT
Fernando Camargo (Harvard Stem Cell Institute)
HIGH-RESOLUTION LINEAGE TRACING IN ADULT STEM CELLS
Michelle Chan (Princeton University)
RECONSTRUCTING TRANSIENT PROGENITOR FIELD DYNAMICS IN STEM CELL-DERIVED EMBRYOIDS
Fei Chen (Broad Institute)
A PLATFORM FOR SINGLE CELL SPATIAL GENOMICS 
Hani Goodarzi (University of California, San Francisco)
GENEVA: IN VIVO MOLECULAR PHENOTYPING OF MULTIPLEXED TUMORS IN CANCER RESEARCH AND DRUG DISCOVERY
Lee Grimes (Cincinnati Childrens Hospital)
IDENTIFICATION AND ISOLATION OF HEMATOPOIETIC STEM CELLS AND PROGENITORS WITH DISCRETE DEVELOPMENTAL GENE EXPRESSION PROGRAMS 
Smita Krishnaswamy (Yale University)
UNCOVERING DISEASE DYNAMICS FROM SINGLE CELL DATA WITH OPTIMAL-TRANSPORT BASED FLOWS AND NEURAL ODEs
Dan Landau (New York Genome Center)
NOVEL APPROACHES IN SINGLE-CELL LINEAGE MAPPING OF HUMAN CLONAL MOSAICISM
Caleb Lareau  (Stanford/ MSKCC)
LATENT VIRAL REACTIVATION REVEALED THROUGH SINGLE-CELL TECHNOLOGIES
Ashley Laughney (Weill Cornell Medicine)
TACKLING THE GENOTYPE-TO-PHENOTYPE PROBLEM IN CANCER EVOLUTION 
Mo Lotfollahi (Wellcome Sanger Institute)
GENERATIVE AI TO UNDERSTAND HEALTH AND DISEASE ACROSS CELLS, TISSUES AND PERTURBATIONS
Jose McFaline-Figueroa (Columbia University)
DEFINING THE RESPONSE TO THERAPEUTIC EXPOSURES USING HIGHLY MULTIPLEX SINGLE-CELL GENOMICS
Michael Meers (Washington University)
SINGLE-CELL APPROACHES FOR MULTIFACTORIAL EPIGENOME PROFILING
Jose Ordovas-Montanes (Boston Childrens Hospital)
TISSUE ECOLOGY OF IMMUNITY AND INFLAMMATION ACROSS BARRIERS
Dana Pe'er (Memorial Sloan Kettering Cancer Center)
CAUSES AND CONSEQUENCES OF PLASTICITY DURING TUMOR PROGRESSION.
Sydney Shaffer (University of Pennsylvania)
SPATIAL TRACKING OF STEM CELL DYNAMICS AND CANCER EVOLUTION 
Efrat Shema (Weizmann Institute of Science)
SINGLE-MOLECULE AND SINGLE-CELL TECHNOLOGIES TO DECODE EPIGENETIC HETEROGENEITY IN CANCER
Mario Suva (Mass General Hospital/Harvard Medical School)
DISSECTING HUMAN GLIOMAS BY SINGLE-CELL GENOMICS
Itay Tirosh (Weizmann Institute of Science)
PAN-CANCER ANALYSIS OF INTRA-TUMOR HETEROGENEITY
Xiao Wang (MIT)
TRANSLATING SPATIAL CELL ATLAS TO TISSUE FUNCTION

Target Audience

This conference will appeal to biologists, computational scientists, physicians and technology developers. Some basic knowledge in these fields will be beneficial. Graduate Students and postdoctoral fellows focusing on these areas are particularly welcome.

Educational Need

The field of single cell biology has erupted the last five years with the introduction of next generation sequencing technologies that probe the genome, transcriptome, epigenome and even spatial positioning of individual cells. As the tools and number of applications increases, there is a need for a review of the field and an intense look to the future with a focus on human disease and single cell technology applications.

Leaning Objectives

•    Understanding of how single cell biology impacts the understanding of human disease 
•    To bring together both single cell biologists and human health leaders 
•    To spark new interactions, collaborations and generate ideas
•    To present new technical breakthroughs
 

Please note the following programme is subject to change.