Dynamic Structures in DNA Damage Responses and Cancer

Synopsis

Key sessions will include:

DNA and RNA complexes
Chromatin Remodeling
Post-translational modifications - Ub, SUMO kinases
The repair interface with Replication
Transcription, and Recombination
Hybrid methods for dynamic structures
Damage signaling and processing
DNA repair and disease

Confirmed Invited Speakers:

Dr. Stephen J. Smerdon
National Institute for Medical Research

Dr Jessica Anne Downs
University of Sussex

Prof. Dr. Caroline Kisker
Rudolf Virchow Center DFG Research Center for Experimental Biomedicine

Prof. Tom Ellenberger
Washington University

Prof. Dorothy Erie
University of North Carolina at Chapel Hill, NC

Prof. Lorena Beese
Duke University Medical Center

Dr. Christopher D. Lima
Memorial Sloan-Kettering Cancer Center

Professor Walter J. Chazin
Vanderbilt University

Dr. Mark Glover
University of Alberta

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

Speakers

Invited Speakers

Steve Smerdon

Programme Leader, The Francis Crick Institute, UK

Caroline Kisker

Professor, University of Wuerzburg

Jessica Downs

Professor, Genome Damage and Stability Centre

Curtis Hodge

Dr, University of Alberta

Dorothy Erie

Professor, University of North Carolina

Wei Yang

Section Chief, National Institutes of Health

Walter Chazin

Founding Director- Center for Structural Biology, Vanderbilt University

Dale Wigley

Professor, Imperial College London

Luca Pellegrini

Senior Lecturer, University of Cambridge

Scott Williams

Principal Investigator, NIH/NIEHS

Christopher Lima

Professor and Member, Sloan-Kettering Institute, HHMI

Dorothee Kern

Prof. of Biochemistry, HHMI Investigator, Brandeis University/HHMI

Karl-Peter Hopfner

Professor, Gene Center

Tom Ellenberger

Professor, Washington University School of Medicine

Lorena Beese

Professor, Duke University Medical Center

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

Programme

Wednesday 12^th February 2014
07:30 – 08:30	Registration & Reception
08:30 -08:45	Opening Comments
Session Title From DNA Complexes to Chromatin Session Session Chair John Tainer
08:45 – 09:15	Walter Chazin	Dynamic hubs in multi-protein machinery
09:15 – 09:35	Gloria Borgstahl	Hyper-phosphorylation in RPA:RAD52 complex function
09:35 – 09:55	Franz Klein	Smc5/6-Mms21 in DHJ formation and resolution
09:55 – 10:25	Karl-Peter Hopfner	Integrative methods for a mega-Dalton chromatin remodeler
10:25 – 10:45	Anna Chambers	RSC2 BAH domain and SRC complex function
10:45 – 11:15	Refreshments
11:15 – 11:45	Jessica Downs	PBAF remodeling complex & transcription repression
11:45 – 12:05	Evi Soutoglou	Compartmentalization of repair at nuclear lamina & pores
12:05 – 12:25	Li Lan	Recruitment of repair proteins to heterochromatin and euchromatin
12:25 – 12:45	Terence Strick	Single Molecule DNA repair pathway reconstruction
12:45 – 12:55	Discussion
12:55 – 16:25	Welcome Lunch and Free Time
Session Title Hybird Methods for Dynamic Structures Session Chair Walter Chazin
16:25 – 16:30	Tom Blundell	Announcements
16:30 – 17:00	Dorothee Kern	Using ancient kinases to unravel cancer drug mechanism
17:00 – 17:20	Ivaylo Ivanov	Integrative modeling of complex nucleic acid assemblies
17:20 – 17:40	Susan Tsutakawa	PCNA with SUMO and Ub by combined methods
17:40 – 18:10		Refreshments
18:10 – 18:30	Qian Wu	Abraxas phosphorylation and BRCA1 dimerization
18:30 – 18:50	Susan Lees-Miller	New roles of DNA-PK in mitosis
18:50 – 19:10	Greg Hura	Comprehensive DNA conformations in mismatch repair
19:10 – 19:30	Angela Eggleston	Nature and DNA repair structural biology
19:30 – 19:40	Discussion
19:40 – 00:00	Dinner at Leisure and Free Time

Thursday 13^th February 2014
Session Title Mismatch Responses and DNA Replication Session Chair Tom Ellenberger
08:15 – 08:20 08:20 – 08:50	John Tainer Lorena Beese	Announcements Mismatch and fidelity
08:50 - 09:10	Jean-Baptist Charbonnier	MutL homologs and cancer
09:10 – 09:30 09:30 – 10:00 10:00 – 10:20 10:20 – 10:45 10:45 – 11:15	Alba Guarne Dorothy Erie Cynthia McMurray Luca Pellegrini	Transient MMR interactions MMR initiation by single-molecule methods MSH2-MSH3 plus OGG1 in trinucleotide expansion Refreshments Helicase-polymerase coupling in the eukaryotic replisome
11:15 – 11:35	Brandt Eichman	DNA junction recognition
11:35 – 11:55	Samir Hamdan	Dynamics of 5’ nucleases by single molecule imaging
11:55 – 12:15	Piero Bianco	SSB interactome partners and targeting repair
12:15 – 12:35	Murray Junop	Single-stranded annealing shown by DNA complex structure
12:35 – 12:45		Discussion
12:45 – 16:15	Lunch at Leisure and Free Time
Session Title From Structure and Chemistry to Cancer Session Session Chair Dorothee Kern
16:15 – 16:20 16:20 – 16:50	Tom Blundell Wei Yang	Announcements Human polymerase to cancer biology
16:50 – 17:10	Sylvie Doublie	NEIL glycosylases, repair polymorphisms and cancer
17:10 – 17:30	Arne Klungland	Dynamics and disease role of 6-methhyladenine in mRNA
17:30 – 17:50	Herwig Schuler	PARP inhibitors : structures, selectivity and pharmacology
17:50 – 18:10		Refreshments
18:10 – 18:25 18:25 – 18:40 18:40 – 19:00 19:00 – 19:30	Luxin Sun Eva Barkauskaite Hideki Aihara Tom Ellenberger	BRCA1 BRCT inhibitors for cancer therapy Poly(ADP-ribose) glycohydrolase structure and activity Novel TDP2 interaction with ubiquitin by NMR Targeting poly-(ADP-ribose) Glycohydrolase for Apoptosis
19:30 – 19:40 19:40 – 21:00 21:00 – 00:00	Discussion Cocktails and General Discussion Dinner at Restaurant with Optional Mentor Tables

Friday 14^th February 2014
Session Title Dynamic machines & signaling Session Chair Caroline Kisker
08:15 – 08:20 08:20 – 08:50	John Tainer Christopher Lima	Announcements RNA processing by the Eukaryotic RNA exosome
08:50 – 09:10	Mihaly Kovacs	Switching DNA-bound RecQ Helicase for repair
09:10 – 09:30	Opher Gileadi	Crystal structure of human Bloom helicase
09:30 – 09:50	Shunichi Takeda	CtlP and Dna2 nucleases form 3’ ends for recombination
09:50 – 10:10	Penny Jeggo	Regulating DSB repair pathway choice
10:10 – 10:35	Refreshments
10:35 – 10:55	Anthony Davis	DNA-PK and DSBR
10:55 – 11:15	Valerie Garcia	Tel1(ATM) suppresses meiotic DSB formation in chromatin
11:15 – 11:35	David O Ferguson	Control of ATM and CDK2/cyclin A kinases by MRN complex
11:35 – 11:55 11:55 – 12:25	Takashi Ochi Tom Blundell	PAXX Paralog of XRCC4 and XLF Spatial-Temporal Organisation of DSBR & cancer
12:25 – 12:35	Discussion
12:35 – 16:15	Lunch at Leisure and Free Time
Session Title Junctions and switches Session Chair Magnar Bjoras
16:15 – 16:20 16:20 – 16:50	Tom Blundell R. Scott Williams	Announcements Aprataxin resolves adenylated RNA-DNA junctions
16:50 – 17:10	Bjorn Dalhus	EndoV eukaryotic structure & DNA/RNA specificity
17:10 – 17:40	Mark Glover	Flipping the switch on Ubc13 in the DNA damage response
17:40 – 18:00	Jeff Perry	RNF4 repair functions and telomeres
18:00 – 18:25		Refreshments
18:25 – 18:55 18:55 – 19:15 19:15 – 19:35	Steve Smerdon Anthony Oliver Dong Wang	Nbs1 structures, functions and break signaling Rad4TopBP1 & DNA Damage Checkpoint Apparatus Transcriptional fidelity control and lesion recognition
19:35 – 19:45	Discussion
21:00 – 00:00	Gala Night & Group Photo Free Time

Saturday 15^th February 2014
Session Title Bulky lesions, signaling and conformations in damage responses Session Chair Karl-Peter Hopfner
08:15 – 08:20	Tom Blundell	Announcements
08:20 – 08:50	Caroline Kisker	Two faces of XPD by single molecule analyses
08:50 – 09:10	Li Fan	XPD and XP helicases
09:10 – 09:30 09:30 – 10:00 10:00 – 10:20	Jill Fuss Dale Wigley Joanne I. Yeh	DNA-mediated redox signaling & charge transfer by XPD FeS enzyme AddAB CHI recognition & mechanism UV-DDB binding to Damaged DNA induces oligomerization
10:20 – 10:45	Refreshments
10:45 – 11:05	Fernando Gomez-Herreros	TDP2 Protects Transcription
11:05 – 11:25	Xiaochun Yu	Novel functions of ribosylation & PAR-binding domains
11:25 – 11:45	Kristina Lakomek	Heteromeric Rvb1-Rvb2 complex for molecular machines
11:45 – 12:15	John Tainer	Conformations controlling repair responses
12:15 – 12:25	Discussion
12:25 – 12:40	Closing remarks & Farewell: John Tainer and Tom Blundell

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

Prices

Ticket Type	Early Bird	Full Price
Single Choose this option if you will be attending the conference alone, or if you will bring accompanying guests that will not attend the meeting.	$1355	$1490
Shared Choose this option if you wish to share with a colleague who is also attending the conference, or if you wish to be paired with another attendee of the same sex.	$1355	$1490
Student Choose this option if you are a student. Please note all students will be paired with another attendee of the same sex if a room sharer is not specified. If you wish to have your own room, please register under the Single option.	$999	$1250

Additional Person

This is the cost for an additional adult or child to join you in the same room, for the entire conference period. Accompanying persons are not permitted access to the conference. If you wish to extend your stay, please see our 'Extra night' prices.

Adult

$670

Child

$230

Extra nights

Prices are per person.

Adult

$220

Child

$75

All registration fees include 3 nights accommodation and meals during the conference period. Exact inclusions are detailed below.

Our Registration Package: What's Included?

The Fiesta Americana Condesa, Cancun is a fully inclusive property. Our registration and accompanying person fees are inclusive of the following;

Accommodation for 3 Nights
Breakfast, Lunch and Dinner – available at all restaurants according to operational hours or programmed events.
International Bar available by the glass in restaurants and bars according to operational hours.
Pool snacks and International Bar available by the glass at Pool Area
Minibar including: soft drinks, domestic beer, bottled water and coffee. Refreshed daily
24 Hour Room Service
In Room amenity – Bottle of wine, per room, per stay
Complimentary WI-FI in Conference Room
Complimentary WI-FI in Guest Room
Gala Night Entry (includes an open bar)

Please Note: Accompanying persons are not permitted access to the conference.

Additional nights (per person) are inclusive of the following;

Accommodation for 1 Night
Lunch on day of arrival
Dinner on day of arrival
Breakfast on day of departure
International bar available by the glass in restaurants and bars from lunch on day of arrival until breakfast on day of departure.

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

Grants

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

Venue

Fiesta Americana Condesa

This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

Lagoon Pool
Extensive Health Club and Spa
Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas

The Fiesta Americana Condesa, Cancun is the 2015 Winner of the Trip Advisor Certificate of Excellence and also received the Travellers Choice Award in 2014.

The remains of ancient Mayan cities are scattered throughout the Yucatan Peninsula and no trip to Cancun would be complete without a visit to these majestic temples and pyramids set amongst lush tropical vegetation. We will be working very closely with a reputable tour company who will be organising trips to Tulum, Chichen Itza, Coba and Xcaret to name a few, some of which may require a full day. Full day excursions will be arranged pre or post conference and may be on an individual or group booking so we would recommend booking extra nights to extend your stay as early as possible to avoid disappointment should these excursions be of interest to you and/or your party. For further information please contact us.

Venue Rating

Currency

US Dollar (USD)

Address

Fiesta Americana Condesa, Blvd.KukulkÃ¡n km 16.5 Zona Hotelera, Cancun, 77500 Mexico

Nearest Airport

Cancun International Airport

Location

Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.

Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

http://www.tropicalincentives.com/form_gpos/sales/cancun/2016/fusion-conference/

Transportation

Travel Details

Cancun International airport is just a short 15 minute journey from the Fiesta Americana Condesa and is easily accessible from almost every country in the world with many major international airlines providing direct or interconnecting flights on a daily basis.

Airport Transfers

Tropical Incentives are a reputable and trustworthy DMC based in Cancun. The Tropical Incentives team will be on hand to provide a seamless transfer service to and from Cancun International Airport. Tropical Incentives will manage and confirm all transportation bookings. To arrange transportation please contact Tropical Incentives directly via email, phone or the online booking facility (see link below).

Conference Shuttle Service

Tropical Incentives have arranged a conference shuttle service which will run at scheduled times surrounding the conference. The conference shuttle schedule can be found below.

Arrivals (Cancun Airport – Fiesta Americana Condesa)

Sunday 21^st February – Available at 1pm, 3pm, 5pm and 6:30pm
Monday 22^nd February – Available at 1pm, 3pm, 5pm and 6:30pm
Wednesday 24^th February – Available at 1pm, 3pm, 5pm and 6:30pm
Thursday 25^th February – Available at 1pm, 3pm, 5pm and 6:30pm
Saturday 27^th February – Available at 1pm, 3pm, 5pm and 6:30pm
Sunday 28^th February – Available at 1pm, 3pm, 5pm and 6:30pm
Tuesday 1^st March – Available at 1pm, 3pm, 5pm and 6:30pm
Wednesday 2^nd March – Available at 1pm, 3pm, 5pm and 6:30pm
Friday 4^th March – Available at 1pm, 3pm, 5pm and 6:30pm
Saturday 5^th March – Available at 1pm, 3pm, 5pm and 6:30pm

Departures (Fiesta Americana Condesa – Cancun Airport)

Thursday 25^th February – Available at 9am, 11am, 1pm and 3pm
Friday 26^th February – Available at 9am, 11am, 1pm and 3pm
Sunday 28^th February – Available at 9am, 11am, 1pm and 3pm
Monday 29^th February – Available at 9am, 11am, 1pm and 3pm
Wednesday 2^nd March – Available at 9am, 11am, 1pm and 3pm
Thursday 3^rd March – Available at 9am, 11am, 1pm and 3pm
Saturday 5^th March – Available at 9am, 11am, 1pm and 3pm
Sunday 6^th March – Available at 9am, 11am, 1pm and 3pm
Tuesday 8^th March – Available at 9am, 11am, 1pm and 3pm
Wednesday 9^th March – Available at 9am, 11am, 1pm and 3pm

$25 per person, each way (includes taxes)

Please allow at least 45minutes from your flight landing time to the shuttle departure time. In the event of any delays or cancellations, please ensure you contact Tropical Incentives at least 24hours in advance; if Tropical Incentives are not informed within 24hours full cancellation charges will apply.

Upon arrival at the airport, please exit the terminal building and look for ‘Fusion Conferences’ signage where a member of Tropical Incentives team will greet you and escort you to the group transportation.

Please contact Tropical Incentives directly to enquire or make a booking.

Group booking Code: Fusion
Contact: Francisco Mora
Telephone: 998-193-3940 ext 158
Email: guestservices@ticancun.com

Private Transportation

Tropical Incentives also offer a private transfer service for those travelling outside of the available shuttle dates/times mentioned above. The private transfer service vehicles can accommodate a maximum of 6 persons, plus luggage.

$75 per vehicle, each way (includes taxes)

In the event of any delays or cancellations, please ensure you contact Tropical Incentives at least 24hours in advance; if Tropical Incentives are not informed within 24hours full cancellation charges will apply.

Upon arrival at the airport, please exit the terminal building and look for ‘Fusion Conferences’ signage where a member of Tropical Incentives team will greet you and escort you to your transportation.

Please contact Tropical Incentives directly to enquire or make a booking.

Group booking Code: Fusion
Contact: Francisco Mora
Telephone: 998-193-3940 ext 158
Email: guestservices@ticancun.com

** Please note that Fusion Conferences is not responsible for any bookings made with Tropical Incentives as transportation is not included in the registration package **

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

http://www.tropicalincentives.com/form_gpos/sales/cancun/2016/fusion-conference/

Local Activities

Half Day Activities

Tropical Incentives are a reputable and reliable company offering a variety of fascinating trips and excursions for either a half or full day. To make an enquiry please contact Francisco Mora at Tropical Incentives or alternatively, if you would like to proceed with a booking (individual/group) please follow the link below which will take you directly to an online booking facility giving details of tours available.

Contact: Francisco Mora
Email: guestservices@ticancun.com

Our half day tours can be booked during the conference period between the available free times scheduled in the programme. The half day tours are available to both individual and group bookings.

The following activities are available at Aquaworld which is based in the Marina directly opposite the Fiesta Americana Condesa hotel and therefore no transportation is necessary.

Aquatwister

Experience Aquaworld’s ultimate tour adventure on board a high speed jet boat ride, Aquatwister. This is a roller coaster of manoeuvres orchestrated by a highly skilled captain and drivers on board and provides an amazing combination of nature, emotion, fun and adrenaline in one adventure.

Duration: 30 minutes
Please be at the marina 30 minutes in advance of activity.
Capacity: 20 persons per boat
Price: $69.60 per person
Dock fee: $8 (cash)
Gratuity: $5

Inclusive of:
Lockers, Life jackets and bottled water

Sky Ridder

Live this exciting experience flying in couples over the Caribbean Sea and experiencing an amazing aerial view.

Duration: 30-40 minutes includes 10 minute flying time at an altitude of 100mtrs
Please be at the Aquaworld hut (located by the hotel pool) 15 minutes in advance of activity.
Capacity: Maximum 8 person per boat
Price: $63.80 per couple
Gratuity: $5

Inclusive of:
10 minutes flying time, life jackets and bottled water

*Bathing suit, towel, shorts, T-shirts, sandals or wet shoes, sunglasses and water camera recommended.
*Service charge of $5 for any lost locker keys
*Biodegradable suntan lotion is only permitted on the reef

Jungle Tour

Enjoy this fascinating adventure, driving a Jet Ski boat for 2 persons through the mangroves of Nichupte Lagoon, explore the wonders of Cancun’s jungle and the exotic wild life and admire the colourful sea life while you snorkel at one of the greatest coral reefs in Punta Nizuc.

Duration: 2:30 hrs. (45 minutes each way driving and 40 minutes for snorkelling)
Please be at the marina 30 minutes in advance of activity.
Capacity: 2 persons per boat
Price: $69.60 (Single persons would pay full boat rate)
Dock Fee and Reef tax: $11 (cash)
Gratuity: $5

Inclusive of:
1x Guide per 10 persons
Aquaray speed boat for 2 persons
Snorkel Equipment (new snorkelling gear, life vest, mask, fins)
Jungle Tour
Dressing Room, Showers and Lockers
Bottled water
TI Staff present

*Bathing suit, towel, shorts, T-shirts, sandals or wet shoes, sunglasses and water camera recommended.
*Biodegradable suntan lotion is only permitted on the reef

Wave Runner

Drive and Speed on board of a 700 Yamaha wave runner across the Caribbean Sea.

Duration: 30 minutes
Please be at the Aquaworld hut (located by the hotel pool) 15 minutes in advance of activity.
Price: $63.80 (Single persons would pay full boat rate)
Gratuity: $5

Inclusive of:
1 Guide per 10 persons
Life jackets and lockers
Bottled water

*Bathing suit, towel, shorts, T-shirts, sandals or wet shoes, sunglasses and water camera recommended.
**Biodegradable suntan lotion is only permitted on the reef**

Sub See

An extraordinary way to admire the marine life and the reef’s ecosystem without getting wet! Be part of this unique adventure on board The Sub See Explorer, a glass bottom boat like a yellow submarine with huge glass panels on the sides, from where you will be able to watch the multi-coloured species of the Scorpion´s coral reef.

Duration: 2 hrs.
Please be at the marina 30 minutes in advance of activity
Capacity: Boat can hold 66 passengers
Price: $46.40 per person
Dock Fee and Reef tax: $10
Gratuity: $5

Inclusive of:
Boat transportation on board of Reef Express
Specialized Guides
Beverages (Beer, Soft Drinks and water)
Bottled Water
TI Staff present

*Bathing suit, towel, shorts, T-shirts, sandals or wet shoes, sunglasses and water camera recommended.
**Biodegradable suntan lotion is only permitted on the reef**

Full Day Activities

To make an enquiry or booking (individual/group), please contact Francisco Mora at Tropical Incentives.

Francisco Mora
Email: guestservices@ticancun.com

A Tropical Incentive representative will also be available during the conference period at the hotel, so should you have any questions about a booked tour you can always ask upon arrival or at any time during your stay.

Our full day tours are offered pre and post conference dates. If you require any additional nights at the Fiesta Americana Condesa due to a full day excursion, please ensure you book these in advance to avoid disappointment. The full days tours are available to both individual and group bookings.

Tulum And Playa Del Carmen Shopping Tour

Our journey begins in the magical ancient Tulum Archaeological Zone, discovered by John L. Stephens in 1842. Perched on top of a cliff facing the Caribbean Sea, it is the only entire walled in-group of Mayan Ruins ever discovered. Under the advice of an official English speaking tour guide, the group will go around the structures getting the history and spirit of the Mayans. Afterwards we head Playa del Carmen, an authentic Mexican town, popular because of its beautiful beaches with turquoise water colour and the famous 5^th Avenue where the participants will browse around the shops aside to explore. All kind of typical items, handcrafts, pottery, typical rugs most of them hand made by top artisans, fine boutiques selling everything imaginable. A unique experience! A group lunch can be arranged in one of the restaurants or it can be at leisure.

Ek Balam and Cenote

Visit the archaeological site of Ek-Balam. Ek Balam means Bright Star Jaguar in Maya language. This ancient Maya city had its glory before Chichen Itza. This archaeological site is one of the latest attractions because of its most recent restoration. Discover the mysterious Maya Cenote, enjoy its beautiful natural formations and great natural pool of 80m diameter. During the tour you will see different Maya communities. Take home your memories with the beautiful photographs taken by native photographers during the activities.

Sea Passion Catamaran

Isla Mujeres (Island of Women) is one of the Mexican Caribbean’s favourite destinations. Sail the beautiful turquoise bay from Cancun to Isla Mujeres aboard the Sea Passion I or Sea Passion III, a one-of-a-kind 75 & 60 foot maxi-catamarans, designed for passenger comfort. Enjoy a sail and snorkelling in the National Marine Park. Relax. In the full day activity the participants will have the opportunity to disembark in the Island. You can enjoy exquisite dining at the Beach Club “ElPescador” and the overwhelming views of the turquoise ocean decorated by coconut palm trees and hammocks.

Selvatica Extreme Canopy Tour

Located between Cancun and Playa del Carmen, only 35 minutes form Cancun’s International Airport. Over 250 acres of Tropical Jungle, in Selvatica you will be able to experience a unique adventure in the longest zip-line circuit in North America, recognized by Travel & Leisure magazine as one of the 35 great adventures in the World, divided in 12 zip lines varying in lengths and heights from 270 ft. to over 2,000 ft, it will make you fly over the jungle. Take a ride on a military vehicle through the jungle to get to the millenary natural cenote. With crystal and pristine waters you will be able to swim choosing between a water zip line or the diving platform. Live this unique and exciting adventure and feel the emotion and adrenaline running through your body.

Coba

Deep in the heart of the Quintana Roo jungle and only 24 miles from southwest of Tulum, approximately 2 1/2 south of Cancun is COBA, an archaeological site that dates from the Classis period. Unlike other Mayan sites in Quintana Roo, Coba was still occupied after the Spanish Conquest.
This incredible Site once occupied an area of almost 100 square kilometers (60 st. miles). The pyramid of Nohoch Mul-43 meters (130 ft.) high-is the tallest pre-Hispanic structure in the Yucatan peninsula. The main pyramids are the Coba Group, near the entrance, Las Pinturas (The Paintings), named because of the colour still visible on the arches; the Macanxoc, located next to Macanxoc Lake; and Chumuc Mul, the main stucco pyramid which still contains its original colour.
After a very cultural tour, be prepared to enjoy a delicious lunch in one of the magic restaurants of the area.

For further details on the above and other tours available please contact Tropical Incentives where Francisco Mora or an alternative representative will be happy to assist you.

Contact: Francisco Mora
Email: guestservices@ticancun.com

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

Group Activities

The group tour to Tulum has been jointly organised by Fusion and the conference chairs and we welcome everyone to participate. The group tour is optional so if you wish to join us, please RSVP to sarah@fusion-conferences.com in advance of the conference. This will help us to organise appropriate transportation.

Group Tour to Tulum – Sunday 16th Feb
Price: $52 per person
Gratuity: $5
Includes air conditioned vehicle, individual bags of dry snacks, soft drinks and bottled water, official tourism guide English/Spanish, admission fee in Tulum, round train transportation from Tulum to archaeological zone, TI Escorts and Tax.

Schedule: Depart from hotel around 8:30 am
Arrival in Tulum: 10:15
Depart from Tulum: 11:45
Arrival at Hotel: 13.30
*Comfortable clothing is recommended, lunch is not included and wine, coolers, juice, imported beer etc. available upon request.

The conference chairs would like to invite you to join them on a group tour to Tulum. The activity will take place Sunday 16th February, the day after the conference concludes. This is a great opportunity to socialise with fellow colleagues outside of the conference whilst taking in the beautiful natural sights of the Mayan ruins.

Tulum is located 78 miles south of Cancun, approximately 1:45 hour driving time; It was discovered by John L Stephens in 1842. Perched on top of a cliff facing the beautiful Caribbean Sea, it is the only entirely walled-in group of Mayan ruins ever discovered.

Under the advice of an official English speaking tour guide, the group will walk around the structures absorbing the history and spirit of the Mayan culture.

Please RSVP to sarah@fusion-conferences.com if you wish to join us on the tour to Tulum!

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

Childcare

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

Oral Presenters

A Fusion Conference offers all participants the opportunity to present their current research and findings in a number of different ways. Once registered for the conference you will be able to submit your abstract online and monitor the status through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Oral Presentations

We have a number of oral opportunities available at this meeting. To be considered for an oral presentation, please submit your abstract within the 'Talk Deadline'. Please check the conference programme carefully to note your presentation time (inclusive of Q&A) should you be accepted for an oral presentation.

We recommend you check our website regularly as the conference approaches as regular programme updates will be released under the ‘Programme’ tab on the conference page.

If you have prepared some slides to compliment your presentation please ensure you bring these with you on a USB or portable file saving device.

Those presenting on the first day, please email your slides to us so we can have everything prepared and ready for the first session. Please email your slides to:powerpoint@fusion-conferences.com

Flash Presentations

The Flash Session lasts up to 45minutes. This time is evenly divided between all the Flash Presentations that are accepted so your allocated time can range from 3-5 minutes, depending on popularity. The flash session is an extension of the Poster Session and is designed to offer a select few the opportunity to present orally their poster in a more formal, group setting. To be considered for a flash presentation, please submit your abstract within the 'Talk Deadline'. Abstracts submitted after the 'Talk Deadline' may not be accepted.

Please note, the exact length of your presentation will be noted on the conference programme under the ‘Flash Session’.

At the Conference

On the day of your presentation please make yourself known to the AV team who will be available in the conference room. They will ensure they have everything they need, including your presentation slides or aides. If you have any animations or videos we do advise to run through the presentation with the AV tech just to make sure everything is compatible. We also advise that all speakers make themselves known to the AV tech in the conference room immediately before your session beings. The AV tech will apply your microphone and provide a laser pointer should you have a complimenting presentation. Please note, speakers are not permitted to use their individual laptops, our AV tech will have a master laptop for you to run your presentation from. If you have any questions, please don’t hesitate to approach our AV tech or a member of the Fusion team. We are here to help!

We would like to ask all speakers to adhere to their time slots and respect their fellow presenters. A visual traffic light aide will be available to warn presenters as their time slot decreases.

Download Abstract Template

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

Posters

A Fusion Conference offers all participants the opportunity to present their current research and findings in a number of different ways. Once registered for the conference you will be able to submit your abstract online and monitor the status through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Poster Presentations

To be considered to present a poster, please submit your abstract within the ‘Poster Deadline’. Please check the conference programme carefully to note the poster session date and time. Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation only. Posters exceeding this size may not fit on the poster boards provided and therefore you will be unable to present your poster, so please kindly keep to these measurements. During registration at the conference, if you are presenting a poster please request a poster number from the registration desk. Please do not put up your poster without notifying a member of the Fusion team. Certain adhesive agents are not permitted at some venues therefore; Fusion will be the sole provider of all poster fixings.

POSTER PRIZES FOR STUDENTS AND POST DOCS

At the Conference

Upon arrival at the conference you can put up your poster from registration with the help of the Fusion team. Your poster can remain on display for the entire duration of the conference and we ask that you take down your poster on the final day of the meeting. The poster sessions is usually scheduled on Day 2, but please check the official programme for exact timings. Refreshments will be provided and awards will be given to the best poster displays.

Download Abstract Template

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs

Conference History

12 Feb 2014, 15 Feb 2014

Dynamic Structures in DNA Damage Responses and Cancer

Fiesta Americana Condesa, Cancun, Mexico

Key sessions will include: DNA and RNA complexes Chromatin Remodeling Post-translational modifications - Ub, SUMO kinases The repair interface with Replication Transcription, and Recomb...

22 Feb 2016, 25 Feb 2016

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

Fiesta Americana Condesa, Cancun, Mexico

This conference will focus on insights into dynamic DNA and RNA complexes involved in the damage response and cancer. It will emphasize informal as well as formal discussions together with informative talks and...

11 Feb 2018, 15 Feb 2018

3^rd DNA Replication/Repair Structures and Cancer Conference

Fiesta Americana Condesa, Cancun, Mexico

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a...

16 Feb 2020, 20 Feb 2020

4^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20

Melia Nassau Beach All Inclusive, Nassau, Bahamas

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate DNA repair in the context of oncogene-induced replication stress and elevated transcription. Intertwined roles of repair with replica...

27 Apr 2022, 01 May 2022

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

Fiesta Americana Condesa Cancun All Inclusive, Cancun, Mexico

Future master keys to cancer biology and advanced therapies are being forged from mechanistic understanding of the intertwined roles of DNA repair with DNA replication stress, transcription and immune responses. The remarkable stability of the hum...

14 Feb 2024, 18 Feb 2024

6^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC24

Fiesta Americana Condesa Cancun All Inclusive, Cancun, Mexico

Important fundamental breakthroughs in cancer biology have come from the basic research discovery that defects in the tumor suppressor and DNA repair genes BRCA1/2 genes predispose to breast, ovarian, prostate, and pancreatic cancers. Furthermore,...

Dynamic Structures in DNA Damage Responses and Cancer

12 Feb 2014 - 15 Feb 2014

Cancun, Mexico

Chairs