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- Dynamic Structures in DNA Damage Responses & Cancer
Dynamic Structures in DNA Damage Responses & Cancer
12 Feb - 15 Feb 2014
Cancun, Mexico
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Synopsis
Key sessions will include:
- DNA and RNA complexes
- Chromatin Remodeling
- Post-translational modifications - Ub, SUMO kinases
- The repair interface with Replication
- Transcription, and Recombination
- Hybrid methods for dynamic structures
- Damage signaling and processing
- DNA repair and disease
Confirmed Invited Speakers:
Dr. Stephen J. Smerdon
National Institute for Medical Research
Dr Jessica Anne Downs
University of Sussex
Prof. Dr. Caroline Kisker
Rudolf Virchow Center DFG Research Center for Experimental Biomedicine
Prof. Tom Ellenberger
Washington University
Prof. Dorothy Erie
University of North Carolina at Chapel Hill, NC
Prof. Lorena Beese
Duke University Medical Center
Dr. Christopher D. Lima
Memorial Sloan-Kettering Cancer Center
Professor Walter J. Chazin
Vanderbilt University
Dr. Mark Glover
University of Alberta
Confirmed Speakers
Chairs
Invited Speakers
Steve Smerdon
Programme Leader, The Francis Crick Institute, UK
Caroline Kisker
Professor, University of Wuerzburg
Jessica Downs
Professor, Genome Damage and Stability Centre
Curtis Hodge
Dr, University of Alberta
Dorothy Erie
Professor, University of North Carolina
Wei Yang
Section Chief, National Institutes of Health
Walter Chazin
Professor and Senior Associate Dean; Founding Director, Center for Structural Biology, Vanderbilt University
Dale Wigley
Professor, Imperial College London
Luca Pellegrini
Senior Lecturer, University of Cambridge
Scott Williams
Principal Investigator, NIH/NIEHS
Christopher Lima
Professor and Member, Sloan-Kettering Institute, HHMI
Dorothee Kern
Prof. of Biochemistry, HHMI Investigator, Brandeis University/HHMI
Karl-Peter Hopfner
Professor, Gene Center
Tom Ellenberger
Professor, Washington University School of Medicine
Lorena Beese
Professor, Duke University Medical Center
Programme
Wednesday 12th February 2014 |
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07:30 – 08:30 |
Registration & Reception |
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08:30 -08:45 |
Opening Comments |
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Session Title From DNA Complexes to Chromatin Session |
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08:45 – 09:15 |
Walter Chazin |
Dynamic hubs in multi-protein machinery |
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09:15 – 09:35 |
Gloria Borgstahl |
Hyper-phosphorylation in RPA:RAD52 complex function |
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09:35 – 09:55 |
Franz Klein |
Smc5/6-Mms21 in DHJ formation and resolution |
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09:55 – 10:25 |
Karl-Peter Hopfner |
Integrative methods for a mega-Dalton chromatin remodeler |
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10:25 – 10:45 |
Anna Chambers
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RSC2 BAH domain and SRC complex function
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10:45 – 11:15 |
Refreshments |
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11:15 – 11:45 |
Jessica Downs |
PBAF remodeling complex & transcription repression |
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11:45 – 12:05 |
Evi Soutoglou |
Compartmentalization of repair at nuclear lamina & pores |
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12:05 – 12:25 |
Li Lan |
Recruitment of repair proteins to heterochromatin and euchromatin |
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12:25 – 12:45 |
Terence Strick |
Single Molecule DNA repair pathway reconstruction |
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12:45 – 12:55 |
Discussion |
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12:55 – 16:25 |
Welcome Lunch and Free Time |
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Session Title Hybird Methods for Dynamic Structures |
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16:25 – 16:30 |
Tom Blundell |
Announcements |
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16:30 – 17:00 |
Dorothee Kern |
Using ancient kinases to unravel cancer drug mechanism |
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17:00 – 17:20 |
Ivaylo Ivanov |
Integrative modeling of complex nucleic acid assemblies |
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17:20 – 17:40 |
Susan Tsutakawa |
PCNA with SUMO and Ub by combined methods |
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17:40 – 18:10 |
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Refreshments |
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18:10 – 18:30 |
Qian Wu |
Abraxas phosphorylation and BRCA1 dimerization |
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18:30 – 18:50 |
Susan Lees-Miller |
New roles of DNA-PK in mitosis |
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18:50 – 19:10
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Greg Hura
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Comprehensive DNA conformations in mismatch repair
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19:10 – 19:30 |
Angela Eggleston |
Nature and DNA repair structural biology |
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19:30 – 19:40 |
Discussion |
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19:40 – 00:00 |
Dinner at Leisure and Free Time |
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Thursday 13th February 2014 |
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Session Title Mismatch Responses and DNA Replication |
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08:15 – 08:20 08:20 – 08:50 |
John Tainer Lorena Beese |
Announcements Mismatch and fidelity |
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08:50 - 09:10 |
Jean-Baptist Charbonnier |
MutL homologs and cancer |
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09:10 – 09:30 09:30 – 10:00 10:00 – 10:20 10:20 – 10:45 10:45 – 11:15 |
Alba Guarne Dorothy Erie Cynthia McMurray
Luca Pellegrini |
Transient MMR interactions MMR initiation by single-molecule methods MSH2-MSH3 plus OGG1 in trinucleotide expansion Refreshments Helicase-polymerase coupling in the eukaryotic replisome |
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11:15 – 11:35 |
Brandt Eichman |
DNA junction recognition |
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11:35 – 11:55 |
Samir Hamdan |
Dynamics of 5’ nucleases by single molecule imaging |
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11:55 – 12:15 |
Piero Bianco |
SSB interactome partners and targeting repair |
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12:15 – 12:35 |
Murray Junop |
Single-stranded annealing shown by DNA complex structure |
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12:35 – 12:45 |
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Discussion |
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12:45 – 16:15 |
Lunch at Leisure and Free Time |
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Session Title From Structure and Chemistry to Cancer Session |
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16:15 – 16:20 16:20 – 16:50 |
Tom Blundell Wei Yang |
Announcements Human polymerase to cancer biology |
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16:50 – 17:10 |
Sylvie Doublie |
NEIL glycosylases, repair polymorphisms and cancer |
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17:10 – 17:30 |
Arne Klungland |
Dynamics and disease role of 6-methhyladenine in mRNA |
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17:30 – 17:50 |
Herwig Schuler |
PARP inhibitors : structures, selectivity and pharmacology |
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17:50 – 18:10 |
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Refreshments |
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18:10 – 18:25 18:25 – 18:40 18:40 – 19:00 19:00 – 19:30 |
Luxin Sun Eva Barkauskaite Hideki Aihara Tom Ellenberger |
BRCA1 BRCT inhibitors for cancer therapy Poly(ADP-ribose) glycohydrolase structure and activity Novel TDP2 interaction with ubiquitin by NMR Targeting poly-(ADP-ribose) Glycohydrolase for Apoptosis |
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19:30 – 19:40 19:40 – 21:00 21:00 – 00:00 |
Discussion Cocktails and General Discussion |
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Friday 14th February 2014 |
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Session Title Dynamic machines & signaling |
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08:15 – 08:20 08:20 – 08:50 |
John Tainer Christopher Lima |
Announcements RNA processing by the Eukaryotic RNA exosome |
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08:50 – 09:10 |
Mihaly Kovacs |
Switching DNA-bound RecQ Helicase for repair |
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09:10 – 09:30 |
Opher Gileadi |
Crystal structure of human Bloom helicase |
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09:30 – 09:50 |
Shunichi Takeda |
CtlP and Dna2 nucleases form 3’ ends for recombination |
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09:50 – 10:10 |
Penny Jeggo |
Regulating DSB repair pathway choice |
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10:10 – 10:35 |
Refreshments |
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10:35 – 10:55 |
Anthony Davis |
DNA-PK and DSBR |
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10:55 – 11:15 |
Valerie Garcia |
Tel1(ATM) suppresses meiotic DSB formation in chromatin |
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11:15 – 11:35 |
David O Ferguson |
Control of ATM and CDK2/cyclin A kinases by MRN complex |
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11:35 – 11:55 11:55 – 12:25 |
Takashi Ochi Tom Blundell |
PAXX Paralog of XRCC4 and XLF Spatial-Temporal Organisation of DSBR & cancer |
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12:25 – 12:35 |
Discussion |
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12:35 – 16:15 |
Lunch at Leisure and Free Time |
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Session Title Junctions and switches |
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16:15 – 16:20 16:20 – 16:50 |
Tom Blundell R. Scott Williams |
Announcements Aprataxin resolves adenylated RNA-DNA junctions |
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16:50 – 17:10 |
Bjorn Dalhus |
EndoV eukaryotic structure & DNA/RNA specificity |
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17:10 – 17:40 |
Mark Glover |
Flipping the switch on Ubc13 in the DNA damage response |
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17:40 – 18:00 |
Jeff Perry |
RNF4 repair functions and telomeres |
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18:00 – 18:25 |
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Refreshments |
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18:25 – 18:55 18:55 – 19:15 19:15 – 19:35 |
Steve Smerdon Dong Wang |
Nbs1 structures, functions and break signaling Rad4TopBP1 & DNA Damage Checkpoint Apparatus Transcriptional fidelity control and lesion recognition |
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19:35 – 19:45 |
Discussion |
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21:00 – 00:00 |
*Gala Night & Group Photo* Free Time |
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Saturday 15th February 2014 |
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Session Title Bulky lesions, signaling and conformations in damage responses |
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08:15 – 08:20 |
Tom Blundell |
Announcements |
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08:20 – 08:50 |
Caroline Kisker |
Two faces of XPD by single molecule analyses |
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08:50 – 09:10 |
Li Fan |
XPD and XP helicases |
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09:10 – 09:30 09:30 – 10:00 10:00 – 10:20 |
Jill Fuss Dale Wigley Joanne I. Yeh |
DNA-mediated redox signaling & charge transfer by XPD FeS enzyme AddAB CHI recognition & mechanism UV-DDB binding to Damaged DNA induces oligomerization |
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10:20 – 10:45 |
Refreshments |
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10:45 – 11:05 |
Fernando Gomez-Herreros |
TDP2 Protects Transcription |
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11:05 – 11:25 |
Xiaochun Yu |
Novel functions of ribosylation & PAR-binding domains |
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11:25 – 11:45 |
Kristina Lakomek |
Heteromeric Rvb1-Rvb2 complex for molecular machines |
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11:45 – 12:15 |
John Tainer |
Conformations controlling repair responses |
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12:15 – 12:25 |
Discussion |
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12:25 – 12:40 |
Closing remarks & Farewell: John Tainer and Tom Blundell |
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Venue & Location
Fiesta Americana Condesa
This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
Hotel Facilities
- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
The Fiesta Americana Condesa, Cancun is the 2015 Winner of the Trip Advisor Certificate of Excellence and also received the Travellers Choice Award in 2014.
The remains of ancient Mayan cities are scattered throughout the Yucatan Peninsula and no trip to Cancun would be complete without a visit to these majestic temples and pyramids set amongst lush tropical vegetation. We will be working very closely with a reputable tour company who will be organising trips to Tulum, Chichen Itza, Coba and Xcaret to name a few, some of which may require a full day. Full day excursions will be arranged pre or post conference and may be on an individual or group booking so we would recommend booking extra nights to extend your stay as early as possible to avoid disappointment should these excursions be of interest to you and/or your party. For further information please contact us.
General Information
Venue Rating
★ ★ ★ ★ ★
Currency
US Dollar (USD)
Address
Fiesta Americana Condesa, Blvd.Kukulkán km 16.5 Zona Hotelera, Cancun, 77500 Mexico
Nearest Airport
Cancun International Airport
Location
Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.
Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.
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Conference Manager
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