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- 2nd Dynamic DNA & RNA Structures in Damage Responses & Cancer Conference
2nd Dynamic DNA & RNA Structures in Damage Responses & Cancer Conference
22 Feb - 25 Feb 2016
Cancun, Mexico
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Report
The 2016 conference focused on insights into dynamic DNA and RNA complexes acting in DNA damage response and cancer and comprising targets for advanced cancer interventions and for understanding and preventing carcinogenesis. Returning conference chairs, Sir Tom Blundell (FRS, FMedSci, Department of Biochemistry, University of Cambridge, UK) and Dr. John Tainer (Director (SIBYLS Advanced Light Source, Professor, MD Anderson Cancer Center, Houston, Texas, USA) brought together under one roof many of the people driving advances in defining the relevant structural biology and mechanisms, in order to enable uniquely productive and informative interactions for those working on DNA damage responses and cancer. The meeting emphasized informal as well as formal discussions in concert with informative talks and poster sessions.
The talks concerned the frontiers of structural biology for DNA and RNA damage responses and cancer. Highlights on damage responses included cutting-edge structural and single-molecule approaches to characterize damage recognition, ribonucleotide repair, non-coding RNAs, the connection of inflammation with DNA damage, and epigenetics in the repair responses. Discussion was vigorous and informative but the chairs kept the meeting on time to preserve time for informal discussions and subgroup meetings on collaborations. The conference venue had breath-taking views of the Caribbean Sea and white sandy beaches that facilitated informal as well as formal interactions and conversations. One thing that differentiates this conference from others is the combination of top researchers with younger investigators and the very effective interactions among them.
The Poster Session was extremely successful and generated many interactive discussions. We were delighted to award five prizes to the following winners;
1st Place - Ms. Julia Reinert
2nd Place - Ms. Somaira Nowsheen
3rd Place - Ms. Elizabeth O'Brien
4th Place - Mr. Shun-Hsiao Lee
5th Place - Mr. Cory Rice
The Closing Comments by Walter Chazin and Tom Blundell generated a vibrant discussion linking DNA repair enzymes to changes in expression and even animal behavior. There was the feeling that there is an increasing need to form partnerships between creative talent in the academic sector with innovation and technical advances being championed by industry. Overall, several insights were discussed. During the conference collaborations were established, which may well lead to some of the next breakthrough results.
The meeting was expertly organized and supported by Fusion Conferences, Ltd. We thank Laura Trundle and her team for their helpful interactions with the organisers and participants.
Synopsis
This conference will focus on insights into dynamic DNA and RNA complexes involved in the damage response and cancer. It will emphasize informal as well as formal discussions together with informative talks and poster sessions. DNA repair is a target for advanced cancer interventions. DNA repair systems are also essential for preventing carcinogenesis. The 2016 conference will focus on dynamic complexes and the control of biological outcomes relevant to cancer biology and the development of new therapeutic targets and strategies. Talks will include highlights on damage responses including cutting-edge structural and single-molecule approaches to characterize damage recognition, ribonucleotide repair, non-coding RNAs, the inflammation – damage connection, and epigenetics in the repair responses.
Key Sessions
Key sessions will include emerging results and breakthrough methods concerning:
- DNA and RNA complexes
- Chromatin Remodeling
- Post-translational modifications
- Interface of repair with Replication, Transcription and Recombination
- RNA responses to damage
- Pathway selection & cross-talk
- Damage signaling and processing
- DNA repair and disease
Confirmed Speakers
Walter Chazin (Vanderbilt)
'WHAT ARE THOSE Fe-S CLUSTERS DOING?'
Wei Yang (NIH)
'ENZYME CATALYSIS BY A HIT-AND-RUN METAL ION'
Lorena S. Beese (Duke University Medical Center)
Susan Lees-miller (University of Calgary)
'APLF IS INTRINSICALLY FLEXIBLE AND STABILIZES AN EXTENDED FUNCTIONAL CORE COMPLEX FOR EFFICIENT NON-HOMOLOGOUS END JOINING'
Magnar Bjorås (Oslo University Hospital)
'MODULATING BEHAVIOR BY OXIDATIVE DNA BASE LESION REPAIR'
Tom Ellenberger (Washington University in St. Louis)
'TARGETING POLY(ADP-RIBOSE) TURNOVER FOR CANCER THERAPY'
Sheila David (UC Davis)
'MUTYH, CHEMISTRY AND CANCER: IT’S ALL ABOUT THE BASE'
Bennett Van Houten (University of Pittsburgh and Carnegie Mellon University)
'SINGLE MOLECULE ANALYSIS OF DNA REPAIR ENZYMES REVEALS A NOVEL “RECOGNITION AT DISTANCE” MECHANISM'
Stephen West (The Francis Crick Institute)
'ACTIVATION OF MUS81 STRUCTURE-SELECTIVE ENDONUCLEASE BY FORMATION OF THE SMX COMPLEX'
Dorothy Erie (University of North Carolina)
'CHARACTERIZATOIN OF THE ASSEMBLY OF MUTS AND MUTL HOMOLOGS AT A MISMATCH'
Titia de Lange (The Rockefeller University)
'CHROMOTHRIPSIS FROM TELOMERE FUSIONS'
Karl-Peter Hopfner (Ludwig-Maximilians-University Munich)
'STRUCTURAL MECHANISM OF ATP-DEPENDENT DNA BINDING AND DNA END JOINING BY EUKARYOTIC Rad50'
Jessica Downs (University of Sussex)
'PROTECTIVE PACKAGING FOR DNA: THE ROLE OF THE PBAF AND INO80 CHROMATIN REMODELLING COMPLEXES IN MAINTAINING GENOME STABILITY'
Jean-Baptiste Charbonnier (Institute of Integrated Biology of the Cell)
'PIVOTAL ROLES OF MUTL HOMOLOGS IN DNA REPAIR AND RECOMBINATION'
Dale Wigley (Imperial College London)
'STRUCTURE AND MECHANISM OF ADDAB AND RECBCD COMPLEXES'
Titia Sixma (Netherlands Cancer Institute)
'SNAPSHOTS OF DNA MISMATCH REPAIR: TRAPPING TRANSIENT STATES'
Samir Hamdan (King Abdullah University of Science and Technology)
'PROBABILISTIC ACTIVE SITE ASSEMBLY CONTROLS CATALYTIC SELECTIVITY IN HUMAN FLAP ENDONUCLEASE-1'
Takashi Ochi (University of Cambridge)
'SCAFFOLDS WITH STRINGS ATTACHED OF MULTI-PROTEIN ASSEMBLIES IN NON-HOMOLOGOUS END JOINING'
Steve Smerdon (Medical Research Council)
'THE MOLECULAR BASIS OF Nbs1-Mdc1 INTERACTIONS – NEW TRICKS FOR OLD DOGS!'
Terence Strick (University of Paris – Diderot)
'CORRELATIVE SINGLE-MOLECULE ANALYSIS OF DYNAMIC COMPLEXES IN DNA REPAIR'
Mark Glover (University of Alberta)
'MECHANISM OF RNF8 STIMULATION OF Ubc13 AND ROLE IN DNA DAMAGE SIGNALING'
Ilya Finkelstein (UT-Austin)
'SINGLE-MOLECULE VIEWS OF EUKARYOTIC DNA MISMATCH REPAIR'
Aidan Doherty (University of Sussex)
'UNRAVELING THE ROLES OF PRIMASE-POLYMERASES IN DNA REPLICATION AND REPAIR'
Confirmed Speakers
Chairs
Invited Speakers
Wei Yang
Section Chief, National Institutes of Health
Walter Chazin
Professor and Senior Associate Dean; Founding Director, Center for Structural Biology, Vanderbilt University
Sheila David
Professor of Chemistry, University of California, Davis
Ben Van Houten
Richard M. Cyert Professor of Molecular Oncology, UPMC Hillman Cancer Center
Jessica Downs
Professor, Genome Damage and Stability Centre
Magnar Bjørås
Professor, Oslo University Hospital
Susan Lees-Miller
Professor, University of Calgary
Jean-Baptiste Charbonnier
Team Leader, CEA-CNRS-Univ Paris Saclay, France
Dorothy Erie
Professor, University of North Carolina
Tom Ellenberger
Professor, Washington University School of Medicine
Titia Sixma
Group leader, Netherlands Cancer Institute
Samir Hamdan
Assistant Professor of Bioscience, King Abdullah University of Science and Technology
Steve Smerdon
Programme Leader, The Francis Crick Institute, UK
Steve West
Principal Group Leader, Francis Crick Institute
Titia de Lange
Leon Hess Professor, The Rockefeller University
Karl-Peter Hopfner
Professor, Gene Center
Mark Glover
Professor, University of Alberta
Terence Strick
Research Director, Ecole normale supérieure/CNRS
Dale Wigley
Professor, Imperial College London
Takashi Ochi
Research Associate, University of Cambridge
Aidan Doherty
Professor of Biochemistry, University of Sussex
Lorena Beese
Professor, Duke University Medical Center
Ilya Finkelstein
Associate Professor, UT-Austin
Programme
DISCUSSION IS VALUED: 5 MINUTES IS SAVED FOR DISCUSSION AFTER EACH TALK
Monday 22nd February 2016 |
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14:00 – 14:45 |
Registration |
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14:00 – 14:45 |
Group Welcome Lunch |
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HOMOLOGOUS RECOMBINATION INTERACTIONS |
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14:45 – 15:00 |
Welcome and Opening Remarks by Tom Blundell & John Tainer |
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15:00 – 15:20 |
Stephen West |
ACTIVATION OF MUS81 STRUCTURE-SELECTIVE ENDONUCLEASE BY FORMATION OF THE SMX COMPLEX |
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15:25 – 15:45 |
Priscilla K Cooper |
XPG PARTNERS WITH BRCA1 AND BRCA2 IN HOMOLOGOUS RECOMBINATION TO MAINTAIN GENOME STABILITY |
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15:50 – 16:00 |
Kara Bernstein |
THE CONCERTED FUNCTION OF THE SHU COMPLEX AND THE RAD51 PARALOGS IN RAD51 PRESYNAPTIC ASSEMBLY |
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16:05 – 16:15 |
Christian Biertuempfel |
HUMAN HOLLIDAY JUNCTION RESOLVASE GEN1 USES A CHROMODOMAIN FOR EFFICIENT DNA RECOGNITION AND CLEAVAGE |
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16:20 – 16:40 |
Dale Wigley |
STRUCTURE AND MECHANISM OF ADDAB AND RECBCD COMPLEXES |
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16:45 – 17:15 |
Refreshments and Poster Set Up |
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17:15 – 17:35 |
Karl-Peter Hopfner |
STRUCTURAL MECHANISM OF ATP-DEPENDENT DNA BINDING AND DNA END JOINING BY EUKARYOTIC Rad50 |
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17:40 – 18:00 |
Steve Smerdon |
THE MOLECULAR BASIS OF Nbs1-Mdc1 INTERACTIONS – NEW TRICKS FOR OLD DOGS! |
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18:05 – 18:15 |
Yaron Galanty |
SYSTEMATIC E2 SCREENING REVEALS A UBE2D-RNF138-CtIP AXIS PROMOTING DNA REPAIR |
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18:20 – 18:30 |
Aaron Alt |
STRUCTURE AND FUNCTION OF THE CHROMATIN TARGETING DOMAIN OF ONCOGENE CHD5 |
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18:35 – 18:45 |
Christos Coucoravas |
ROLE OF SPECIFIC NON-CODING RNAS IN DNA DOUBLE-STRAND BREAK REPAIR |
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18:50 – 19:00 |
General Discussion |
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19:00 – 19:45 |
Poster Highlights |
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19:45 |
Dinner at Leisure |
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Tuesday 23rd February 2016 |
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07:00 – 08:30 |
Breakfast |
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BREAK REPAIR |
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08:30 – 08:40 |
Tom Blundell |
Opening Comments |
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08:40 – 09:00 |
Susan Lees-Miller |
APLF IS INTRINSICALLY FLEXIBLE AND STABILIZES AN EXTENDED FUNCTIONAL CORE COMPLEX FOR EFFICIENT NON-HOMOLOGOUS END JOINING |
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09:05 – 09:15 |
Anthony Davis |
PHOSPHORYLATION OF Ku70 (OR SIMPLY Ku) DICTATES DNA DOUBLE-STRAND BREAK REPAIR PATHWAY CHOICE IN S PHASE |
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09:20 – 09:40 |
Takashi Ochi |
SCAFFOLDS WITH STRINGS ATTACHED OF MULTI-PROTEIN ASSEMBLIES IN NON-HOMOLOGOUS END JOINING |
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09:45 – 10:05 |
Tom Blundell |
NON-HOMOLOGOUS END JOINING IN SPACE AND TIME: SCAFFOLDS, STRINGS AND STAGES |
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10:10 – 10:30 |
Jean-Baptiste Charbonnier |
PIVOTAL ROLES OF MUTL HOMOLOGS IN DNA REPAIR AND RECOMBINATION |
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10:35 – 11:05 |
Refreshments and Informal Poster Viewing |
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11:05 – 11:25 |
Aidan Doherty |
UNRAVELING THE ROLES OF PRIMASE-POLYMERASES IN DNA REPLICATION AND REPAIR |
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11:30 – 11:40 |
Marcus Wilson |
STRUCTURAL BASIS FOR 53BP1 RECRUITMENT TO DNA DOUBLE-STRAND BREAKS |
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11:45 – 11:55 |
Alba Guarne |
A NOVEL NON-CANONICAL FHA DOMAIN-BINDING INTERFACE MEDIATES THE INTERACTION BETWEEN RAD53 AND DBF4 PROTEINS |
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12:00 – 12:10 |
Luxin Sun |
STRUCTURAL INSIGHT INTO BLM RECOGNITION BY TOPBP1 IN MAINTENANCE OF GENOME STABILITY |
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12:15 – 12:35 |
Mark Glover |
MECHANISM OF RNF8 STIMULATION OF Ubc13 AND ROLE IN DNA DAMAGE SIGNALING |
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12:40 – 12:50 |
General Discussion |
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12:50 – 16:00 |
Lunch at Leisure & Free Time |
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THE DAMAGE RESPONSE: TRANSCRIPTION, REPLICATION, AND CHROMOSOME DYNAMICS |
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16:00 – 16:10 |
Priscilla K Cooper |
Opening Comments |
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16:10 – 16:30 |
Yuan He |
STRUCTURAL BASIS OF EUKARYOTIC TRANSCRIPTION PROMOTER OPENING AT NEAR-ATOMIC RESOLUTION |
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16:35 – 16:45 |
Ivaylo Ivanov |
INTEGRATIVE MODELING OF MACROMOLECULAR ASSEMBLIES FROM LOW TO NEAR-ATOMIC RESOLUTION |
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16:50 – 17:00 |
Sylvie Doublié |
WHEN THE (3') END JUSTIFIES THE MEANS OR HOW A FAMILY A POLYMERASE SOLVES A MAJOR CHALLENGE |
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17:05 – 17:25 |
Jessica Downs |
PROTECTIVE PACKAGING FOR DNA: THE ROLE OF THE PBAF AND INO80 CHROMATIN REMODELLING COMPLEXES IN MAINTAINING GENOME STABILITY |
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17:30 – 18:10 |
Refreshments and Informal Poster Viewing |
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18:10 – 18:20 |
Julia Reinert |
THE N-TERMINAL DOMAIN ENCIRCLES DNA TO ANCHOR YEAST RIF1 TO TELOMERIC AND NON-TELOMERIC DNA ENDS |
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18:25 – 18:45 |
Titia de Lange |
CHROMOTHRIPSIS FROM TELOMERE FUSIONS |
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18:50 – 19:00 |
General Discussion |
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19:00 – 20:30 |
Poster Session, Cocktails & Refreshments |
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20:30 |
Dinner at Leisure |
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Wednesday 24th February 2016 |
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07:00 – 08:30 |
Breakfast |
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CATALYSIS AND DYNAMICS |
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08:30 – 08:40 |
Jane Grasby |
Opening Comments |
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08:40 – 09:00 |
Wei Yang |
ENZYME CATALYSIS BY A HIT-AND-RUN METAL ION |
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09:05 – 09:15 |
Piero Bianco |
THE ROLES OF SSB AND RecG IN STALLED DNA REPLICATION FORK RESCUE IN E.COLI |
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09:20 – 09:40 |
Walter Chazin |
WHAT ARE THOSE Fe-S CLUSTERS DOING? |
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09:45 – 09:55 |
Elizabeth O'Brien |
A REDOX DNA-BINDING SWITCH IN THE [4FE4S] DOMAIN OF HUMAN DNA PRIMASE REGULATES ACTIVITY |
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10:00 – 10:10 |
David Rueda |
ACTIVATION-INDUCED DEOXYCYTIDINE DEAMINASE (AID) CO-TRANSCRIPTIONAL SCANNING AT SINGLE-MOLECULE RESOLUTION |
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10:15 – 10:45 |
Refreshments and Informal Poster Viewing |
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10:45 – 11:05 |
Terence Strick |
CORRELATIVE SINGLE-MOLECULE ANALYSIS OF DYNAMIC COMPLEXES IN DNA REPAIR
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11:10 – 11:30 |
Bennett Van Houten |
SINGLE MOLECULE ANALYSIS OF DNA REPAIR ENZYMES REVEALS A NOVEL “RECOGNITION AT DISTANCE” MECHANISM |
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11:35 – 11:45 |
Emily Beckwitt |
SINGLE MOLECULE STUDIES OF XPA ON DNA |
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11:50 – 12:10 |
Samir Hamdan |
PROBABILISTIC ACTIVE SITE ASSEMBLY CONTROLS CATALYTIC SELECTIVITY IN HUMAN FLAP ENDONUCLEASE-1 |
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12:15 – 12:25 |
General Discussion |
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12:25 – 16:00 |
Lunch at Leisure & Free Time |
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MISMATCH AND EXCISION REPAIR |
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16:00 – 16:10 |
Sylvie Doublié |
Opening Comments |
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16:10 – 16:30 |
Dorothy Erie |
CHARACTERIZATOIN OF THE ASSEMBLY OF MUTS AND MUTL HOMOLOGS AT A MISMATCH |
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16:35 – 16:55 |
Titia Sixma |
SNAPSHOTS OF DNA MISMATCH REPAIR: TRAPPING TRANSIENT STATES |
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17:00 – 17:20 |
Lorena Beese |
MMR AND EXOI FUNCTIONAL CONFORMATIONS |
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17:25 – 17:35 |
Susan Tsutakawa |
MEASURE THRICE-CUT ONCE IN STRUCTURE SPECIFIC FLAP ENDONUCLEASE |
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17:40 – 18:10 |
Refreshments and Informal Poster Viewing |
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18:10 – 18:30 |
Ilya Finkelstein |
SINGLE-MOLECULE VIEWS OF EUKARYOTIC DNA MISMATCH REPAIR
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18:35 – 18:45 |
Brandt Eichman |
GLYCOSYLASE RECOGNITION OF DNA DAMAGE WITHOUT BASE FLIPPING ENABLES BASE EXCISION REPAIR OF BULKY LESIONS |
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18:50 – 19:00 |
Luay Joudeh |
DISSECTING THE STIMULATION OF FEN1 ACTIVITY BY PCNA ON FLAP SUBSTRATES AT THE SINGLE MOLECULE LEVEL |
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19:05 – 19:15 |
Jane Grasby |
CELLULAR ACTIVE N-HYDROXYUREA INHIBITORS OF HUMAN FLAP ENDONUCLEASE 1 |
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19:20 – 19:30 |
General Discussion |
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20:00 |
Gala Dinner, Group Photo & Poster Awards |
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Thursday 25th February 2016 |
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07:00 – 08:50 |
Breakfast |
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DNA DAMAGE, FUNCTIONAL FLEXIBILITY AND DISEASE |
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08:50 – 09:00 |
Walter Chazin |
Opening Comments |
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09:00 – 09:20 |
Tom Ellenberger |
TARGETING POLY(ADP-RIBOSE) TURNOVER FOR CANCER THERAPY |
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09:25 – 09:35 |
France Carrier |
THE HETEROGENOUS RIBONUCLEOPROTEIN A18 (hnRNP A18) PROMOTES TUMOR GROWTH BY INCREASING PROTEIN TRANSLATION OF SELECTED TRANSCRIPTS IN CANCER CELLS IN RESPONSE TO CELLULAR STRESS |
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09:40 – 09:50 |
Qian Wu |
STRUCTURE OF BRCA1-BRCT/ABRAXAS COMPLEX REVEALS PHOSPHORYLATION-DEPENDENT BRCT DIMERIZATION AT DNA DAMAGE SITES |
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09:55 – 10:15 |
Sheila David |
MUTYH, CHEMISTRY AND CANCER: IT’S ALL ABOUT THE BASE |
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10:20 – 10:50 |
Refreshments |
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10:50 – 11:00 |
Wilson Chun Yu Lau |
MOLECULAR ARCHITECTURE OF THE Ub-PCNA/Pol η COMPLEX BOUND TO DNA |
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11:05 – 11:25 |
Magnar Bjørås |
MODULATING BEHAVIOR BY OXIDATIVE DNA BASE LESION REPAIR |
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11:30 – 11:50 |
John Tainer |
THE RISE OF THE MACHINES |
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11:55 – 12:05 |
General Discussion |
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12:05 – 12:15 |
Closing Comments by Walter Chazin and Tom Blundell |
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Friday 26th February 2016 |
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08:15 – 17:30 |
Chichen-Itzá Group Tour |
Supported by
Venue & Location
Fiesta Americana Condesa
This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
Hotel Facilities
- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
The Fiesta Americana Condesa, Cancun is the 2015 Winner of the Trip Advisor Certificate of Excellence and also received the Travellers Choice Award in 2014.
The remains of ancient Mayan cities are scattered throughout the Yucatan Peninsula and no trip to Cancun would be complete without a visit to these majestic temples and pyramids set amongst lush tropical vegetation. We will be working very closely with a reputable tour company who will be organising trips to Tulum, Chichen Itza, Coba and Xcaret to name a few, some of which may require a full day. Full day excursions will be arranged pre or post conference and may be on an individual or group booking so we would recommend booking extra nights to extend your stay as early as possible to avoid disappointment should these excursions be of interest to you and/or your party. For further information please contact us.
General Information
Venue Rating
★ ★ ★ ★ ★
Currency
US Dollar (USD)
Address
Fiesta Americana Condesa, Blvd.Kukulkán km 16.5 Zona Hotelera, Cancun, 77500 Mexico
Nearest Airport
Cancun International Airport
Location
Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.
Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.
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Conference Manager
Sarah Trundle
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