3 rd DNA Replication/Repair Structures and Cancer&nbsp;Conference

Report

The 3rd DNA Replication/Repair Structures and Cancer Conference, which took place in Cancun, Mexico from 11-15 February 2018, centered on developing an actionable mechanistic knowledge of DNA replication and repair responses to stress for advanced cancer intervention strategies. Returning conference chairs, Sir Tom Blundell (FRS, FMedSci, Department of Biochemistry, University of Cambridge, UK) and Dr. John Tainer (Director SIBYLS Advanced Light Source, Professor and Director of Structural Biology, MD Anderson Cancer Center, Houston, Texas, USA) brought to Cancun many of the people driving advances in relevant structural biology and mechanisms, enabling uniquely productive and informative interactions for those working on DNA replication, damage responses and cancer. There was a total of 157 attendees who travelled worldwide to join us; Australia, USA, UK, The Netherlands, Japan, France, Saudi Arabia, China, South Korea, Germany, Italy, Poland, Canada, Sweden and Austria are just a few of the countries that were represented. Talks and poster sessions focused on cutting-edge structural and single-molecule approaches and novel mechanistic insights.

The remarkable stability of the human genome is lost in cancer cells due to the loss of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a surprisingly fragile and complex process requiring fork protection and restart, R-loop resolution, and repair. Unresolved replication and repair intermediates signal apoptosis. The synthetic lethality and essentiality resulting from replication-repair stresses thus suggest repair inhibitors as tools to control pathway selection and damage outcomes and to design advanced therapeutics.

The 2018 meeting focused on structural and mechanistic insights into dynamic protein, DNA and RNA complexes acting in DNA replication and repair events relevant to cancer. The large diverse audience including many internationally distinguished speakers and the lively debates emphasised the importance of the theme. Comments from participants of all career stages emphasised their wish to see the series continue in this format and location.

“You and Tom did a really wonderful job putting together the conference with Laura and her colleagues. The science, discussions and location were all spot-on! I very much enjoyed participating in your conference and hope that I will have the opportunity to doing so again should you organise further events of this type.” Prof. Stephen Jackson (Wellcome Trust/Cancer Research UK Gurdon Institute)

The first day begun with a lively discussion of DNA Replication Machinery chaired by John Tainer and focused on structural features of high fidelity DNA replication and its enforcement. This was presented by an impressive line-up of international speakers. On this first day we had two breaks in the lecture schedule for sessions, expertly chaired by Susan Tsutakawa and Chris Brosey, of Meet the Poster Presenters, where all gave concise introductions and invitations to their poster. The evening concluded with an exciting plenary overview by Bruce Stillman from Cold Spring Harbor Laboratory on the structure, function and human genetics of the origin recognition complex and chromosome duplication.

The second day theme was replication fork stability, including mechanisms for maintaining genome stability at forks and for remodeling stalled replication forks. The following session focused further on sensing & signaling cellular genome instability. Mechanistic aspects were informed by amazing structural insights arising from state of the art techniques, for example of the structures of poly(ADP-ribose) polymerase enzymes. This session culminated in a brilliant plenary talk encompassing advances on cellular responses to DNA double-strand breaks by Steve Jackson of the Wellcome Trust/Cancer Research UK Gurdon Institute. The evening of the second day included sessions on defining & targeting the damage response. The final session, late in the evening but still with full attendance, was introduced by Tom Blundell, describing an opportunity to contribute to a themed volume of Progress in Biophysics and Molecular Biology, to be published by Elsevier.

These exciting sessions included breaks for discussions with refreshments & poster viewing, further sessions to ‘Meet the Poster Presenters’, and a short break for leisure in the afternoon. Some sought relaxing conversations on the beautiful beach 50 meters from the restaurants and lecture room! Discussions often further took place over dinner that could be taken at several lovely restaurants in the hotel.

The third day began with sessions on mutational signatures & mechanisms, focusing on mutagenesis in cancer, the concerted roles of genes in the protection of common fragile sites, the characterization of genomic rearrangements and DNA damage recognition. This session culminated with a fascinating plenary talk from Serena Nik-Zainal of the Wellcome Trust Sanger Institute. She detailed mechanistic insights and clinical applications of advances emerging from mutational signatures.

After a snorkeling expedition for some of the more energetic participants and informal afternoon discussions by others, the talks focused on DNA double-strand-break repair through Non-Homologous End Joining. This session was anchored by many strong talks and especially by the breakthrough new structure of the giant DNA-PK molecule, the largest single chain kinase in the human genome, which furthermore forms a point for assembly of many other components. New methods of investigating DNA end joining using proteomics-grade strategies for integrative structural biology and modelling were discussed, as well as exciting single-molecule analyses by Terence Strick measuring the time frame and energetics from the core and added components for this multicomponent DNA repair system.

The fourth day, Wednesday, started with talks and discussions of resection, repair and break signaling in homologous recombination of DNA double-strand breaks. One of the highlights was the way rad51 filament defines remodeling by human Rad51c-XRCC3. The discussion continued with a focus on DNA intermediates in repair and replication, and a discussion of mutagenesis, culminating with a very stimulating integrative plenary talk by Stephen West of the Francis Crick Institute on unresolved DNA intermediates as a source of DNA breaks and chromosome aberrations. The evening session continued with talks and discussions on coupling repair to replication and mitosis, with many stand out talks including those by Titia Sixma of the Netherlands Cancer Institute on structural biology of DNA mismatch repair and by Susan Lees-Miller of University of Calgary on non-repair functions of DNA-PKcs. All of this discussion included a look behind the scenes on publishing with the Nature research journals by Beth Moorefield that was followed by a gala dinner and poster awards (see below).

Despite the intensive schedule in talks and interactions, the final day continued with the same intensity of brilliant and exciting presentations on damage interactions with expression & chromatin. Talks included DNA damage sensor roles during base excision repair, structural analysis of protein DNA remodeler and structure and regulation of human ino80 complex by Dale Wigley. John Tainer from the MD Anderson Cancer Center completed the meeting with an exciting thought piece on the “rise of the molecular machines with cancer implications”.

The closing comments from the organisers expressed their happiness with the range of superb talks – probably the most intense five day meeting many have had for a long time and a great learning period. The meeting was attended by an enthusiastic and diverse audience, both with respect to stage of career, gender and nationality. We were proud to see that 20% of our attendees were students and this was due to the special rate offered by Fusion enabling many students to attend at cost price when accompanied by an academic.

The topic of DNA damage response and repair and its interface with replication remains an exciting area of research, still with many unanswered questions.

“Thank you, and all the organisers, so much for this wonderful opportunity to meet other researchers and make valuable contacts. I won't hesitate to say that this is one of the best conferences I've been to so far. Organisation is perfect and I will definitely want to attend in next edition…” Dr. Jacek Kabzinski (Medical University of Lodz)

Congratulations to all of those who received an award, details of which can be found below.

Organisers Short Talk Award

Noa Lamm-Shale (Children's Medical Research Institute)
Ravindra Amunugama (Harvard Medical School)

Poster Prize Awards

Zhe Yang (The Rockefeller University)
Taiana Maia de Oliveira (AstraZeneca)
Marcel Tuppi (Goethe-Universität Frankfurt)
Harshad Ghodke (University of Wollongong)
Benjamin Foster (IFE, Helmholtz Zentrum München)
Elizabeth O'Brien (California Institute of Technology)

FEBS Short Talk Award

Domi Baretic (MRC Laboratory of Molecular Biology)
Franz Klein (MFPL, University of Vienna)

We thank AstraZeneca for generously supporting this meeting and emphasising the importance of knowledge exchange between academia and industry, which is critical in our area and in this case can assist in the early development of new therapeutics for cancer. We also thank all our other wonderful sponsors; TESARO, Oncotarget, Repare Therapeutics, DECTRIS, artios, FEBS, Worldwide Cancer Research and the University of Pittsburgh. Their support was greatly appreciated and enabled us to fund many participants who otherwise may not have been able to attend. Special thanks to Elsevier for supporting the meeting and publishing the themed volume on selected talks.

The meeting was expertly organized, smoothly run, and supported by Fusion Conferences, Ltd. We thank Laura Trundle and her team for their helpful interactions with organisers and participants.

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3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Synopsis

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a surprisingly fragile and complex process requiring fork protection and restart, template-switching, R-loop resolution, gap-filling, and repair. Unresolved replication and repair intermediates signal apoptosis. The synthetic lethality and essentiality resulting from replication-repair stresses thus suggest repair inhibitors as tools to control pathway selection and damage outcomes and to design advanced therapeutics.

The 3rd DNA Replication/Repair Structures & Cancer conference in February 2018 will focus on structural and mechanistic insights into dynamic protein, chromatin, DNA and RNA complexes acting in DNA replication and repair events relevant to cancer. Conference talks and discussions will center on developing an actionable mechanistic knowledge of DNA replication and repair stress responses suitable to guide advanced intervention strategies for cancer. The conference will emphasize an environment suitable for initiating productive collaborations. It will include vibrant informal and formal discussions together with informative talks and poster sessions.

To include late-breaking advances and innovating new investigators, one or more talks for every session will be selected from submitted abstracts. Meeting attendance is limited. Applicants seeking to present talks or posters are strongly encouraged to submit applications and abstracts early. All presenters are asked to focus on unpublished work, cutting-edge approaches and novel mechanistic insights that aid prediction of biological outcomes and plans to best apply basic research advances for cancer research and treatment.

What makes this meeting unique? Professor Ben Van Houten from the University of Pittsburgh says:

‘I can honestly say your meeting, by combining hard core structure-function studies with beautiful biology, hits an important area that many meetings miss; being part of that science is just terrific.’

Join the conference LinkedIn group to keep up to date with announcements and latest news concerning the conference.

Key Sessions

Sessions will include emerging results and breakthrough methods concerning:

Repair and replication complexes, structures and mechanisms
Mutational signatures, kataegis, DNA repair, and cancer
Damage signaling, pathway selection & cross-talk
Targeting synthetic lethality and essentiality for damage responses
Chromatin and chromosome instability
Epigenetics, DNA damage and repair
PARP, PARG, and metabolic signaling
Mitochondrial replication/repair and damage signaling
RNA damage responses and actions in repair
DNA repair, apoptosis and cancer

Confirmed Keynote Speakers

Steve Jackson (University of Cambridge)
'CELLULAR RESPONSES TO DNA DOUBLE-STRAND BREAKS'

Bruce Stillman (CSHL)
'THE ORIGIN RECOGNITION COMPLEX AND CHROMOSOME DUPLICATION: STRUCTURE, FUNCTION AND HUMAN GENETICS'

Steve West (The Francis Crick Institute)
'UNRESOLVED DNA INTERMEDIATES AS A SOURCE OF DNA BREAKS AND CHROMOSOME ABERRATIONS'

Serena Nik-Zainal (University of Cambridge)
'ADVANCES IN THE FIELD OF MUTATIONAL SIGNATURES: MECHANISTIC INSIGHTS AND CLINICAL APPLICATIONS'

Confirmed Invited Speakers

Lorena Beese (Duke University Medical Center)

Simon Boulton (The Francis Crick Institute)
'PITCH MODULATION AND EXTENSION DEFINES RAD51 FILAMENT REMODELLING BY HUMAN RAD51C-XRCC3 COMPLEX'

Chris Brosey (MD Anderson Cancer Center)
'BRIDGING DNA REPAIR AND NAD(H) ENERGETICS: TRACKING ARCHITECTURAL REGULATION OF APOPTOSIS-INDUCING FACTOR DURING PARTHANATOS'

Cynthia Burrows (University of Utah)
'DNA DAMAGE REGULATES GENE EXPRESSION VIA BASE EXCISION REPAIR'

Jean-Baptiste Charbonnier (University Parisâ€Saclay)
'ROLES OF Ku70/Ku80 IN NHEJ, FROM DSB RECOGNITION TO LIGATION'

Walter Chazin (Vanderbilt University)
'UNDERSTANDING HOW DNA PRIMASE WORKS REQUIRES KNOWLEDGE OF ITS ARCHITECTURAL DYNAMICS'

Karlene Cimprich (Stanford University School of Medicine)
'MECHANISMS FOR MAINTAINING GENOME STABILITY AT THE REPLICATION FORK'

David Cortez (Vanderbilt University)
'FUNCTIONS OF SINGLE-STRAND DNA BINDING PROTEINS IN MAINTAINING GENOME STABILITY'

Sheila David (University of California, Davis)
'BASE EXCISION REPAIR GLYCOSYLASES MUTYH AND NEIL1: THE GOOD, THE BAD AND THE DAMAGED'

Michelle Debatisse (Gustave Roussy Institute)
'COMMON FRAGILE SITE INSTABILITY: A RACE AGAINST TIME'

Sylvie Doublié (University of Vermont)
'STRUCTURAL ANALYSES OF DNA POLYMERASE THETA VARIANTS'

Structural analyses of DNA polymerase theta variants'

Brandt Eichman (Vanderbilt University)
'MECHANISMS OF REMODELING STALLED REPLICATION FORKS'

Dorothy Erie (University of North Carolina)

Ilya Finkelstein (University of Texas at Austin)
'ASSEMBLING THE HUMAN RESECTOSOME ONE MOLECULE AT A TIME'

Marco Foiani (University of Milan)
'AN INTEGRATED ATR, ATM AND mTOR-MECHANICAL NETWORK CONTROLLING NUCLEAR PLASTICITY AND CELL MIGRATIONB'

Mark Glover (University of Alberta)
'PNKP - A MEANS TO FIX THE ENDS'

Jane Grasby (Krebs Institute)
'COUPLING RECOGNITION AND REACTIVITY IN A STRUCTURE-SPECIFIC NUCLEASE'

Samir Hamdan (KAUST)
'SINGLE MOLECULE VIEW OF THE STRUCTURE SPECIFIC 5' NUCLEASES'

Reuben Harris (University of Minnesota)
'APOBEC MUTAGENESIS IN CANCER'

Karl-Peter Hopfner (Ludwig-Maximilians-University Munich)
'STRUCTURAL ANALYSIS OF PROTEIN DNA REMODELLER'

Ben Van Houten (University of Pittsburgh)
'DAMAGE SENSOR ROLE OF UV-DDB DURING BASE EXCISION REPAIR:STIMULATION OF APE1 AND OGG1'

Meindert Lamers (Leiden University Medical Center)
'STRUCTURAL FEATURES OF HIGH FIDELITY DNA REPLICATION'

Susan Lees-Miller (Arnie Charbonneau Cancer Institute)
'NON-REPAIR FUNCTIONS OF DNA-PKcs'

Karolin Luger (University of Colorado at Boulder)
'POLY (ADP-RIBOSE) POLYMERASE 1 IN DNA DAMAGE RECOGNITION'

Mauro Modesti (Cancer Research Center of Marseille)
'DYNAMICS AND MECHANICS OF DNA TETHERING BY CORE c-NHEJ FACTORS AND BY THE MRE11/RAD50/NBS1 COMPLEX'

Zachary Nagel (Harvard University)
'COMPREHENSIVE ANALYSIS OF DNA REPAIR CAPACITY IN NORMAL AND CANCEROUS CELLS'

Mark O'Connor (AstraZeneca)
'TARGETING THE REPLICATION STRESS RESPONSE IN CANCER'

John Pascal (Université de Montréal)
'STRUCTURAL BIOLOGY OF POLY(ADP-ribose) POLYMERASE ENZYMES'

Tanya Paull (University of Texas at Austin)
'THE Mre11-Rad50-Nbs1 COMPLEX AND REGULATION OF DNA REPAIR'

Phoebe Rice (University of Chicago)
'AN MCM-RELATED HELICASE AND OTHER REPLICATION-RELATED MACHINERY FOUND ON THE MOBILE ELEMENT BEHIND THE MRSA EPIDEMIC'

Andrej Sali (University of California, San Francisco)
'INTEGRATIVE STRUCTURE MODELING OF DNA-PKcs'

Orlando Scharer (Ulsan National Institute of Science and Technology)
'REPLICATIVE AND TRANSLESION SYNTHESIS DNA POLYMERASES IN ICL REPAIR'

Katharina Schlacher (MD Anderson Cancer Center)
'RAD51C IN DNA FORK PROTECTION AND STABILITY'

David Schriemer (University of Calgary)
'PROTEOMICS-GRADE STRATEGIES FOR INTEGRATIVE STRUCTURAL BIOLOGY'

Titia Sixma (NKI)
'STRUCTURAL BIOLOGY OF DNA MISMATCH REPAIR'

Maria Spies (University of Iowa)
'INHIBITORS OF THE RAD52-ssDNA INTERACTION'

Terence Strick (Institut Jacques Monod)
'SINGLE-MOLECULE ANALYSIS OF MULTICOMPONENT DNA REPAIR SYSTEMS'

Madalena Tarsounas (The CR-UK/MRC Oxford Institute for Radiation Oncology)
'WNT/b-CATENIN SIGNALING IN BRCA-DEFICIENT CELLS'

Susan Tsutakawa (Lawrence Berkeley National Laboratory)
'PHOSPHATE STEERING IS CRITICAL FOR CATALYSIS AND PREVENTION OF OFF-TARGET INCISIONS IN HUMAN FLAP ENDONUCLEASE'

Ashok Venkitaraman (University of Cambridge)
'INSIGHTS INTO CARCINOGENESIS FROM STRUCTURAL AND BIOLOGIC ANALYSES OF THE BRCA2 TUMOUR SUPPRESSOR'

Dale Wigley (Imperial College London)
'STRUCTURE AND REGULATION OF HUMAN INO80 COMPLEX'

Scott Williams (NIEHS)
'ENFORCEMENT OF DNA LIGATION FIDELITY'

Supported By

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3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Speakers

Plenary Speakers

Steve West

Senior Group Leader, Francis Crick Institute

Bruce Stillman

President and Professor, Cold Spring Harbor Laboratory

Stephen Jackson

Head of Cancer Research UK Laboratories, CRUK- Cambridge Institute

Serena Nik-Zainal

., University of Cambridge

Invited Speakers

Madalena Tarsounas

CR-UK Senior Group Leader, The CR-UK/MRC Oxford Institute for Radiation Oncology, University of Oxford

Marco Foiani

Scientific Director, IFOM- the FIRC Institute of Molecular Oncology

Katharina Schlacher

Associate Professor, MD Anderson Cancer Center

Simon Boulton

Principal Group Leader, The Francis Crick Institute

Tanya Paull

Professor, The University of Texas at Austin

Andrej Sali

Professor, University of California, San Francisco

David Cortez

Professor, Vanderbilt University

Titia Sixma

Group leader, Netherlands Cancer Institute

Karolin Luger

Investigator, HHMI; Professor, CU Boulder, University of Colorado Boulder

Cynthia Burrows

Distinguished Professor, University of Utah

Walter Chazin

Founding Director- Center for Structural Biology, Vanderbilt University

Chris Brosey

Research Scientist, The University of Texas M.D. Anderson Cancer Center

Ilya Finkelstein

Associate Professor, UT-Austin

Susan Tsutakawa

Research Scientist, Lawrence Berkeley National Laboratory

Brandt Eichman

Professor, Vanderbilt University

Mark O'Connor

Chief Scientist, AstraZeneca

Mark Glover

Professor, University of Alberta

Sylvie Doublié

Professor, University of Vermont

Meindert Lamers

Associate Professor, Leiden University Medical Center

Mauro Modesti

Principal Investigator, Cancer Research Center of Marseille

David Schriemer

Professor, University of Calgary

Dorothy Erie

Professor, University of North Carolina

Maria Spies

Professor of Biochemistry and Molecular Biology, University of Iowa

Michelle Debatisse

Researcher, UMR8200 CNRS

Reuben Harris

Professor, University of Minnesota

Sheila David

Professor of Chemistry, University of California, Davis

Ben Van Houten

Richard M. Cyert Professor of Molecular Oncology, UPMC Hillman Cancer Center

Karlene Cimprich

Professor, Stanford University

Karl-Peter Hopfner

Professor, Gene Center

Jean-Baptiste Charbonnier

Team Leader, CEA-CNRS-Univ Paris Saclay, France

Orlando D. SchÃ¤rer

Associate Director, Institute for Basic Science

Ashok Venkitaraman

Director, MRC Cancer Unit, University of Cambridge

Samir Hamdan

Assistant Professor of Bioscience, King Abdullah University of Science and Technology

John Pascal

Professor, Université de Montréal

Susan Lees-Miller

Professor, University of Calgary

Dale Wigley

Professor, Imperial College London

Zachary Nagel

Assistant Professor of Radiation Biology, Harvard U

Lorena Beese

Professor, Duke University Medical Center

Phoebe Rice

Professor, The University of Chicago

Scott Williams

Principal Investigator, NIH/NIEHS

Terence Strick

Research Director, Ecole normale supÃ©rieure/CNRS

Jane Grasby

Professor of Biological Chemistry, University of Sheffield

Supported By

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Gold

Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Programme

DISCUSSION IS VALUED: 5 MINUTES IS SAVED FOR DISCUSSION AFTER EACH TALK

SUNDAY 11^TH FEBRUARY 2018
09:00 – 15:00	Group Trip: Tulum (signups required in advance)
15:00 – 16:00	Registration & Welcome Reception
16:00 – 16:10	Welcome and Opening Remarks by John Tainer & Tom Blundell
SUNDAY PM	DNA Replication Machinery Session Chair: John Tainer
16:10 – 16:30	Meindert Lamers Leiden University Medical Center	STRUCTURAL FEATURES OF HIGH FIDELITY DNA REPLICATION
16:35 – 16:45	Ravindra Amunugama * Harvard Medical School	REPLICATION FORK REVERSAL DURING DNA INTERSTRAND CROSSLINK REPAIR REQUIRES CMG HELICASE UNLOADING
16:50 – 17:00	Philipp Oberdoerffer * NCI	REPLICATION STRESS SHAPES A PROTECTIVE CHROMATIN ENVIRONMENT ACROSS FRAGILE GENOMIC REGIONS
17:05 – 17:25	Samir Hamdan KAUST	SINGLE MOLECULE VIEW OF THE STRUCTURE SPECIFIC 5 NUCLEASES
17:30 – 17:50	Scott Williams NIEHS	ENFORCEMENT OF DNA LIGATION FIDELITY
17:55 – 18:20	Meet the Poster Presenters I Moderators: Susan Tsutakawa and Chris Brosey
18:20 – 18:50	Refreshments
18:50 – 19:10	Meet the Poster Presenters II Moderators: Susan Tsutakawa and Chris Brosey
19:10 – 19:20	Tahir Tahirov * Nebraska Medical Center	ELABORATED ACTION OF THE HUMAN PRIMOSOME
19:25 – 19:45	Walter Chazin Vanderbilt University	UNDERSTANDING HOW DNA PRIMASE WORKS REQUIRES KNOWLEDGE OF ITS ARCHITECTURAL DYNAMICS
19:50 – 20:30	Plenary Speaker: Bruce Stillman Cold Spring Harbor Laboratory	THE ORIGIN RECOGNITION COMPLEX AND CHROMOSOME DUPLICATION: STRUCTURE, FUNCTION AND HUMAN GENETICS
20:35	Dinner at Leisure

MONDAY 12^TH FEBRUARY 2018
07:00 – 08:15	Breakfast
MONDAY AM	Replication Fork Stability Session Chair: Marco Foiani
08:15 – 08:20	Session Introduction by Marco Foiani
08:20 – 08:40	Karlene Cimprich Stanford University	MECHANISMS FOR MAINTAINING GENOME STABILITY AT THE REPLICATION FORK
08:45 – 09:05	Brandt Eichman Vanderbilt University	MECHANISMS OF REMODELING STALLED REPLICATION FORKS
09:10 – 09:30	David Cortez Vanderbilt University	FUNCTIONS OF SINGLE-STRAND DNA BINDING PROTEINS IN MAINTAINING GENOME STABILITY
09:35 – 09:45	Martin Cohn * University of Oxford	IDENTIFICATION OF UHRF2 (RNF107) AS A NOVEL ICL SENSOR PROTEIN REQUIRED FOR THE FANCONI ANEMIA PATHWAY
09:50 – 10:10	Katharina Schlacher MD Anderson Cancer Center	RAD51C IN DNA FORK PROTECTION AND STABILITY
10:15 – 10:45	Refreshments & Poster Viewing
MONDAY AM	Sensing & Signaling Cellular Genome Instability Session Chair: Katharina Schlacher
10:45 – 10:50	Session Introduction by Katharina Schlacher
10:50 – 11:10	Marco Foiani IFOM - FIRC Institute of Molecular Oncology	AN INTEGRATED ATR, ATM AND mTOR-MECHANICAL NETWORK CONTROLLING NUCLEAR PLASTICITY AND CELL MIGRATION
11:15 – 11:25	Noa Lamm-Shalem * Childrens Medical Research Institute	ATR AND mTOR REGULATE NUCLEUR ACTIN POLYMERIZATION IN RESPONSE TO REPLICATION STRESS TO ALTER NUCLEUR ARCHITECTURE AND MAINTAIN GENOME STABILITY
11:30 – 11:50	John Pascal Université de Montréal	STRUCTURAL BIOLOGY OF POLY(ADP-ribose) POLYMERASE ENZYMES
11:55 – 12:15	Chris Brosey University of Texas M.D. Anderson Cancer Center	BRIDGING DNA REPAIR AND NAD(H) ENERGETICS: TRACKING ARCHITECTURAL REGULATION OF APOPTOSIS-INDUCING FACTOR DURING PARTHANATOS
12:20 – 13:00 Partially sponsored by Worldwide Cancer Research	Plenary Speaker: Steve Jackson Wellcome Trust/Cancer Research UK Gurdon Institute	CELLULAR RESPONSES TO DNA DOUBLE-STRAND BREAKS
13:05 – 16:25	Lunch at Leisure & Free Time
MONDAY PM	Defining & Targeting The Damage Response Session Chair: Susan Lees-Miller
16:25 – 16:30	Session Introduction by Susan Lees-Miller
16:30 – 16:50	Mark OConnor AstraZeneca	TARGETING THE REPLICATION STRESS RESPONSE IN CANCER
16:55 – 17:15	Jane Grasby Krebs Institute	COUPLING RECOGNITION AND REACTIVITY IN A STRUCTURE-SPECIFIC NUCLEASE
17:20 – 17:30	Mohiuddin * The Hospital for Sick Children	CTIP-BRCA1 COMPLEX AND MRE11 NUCLEASE PLAY A CRITICAL ROLE IN MAINTAINING REPLICATION FORKS IN THE PRESENCE OF CHAIN TERMINATING NUCLEOTIDE ANALOGS
17:35 – 18:15	Meet the Poster Presenters III Moderators: Susan Tsutakawa and Chris Brosey
18:15 – 18:55	Poster Session & Refreshments (even poster numbers only)
18:55 – 19:15	Madalena Tarsounas University of Oxford	WNT/b-catenin signaling in BRCA-deficient cells
19:20 – 19:40	Maria Spies University of Iowa	INHIBITORS OF THE RAD52-ssDNA INTERACTION
19:45 – 19:55	Mona Al-Mugotir * UNMC Eppley Institute	TARGETING RAD52 PROTEIN-PROTEIN INTERACTIONS IN CANCER THERAPY
20:00 – 20:20	Zachary Nagel Harvard University	COMPREHENSIVE ANALYSIS OF DNA REPAIR CAPACITY IN NORMAL AND CANCEROUS CELLS
20:25 – 20:40	Publication Opportunity: Progress in Biophysics and Molecular Biology (Published by Elsevier) Announcement by Tom Blundell
20:40	Dinner at Leisure

TUESDAY 13^TH FEBRUARY 2018
07:00 – 08:15	Breakfast
TUESDAY AM	Mutational Signatures & Mechanisms Session Chair: Bennett Van Houten
08:15 – 08:20	Session Introduction by Bennett Van Houten
08:20 – 08:40	Reuben Harris University of Minnesota	APOBEC MUTAGENESIS IN CANCER
08:45 – 08:55	Agnel Sfeir * NYU School of Medicine	POLYMERASE THETA PROMOTES ERROR-PRONE REPAIR BY alt-NHEJ AT THE EXPENSE OF ERROR-FREE HR
09:00 – 09:10	Xiaohua Wu * The Scripps Research Institute	THE CONCERTED ROLES OF FANCM AND Rad52 IN THE PROTECTION OF COMMON FRAGILE SITES
09:15 – 09:35	Ashok Venkitaraman University of Cambridge	INSIGHTS INTO CARCINOGENESIS FROM STRUCTURAL AND BIOLOGIC ANALYSES OF THE BRCA2 TUMOUR SUPPRESSOR
09:40 – 10:10	Group Photo, Refreshments & Poster Viewing
10:10 – 10:20	Anne Bothmer * Editas Medicine	CHARACTERIZATION OF GENOMIC REARRANGEMENTS IN RESPONSE TO CRISPR/Cas9-INDUCED DOUBLE-STRAND BREAKS
10:25 – 10:45	Susan Tsutakawa Lawrence Berkeley National Laboratory	PHOSPHATE STEERING IS CRITICAL FOR CATALYSIS AND PREVENTION OF OFF-TARGET INCISIONS IN HUMAN FLAP ENDONUCLEASE
10:50 – 11:10	Karolin Luger University of Colorado Boulder	POLY (ADP-RIBOSE) POLYMERASE 1 IN DNA DAMAGE RECOGNITION
11:15 – 11:35	Michelle Debatisse UMR8200 CNRS	COMMON FRAGILE SITE INSTABILITY: A RACE AGAINST TIME
11:40 – 12:20	Plenary Speaker: Serena Nik-Zainal University of Cambridge	ADVANCES IN THE FIELD OF MUTATIONAL SIGNATURES: MECHANISTIC INSIGHTS AND CLINICAL APPLICATIONS
12:25 – 16:30	Lunch at Leisure & Free Time
12:40 – 16:00	Group Trip: Snorkeling (signups required in advance)
TUESDAY PM	Non-Homologus End Joining Session Chair: Simon Boulton
16:30 – 16:35	Session Introduction by Simon Boulton
16:35 – 16:55	Tom Blundell University of Cambridge	DNA-PKcs STRUCTURE FORMS A STAGE FOR THE ACTORS AND SUGGESTS AN ALLOSTERIC MECHANISM FOR MODULATING DNA DOUBLE-STRAND-BREAK REPAIR
17:00 – 17:20	David Schriemer University of Calgary	PROTEOMICS-GRADE STRATEGIES FOR INTEGRATIVE STRUCTURAL BIOLOGY
17:25 – 17:35	Benjamin Stinson * Harvard Medical School	NON-HOMOLOGOUS END JOINING OPERATES BY A “LIGASE-FIRST” MECHANISM
17:40 – 18:00	Terence Strick Institut Jacques Monod	SINGLE-MOLECULE ANALYSIS OF MULTICOMPONENT DNA REPAIR SYSTEMS
18:05 – 18:25	Andrej Sali UCSF	INTEGRATIVE STRUCTURE MODELING OF DNA-PKcs
18:30 – 19:10	Poster Session & Refreshments (odd poster numbers only)
19:10 – 19:30	Jean-Baptiste Charbonnier CEA-CNRS-Univ Paris Saclay	ROLES OF Ku70/Ku80 IN NHEJ, FROM DSB RECOGNITION TO LIGATION
19:35 – 19:55	Tanya Paull The University of Texas at Austin	INTERSECTIONS BETWEEN MRN AND THE NON-HOMOLOGOUS END JOINING MACHINERY
20:00 – 20:20	Mark Glover University of Alberta	PNKP - A MEANS TO FIX THE ENDS
20:25	Dinner at Leisure

WEDNESDAY 14^TH FEBRUARY 2018
07:00 – 08:15	Breakfast
WEDNESDAY AM	Resection, Repair and Break Signaling in Homologous Recombination Session Chair: Lorena Beese
08:15 – 08:20	Session Introduction by Lorena Beese
08:20 – 08:40	Mauro Modesti Cancer Research Center of Marseille	DYNAMICS AND MECHANICS OF DNA TETHERING BY CORE c-NHEJ FACTORS AND BY THE MRE11/RAD50/NBS1 COMPLEX
08:45 – 09:05	Ilya Finkelstein UT-Austin	ASSEMBLING THE HUMAN RESECTOSOME ONE MOLECULE AT A TIME
09:10 – 09:20	Michael Trakselis * Baylor University	FUNCTION AND REGULATION OF MCM8-9 IN DNA RECOMBINATION
09:25 – 09:35	Domi Baretic * MRC Laboratory of Molecular Biology	STRUCTURAL INSIGHTS INTO THE ACTIVATION OF ATM AND ATR KINASES
09:40 – 10:00	Simon Boulton The Francis Crick Institute	PITCH MODULATION AND EXTENSION DEFINES RAD51 FILAMENT REMODELLING BY HUMAN RAD51C-XRCC3 COMPLEX
10:05 – 10:50	Poster Session & Refreshments (all posters)
WEDNESDAY AM	DNA Intermediates in Repair, Replication, and Mutagensis Session Chair: Richard Wood
10:50 – 10:55	Session Introduction by Richard Wood
10:55 – 11:05	Markus Löbrich * Darmstadt University of Technology	ATRX PROMOTES DNA REPAIR SYNTHESIS AND CROSS-OVER FORMATION DURING HOMOLOGOUS RECOMBINATION
11:10 – 11:20	Charles Bell * The Ohio State University	STRUCTURE AND MECHANISM OF THE RED RECOMBINATION SYSTEM FROM BACTERIOPHAGE LAMBDA
11:25 – 11:35	Franz Klein * University of Vienna	THE RELEASE OF MEIOTIC dsDNA FRAGMENTS PROMPTS A NOVEL VIEW ON DSB FORMATION
11:40 – 11:50	David Yu * Emory University School of Medicine	SAMHD1 PROMOTES DNA END RESECTION TO FACILITATE DNA REPAIR BY HOMOLOGOUS RECOMBINATION
11:55 – 12:15	Sylvie Doublié University of Vermont	STRUCTURAL ANALYSES OF DNA POLYMERASE THETA VARIANTS
12:20 – 12:30	Marc Delarue * Institut Pasteur	STRUCTURAL BASIS FOR THE ESSENTIAL ROLE OF LOOP1 IN POLYMERASE μ WHILE PROCESSING DOUBLESTRAND BREAKS DNA SUBSTRATES DURING NHEJ
12:35 – 13:15	Plenary Speaker: Stephen West Francis Crick Institute	UNRESOLVED DNA INTERMEDIATES AS A SOURCE OF DNA BREAKS AND CHROMOSOME ABERRATIONS
13:20 – 16:25	Lunch at Leisure & Free Time
WEDNESDAY PM	Coupling Repair to Replication and Mitosis Session Chair: Jane Grasby
16:25 – 16:30	Session Introduction by Jane Grasby
16:30 – 16:50	Orlando D. Schärer Institute for Basic Science	REPLICATIVE AND TRANSLESION SYNTHESIS DNA POLYMERASES IN ICL REPAIR
16:55 – 17:15	Lorena Beese Duke University Medical Center	REPLICATION ASSOCIATED DNA REPAIR
17:20 – 17:40	Dorothy Erie University of North Carolina	COMBINING SINGLE-MOLECULE METHODS TO STUDY DNA MISMATCH REPAIR
17:45 – 17:55	Beth Moorefield * Nature SMB	PUBLISHING WITH THE NATURE RESEARCH JOURNALS: A LOOK BEHIND THE SCENES
17:55 – 18:25	Refreshments & Poster Viewing
18:25 – 18:45	Titia Sixma Netherlands Cancer Institute	USP48 RESTRAINS RESECTION BY SITE-SPECIFIC CLEAVAGE OF THE BRCA1 UBIQUITIN MARK FROM H2A
18:50 – 19:00	Alba Guarne * McGill University	DIFFERENTIAL INTERACTIONS BETWEEN THE SLIDING CLAMP AND MUTL
19:05 – 19:25	Susan Lees-Miller University of Calgary	NON-REPAIR FUNCTIONS OF DNA-PKcs
20:00	Gala Dinner & Poster Awards

THURSDAY 15^TH FEBRUARY 2018
07:00 – 08:15	Breakfast
THURSDAY AM	Damage Interactions With E xpression & Chromatin Session Chair: Tom Blundell
08:15 – 08:20	Session Introduction by Tom Blundell
08:20 – 08:40	Bennett Van Houten University of Pittsburgh Cancer Institute	DAMAGE SENSOR ROLE OF UV-DDB DURING BASE EXCISION REPAIR:STIMULATION OF APE1 AND OGG1
08.45 – 09:05	Cynthia Burrows University of Utah	DNA DAMAGE REGULATES GENE EXPRESSION VIA BASE EXCISION REPAIR
09:10 – 09:30	Karl-Peter Hopfner Gene Center	STRUCTURAL ANALYSIS OF PROTEIN DNA REMODELLER
09:35 – 09:55	Dale Wigley Imperial College London	STRUCTURE AND REGULATION OF HUMAN INO80 COMPLEX
10:00 – 10:30	Refreshments
THURSDAY AM	DNA Sculpting & Human Disease Session Chair: Dorothy Erie
10:30 – 10:35	Session Introduction by Dorothy Erie
10:35 – 10:45	Dong Wang * UCSD	MOLECULAR MECHANISM OF TRANSCRIPTION TRANSCRIPTION-COUPLED REPAIR
10:50 – 11:10	Phoebe Rice The University of Chicago	AN MCM-RELATED HELICASE AND OTHER REPLICATION-RELATED MACHINERY FOUND ON THE MOBILE ELEMENT BEHIND THE MRSA EPIDEMIC
11:15 – 11:35	Sheila David University of California, Davis	BASE EXCISION REPAIR GLYCOSYLASES MUTYH AND NEIL1: THE GOOD, THE BAD AND THE DAMAGED
11:40 – 11:50	Ivaylo Ivanov * Georgia State University	LESION SEARCH AND BASE EXTRUSION STRATEGY OF THYMINE DNA GLYCOSYLASE
11:55 – 12:15	John Tainer MD Anderson Cancer Center	THE RISE OF THE MOLECULAR MACHINES WITH CANCER IMPLICATIONS
12:20 – 12:30	Closing Comments by John Tainer & Tom Blundell

FRIDAY 16^TH FEBRUARY 2018
07:15 – 19:00	Group Trip: Chichen Itza (signups in advance required)

*Selected from abstracts.

MEET OUR POSTER PRESENTERS
Poster #	Name	Organisation	Country
1	Noritaka Adachi	Yokohama City University	Japan
2	Matthew Bochman	Indiana University	USA
3	Gloria Borgstahl	Eppley Institute for Research in Cancer	USA
4	Amer Bralic	King Abduallah University of Science and Technology	Saudi Arabia
5	Brian Caldwell	Ohio State Biochemistry Program	USA
6	Rodrigo Orlandini de Castro	Oklahoma Medical Research Foundation	USA
7	Petr Cejka	Institute for Research in Biomedicine	Switzerland
8	Heejin Chung	Sungkyunkwan University	South Korea
9	Anders Clausen	University of Gothenburg	Sweden
10	Debanu Das	Accelero Biostructures	USA
11	Anthony Davis	UT Southwestern Medical Center	USA
12	Ambra Dondi	European Institute of Oncology	Italy
13	Pauline Douglas	University of Calgary	Canada
14	Amira Fitieh	University of Alberta	Canada
15	Benjamin Foster	IFE, Helmholtz Zentrum München	Germany
16	Harshad Ghodke	University of Wollongong	Australia
17	Morgan Hepburn	University of Calgary	Canada
18	Han Ho	University of Wollongong	Australia
19	JinKyung Hong	Sungkyunkwan University School of Medicine	South Korea
20	Jerry Houl	University of Texas MD Anderson Cancer Center	USA
21	Christopher Jackson	Yale University	USA
22	Seong-Whan Jeong	The Catholic University of Korea	South Korea
23	David Jeruzalmi	City College of New York	USA
24	Nicholas Jette	University of Calgary	Canada
25	Stanislaw Jozwiakowski	University of Zurich	Switzerland
26	Jacek Kabzinski	Medical University of Lodz	Poland
27	Yoko Katsuki	Kyoto University	Japan
28	Yoori Kim	The University of Texas at Austin	USA
29	Ina Klusmann	Universitätsmedizin Göttingen	Germany
30	Rebecca Ley	University of Sheffield	UK
31	Ireneusz Majsterek	Medical University of Lodz	Poland
32	Lucia Francesca Massari	European Institute of Oncology	Italy
33	Riccardo Miggiano	University of Piemonte Orientale	Italy
34	Yeom Mina	Sungkyunkwan University School of Medicine	South Korea
35	Davide Moiani	UT MD Anderson Cancer Center	USA
36	Elizabeth OBrien	California Institute of Technology	USA
37	Taiana Maia de Oliveira	AstraZeneca	UK
38	Richard Pomerantz	Temple University	USA
39	Fahad Rashid	KAUST	Saudi Arabia
40	Samuel Redstone	University of Utah	USA
41	Liton Kumar Saha	Kyoto University	Japan
42	Lauren Salay	Vanderbilt University	USA
43	Daniel Saltzberg	University of California San Francisco	USA
44	Altaf Sarker	Lawrence Berkeley National Lab	USA
45	Lisa Schubert	University of Copenhagen	Denmark
46	Runze Shen	The University of Texas M.D. Anderson Cancer Center	USA
47	Agnieszka Anna SmoliÅ„ska	Ernst-Moritz-Arndt-University Greifswald	Germany
48	Lucas Struble	UNMC Eppley Institute	USA
49	Michal Roman Szymanski	University of Gdansk and Medical University of Gdansk	Poland
50	Roopa Thapar	MD Anderson Cancer Research Center	USA
51	Marcel Tuppi	Goethe-Universität Frankfurt	Germany
52	Felicity Watts	University of Sussex	UK
53	Richard Wood	The University of Texas MD Anderson Cancer Center	USA
54	Dongyi Xu	Peking University	China
55	Yixi Xu	Peking University	China
56	Zhe Yang	The Rockefeller University	USA
57	Manal Zaher	King Abdullah University of Science and Technology	Saudi Arabia

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3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Prices

Ticket Type	Early Bird	Full Price
Single Choose this option if you will be attending the conference alone, or if you will bring accompanying guests that will not attend the meeting.	$1779	$1954
Shared Choose this option if you wish to share with a colleague who is also attending the conference, or if you wish to be paired with another attendee of the same sex.	$1779	$1954
Student Choose this option if you are a student. Please note all students will be paired with another attendee of the same sex if a room sharer is not specified. If you wish to have your own room, please register under the Single option.	$1451	$1626

Additional Person

This is the cost for an additional adult or child to join you in the same room, for the entire conference period. Accompanying persons are not permitted access to the conference. If you wish to extend your stay, please see our 'Extra night' prices.

Adult

$809

Child

$355

Extra nights

Prices are per person.

Adult

$292

Child

$71

What's Included in our Registration Fees?

Our registration fees are inclusive of the following during the conference period only:

- Conference registration.
- 4 nights’ fixed accommodation (11, 12, 13 and 14 February 2018) on a single basis for academics and industry, on a shared basis for students.
- Breakfast, Lunch and Dinner – available at all restaurants according to operational hours or programmed events.
- International Bar available by the glass in restaurants and bars according to operational hours.
- Pool snacks and International Bar available by the glass at pool area.
- Minibar including: soft drinks, domestic beer, bottled water and coffee. Refreshed daily.
- 24 Hour Room Service.
- In room amenity – bottle of wine, per room, per stay.
- Gala Night entry (includes an open bar).
- Complimentary WIFI in both conference rooms and your guest room.

What's Included in our Accompanying Adult Fees?

Our accompanying adult fees are inclusive of the following during the conference period only:

- 4 nights’ fixed accommodation (11, 12, 13 and 14 February 2018) on a shared basis with a conference participant.
- Breakfast, Lunch and Dinner – available at all restaurants according to operational hours or programmed events.
- International Bar available by the glass in restaurants and bars according to operational hours.
- Pool snacks and International Bar available by the glass at pool area.
- Minibar including: soft drinks, domestic beer, bottled water and coffee. Refreshed daily.
- 24 Hour Room Service.
- In room amenity – bottle of wine, per room, per stay.
- Gala Night entry (includes an open bar).
- Complimentary WIFI in both conference rooms and your guest room.

Important Note: Accompanying persons are not permitted access to the conference.

What's Included in our Accompanying Child Fees?

Our accompanying child fees are inclusive of the following during the conference period only:

- 4 nights’ fixed accommodation (11, 12, 13 and 14 February 2018) on a shared basis with the parent/s.
- Breakfast, Lunch and Dinner – available at all restaurants according to operational hours or programmed events.
- International Bar available by the glass in restaurants and bars according to operational hours.
- Pool snacks and International Bar available by the glass at pool area.
- Minibar including: soft drinks, bottled water and coffee. Refreshed daily.
- 24 hour room service.
- Gala Night entry (includes soft drinks).
- Complimentary WIFI in both conference rooms and your guest room.

Important Note: Accompanying child fees are applicable for children aged 5-12 years. Children aged 0-4 years stay free of charge with a parent. Children aged 13 years and older are classified as an adult at this venue (Fiesta Americana Condesa). Roll out beds are available upon request but can only be guaranteed at the point of check-in.

What's Included in our Extra Night Fees?

Additional nights are inclusive of one night’s accommodation and the all-inclusive food and beverage package.

Important Note: Extra night child fees are applicable for children aged 5-12 years.

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3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Grants

3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Supported By

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3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Venue

Fiesta Americana Condesa

This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

Lagoon Pool
Extensive Health Club and Spa
Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas

The Fiesta Americana Condesa, Cancun is the 2015 Winner of the Trip Advisor Certificate of Excellence and also received the Travellers Choice Award in 2014.

The remains of ancient Mayan cities are scattered throughout the Yucatan Peninsula and no trip to Cancun would be complete without a visit to these majestic temples and pyramids set amongst lush tropical vegetation. We will be working very closely with a reputable tour company who will be organising trips to Tulum, Chichen Itza, Coba and Xcaret to name a few, some of which may require a full day. Full day excursions will be arranged pre or post conference and may be on an individual or group booking so we would recommend booking extra nights to extend your stay as early as possible to avoid disappointment should these excursions be of interest to you and/or your party. For further information please contact us.

Venue Rating

Currency

US Dollar (USD)

Address

Fiesta Americana Condesa, Blvd.KukulkÃ¡n km 16.5 Zona Hotelera, Cancun, 77500 Mexico

Nearest Airport

Cancun International Airport

Location

Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.

Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.

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3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Transportation

Cancun International airport is just a short 20-minute journey from the Fiesta Americana Condesa and is easily accessible from almost every country in the world with many major international airlines providing direct or interconnecting flights on a daily basis.

Amstar are a reputable and trustworthy DMC based in Cancun. The Amstar team will be on hand to provide a seamless transfer service to and from Cancun International Airport. Amstar will manage and confirm all transportation bookings, therefore please contact them directly with any questions (see contact info below). To book a transfer, please do so via the online booking facility here.

Contact Name: Daniela Jiménez
Contact Telephone: +52 (998) 881 9587 Ext. 4245
Contact Email: dajimene@amstardmc.com

Private Airport Transfers

Private Transportation prices to and from Cancun International Airport and to and from the Fiesta Americana Condesa hotel are as follows:

Number of Passengers	Price (One Way, Per Vehicle)	Price (Return Trip, Per Vehicle)
1 - 3 Passengers plus luggage	$39.00 USD	$77.00 USD
4 - 7 Passenger plus luggage	$44.00 USD	$85.00 USD
8 - 10 Passengers plus luggage	$53.00 USD	$103.00 USD

Note: Prices do not include gratuity.

Includes:
- Private van with bilingual driver.
- Amenities on arrival (bottled water per person).

If your flight is delayed or your wait at immigration is more than 45 minutes, please contact Amstar as soon as you can to keep them updated with your situation. It’s important Amstar are informed of any delays as soon as you are made aware so the transfer can be rescheduled. Note: If you wish to cancel your transfer, please inform Amstar at least 72 hours in advance otherwise full cancellation charges will apply. If you fail to inform Amstar of any amendments to your travel schedule and consequently do not turn up at the date and time booked, full cancellation charges will apply for no shows.

Upon arrival at the airport, please exit the terminal building and look for ‘Fusion Conferences’ signage where a member of the Amstar team will greet you and escort you to the vehicle. For departures, please wait in the hotel lobby at your requested pick-up time where your driver will meet you.

For arrival transfers and round-trip transfers, payment has to be made online at the time of booking. For return transfers, payment can be made online at the time of booking or at the Amstar Transfers desk during the conference via card or cash (USD or MXN).

For frequently asked questions please take a look at the FAQ section on the Amstar website.

To make a booking with Amstar Transfers, please follow this link to access the online booking facility. If you have any questions for Amstar Transfers, please contact them directly.

Contact Name: Daniela Jiménez
Contact Telephone: +52 (998) 881 9587 Ext. 4245
Contact Email: dajimene@amstardmc.com

IMPORTANT: PLEASE PRINT YOUR CONFIRMATION OR CONFIRMATION NUMBER AND BRING IT WITH YOU.

** Please note Fusion Conferences accept no responsibility for any bookings made with Amstar Transfers or any other transportation supplier **

Shared Shuttle Service

The Amstar Shuttle is a shared service with other Amstar guests and may include 3-4 stops before reaching the Fiesta Americana Condesa. This service operates for flights arriving at Cancun Airport between 7:00am - 17:00pm EST and for flights departing Cancun Airport between 7:00am - 18:00pm EST from the 07^th February until 08^th March 2018.

Shared Transportation prices to and from Cancun International Airport and to and from the Fiesta Americana Condesa hotel are as follows:

Price (One Way, Per Person)	Price (Return Trip, Per Person)
$10.00 USD	$20.00 USD

Note: Prices do not include gratuity.

Includes:
- Shared transfer with non-group participants from nearby resorts.
- Just a few stops en route to the Fiesta Americana Condesa.
- Comfortable, fully air-conditioned vehicle.

Please note that the shared shuttle operates for flights arriving at Cancun Airport between 7:00am - 17:00pm EST and for flights departing Cancun Airport between 7:00am - 18:00pm EST. If your flight times fall outside of the shuttle schedule, you will need to opt for a private transfer.

Amstar will monitor your flight arrival information and adjust your pick-up time accordingly in the event of a delay. Should you change your inbound or outbound flight for any reason, please ensure you inform Amstar of the changes so they monitor the correct flight. Note: If you wish to cancel your place on the shuttle, please inform Amstar at least 72 hours in advance otherwise full cancellation charges will apply. Full cancellation charges will apply for no shows.

Upon arrival at the airport, please exit the terminal building and look for ‘Amstar’ signage where a member of the Amstar team will greet you and escort you to the vehicle. For departures, please wait in the hotel lobby at your requested pick-up time where your driver will meet you.

For frequently asked questions please take a look at the FAQ section on the Amstar website.

IMPORTANT: PLEASE PRINT YOUR CONFIRMATION OR CONFIRMATION NUMBER AND BRING IT WITH YOU.

** Please note Fusion Conferences accept no responsibility for any bookings made with Amstar Transfers or any other transportation supplier **

Taxis

If you do not wish to make a reservation in advance and would prefer to take a taxi upon arrival at the airport, or from the hotel, please check that the vehicle and driver are licensed and be vigilant at all times. If you are unsure about the driver or if the vehicle is unmarked, wait until another taxi becomes available or telephone Amstar to see if they can immediately send a car.

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3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Local Activities

Details will be available at a later date.

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3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Group Activities

We have arranged three exciting group activities for the 2018 DRRSC participants. This is a great opportunity to socialise with fellow colleagues outside of the conference whilst taking in the beautiful natural sights of Mexico. Please find details, timings and prices for the activities below. The activities are either scheduled pre or post conference, or during free time between sessions. Please carefully check the date and timings of each activity before signing up.

Tulum Trip – Sunday 11^th February 2018

Tulum is located 78 miles South of Cancun, about a 1:45 minute drive. It was discovered by John Stephens in 1842. Perched on top of a cliff facing the Caribbean Sea, it is the only entirely walled-in group of Mayan ruins ever discovered. Under the advice of an official English speaking tour guide, the group will go around the structures getting the history and spirit of the Mayan.

Price: $63.00
*please note prices do not include gratuity.

Includes:
-Air-conditioned vehicle
-Beverages on board: Soft drinks, bottled water (Estimated: 3 drinks per person)
-Individual bags of dry snacks on board
-Official Tourism Guides English/Spanish
-Admission fee in Tulum
-Round train transportation from Tulum parking lot to the archaeological zone.
-T.I. Escorts
-Tax

Itinerary for Sunday 11^th February 2018:
08:50 Participants ready at the hotel lobby
09:00 Depart from hotel
10:45 Estimated arrival to Tulum
11:00 – 13:00 Guided Tour / Free Time
13:15 Depart from Tulum
15:00 Estimated arrival to Hotel (At the very latest)

*Minimum of 10 people required*

Please note that sign-ups are required by Monday 15^th January, please contact sarah@fusion-conferences.com if you’d like to participate. Payment for the trip is required pre-conference, more details will be provided after signing up. Note this is a non-refundable fee should you later change your mind and decide not to participate.

Snorkel Trip – Tuesday 13^th February 2018

Departing from Aquaworld marina we take you on a motor boat to Punta Nizuc reef area where you disembark to the floating platform. Here you adorn your snorkel gear and you’re ready to take the plunge and snorkel as long as you like in the crystal clear turquoise waters.

Price: $57.00 per person (adult)
Price: $36.00 per person (child 4-10 years)
*please note prices do not include gratuity.

Includes:
-Travel through the lagoon and mangrove channels
-Snorkel guided tours
-Full snorkel equipment with a new tube as a gift
-Beer, sodas and bottled water
-Docking fee

Itinerary for Tuesday 13^th February 2018:
12:40 Walk to Aquaworld Marina from hotel (10-15 mins, across the road from hotel)
13:00 Boat trip from Aquaworld Marina
13:45 Snorkelling
15:00 Return boat trip from Snorkelling
15:45 Walk from Aquaworld Marina to hotel

*Minimum of 10 people required*

Chichen Itzá Trip – Friday 16^th February 2018

Chichén Itzá, recently nominated one of the new 7^th Wonders of the World. Chichén Itzá is located 125 miles West of Cancun about 2:15 hrs. It is the most visited archaeological site on the Peninsula, famed for its extraordinary architectural beauty.

Price: $140 per person
*please note price does not include gratuity

Includes:
-Air-conditioned vehicles
-Beverages on board: Soft drinks, water
-Individual bags of dry snacks on board
-Official Tourism Guides English/Spanish
-Admission fee at Chichen Itza
-Reserved Area at the restaurant
-Buffet lunch (2 beverages included)
-Typical Regional dances during lunch (by local people – not professional at no additional cost)
-Signs for the vehicles
-T.I. Escorts
-Federal Tax

Note: All food and beverages a la carte is subject to 10% TI Administrative Fee

Itinerary for Friday 16^th February 2018:
08.20 Participants ready at hotel lobby
08.30 Depart from Hotel
11:00 Estimated arrival to Chichen Itza
11:15 - 13:00 Guided visit of the Archaeological Site
13:15 Depart for Restaurant
13:30 - 14:30 Lunch
14:45 Board the vehicle
17:30 Estimated return to hotel

*Minimum of 5 people required*

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If you're interested in sponsoring this conference please contact us.

3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Childcare

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If you're interested in sponsoring this conference please contact us.

3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Oral Presenters

We have a number of oral opportunities available at this meeting. To be considered for a talk, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Please take note of the oral submission deadline: 08 September 2017.

Please check the conference programme carefully to note your presentation time (inclusive of Q&A) should you be accepted for an oral presentation. We recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference page.

Your Presentation on the Day

If you have prepared some slides to accompany your talk please ensure you bring these with you on a USB or portable file saving device.

For those presenting on the first day, please email your slides to us so we can have everything prepared and ready for the first session. Please email your slides to: admin@fusion-conferences.com

On the day of your presentation please make yourself known to the AV team who will be available in the conference room. If you have any animations or videos we do advise to run through the presentation with the AV tech to make sure everything is compatible. We also advise that all speakers make themselves known to the AV tech in the conference room immediately before your session beings. The AV tech will apply your microphone and provide a laser pointer should you have an accompanying presentation. We prefer speakers to use our master laptop to run presentations from, however, if you prefer to use your own laptop, please notify us in advance.

It is important that all speakers adhere to their presentation time and respect their fellow presenters. A visual traffic light aide will be available to warn presenters and the audience as your time decreases.

If you have any questions, please don’t hesitate to approach our AV tech or a member of the Fusion team.

Helpful Tips for Presentation Slides

Aspect Ratio: On Screen Show (16:9) and in Landscape Orientation.
File Type: Please save your presentation in PPT, PPTS or Keynote format.
Video Clips: Please save these separately and do not build them into the presentation. Videos will be played via the AV control desk using the master laptop or Mac.

Download Abstract Template

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If you're interested in sponsoring this conference please contact us.

3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Posters

We have a number of poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Please take note of the late-breaking poster submission deadline: 30 November 2017.

Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.

Displaying & Presenting Your Poster

During conference registration if you are presenting a poster please request a poster number from the registration desk. Please do not put up your poster without notifying a member of the Fusion team. Certain adhesive agents are not permitted at some venues therefore; Fusion will be the sole provider of all poster fixings.

You can display your poster from registration. Your poster can remain on display for the entire duration of the conference and we ask that posters are taken down on the final day of the meeting. The poster session is usually scheduled on Day 3, but please check the official programme for exact timings. Refreshments will be provided and the poster prizes will be awarded during the conference Gala Night that evening.

Self Introductions

Discussions are at the heart of this conference. We are therefore asking each poster presenter to give a 1minute self-introduction on Sunday 11^th February. We wish to ensure that your face as well as your interests and efforts are known to the other participants so they may find you for discussions during the meeting. You should use this time to pitch your poster to the other conference attendees.

Here is what you should be prepared for Sunday night.

You will be grouped into one of two groups; each group will be called to the front of the room and presenters will be called to the mic in alphabetical order by the flash coordinators. Note only 1minute is allocated to each person, therefore, please try to keep your introduction as concise as possible following the format below.

Self Introduction Format

Your name and your PI's laboratory (if you are not the PI), your institute, your country.
What protein/system are you working on?
What is your question?
What techniques did you use?
Title of poster, note poster number (will be provided by Fusion at registration).
What would you like to learn from others at this conference or get feedback on?
Where can someone interested in talking with you find you? On the beach, at the bar, in the lobby, or in the poster room.

Slide Format

Please ensure your slide is the following size; widescreen (16:9). We will be merging slides and if you use alternative formatting, the contents of your slide will be distorted. Animations are not permitted. A slide template can be found here.

2018 DRRSC Poster Prize

The conference chairs will be awarding several cash poster prizes for the best poster presentations. To be in with a chance of winning, submit your poster by 30 November 2017. The winners will be selected shortly after the Poster Session and the prizes awarded at the Gala Dinner. Good luck!

Download Abstract Template

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3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs

Conference History

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This conference will focus on insights into dynamic DNA and RNA complexes involved in the damage response and cancer. It will emphasize informal as well as formal discussions together with informative talks and...

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3^rd DNA Replication/Repair Structures and Cancer Conference

Fiesta Americana Condesa, Cancun, Mexico

16 Feb 2020, 20 Feb 2020

4^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20

Melia Nassau Beach All Inclusive, Nassau, Bahamas

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate DNA repair in the context of oncogene-induced replication stress and elevated transcription. Intertwined roles of repair with replica...

27 Apr 2022, 01 May 2022

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

Fiesta Americana Condesa Cancun All Inclusive, Cancun, Mexico

Future master keys to cancer biology and advanced therapies are being forged from mechanistic understanding of the intertwined roles of DNA repair with DNA replication stress, transcription and immune responses. The remarkable stability of the hum...

14 Feb 2024, 18 Feb 2024

6^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC24

Fiesta Americana Condesa Cancun All Inclusive, Cancun, Mexico

Important fundamental breakthroughs in cancer biology have come from the basic research discovery that defects in the tumor suppressor and DNA repair genes BRCA1/2 genes predispose to breast, ovarian, prostate, and pancreatic cancers. Furthermore,...

Supported By

Diamond

Gold

Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

3^rd DNA Replication/Repair Structures and Cancer Conference

11 Feb 2018 - 15 Feb 2018

Cancun, Mexico

Chairs