Registration deadlines
Early Bird - 26 May 2025
Talk Submission - 26 Aug 2025
Poster Submission - 25 Nov 2025
Registration Deadline - 25 Nov 2025
Register24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
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Register by 26 May 2025 to take advantage of our Super Early Bird fees, saving $250 from the single standard price!
This is a transformative time in cancer research and its impacts on advanced therapies. Basic knowledge of DNA Damage Reponses (DDR) and their functional integration with the therapeutically relevant immune responses are fundamentally advancing cancer biology and medicine. Besides being classified by tissue origins, cancers are increasingly being understood at the cellular and molecular level, allowing effective targeting with synthetic lethality for precision oncology. Precision therapies offer the potential for enhanced efficacy with reduced toxicities but come with the major challenge of preexisting or developed resistance. Clinically, most of the resistance to DDR inhibitors arises from the restoration of DNA repair pathways through reversion mutants or rewiring the DDR network. It is increasingly clear that DDR regulation and repair pathway choices drive therapeutic sensitivity and resistance responses. These findings underscore the critical need to develop actionable structural and mechanistic knowledge, spanning from nanoscale of individual enzymes to the mesoscale of regulated protein-complexes and their network responses.
Recent breakthroughs in experimental methodologies (particularly cryo electron microscopy, electron tomography, mass spectrometry, X-ray scattering, and single-molecule biophysical techniques) have enabled the studies of increasingly complex and dynamic biological systems. These cutting-edge tools enable the integration of in vitro and in situ studies to reveal the detailed mechanisms underpinning cellular processes. Furthermore, the rapid evolution of artificial intelligence (AI) and its expanding applications in structural and mechanistic investigations are driving the field toward the integration of atomic-level structural data with physiological outputs. These advances present game-changing opportunities that enable us to tackle increasingly complex and challenging scientific problems, while also requiring fresh approaches.
The 7th DNA Replication/Repair Structures & Cancer Conference (7th DRRSC) on 24-28 February 2026 will bring together scientists from diverse fields to exchange cutting-edge research findings and stimulate new ideas and approaches to address the critical challenges in cancer research. Furthermore, due to the current challenging funding landscape, it is critical to form partnerships of creative talent to address large-scale problems efficiently. The meeting is designed to optimize opportunities for productive discussion, interaction, and collaboration. Conference talks and discussions will center on developing actionable mechanistic knowledge of DNA replication, transcription and repair stress responses and their inflammation impacts suitable to guide cancer research and intervention. A focus will be on leveraging the synthetic lethality concept for DDR defects. Talks will include emerging basic and clinical findings, cutting-edge trans-disciplinary methodologies and structural and mechanistic insights for dynamic complexes. The vibrant discussions and exchange of ideas will catalyze productive collaborations and offer new insights that will support research both within and between individual labs as well as across the broader scientific community.
Professor Ben Van Houten from the University of Pittsburgh says: “I can honestly say your meeting, by combining hard core structure-function studies with beautiful biology, hits an important area that many meetings miss; being part of that science is just terrific.”
Professor John Tainer from the University of Texas MD Anderson Cancer Centre says: “Most participants contribute unpublished data and powerful discussions that identify and fill knowledge gaps with game-changing insights that make me want to stand up and cheer.”
Johannes Walter (Havard University)
COPING WITH OBSTACLES DURING DNA REPLICATION
Joanna Loizou (Institute of Cancer Research)
Katharina Schlacher (MDACC)
David Barford (University of Cambridge)
UNDERSTANDING KINETOCHORE MECHANISMS FROM STRUCTURES OF IN VITRO-RECONSTITUTED COMPLEXES AND cryo-ET OF NATIVE COMPLEXES
Simon Boulton (Francis Crick Institute)
Karlene Cimprich (Stanford University)
NEW MECHANISMS FOR THE MAINTENANCE OF GENOME STABILITY AT THE REPLICATION FORK
Francesca Citron (MDACC)
WRAD MOONLIGHTING: A DANCE BETWEEN CHROMATIN REMODELERS AND DNA REPLICATION
Brandt Eichman (Vanderbilt University)
MECHANISMS OF REPLICATION FORK REVERSAL
Karl-Peter Hopfner (University of Munich)
Maira Jasin (Memorial Sloan Kettering Cancer Center)
Susan Lees-Miller (University of Calgary)
Georges Mer (Mayo Clinic)
MECHANISMS OF UBIQUITIN SIGNALING IN DNA DAMAGE REPAIR
Lori Passmore (University of Cambridge)
MECHANISTIC STUDIES OF DNA CROSSLINK REPAIR
Anna Pluciennik (Thomas Jefferson University)
CROSSTALK BETWEEN DNA REPAIR SYSTEMS IN GENOME INSTABILITY
Eli Rothenberg (New York University)
Jessica Tyler (Weill Cornell Medicine)
Bennett Van Houten (University of Pittsburgh)
Helen Walden (University of Glasglow)
TARGETTING USP1-UAF1 ACTIVITY IN THE FANCONI ANEMIA PATHWAY
Steve West (Francis Crick Institute)
DNA REPAIR PROTEINS: STRUCTURES AND FUNCTIONS
Scott Williams (NIH)
STRUCTURE AND FUNCTION OF DNA HELICASES REGULATING NEURODEGENERATIVE DISEASE AND VIRAL REPLICATION
Gijs Wuite (Vrije Universiteit Amsterdam)
UNRAVELLING THE MECHANICS AND STRUCTURE OF WHOLE MITOTIC CHROMOSOMES
Ruiming Xu (Institute of Biophysics)
MECHANISM OF REPLICATION-COUPLED RETROELEMENT INSERTION
Wei Yang (NIH)
Timothy Yap (MDACC)
NOVEL CLINICAL STRATEGIES IN TARGETING SYNTHETIC LETHALITY: CURRENT SUCCESSES AND CHALLENGES
Xiaolan Zhao (Memorial Sloan Kettering Cancer Center)
REGULATION OF RECOMBINATION INTERMEDIATES
24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
Chairs
Joanna Loizou
Institute of Cancer Research
Katharina Schlacher
MDACC
Johannes Walter
Havard University
David Barford
University of Cambridge
Simon Boulton
Francis Crick Institute
Karlene Cimprich
Stanford University
Francesca Citron
MDACC
Brandt Eichman
Vanderbilt University
Karl-Peter Hopfner
University of Munich
Maira Jasin
Memorial Sloan Kettering Cancer Center
Susan Lees-Miller
University of Calgary
Georges Mer
Mayo Clinic
Lori Passmore
University of Cambridge
Anna Pluciennik
Thomas Jefferson University
Eli Rothenberg
New York University
Jessica Tyler
Weill Cornell Medicine
Bennett Van Houten
University of Pittsburgh
Helen Walden
University of Glasglow
Steve West
Francis Crick Institute
Scott Williams
NIH
Gijs Wuite
Vrije Universiteit Amsterdam
Ruiming Xu
Institute of Biophysics
Wei Yang
NIH
Timothy Yap
MDACC
Xiaolan Zhao
Memorial Sloan Kettering Cancer Center
24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
Chairs
Although the programme has not yet been released, we are able to confirm that the main conference programme should begin no earlier than 14:00 with opening comments on Tuesday 24 February 2026. The conference will conclude no later than 12:30 on Saturday 28 February 2026.
24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
Chairs
| Ticket Type | Early Bird | Full Price |
|---|---|---|
|
Single
Choose this option if you will be attending the conference alone, or if you will bring accompanying guests that will not attend the meeting.
|
$2650 | $2900 |
|
Shared
Choose this option if you wish to share with a colleague who is also attending the conference, or if you wish to be paired with another attendee of the same sex.
|
$2195 | $2446 |
|
Student
Choose this option if you are a student. Please note all students will be paired with another attendee of the same sex if a room sharer is not specified. If you wish to have your own room, please register under the Single option.
|
$1550 | $1550 |
Adult
$1201
Child
$357
Adult
$415
Child
$84
Register by 26 May 2025 to take advantage of our Super Early Bird fees, saving $250 from the single standard price!
Our registration fees are inclusive of the following at SLS Playa Mujeres during the conference period only:
- Conference registration.
- 4 nights’ fixed accommodation (24, 25, 26, 27 Feb 2026) on a single or shared basis in a Delight King or Queen room.
- Breakfast, lunch and dinner available at restaurants according to their operational hours.
- Unlimited alcoholic beverages, cocktails and soft drinks available at restaurants and bars according to their operational hours.
- Daily coffee breaks.
- Gala dinner with an open bar.
- Room service.
- In-room minibar replenished daily with drinks.
- Complimentary WIFI throughout the hotel.
Our accompanying adult fees are inclusive of the following at SLS Playa Mujeres during the conference period only:
- 4 nights’ fixed accommodation (24, 25, 26, 27 Feb 2026) on a shared basis with a conference participant in a Delight King or Queen room.
- Breakfast, lunch and dinner available at restaurants according to their operational hours.
- Unlimited alcoholic beverages, cocktails and soft drinks available at restaurants and bars according to their operational hours.
- Gala dinner with an open bar.
- Room service.
- In-room minibar replenished daily with drinks.
- Complimentary WIFI throughout the hotel.
Important Note: Accompanying guests are not permitted access to the conference.
Our accompanying child fees are inclusive of the following at SLS Playa Mujeres during the conference period only:
- 4 nights’ fixed accommodation (24, 25, 26, 27 Feb 2026) on a shared basis with the parent/s in a Delight King or Queen room, maximum capacity 4 adults per room.
- Breakfast, lunch and dinner available at restaurants according to their operational hours.
- Unlimited soft drinks available at restaurants and bars according to their operational hours.
- Gala dinner with soft drinks.
- Complimentary WIFI throughout the hotel.
Important Note: Accompanying child fees are applicable for children aged 4-11 years. Children 3 years or younger stay free of charge with a parent. Children aged 12 years and older are classified as an adult at this venue (SLS Playa Mujeres). Please kindly ensure your child / children are supervised at all times during conference and related events. Childcare services are available at the hotel, please contact Felicity for further information.
Our extra night fees are inclusive of the following at SLS Playa Mujeres:
- 1 night’s accommodation for 1 person in a Delight King or Twin room.
- Breakfast, lunch and dinner available at restaurants according to their operational hours.
- Unlimited alcoholic beverages, cocktails and soft drinks available at restaurants and bars according to their operational hours.
- Room service.
- In-room minibar replenished daily with drinks.
- Complimentary WIFI throughout the hotel.
Important Note: If you wish to extend your stay more than 1 night pre/post conference, this is possible to book via Fusion, but please contact Felicity for assistance and prices. Extra night child fees are applicable for children aged 4-11 years. Children 3 years or younger stay free of charge with a parent. Children aged 12 years and older are classified as an adult at this venue (SLS Playa Mujeres).
Prices and hotel availability are subject to change without notice.
24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
Chairs
We have two grant offers available for early career reseachers, see below for more information!
We have 20 x $500 registration grants available to help defray the meeting costs for early career researchers. If you are a student, postdoc or junior faculty (within 3 years of your position), you are eligible. These grants will be applied to the first 20 early career researchers that register providing you have included an abstract for consideration for a talk or poster.
We have a limited number of $1,000 registration grants available to help defray the meeting costs for early career researchers. If you are a student, postdoc or junior faculty (within 3 years of your position), you are eligible. To apply please email the conference manager, Felicity Harrap.
Your application should include your name, organisation, career level, an abstract for consideration for a talk or poster, and a short summary answering the below questions (no more than 50-100 words per question).
• What cutting edge aspects of your work will you share at the meeting?
• Why do you require financial support to attend?
• How will attending 7DRRSC benefit your research and career?
Deadline for applications: 26 August 2025. Successful applicants will be informed shortly following the deadline.
24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
Chairs
24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
Chairs
The DNA Research Network is an excellent platform to connect with fellow attendees and likeminded researchers prior to the conference.
The Linkedin Group is designed to bring together the global community of researchers and scientists interested in the study of DNA. Relevant specialties are wide-ranging, reflecting the importance of DNA Research in many aspects of health and disease, including; DNA Repair, DNA Replication, DNA Damage, Cancer, Chromosomal Instability, RNA and Nucleic Acids. The group is open to all and is intended as a networking forum for past, present and future participants of Fusion Conferences as well as those interested in the related topics.
24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
Chairs
SLS Playa Mujeres is a luxury all-inclusive resort located in the beautiful Playa Mujeres area near Cancun, Mexico. The newly built hotel has a contemporary design and an upscale/chic atmosphere. The hotel features stylish and spacious accommodation, offering modern amenities and private balconies. Guests can enjoy a range of gourmet dining options, activities and facilities within the all-inclusive package including; 4 swimming pools, a secluded private beach, 18 bars/restaurants, 24 hour room service, kids and teens club, outdoor adventure course and splash zone, fitness centre, group fitness classes and non-motorized water sports.
Venue Rating
Currency
US Dollar (USD)
Address
Supermanzana 3 Manzana 1, 77400 Cancún, Quintana Roo, Mexico
Nearest Airport
Cancun International Airport
Hotel Facilities
18 restaurants/bars
4 swimming pools
Private beach
Water park
Non-motorized watersports
Daily resort activities
Kids/teens club
Nightly entertainment
24 hour room service
Fitness center
Mexico is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.
Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.
24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
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Cancun International Airport is approximately 35 minutes from SLS Playa Mujeres. Unlike other airports, Cancun airport transfer services must be pre-arranged. To obtain safe, licensed and bilingual transportation services please ensure you book your arrival and return transportation online with an authorised transportation company prior to your arrival to ensure a smooth journey without delays.
If you wish to share a return transfer to the airport then we would suggest waiting and organising this on-site at the hotel. The hotel have registered taxis readily available, you simply need to speak to the concierge on the day of your departure (approx $56 to Cancun International Airport). This will allow attendees to share return transfers with others who have similar flight times.
There are many alternative transportation companies operating in the Cancun area who will be able to provide a quotation for your trip. The following companies are well reviewed on Trip Advisor and quotations can be obtained and bookings can be made directly via their websites.
Amstar
Transportation is the sole responsibility of the delegate. Please ensure you conduct your own research and double check your booking details ahead of your arrival. Fusion Conferences are unable to assist with or confirm transportation bookings due to insurance limitations. Thank you for your understanding.
24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
Chairs
Please come back soon for further information regarding local activities.
24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
Chairs
Please come back soon for further information regarding group activities.
24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
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24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
Chairs
We have several oral opportunities available at this meeting. To be considered for a talk, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.
If you are unable to register for the conference for any reason, but still wish to submit an abstract for consideration, please email the Conference Manager directly.
Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.
If you are accepted for a talk, we recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference website.
On the day of your presentation please make yourself known to our AV technician who will be present in the conference room. We advise running through your presentation at least 30minutes prior to your session commencing to ensure your slides and any videos or animations appear as expected. We prefer our speakers to run their presentation from the master PC or Mac, however, if you prefer to use your own laptop then please notify us prior to the session. A HDMI or VGA cable is usually available on the podium.
Our AV technician will apply your microphone and provide a combined slide advancer and laser pointer.
We ask all speakers to adhere to their time slots and respect their fellow presenters. A visual traffic light aide will be available to warn presenters as their time decreases.
Please make sure your presentation adheres to the following guidelines.
Aspect Ratio: On Screen Show (16:9)
File Type: Please save your presentation in PPT, PPTS or Keynote format.
24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
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We have several poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.
Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.
Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.
Please bring your poster to registration and hand this to a member of the Fusion team. They will advise of your poster number and display your poster for you.
Your poster will remain on display for the duration of the conference, allowing presenters to take advantage of the refreshment breaks and free time for valuable networking opportunities, in addition to the official poster session.
Please check the programme and note the date and time of the poster session(s). Your poster will be judged during the poster session and prizes will be awarded at the Gala Dinner.
Posters will be taken down by the Fusion team and will be ready for collection at the Fusion desk on the final day of the conference.
Download Abstract Template24 Feb 2026 - 28 Feb 2026
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Playa Mujeres, Mexico
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12 Feb 2014, 15 Feb 2014
Fiesta Americana Condesa, Cancun, Mexico
Key sessions will include: DNA and RNA complexes Chromatin Remodeling Post-translational modifications - Ub, SUMO kinases The repair interface with Replication Transcription, and Recomb...
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This conference will focus on insights into dynamic DNA and RNA complexes involved in the damage response and cancer. It will emphasize informal as well as formal discussions together with informative talks and...
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The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a...
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16 Feb 2020, 20 Feb 2020
#DRRSC20
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The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate DNA repair in the context of oncogene-induced replication stress and elevated transcription. Intertwined roles of repair with replica...
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27 Apr 2022, 01 May 2022
#DRRSC22
Fiesta Americana Condesa Cancun All Inclusive, Cancun, Mexico
Future master keys to cancer biology and advanced therapies are being forged from mechanistic understanding of the intertwined roles of DNA repair with DNA replication stress, transcription and immune responses. The remarkable stability of the hum...
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14 Feb 2024, 18 Feb 2024
#DRRSC24
Fiesta Americana Condesa Cancun All Inclusive, Cancun, Mexico
Important fundamental breakthroughs in cancer biology have come from the basic research discovery that defects in the tumor suppressor and DNA repair genes BRCA1/2 genes predispose to breast, ovarian, prostate, and pancreatic cancers. Furthermore,...
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24 Feb 2026, 28 Feb 2026
#DRRSC26
SLS Playa Mujeres, Playa Mujeres, Mexico
Register by 26 May 2025 to take advantage of our Super Early Bird fees, saving $250 from the single standard price! This is a transformative time in cancer research and its impacts on advanced therapies. Basic ...
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If you are interested in this meeting but not yet ready to register, you can sign up for updates here and our team will keep you updated regarding deadline reminders and grant opportunities relating to this meeting only.
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