Programme
Thursday 12th February 2015 |
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12:00 – 15:00 |
Registration |
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13:00 -14:15 |
Welcome Lunch |
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Repair pathway choices and therapeutic outcomes (1) |
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15:30 – 15:45 |
Opening Speech |
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15:45 – 16:30 |
Andre Nussenzweig National Institutes of Health |
TUMOR PROMOTING ROLE OF THE DNA DAMAGE RESPONSE |
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16:30 – 17:00 |
Barry Sleckman |
TARGETING ABERRANT DNA DOUBLE STRAND BREAK REPAIR IN G1-PHASE CELLS |
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17:00 – 17:30 |
David Ferguson |
THE MRN COMPLEX AS A POTENTIAL TARGET FOR CANCER THERAPY |
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17:30 – 18:00 |
Refreshments |
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Repair pathway choices and therapeutic outcomes (2) |
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18:00 – 18:30 |
Simon Powell |
BACK-UP PATHWAYS FOR BRCA1-BRCA2 MEDIATED HOMOLOGOUS RECOMBINATION |
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18:30 – 19:00 |
Junjie Chen |
MULTIPLE REPAIR PATHWAYS DETERMINE THERAPEUTIC OUTCOMES |
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19:00 – 19:30 |
Roger Greenberg |
GENETIC INTERACTIONS WITHIN THE BRCA TUMOR SUPPRESSOR NETWORK |
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19:30 – 20:00 |
Ralph Scully |
RECOMBINATION CONTROL BY BRCA1 AND BRCA2 AT STALLED MAMMALIAN REPLICATION FORKS: OPPORTUNITIES FOR THERAPY |
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20:00 – 20:15 |
Richard Pomerantz |
TARGETED KILLING OF BRCA DEFICIENT CELLS BY A SMALL-MOLECULE INHIBITOR OF RAD52 |
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20:15 – 20:30 |
Panel Discussion PM |
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20:30 |
Dinner at Leisure & Free Time |
Friday 13th February 2015 |
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07:00 -08:30 |
Breakfast |
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Emerging therapeutic targets and clinical trials for cancer therapy |
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08:30 – 09:15 |
Thomas Helleday |
TARGETING MTH1 FOR TREATMENT OF CANCER
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09:15 – 09:45 |
Wolf-Dietrich Heyer |
RECOMBINATIONAL DNA REPAIR: FROM BASIC MECHANISM TO CANCER THERAPY |
09:45 – 10:15 |
Philip Connell |
DEVELOPMENT OF RAD51-MODULATING COMPOUNDS AS POTENTIAL ONCOLOGY DRUGS |
10:15 – 10:45 |
Robert W. Sobol |
TARGETING ADP-RIBOSYLATION PROTEINS IN GLIOMA STEM CELLS |
10:45 -11:00 |
Kent W Mouw Dana-Farber Cancer Institute |
ERCC2 MUTATIONS CONFER LOSS OF NUCLEOTIDE EXCISION REPAIR CAPACITY AND PREDICT RESPONSE TO CISPLATIN-BASED CHEMOTHERAPY IN UROTHELIAL CARCINOMA |
11:00 – 11:15 |
Refreshments |
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11:15 – 11:45 |
Jorge Reis-Filho |
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11:45 – 12:15 |
Henning Willers |
TARGETING DNA DOUBLE-STRAND BREAK INDUCTION AND REPAIR IN |
12:15 – 12:30 |
Bernd Kaina |
SURVIVAL AND DEATH STRATEGIES OF GLIOMA AND MALIGNANT MELANOMA CELLS EXPOSED TO ALKYLATING ANTICANCER DRUGS |
12:30 – 12:45 |
Panel Discussion AM |
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12:45 – 16:00 |
Lunch at Leisure & Free Time |
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Multiple targets and cellular processes involved in cancer development and treatment |
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16:00 – 16:30 |
Tanya Paull |
REGULATION OF SAE2 AND CTIP ACTIVITY THROUGH PHOSPHORYLATION
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16:30 – 17:00 |
Binghui Shen |
ALPHA-SEGMENT ERROR EDITING BY THE MAMMALIAN FEN1/MUTSΑ FUNCTIONAL COMPLEX
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17:00 – 17:15 |
Katharina Schlacher |
RECRUITMENT OF 53BP1 FOR REPLICATION FORK RESTART AND STABILITY DEPENDS UPON A PHOSPHATASE-INDEPENDENT PTEN ACTIVITY |
17:15 – 17:30 |
Gregory C. Stachelek |
ARYL SULFONAMIDES ARE A NOVEL CLASS OF HOMOLOGY-DEPENDENT DNA REPAIR INHIBITORS WITH ANTINEOPLASTIC ACTIVITY |
17:30 – 18:00 |
Susana Gonzalo |
VITAMIN D RECEPTOR MODULATES DNA REPAIR: IMPLICATIONS FOR BREAST CANCER AND PROGERIA |
18:00 – 18:30 |
Refreshments |
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18:30 – 19:15 |
Giulio Draetta |
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19:15 – 19:45 |
Kyle Miller |
ATM LINKS ENDOGENOUS OXIDATIVE STRESS TO TUMOR PROMOTION |
19:45 – 20:00 |
Srividya Bhaskara |
HISTONE DEACETYLASES 1,2: GUARDIANS OF GENOME STABILITY
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20:00 – 20:15 |
Sergio Ruiz CNIO |
REPLICATIVE STRESS DURING SOMATIC CELL REPROGRAMMING |
20:15 – 20:30 |
Panel Discussion PM |
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20:30 |
Dinner at Leisure & Free Time |
Saturday 14th February 2015 |
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07:00 – 08:30 |
Breakfast |
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Current and potential therapeutic targets in DNA repair pathways |
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08:30 – 09:15 |
John Tainer |
ZEROING IN ON MASTER KEYS TO EXCEPTIONAL RESPONDERS FOR CANCERS |
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09:15 – 09:45 |
Jean Gautier |
Mechanisms of MYC-driven genomic instability |
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09:45 – 10:00 |
Bipasha Mukherjee |
Inhibition of DNA Double-Strand Break Repair by A Dual PI3K/mTOR Inhibitor as a Strategy for Radiosensitization of Glioblastoma
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10:00 – 10:30 |
Zhongsheng You |
COORDINATED REGULATION OF EXO1 IN DNA END RESECTION AND ITS IMPLICATIONS IN CANCER THERAPY |
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10:30 – 10:45 |
Anand Jeyasekharan Cancer Science Institute of Singapore |
BRCA2-RAD51 NUCLEAR EXPORT; FROM MOLECULAR MECHANISM TO A BIOMARKER OF HOMOLOGOUS RECOMBINATION DEFICIENCY |
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10:45 – 11:00 |
Sharon Cantor |
A NOVEL MECHANISM OF THERAPY RESISTANCE IN BRCA2-MUTANT CELLS |
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11:00 – 11:30 |
Refreshments |
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11:30 – 12:00 |
Karen Knudsen |
TARGETING HORMONE-DNA REPAIR CROSSTALK IN PROSTATE CANCER: MECHANISMS AND IMPLICATIONS FOR THERAPEUTIC INTERVENTION |
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12:00 – 12:30 |
Bill Plunkett |
MECHANISM-BASED THERAPEUTIC STRATEGY TO TARGET A RECURRENT GENETIC LESION IN THE HOMOLOGOUS RECOMBINATION REPAIR PATHWAY |
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12:30 – 12:45 |
Panel Discussion |
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12:45 – 16:30 |
Lunch at Leisure & Free Time |
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Checkpoint kinases as therapeutic targets |
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16:30 – 17:00 |
Helen Piwnica-Worms |
DNA DAMAGE, CHECKPOINT SIGNALING AND THERAPEUTIC OPPORTUNITIES |
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17:00 – 17:30 |
Eric Brown |
ATR INHIBITION AS A BROAD SPECTRM CANCER THERAPY TARGETED BY COMMON CANCER-ASSOCIATED MUTATIONS |
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17:30 – 18:00 |
Lee Zou |
ALTERNATIVE LENGTHENING OF TELOMERES RENDERS CANCER CELLS HYPERSENSITIVE TO ATR INHIBITORS |
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18:00 – 18:15 |
Xuetong Shen |
REGULATION OF KEY CHECKPOINT KINASES BY ATP-DEPENDENT CHROMATIN REMODELING COMPLEXES – NOVEL PATHWAYS TO TARGET IN CANCER
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18:15 – 18:45 |
Christopher Bakkenist |
INHIBITION OF ATR KINASE ACTIVITY FOR THE TREATMENT OF LUNG CANCER |
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18:45 – 19:00 |
Panel Discussion |
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19:00 – 20:00 |
Poster Session & Cocktails |
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20:15 – 23:00 |
Gala Night, Group Photo & Poster Awards *Lower Pool Deck* |
Sunday 15th February 2015 |
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07:00 -08:30 |
Breakfast |
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DNA double-strand repair pathways in response to anti-cancer therapies (1) |
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08:30 – 09:15 |
Maria Jasin |
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09:15 -09:45 |
Xiaochun Yu |
NOVEL POLY(ADP-RIBOSE) BINDING DOMAINS AND POLY(ADP-RIBOSE)-DEPENDENT SIGNAL TRANSDUCTION |
09:45 – 10:15 |
Jeffrey Parvin |
BRCA1, 53BP1, AND SUMO FACTORS IN DNA DOUBLE-STRAND BREAK REPAIR |
10:15 – 10:45 |
Jac Nickoloff |
METNASE AND EEPD1: TWO NUCLEASES THAT REGULATE DSB REPAIR, REPLICATION STRESS RESPONSES AND GENOME STABILITY
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10:45 – 11:15 |
Refreshments |
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DNA double-strand repair pathways in response to anti-cancer therapies (2) |
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11:15 – 11:30 |
Junran Zhang |
RNF126 PROMOTES HOMOLOGOUS RECOMBINATION VIA REGULATING E2F1-MEDIATED BRCA1 EXPRESSION |
11:30 – 11:45 |
Markus Löbrich |
NEK1 PHOSPHORYLATES RAD54 TO PROMOTE HOMOLOGOUS RECOMBINATION |
11:45 – 12:00 |
Tomasz Skorski Temple University School of Medicine |
GENE EXPRESSION AND MUTATION ANALYSIS (GEMA) –GUIDED PRECISION MEDICINE TARGETING PARP1 TO INDUCE SYNTHETIC LETHALITY IN DNA-PK –DEFICIENT QUIESCENT AND BRCA -DEFICIENT PROLIFERATING LEUKEMIA STEM AND PROGENITOR CELLS |
12:00 – 12:15 |
Panel Discussion |
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12:15 – 12:30 |
Closing Remarks |