Programme
MONDAY 27TH FEBRUARY 2017 |
||
14:00 – 14:45 |
Registration & Reception |
|
14:00 – 14:45 |
Welcome Lunch |
|
14:45 – 15:00 |
Opening Comments |
|
MECHANISMS OF GENOME MAINTENANCE |
||
15:00 – 15:30 |
Karlene Cimprich |
WHEN RNA MEETS DNA: DANGEROUS LIAISONS IN THE GENOME |
15:30 – 16:00 |
Jean Gautier |
MOVING DNA DOUBLE-STRAND BREAKS |
16:00 – 16:30 |
Dipanjan Chowdhury |
TIRR MASKS THE HISTONE METHYL-LYSINE BINDING FUNCTION OF 53BP1 TO REGULATE ITS ACTIVITY |
16:30 – 17:00 |
Jingsong Yuan |
RPA-BINDING PROTEIN ETAA1 PARTICIPATES IN THE ACTIVATION OF ATR SIGNALING PATHWAY IN RESPONSE TO DNA REPLICATION STRESS |
17:00 – 17:30 |
Lorraine Symington |
DNA END RESECTION AND REPAIR PATHWAY CHOICE |
17:30 – 18:00 |
Refreshments |
|
18:00 – 18:30 |
Zhenkun Lou |
UFMYLATION SIGNALLING IN THE DNA DAMAGE RESPONSE |
18:30 – 18:45 |
Nima Mosammaparast Washington University in St. Louis |
A UBIQUITIN-DEPENDENT SIGNALING AXIS SPECIFIC FOR ALKYLATION DAMAGE REPAIR |
18:45 – 19:00 |
Wei Zhang |
SELECTIVE MODULATION OF HUMAN E3 LIGASES AND DEUBIQUITINASES FOR CANCER THERAPY BY ENGINEERED UBIQUITIN VARIANTS |
19:00 – 19:30 |
Robert A Hromas |
THE ENDONUCLEASE EEPD1 IS A GATEKEEPER FOR 5’ END RESECTION FOR HOMOLOGOUS RECOMBINATION AND RESCUE OF STRESSED REPLICATION FORKS |
19:30 – 19:45 |
Eli Rothenberg New York University School of Medicine |
SPATIOTEMPORAL DYNAMICS OF THE INTERNAL ORGANIZATION OF INDIVIDUAL DSB REPAIR FOCI |
19:45 – 20:15 |
Yinsheng Wang UC Riverside |
POST-TRANSLATIONAL REGULATIONS OF REPAIR OF INTERSTRAND CROSS-LINK LESIONS AND DNA DOUBLE-STRAND BREAKS |
20:15 |
Dinner at Leisure |
TUESDAY 28TH FEBRUARY 2017 |
||
07:00 – 08:30 |
Breakfast *Kalmia Buffet Restaurant* |
|
EMERGING CONCEPTS IN TARGETED THERAPIES |
||
08:30 – 09:00 |
Mark J OConnor |
EXPLOITING CANCER REPLICATION STRESS USING PHARMACOLOGICAL INHIBITORS OF ATR AND WEE1 |
09:00– 09:30 |
Akihiro Ohashi Takeda |
A NOVEL CDC7-SELECTIVE INHIBITOR TAK-931 WITH POTENT ANTITUMOR ACTIVITY |
09:30 – 10:00 |
Giulio Draetta |
CRITICAL VULNERABILITIES OF PANCREATIC CANCER CELL SUBPOPULATIONS
|
10:00 – 10:45 |
Refreshments & Group Photo |
|
10:45 – 11:15 |
Lauren Averett Byers |
TARGETING DNA DAMAGE RESPONSE (DDR) FOR THE TREATMENT OF LUNG CANCER
|
11:15 – 11:30 |
Laura Butler |
POTENT AND SELECTIVE ATR INHIBITORS FOR THE TREATMENT OF HOMOLOGOUS-RECOMBINATION DEFICIENT AND PARPi-RESISTANT CANCERS |
11:30 – 12:00 |
Philip Hinds |
TARGETING SENESCENCE AS A TUMOR PROMOTER IN CELLS WITH DEFECTIVE DDR OR REPLICATION STRESS |
12:00 – 12:15 |
Naoaki Fujii
|
DISCOVERY OF SMALL MOLECULE INHIBITORS TARGETING THE TRANSLESION DNA SYNTHESIS MACHINERY |
12:15 – 16:15 |
Lunch at Leisure & Free Time |
|
CLINICAL EXPLORATION OF DEFECTS IN DNA DAMAGE CHECKPOINT AND DNA REPAIR |
||
16:15 – 16:45 |
Elizabeth Swisher |
DNA THERAPIES FOR OVARIAN CANCER AND PREDICTORS OF RESPONSE AND RESISTANCE |
16:45 – 17:15 |
Yi Fan University of Pennsylvania |
DNA-PK-MEDIATED THERAPY RESISTANCE IN CANCER STEM CELLS |
17:15 – 17:45 |
Shridar Ganesan |
PROTEIN (LYSINE) METHYLTRANSFERASES G9A AND GLP1 PROMOTE RESPONSES TO DNA DAMAGE |
17:45 – 18:15 |
Guang Peng
|
DYSFUNCTIONAL UBIQUITINATION PROCESS GENERATES A THERAPEUTIC VULNERABILITY IN ARID1A-DEFICIENT CANCERS FOR DNA DAMAGE CHECKPOINT INHIBITORS |
18:15 – 18:45 |
Mien-Chie Hung |
MARKER-GUIDED COMBINATION THERAPY WITH PARP INHIBITORS |
18:45 – 19:30 |
Poster Session & Refreshments |
|
19:30 |
Dinner at Leisure |
WEDNESDAY 1ST MARCH 2017 |
||
07:00 – 08:30 |
Breakfast *Kalmia Buffet Restaurant* |
|
CHROMATIN BIOLOGY AND DNA DAMAGE RESPONSE |
||
08:30 – 09:00 |
Michelle Barton |
TRIM24: AN INTERSECTION BETWEEN P53 REGULATION AND EPIGENETIC FUNCTION |
09:00 – 09:15 |
Sudhakar Jha |
ROLE OF RVBS IN MAINTAINING TIP60.COM’S OPTIMAL ACTIVITY FOR DNA DAMAGE RESPONSE |
09:15 – 09:45 |
Brendan Price |
CHROMATIN DYNAMICS, EPIGENETICS AND THE REPAIR OF DNA BREAKS |
09:45 – 10:15 |
Refreshments |
|
10:15 – 10:30 |
David Yu |
EXPLOITING A NOVEL ROLE FOR SAMHD1 IN DNA END RESECTION FOR DISCRIMINATING RADIATION VS CHEMOTHERAPY RESISTANCE FOR PERSONALIZING CANCER THERAPY |
10:30 – 11:00 |
Jac A. Nickoloff |
NUCLEASES AND SIGNALING PATHWAYS IN REPLICATION STRESS RESPONSES |
11:00 – 11:30 |
Jos Jonkers |
GENETIC DISSECTION OF TUMOR DEVELOPMENT, THERAPY RESPONSE AND RESISTANCE IN MOUSE MODELS OF BRCA-DEFICIENT BREAST CANCER |
11:30 – 12:00 |
Kyungjae Myung |
A NOVEL CHEMOTHERAPEUTIC AGENT TO TREAT TUMORS WITH DNA MISMATCH REPAIR DEFICIENCIES |
12:00 – 16:15 |
Lunch at Leisure & Free Time |
|
ARISING TOPICS IN GENOME MAINTENANCE |
||
16:15 – 16:45 |
Richard Wood |
DNA POLYMERASES WITH DISTINCT MECHANISMS FOR MAINTAINING CHROMOSOME STABILITY
|
16:45 – 17:00 |
Richard Pomerantz |
DNA POLYMERASE Θ SPECIALIZES IN INCORPORATING SYNTHETIC EXPANDED-SIZE (XDNA) NUCLEOTIDES |
17:00 – 17:30 |
Daniel Durocher |
PROSPECTIVE IDENTIFICATION OF VULNERABILITIES TO DNA REPAIR INHIBITORS |
17:30 – 18:00 |
Reuben Harris |
MUTAGENESIS BY APOBEC3 ENZYMES IN CANCER |
18:00 – 18:30 |
Matthew Weitzman |
APOBEC3A SENSITIZES CANCER CELLS TO CHECKPOINT INHIBITORS |
18:30 – 18:45 |
Katharina Schlacher |
TP53 PROMOTES GENOMIC STABILITY AND REPLICATION PATHWAY HOMEOSTASIS BY EPIGENETICS-ENABLED MRE11 REPLICATION RESTART |
18:45 – 19:00 |
Ranjit Bindra |
ONCOMETABOLITES INDUCE A BRCANESS STATE THAT CAN BE EXPLOITED BY PARP INHIBITORS |
19:00 – 20:00 |
Poster Session & Refreshments |
|
20:15 |
*Gala Dinner & Poster Awards* |
THURSDAY 2ND MARCH 2017 |
||
07:00 – 08:30 |
Breakfast *Kalmia Buffet Restaurant* |
|
DEVELOPING IDEAS IN CANCER TREATMENT |
||
08:30 – 09:00 |
Chuan-Yuan Li |
DNA DOUBLE STRAND BREAKS INDUCED BY SUBLETHAL ACTIVATION OF APOPTOTIC CASPASES AND THEIR ROLES IN CARCINOGENESIS AND TUMOUR GROWTH |
09:00 – 09:30 |
Chris Bakkenist University of Pittsburg |
DNA DAMAGE SIGNALING TO IMMUNE CHECKPOINTS |
09:30 – 10:00 |
Yves Pommier |
TOPOISOMERASE CLEAVAGE COMPLEXES AND GENOMIC STABILITY |
10:00 – 10:30 |
Refreshments |
|
10:30 – 11:00 |
Fen Xia |
IONIZING RADIATION-INDUCED SYNTHETIC LETHALITY OF PARP INHIBITION IN BRCA1-PROFICIENT CANCER CELLS DEPENDS ON P53 |
11:00 – 11:30 |
Eric A. Hendrickson |
THE ROLES OF DNA LIGASES IN CHROMOSOMAL TRANSLOCATIONS AND TELOMERE FUSIONS |
11:30 – 11:45 |
Olimpia Alessandra Buoninfante |
A NOVEL SYNTHETIC LETHALITY IN THE DDT NETWORK: STRATEGIES FOR PRECISION CANCER THERAPY |
11:45 – 12:00 |
Closing Comments |