2 nd &nbsp;Dynamic DNA and RNA Structures in Damage Responses &amp; Cancer Conference

Synopsis

This conference will focus on insights into dynamic DNA and RNA complexes involved in the damage response and cancer. It will emphasize informal as well as formal discussions together with informative talks and poster sessions. DNA repair is a target for advanced cancer interventions. DNA repair systems are also essential for preventing carcinogenesis. The 2016 conference will focus on dynamic complexes and the control of biological outcomes relevant to cancer biology and the development of new therapeutic targets and strategies. Talks will include highlights on damage responses including cutting-edge structural and single-molecule approaches to characterize damage recognition, ribonucleotide repair, non-coding RNAs, the inflammation – damage connection, and epigenetics in the repair responses.

Key Sessions

Key sessions will include emerging results and breakthrough methods concerning:

DNA and RNA complexes
Chromatin Remodeling
Post-translational modifications
Interface of repair with Replication, Transcription and Recombination
RNA responses to damage
Pathway selection & cross-talk
Damage signaling and processing
DNA repair and disease

Confirmed Speakers

Walter Chazin (Vanderbilt)
'WHAT ARE THOSE Fe-S CLUSTERS DOING?'

Wei Yang (NIH)
'ENZYME CATALYSIS BY A HIT-AND-RUN METAL ION'

Lorena S. Beese (Duke University Medical Center)

Susan Lees-miller (University of Calgary)
'APLF IS INTRINSICALLY FLEXIBLE AND STABILIZES AN EXTENDED FUNCTIONAL CORE COMPLEX FOR EFFICIENT NON-HOMOLOGOUS END JOINING'

Magnar Bjorås (Oslo University Hospital)
'MODULATING BEHAVIOR BY OXIDATIVE DNA BASE LESION REPAIR'

Tom Ellenberger (Washington University in St. Louis)
'TARGETING POLY(ADP-RIBOSE) TURNOVER FOR CANCER THERAPY'

Sheila David (UC Davis)
'MUTYH, CHEMISTRY AND CANCER: IT’S ALL ABOUT THE BASE'

Bennett Van Houten (University of Pittsburgh and Carnegie Mellon University)
'SINGLE MOLECULE ANALYSIS OF DNA REPAIR ENZYMES REVEALS A NOVEL “RECOGNITION AT DISTANCE” MECHANISM'

Stephen West (The Francis Crick Institute)
'ACTIVATION OF MUS81 STRUCTURE-SELECTIVE ENDONUCLEASE BY FORMATION OF THE SMX COMPLEX'

Dorothy Erie (University of North Carolina)
'CHARACTERIZATOIN OF THE ASSEMBLY OF MUTS AND MUTL HOMOLOGS AT A MISMATCH'

Titia de Lange (The Rockefeller University)
'CHROMOTHRIPSIS FROM TELOMERE FUSIONS'

Karl-Peter Hopfner (Ludwig-Maximilians-University Munich)
'STRUCTURAL MECHANISM OF ATP-DEPENDENT DNA BINDING AND DNA END JOINING BY EUKARYOTIC Rad50'

Jessica Downs (University of Sussex)
'PROTECTIVE PACKAGING FOR DNA: THE ROLE OF THE PBAF AND INO80 CHROMATIN REMODELLING COMPLEXES IN MAINTAINING GENOME STABILITY'

Jean-Baptiste Charbonnier (Institute of Integrated Biology of the Cell)
'PIVOTAL ROLES OF MUTL HOMOLOGS IN DNA REPAIR AND RECOMBINATION'

Dale Wigley (Imperial College London)
'STRUCTURE AND MECHANISM OF ADDAB AND RECBCD COMPLEXES'

Titia Sixma (Netherlands Cancer Institute)
'SNAPSHOTS OF DNA MISMATCH REPAIR: TRAPPING TRANSIENT STATES'

Samir Hamdan (King Abdullah University of Science and Technology)
'PROBABILISTIC ACTIVE SITE ASSEMBLY CONTROLS CATALYTIC SELECTIVITY IN HUMAN FLAP ENDONUCLEASE-1'

Takashi Ochi (University of Cambridge)
'SCAFFOLDS WITH STRINGS ATTACHED OF MULTI-PROTEIN ASSEMBLIES IN NON-HOMOLOGOUS END JOINING'

Steve Smerdon (Medical Research Council)
'THE MOLECULAR BASIS OF Nbs1-Mdc1 INTERACTIONS – NEW TRICKS FOR OLD DOGS!'

Terence Strick (University of Paris – Diderot)
'CORRELATIVE SINGLE-MOLECULE ANALYSIS OF DYNAMIC COMPLEXES IN DNA REPAIR'

Mark Glover (University of Alberta)
'MECHANISM OF RNF8 STIMULATION OF Ubc13 AND ROLE IN DNA DAMAGE SIGNALING'

Ilya Finkelstein (UT-Austin)
'SINGLE-MOLECULE VIEWS OF EUKARYOTIC DNA MISMATCH REPAIR'

Aidan Doherty (University of Sussex)
'UNRAVELING THE ROLES OF PRIMASE-POLYMERASES IN DNA REPLICATION AND REPAIR'

Supported By

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

Speakers

Invited Speakers

Wei Yang

Section Chief, National Institutes of Health

Walter Chazin

Founding Director- Center for Structural Biology, Vanderbilt University

Sheila David

Professor of Chemistry, University of California, Davis

Ben Van Houten

Richard M. Cyert Professor of Molecular Oncology, UPMC Hillman Cancer Center

Jessica Downs

Professor, Genome Damage and Stability Centre

Magnar BjÃ¸rÃ¥s

Professor, Oslo University Hospital

Susan Lees-Miller

Professor, University of Calgary

Jean-Baptiste Charbonnier

Team Leader, CEA-CNRS-Univ Paris Saclay, France

Dorothy Erie

Professor, University of North Carolina

Tom Ellenberger

Professor, Washington University School of Medicine

Titia Sixma

Group leader, Netherlands Cancer Institute

Samir Hamdan

Assistant Professor of Bioscience, King Abdullah University of Science and Technology

Steve Smerdon

Programme Leader, The Francis Crick Institute, UK

Steve West

Senior Group Leader, Francis Crick Institute

Titia de Lange

Leon Hess Professor, The Rockefeller University

Karl-Peter Hopfner

Professor, Gene Center

Mark Glover

Professor, University of Alberta

Terence Strick

Research Director, Ecole normale supÃ©rieure/CNRS

Dale Wigley

Professor, Imperial College London

Takashi Ochi

Research Associate, University of Cambridge

Aidan Doherty

Professor of Biochemistry, University of Sussex

Lorena Beese

Professor, Duke University Medical Center

Ilya Finkelstein

Associate Professor, UT-Austin

Supported By

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

Programme

DISCUSSION IS VALUED: 5 MINUTES IS SAVED FOR DISCUSSION AFTER EACH TALK

Monday 22^nd February 2016
14:00 – 14:45	Registration
14:00 – 14:45	Group Welcome Lunch Kalmia Buffet Restaurant
HOMOLOGOUS RECOMBINATION INTERACTIONS Session Chair: John Tainer
14:45 – 15:00	Welcome and Opening Remarks by Tom Blundell & John Tainer
15:00 – 15:20	Stephen West Francis Crick Institute	ACTIVATION OF MUS81 STRUCTURE-SELECTIVE ENDONUCLEASE BY FORMATION OF THE SMX COMPLEX
15:25 – 15:45	Priscilla K Cooper Lawrence Berkeley National Laboratory	XPG PARTNERS WITH BRCA1 AND BRCA2 IN HOMOLOGOUS RECOMBINATION TO MAINTAIN GENOME STABILITY
15:50 – 16:00	Kara Bernstein University of Pittsburgh	THE CONCERTED FUNCTION OF THE SHU COMPLEX AND THE RAD51 PARALOGS IN RAD51 PRESYNAPTIC ASSEMBLY
16:05 – 16:15	Christian Biertuempfel Max Planck Institute of Biochemistry	HUMAN HOLLIDAY JUNCTION RESOLVASE GEN1 USES A CHROMODOMAIN FOR EFFICIENT DNA RECOGNITION AND CLEAVAGE
16:20 – 16:40	Dale Wigley Imperial College London	STRUCTURE AND MECHANISM OF ADDAB AND RECBCD COMPLEXES
16:45 – 17:15	Refreshments and Poster Set Up
17:15 – 17:35	Karl-Peter Hopfner Gene Center	STRUCTURAL MECHANISM OF ATP-DEPENDENT DNA BINDING AND DNA END JOINING BY EUKARYOTIC Rad50
17:40 – 18:00	Steve Smerdon Francis Crick Institute	THE MOLECULAR BASIS OF Nbs1-Mdc1 INTERACTIONS – NEW TRICKS FOR OLD DOGS!
18:05 – 18:15	Yaron Galanty Gurdon Institute, University of Cambridge	SYSTEMATIC E2 SCREENING REVEALS A UBE2D-RNF138-CtIP AXIS PROMOTING DNA REPAIR
18:20 – 18:30	Aaron Alt University of Sussex	STRUCTURE AND FUNCTION OF THE CHROMATIN TARGETING DOMAIN OF ONCOGENE CHD5
18:35 – 18:45	Christos Coucoravas Karolinska Institutet	ROLE OF SPECIFIC NON-CODING RNAS IN DNA DOUBLE-STRAND BREAK REPAIR
18:50 – 19:00	General Discussion Moderators: Susan Lees-Miller and John Tainer
19:00 – 19:45	Poster Highlights Moderators: Susan Tsutakawa and David Finger 2 minute presentations per poster presenter
19:45	Dinner at Leisure

Tuesday 23^rd February 2016
07:00 – 08:30	Breakfast
BREAK REPAIR Session Chair: Tom Blundell
08:30 – 08:40	Tom Blundell University of Cambridge	Opening Comments
08:40 – 09:00	Susan Lees-Miller University of Calgary	APLF IS INTRINSICALLY FLEXIBLE AND STABILIZES AN EXTENDED FUNCTIONAL CORE COMPLEX FOR EFFICIENT NON-HOMOLOGOUS END JOINING
09:05 – 09:15	Anthony Davis UT Southwestern Medical Center	PHOSPHORYLATION OF Ku70 (OR SIMPLY Ku) DICTATES DNA DOUBLE-STRAND BREAK REPAIR PATHWAY CHOICE IN S PHASE
09:20 – 09:40	Takashi Ochi University of Cambridge	SCAFFOLDS WITH STRINGS ATTACHED OF MULTI-PROTEIN ASSEMBLIES IN NON-HOMOLOGOUS END JOINING
09:45 – 10:05	Tom Blundell University of Cambridge	NON-HOMOLOGOUS END JOINING IN SPACE AND TIME: SCAFFOLDS, STRINGS AND STAGES
10:10 – 10:30	Jean-Baptiste Charbonnier CEA-CNRS-Univ Paris Saclay, France	PIVOTAL ROLES OF MUTL HOMOLOGS IN DNA REPAIR AND RECOMBINATION
10:35 – 11:05	Refreshments and Informal Poster Viewing
11:05 – 11:25	Aidan Doherty University of Sussex	UNRAVELING THE ROLES OF PRIMASE-POLYMERASES IN DNA REPLICATION AND REPAIR
11:30 – 11:40	Marcus Wilson Lunenfeld-Tanenbaum Research Institute	STRUCTURAL BASIS FOR 53BP1 RECRUITMENT TO DNA DOUBLE-STRAND BREAKS
11:45 – 11:55	Alba Guarne McMaster University	A NOVEL NON-CANONICAL FHA DOMAIN-BINDING INTERFACE MEDIATES THE INTERACTION BETWEEN RAD53 AND DBF4 PROTEINS
12:00 – 12:10	Luxin Sun University of Alberta	STRUCTURAL INSIGHT INTO BLM RECOGNITION BY TOPBP1 IN MAINTENANCE OF GENOME STABILITY
12:15 – 12:35	Mark Glover University of Alberta	MECHANISM OF RNF8 STIMULATION OF Ubc13 AND ROLE IN DNA DAMAGE SIGNALING
12:40 – 12:50	General Discussion Moderators: Tom Blundell and Magnar Bjørås
12:50 – 16:00	Lunch at Leisure & Free Time
THE DAMAGE RESPONSE: TRANSCRIPTION, REPLICATION, AND CHROMOSOME DYNAMICS Session Chair: Priscilla Cooper
16:00 – 16:10	Priscilla K Cooper Lawrence Berkeley National Laboratory	Opening Comments
16:10 – 16:30	Yuan He Northwestern University	STRUCTURAL BASIS OF EUKARYOTIC TRANSCRIPTION PROMOTER OPENING AT NEAR-ATOMIC RESOLUTION
16:35 – 16:45	Ivaylo Ivanov Georgia State University	INTEGRATIVE MODELING OF MACROMOLECULAR ASSEMBLIES FROM LOW TO NEAR-ATOMIC RESOLUTION
16:50 – 17:00	Sylvie Doublié University of Vermont	WHEN THE (3) END JUSTIFIES THE MEANS OR HOW A FAMILY A POLYMERASE SOLVES A MAJOR CHALLENGE
17:05 – 17:25	Jessica Downs Genome Damage and Stability Centre	PROTECTIVE PACKAGING FOR DNA: THE ROLE OF THE PBAF AND INO80 CHROMATIN REMODELLING COMPLEXES IN MAINTAINING GENOME STABILITY
17:30 – 18:10	Refreshments and Informal Poster Viewing
18:10 – 18:20	Julia Reinert Friedrich Miescher Institute	THE N-TERMINAL DOMAIN ENCIRCLES DNA TO ANCHOR YEAST RIF1 TO TELOMERIC AND NON-TELOMERIC DNA ENDS
18:25 – 18:45	Titia de Lange The Rockefeller University	CHROMOTHRIPSIS FROM TELOMERE FUSIONS
18:50 – 19:00	General Discussion Moderators: Priscilla Cooper and Karl-Peter Hopfner
19:00 – 20:30	Poster Session, Cocktails & Refreshments
20:30	Dinner at Leisure

Wednesday 24^th February 2016
07:00 – 08:30	Breakfast
CATALYSIS AND DYNAMICS Session Chair: Jane Grasby
08:30 – 08:40	Jane Grasby University of Sheffield	Opening Comments
08:40 – 09:00	Wei Yang National Institutes of Health	ENZYME CATALYSIS BY A HIT-AND-RUN METAL ION
09:05 – 09:15	Piero Bianco University at Buffalo	THE ROLES OF SSB AND RecG IN STALLED DNA REPLICATION FORK RESCUE IN E.COLI
09:20 – 09:40	Walter Chazin Vanderbilt University	WHAT ARE THOSE Fe-S CLUSTERS DOING?
09:45 – 09:55	Elizabeth OBrien California Institute of Technology	A REDOX DNA-BINDING SWITCH IN THE [4FE4S] DOMAIN OF HUMAN DNA PRIMASE REGULATES ACTIVITY
10:00 – 10:10	David Rueda Imperial College London	ACTIVATION-INDUCED DEOXYCYTIDINE DEAMINASE (AID) CO-TRANSCRIPTIONAL SCANNING AT SINGLE-MOLECULE RESOLUTION
10:15 – 10:45	Refreshments and Informal Poster Viewing
10:45 – 11:05	Terence Strick CNRS/Institut Jacques Monod	CORRELATIVE SINGLE-MOLECULE ANALYSIS OF DYNAMIC COMPLEXES IN DNA REPAIR
11:10 – 11:30	Bennett Van Houten University of Pittsburgh Cancer Institute	SINGLE MOLECULE ANALYSIS OF DNA REPAIR ENZYMES REVEALS A NOVEL “RECOGNITION AT DISTANCE” MECHANISM
11:35 – 11:45	Emily Beckwitt University of Pittsburgh School of Medicine	SINGLE MOLECULE STUDIES OF XPA ON DNA
11:50 – 12:10	Samir Hamdan King Abdullah University of Science and Technology	PROBABILISTIC ACTIVE SITE ASSEMBLY CONTROLS CATALYTIC SELECTIVITY IN HUMAN FLAP ENDONUCLEASE-1
12:15 – 12:25	General Discussion Moderators: Jane Grasby and Brandt Eichman
12:25 – 16:00	Lunch at Leisure & Free Time
MISMATCH AND EXCISION REPAIR Session Chair: Sylvie Doublié
16:00 – 16:10	Sylvie Doublié University of Vermont	Opening Comments
16:10 – 16:30	Dorothy Erie University of North Carolina	CHARACTERIZATOIN OF THE ASSEMBLY OF MUTS AND MUTL HOMOLOGS AT A MISMATCH
16:35 – 16:55	Titia Sixma Netherlands Cancer Institute	SNAPSHOTS OF DNA MISMATCH REPAIR: TRAPPING TRANSIENT STATES
17:00 – 17:20	Lorena Beese Duke University Medical Center	MMR AND EXOI FUNCTIONAL CONFORMATIONS
17:25 – 17:35	Susan Tsutakawa Lawrence Berkeley National Laboratory	MEASURE THRICE-CUT ONCE IN STRUCTURE SPECIFIC FLAP ENDONUCLEASE
17:40 – 18:10	Refreshments and Informal Poster Viewing
18:10 – 18:30	Ilya Finkelstein UT-Austin	SINGLE-MOLECULE VIEWS OF EUKARYOTIC DNA MISMATCH REPAIR
18:35 – 18:45	Brandt Eichman Vanderbilt University	GLYCOSYLASE RECOGNITION OF DNA DAMAGE WITHOUT BASE FLIPPING ENABLES BASE EXCISION REPAIR OF BULKY LESIONS
18:50 – 19:00	Luay Joudeh King Abdullah University of Science & Technology	DISSECTING THE STIMULATION OF FEN1 ACTIVITY BY PCNA ON FLAP SUBSTRATES AT THE SINGLE MOLECULE LEVEL
19:05 – 19:15	Jane Grasby University of Sheffield	CELLULAR ACTIVE N-HYDROXYUREA INHIBITORS OF HUMAN FLAP ENDONUCLEASE 1
19:20 – 19:30	General Discussion Moderators: Sylvie Doublié and Bennett Van Houten
20:00	Gala Dinner, Group Photo & Poster Awards Lower Pool Deck

Thursday 25^th February 2016
07:00 – 08:50	Breakfast
DNA DAMAGE, FUNCTIONAL FLEXIBILITY AND DISEASE Session Chair: Walter Chazin
08:50 – 09:00		Walter Chazin Vanderbilt University	Opening Comments
09:00 – 09:20		Tom Ellenberger Washington University School of Medicine	TARGETING POLY(ADP-RIBOSE) TURNOVER FOR CANCER THERAPY
09:25 – 09:35		France Carrier University of Maryland, Baltimore	THE HETEROGENOUS RIBONUCLEOPROTEIN A18 (hnRNP A18) PROMOTES TUMOR GROWTH BY INCREASING PROTEIN TRANSLATION OF SELECTED TRANSCRIPTS IN CANCER CELLS IN RESPONSE TO CELLULAR STRESS
09:40 – 09:50		Qian Wu University of Cambridge	STRUCTURE OF BRCA1-BRCT/ABRAXAS COMPLEX REVEALS PHOSPHORYLATION-DEPENDENT BRCT DIMERIZATION AT DNA DAMAGE SITES
09:55 – 10:15		Sheila David University of California, Davis	MUTYH, CHEMISTRY AND CANCER: IT’S ALL ABOUT THE BASE
10:20 – 10:50		Refreshments
10:50 – 11:00		Wilson Chun Yu Lau University of Hong Kong	MOLECULAR ARCHITECTURE OF THE Ub-PCNA/Pol η COMPLEX BOUND TO DNA
11:05 – 11:25		Magnar Bjørås Oslo University Hospital	MODULATING BEHAVIOR BY OXIDATIVE DNA BASE LESION REPAIR
11:30 – 11:50		John Tainer MD Anderson	THE RISE OF THE MACHINES
11:55 – 12:05		General Discussion Moderators: Walter Chazin and Tom Blundell
12:05 – 12:15		Closing Comments by Walter Chazin and Tom Blundell

Friday 26^th February 2016
08:15 – 17:30	Chichen-Itzá Group Tour For those wanting to extend their stay we have organised a private day trip to Chichen-Itzá. Full details can be found under the ‘Group Activities’ tab on the conference website.

Supported By

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

Prices

Ticket Type	Early Bird	Full Price
Single Choose this option if you will be attending the conference alone, or if you will bring accompanying guests that will not attend the meeting.	$1579	$1679
Shared Choose this option if you wish to share with a colleague who is also attending the conference, or if you wish to be paired with another attendee of the same sex.	$1579	$1679
Student Choose this option if you are a student. Please note all students will be paired with another attendee of the same sex if a room sharer is not specified. If you wish to have your own room, please register under the Single option.	$1193	$1293

Additional Person

This is the cost for an additional adult or child to join you in the same room, for the entire conference period. Accompanying persons are not permitted access to the conference. If you wish to extend your stay, please see our 'Extra night' prices.

Adult

$738

Child

$284

Extra nights

Prices are per person.

Adult

$270

Child

$71

All registration fees include 3 nights accommodation and meals during the conference period. Exact inclusions are detailed below.

Accompanying child fees and extra night child fees are applicable for children aged 5-12 years of age. Children aged 13 years and older are classified as an adult at the Fiesta Americana Condesa.

What's Included in our Registration Fees?

The Fiesta Americana Condesa, Cancun offers a 24hour all inclusive service. Our registration and additional adult/child fees are inclusive of the following;

- Accommodation for 3 Nights (22, 23, 24th February 2016)
- Breakfast, Lunch and Dinner – available at all restaurants according to operational hours or programmed events.
- International Bar available by the glass in restaurants and bars according to operational hours.
- Pool snacks and International Bar available by the glass at Pool Area
- Minibar including: soft drinks, domestic beer, bottled water and coffee. Refreshed daily
- 24 Hour Room Service
- In Room amenity – Bottle of wine, per room, per stay
- Gala Night Entry (includes an open bar)
- Complimentary WI-FI in guest rooms and conference rooms

Additional nights (per person) are inclusive of the following;

- Accommodation for 1 Night
- Lunch on day of arrival
- Dinner on day of arrival
- Breakfast on day of departure
- International bar available by the glass in restaurants and bars from lunch on day of arrival until breakfast on day of departure

Supported By

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

Grants

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

Supported By

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

Venue

Fiesta Americana Condesa

This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

Lagoon Pool
Extensive Health Club and Spa
Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas

The Fiesta Americana Condesa, Cancun is the 2015 Winner of the Trip Advisor Certificate of Excellence and also received the Travellers Choice Award in 2014.

The remains of ancient Mayan cities are scattered throughout the Yucatan Peninsula and no trip to Cancun would be complete without a visit to these majestic temples and pyramids set amongst lush tropical vegetation. We will be working very closely with a reputable tour company who will be organising trips to Tulum, Chichen Itza, Coba and Xcaret to name a few, some of which may require a full day. Full day excursions will be arranged pre or post conference and may be on an individual or group booking so we would recommend booking extra nights to extend your stay as early as possible to avoid disappointment should these excursions be of interest to you and/or your party. For further information please contact us.

Venue Rating

Currency

US Dollar (USD)

Address

Fiesta Americana Condesa, Blvd.KukulkÃ¡n km 16.5 Zona Hotelera, Cancun, 77500 Mexico

Nearest Airport

Cancun International Airport

Location

Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.

Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.

Supported By

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

http://www.tropicalincentives.com/form_gpos/sales/cancun/2016/fusion-conference/

Transportation

Travel Details

Cancun International airport is just a short 15 minute journey from the Fiesta Americana Condesa and is easily accessible from almost every country in the world with many major international airlines providing direct or interconnecting flights on a daily basis.

Airport Transfers

Tropical Incentives are a reputable and trustworthy DMC based in Cancun. The Tropical Incentives team will be on hand to provide a seamless transfer service to and from Cancun International Airport. Tropical Incentives will manage and confirm all transportation bookings. To arrange transportation please contact Tropical Incentives directly via email, phone or the online booking facility (see link below).

Conference Shuttle Service

Tropical Incentives have arranged a conference shuttle service which will run at scheduled times surrounding the conference. The conference shuttle schedule can be found below.

Arrivals (Cancun Airport – Fiesta Americana Condesa)

Sunday 21^st February – Available at 1pm, 3pm, 5pm and 6:30pm
Monday 22^nd February – Available at 1pm, 3pm, 5pm and 6:30pm
Wednesday 24^th February – Available at 1pm, 3pm, 5pm and 6:30pm
Thursday 25^th February – Available at 1pm, 3pm, 5pm and 6:30pm
Saturday 27^th February – Available at 1pm, 3pm, 5pm and 6:30pm
Sunday 28^th February – Available at 1pm, 3pm, 5pm and 6:30pm
Tuesday 1^st March – Available at 1pm, 3pm, 5pm and 6:30pm
Wednesday 2^nd March – Available at 1pm, 3pm, 5pm and 6:30pm
Friday 4^th March – Available at 1pm, 3pm, 5pm and 6:30pm
Saturday 5^th March – Available at 1pm, 3pm, 5pm and 6:30pm

Departures (Fiesta Americana Condesa – Cancun Airport)

Thursday 25^th February – Available at 9am, 11am, 1pm and 3pm
Friday 26^th February – Available at 9am, 11am, 1pm and 3pm
Sunday 28^th February – Available at 9am, 11am, 1pm and 3pm
Monday 29^th February – Available at 9am, 11am, 1pm and 3pm
Wednesday 2^nd March – Available at 9am, 11am, 1pm and 3pm
Thursday 3^rd March – Available at 9am, 11am, 1pm and 3pm
Saturday 5^th March – Available at 9am, 11am, 1pm and 3pm
Sunday 6^th March – Available at 9am, 11am, 1pm and 3pm
Tuesday 8^th March – Available at 9am, 11am, 1pm and 3pm
Wednesday 9^th March – Available at 9am, 11am, 1pm and 3pm

$25 per person, each way (includes taxes)

Please allow at least 45minutes from your flight landing time to the shuttle departure time. In the event of any delays or cancellations, please ensure you contact Tropical Incentives at least 24hours in advance; if Tropical Incentives are not informed within 24hours full cancellation charges will apply.

Upon arrival at the airport, please exit the terminal building and look for ‘Fusion Conferences’ signage where a member of Tropical Incentives team will greet you and escort you to the group transportation.

Please contact Tropical Incentives directly to enquire or make a booking.

Group booking Code: Fusion
Contact: Francisco Mora
Telephone: 998-193-3940 ext 158
Email: guestservices@ticancun.com

Private Transportation

Tropical Incentives also offer a private transfer service for those travelling outside of the available shuttle dates/times mentioned above. The private transfer service vehicles can accommodate a maximum of 6 persons, plus luggage.

$75 per vehicle, each way (includes taxes)

In the event of any delays or cancellations, please ensure you contact Tropical Incentives at least 24hours in advance; if Tropical Incentives are not informed within 24hours full cancellation charges will apply.

Upon arrival at the airport, please exit the terminal building and look for ‘Fusion Conferences’ signage where a member of Tropical Incentives team will greet you and escort you to your transportation.

Please contact Tropical Incentives directly to enquire or make a booking.

Group booking Code: Fusion
Contact: Francisco Mora
Telephone: 998-193-3940 ext 158
Email: guestservices@ticancun.com

** Please note that Fusion Conferences is not responsible for any bookings made with Tropical Incentives as transportation is not included in the registration package **

Supported By

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

http://www.tropicalincentives.com/form_gpos/sales/cancun/2016/fusion-conference/

Local Activities

Half Day Activities

Tropical Incentives are a reputable and reliable company offering a variety of fascinating trips and excursions for either a half or full day. To make an enquiry please contact Francisco Mora at Tropical Incentives or alternatively, if you would like to proceed with a booking (individual/group) please follow the link below which will take you directly to an online booking facility giving details of tours available.

Contact: Francisco Mora
Email: guestservices@ticancun.com

Our half day tours can be booked during the conference period between the available free times scheduled in the programme. The half day tours are available to both individual and group bookings.

The following activities are available at Aquaworld which is based in the Marina directly opposite the Fiesta Americana Condesa hotel and therefore no transportation is necessary.

Aquatwister

Experience Aquaworld’s ultimate tour adventure on board a high speed jet boat ride, Aquatwister. This is a roller coaster of manoeuvres orchestrated by a highly skilled captain and drivers on board and provides an amazing combination of nature, emotion, fun and adrenaline in one adventure.

Duration: 30 minutes
Please be at the marina 30 minutes in advance of activity.
Capacity: 20 persons per boat
Price: $69.60 per person
Dock fee: $8 (cash)
Gratuity: $5

Inclusive of:
Lockers, Life jackets and bottled water

Sky Ridder

Live this exciting experience flying in couples over the Caribbean Sea and experiencing an amazing aerial view.

Duration: 30-40 minutes includes 10 minute flying time at an altitude of 100mtrs
Please be at the Aquaworld hut (located by the hotel pool) 15 minutes in advance of activity.
Capacity: Maximum 8 person per boat
Price: $63.80 per couple
Gratuity: $5

Inclusive of:
10 minutes flying time, life jackets and bottled water

*Bathing suit, towel, shorts, T-shirts, sandals or wet shoes, sunglasses and water camera recommended.
*Service charge of $5 for any lost locker keys
*Biodegradable suntan lotion is only permitted on the reef

Jungle Tour

Enjoy this fascinating adventure, driving a Jet Ski boat for 2 persons through the mangroves of Nichupte Lagoon, explore the wonders of Cancun’s jungle and the exotic wild life and admire the colourful sea life while you snorkel at one of the greatest coral reefs in Punta Nizuc.

Duration: 2:30 hrs. (45 minutes each way driving and 40 minutes for snorkelling)
Please be at the marina 30 minutes in advance of activity.
Capacity: 2 persons per boat
Price: $69.60 (Single persons would pay full boat rate)
Dock Fee and Reef tax: $11 (cash)
Gratuity: $5

Inclusive of:
1x Guide per 10 persons
Aquaray speed boat for 2 persons
Snorkel Equipment (new snorkelling gear, life vest, mask, fins)
Jungle Tour
Dressing Room, Showers and Lockers
Bottled water
TI Staff present

*Bathing suit, towel, shorts, T-shirts, sandals or wet shoes, sunglasses and water camera recommended.
*Biodegradable suntan lotion is only permitted on the reef

Wave Runner

Drive and Speed on board of a 700 Yamaha wave runner across the Caribbean Sea.

Duration: 30 minutes
Please be at the Aquaworld hut (located by the hotel pool) 15 minutes in advance of activity.
Price: $63.80 (Single persons would pay full boat rate)
Gratuity: $5

Inclusive of:
1 Guide per 10 persons
Life jackets and lockers
Bottled water

*Bathing suit, towel, shorts, T-shirts, sandals or wet shoes, sunglasses and water camera recommended.
**Biodegradable suntan lotion is only permitted on the reef**

Sub See

An extraordinary way to admire the marine life and the reef’s ecosystem without getting wet! Be part of this unique adventure on board The Sub See Explorer, a glass bottom boat like a yellow submarine with huge glass panels on the sides, from where you will be able to watch the multi-coloured species of the Scorpion´s coral reef.

Duration: 2 hrs.
Please be at the marina 30 minutes in advance of activity
Capacity: Boat can hold 66 passengers
Price: $46.40 per person
Dock Fee and Reef tax: $10
Gratuity: $5

Inclusive of:
Boat transportation on board of Reef Express
Specialized Guides
Beverages (Beer, Soft Drinks and water)
Bottled Water
TI Staff present

*Bathing suit, towel, shorts, T-shirts, sandals or wet shoes, sunglasses and water camera recommended.
**Biodegradable suntan lotion is only permitted on the reef**

Full Day Activities

To make an enquiry or booking (individual/group), please contact Francisco Mora at Tropical Incentives.

Francisco Mora
Email: guestservices@ticancun.com

A Tropical Incentive representative will also be available during the conference period at the hotel, so should you have any questions about a booked tour you can always ask upon arrival or at any time during your stay.

Our full day tours are offered pre and post conference dates. If you require any additional nights at the Fiesta Americana Condesa due to a full day excursion, please ensure you book these in advance to avoid disappointment. The full days tours are available to both individual and group bookings.

Tulum And Playa Del Carmen Shopping Tour

Our journey begins in the magical ancient Tulum Archaeological Zone, discovered by John L. Stephens in 1842. Perched on top of a cliff facing the Caribbean Sea, it is the only entire walled in-group of Mayan Ruins ever discovered. Under the advice of an official English speaking tour guide, the group will go around the structures getting the history and spirit of the Mayans. Afterwards we head Playa del Carmen, an authentic Mexican town, popular because of its beautiful beaches with turquoise water colour and the famous 5^th Avenue where the participants will browse around the shops aside to explore. All kind of typical items, handcrafts, pottery, typical rugs most of them hand made by top artisans, fine boutiques selling everything imaginable. A unique experience! A group lunch can be arranged in one of the restaurants or it can be at leisure.

Ek Balam and Cenote

Visit the archaeological site of Ek-Balam. Ek Balam means Bright Star Jaguar in Maya language. This ancient Maya city had its glory before Chichen Itza. This archaeological site is one of the latest attractions because of its most recent restoration. Discover the mysterious Maya Cenote, enjoy its beautiful natural formations and great natural pool of 80m diameter. During the tour you will see different Maya communities. Take home your memories with the beautiful photographs taken by native photographers during the activities.

Sea Passion Catamaran

Isla Mujeres (Island of Women) is one of the Mexican Caribbean’s favourite destinations. Sail the beautiful turquoise bay from Cancun to Isla Mujeres aboard the Sea Passion I or Sea Passion III, a one-of-a-kind 75 & 60 foot maxi-catamarans, designed for passenger comfort. Enjoy a sail and snorkelling in the National Marine Park. Relax. In the full day activity the participants will have the opportunity to disembark in the Island. You can enjoy exquisite dining at the Beach Club “ElPescador” and the overwhelming views of the turquoise ocean decorated by coconut palm trees and hammocks.

Selvatica Extreme Canopy Tour

Located between Cancun and Playa del Carmen, only 35 minutes form Cancun’s International Airport. Over 250 acres of Tropical Jungle, in Selvatica you will be able to experience a unique adventure in the longest zip-line circuit in North America, recognized by Travel & Leisure magazine as one of the 35 great adventures in the World, divided in 12 zip lines varying in lengths and heights from 270 ft. to over 2,000 ft, it will make you fly over the jungle. Take a ride on a military vehicle through the jungle to get to the millenary natural cenote. With crystal and pristine waters you will be able to swim choosing between a water zip line or the diving platform. Live this unique and exciting adventure and feel the emotion and adrenaline running through your body.

Coba

Deep in the heart of the Quintana Roo jungle and only 24 miles from southwest of Tulum, approximately 2 1/2 south of Cancun is COBA, an archaeological site that dates from the Classis period. Unlike other Mayan sites in Quintana Roo, Coba was still occupied after the Spanish Conquest.
This incredible Site once occupied an area of almost 100 square kilometers (60 st. miles). The pyramid of Nohoch Mul-43 meters (130 ft.) high-is the tallest pre-Hispanic structure in the Yucatan peninsula. The main pyramids are the Coba Group, near the entrance, Las Pinturas (The Paintings), named because of the colour still visible on the arches; the Macanxoc, located next to Macanxoc Lake; and Chumuc Mul, the main stucco pyramid which still contains its original colour.
After a very cultural tour, be prepared to enjoy a delicious lunch in one of the magic restaurants of the area.

For further details on the above and other tours available please contact Tropical Incentives where Francisco Mora or an alternative representative will be happy to assist you.

Contact: Francisco Mora
Email: guestservices@ticancun.com

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2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

Group Activities

Chichen-Itzá Group Tour - Friday 26th February 2016

We have arranged an exciting private group tour for all 2016 DDRC participants. The tour will take place the day immediately following the conference on Friday 26th February 2016.

Chichen-Itzá, recently nominated one of the new 7th wonders is the ancient city whose name means "in the mouth at the Itzáe's Well", was in its time of grandeur (between 800 and 1200 A.D.), the centre of political, religious and military power in Yucatán, if not all of South-eastern Meso America. Chichen-Itzá is located 125 miles West of Cancun about 2:15 hrs. It is the most visited archaeological site on the Peninsula, famed for its extraordinary architectural beauty. When the Spaniards arrived in Chichen-Itzá, it had long been abandoned, a victim of the Mayapan wars. Somewhere between 1196 and 1441 the May culture collapsed on the northern shores of the peninsula. The conqueror found the buildings in ruins; their names and uses lost to time. Present names and uses are intelligent guesses.

The tour is optional and should you wish to participate we would ask that you email laura@fusion-conferences.com to confirm your participation no later than Monday 15^th February as we are required to confirm numbers in advance due to transportation requirements.

Itinerary for Friday 26th February 2016:

08.15 – Meeting Point in Lobby
08.30 – Departure from Hotel
11:00 – Arrival at Chichen-Itzá
11:15 – 13:00 – Guided Visit to the Archaeological Site
13:15 – Departure from Chichen-Itzá to Restaurant
13:30 – 14:30 – Lunch
14:45 – Return to Transportation
17:30 – Estimated Return to Hotel

The price of the tour will vary depending on confirmed numbers. We will confirm the tour price during conference registration. For guidance, please note the following prices dependent on final group size.

$155.00 – Requires 6 participants
$115.00 – Requires 10+ participants
*Please consider an additional $5.00 gratuity, per person.

The above prices include; air conditioned transportation, 2 beverages on board (soft drinks and/or water), tour guide, admission fees at Chichen-Itzá, buffet lunch (food only) and federal tax. Please note the above prices exclude; food and beverages inside the ruins and beverages during lunch.

Please note that payment for the tour will need to be made during conference registration at the Tropical Incentives Hospitality desk. Tropical Incentives will accept both cash and card payments. Please note a surcharge will be added for payments made using card (5% for VISA or Master Card and 6% for AMEX). This is a non-refundable fee should you later change your mind and decide not participate in the tour.

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If you're interested in sponsoring this conference please contact us.

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

Childcare

Supported By

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Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

Oral Presenters

We have a number of oral opportunities available at this meeting. To be considered for a talk, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Please take note of the oral submission deadline: 14 September 2015

Please check the conference programme carefully to note your presentation time (inclusive of Q&A) should you be accepted for an oral presentation. We recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference page.

Your Presentation on the Day

If you have prepared some slides to accompanying your talk please ensure you bring these with you on a USB or portable file saving device.

For those presenting on the first day, please email your slides to us so we can have everything prepared and ready for the first session. Please email your slides to: admin@fusion-conferences.com

On the day of your presentation please make yourself known to the AV team who will be available in the conference room. If you have any animations or videos we do advise to run through the presentation with the AV tech to make sure everything is compatible. We also advise that all speakers make themselves known to the AV tech in the conference room immediately before your session beings. The AV tech will apply your microphone and provide a laser pointer should you have an accompanying presentation. We prefer speakers to use our master laptop to run presentations from, however, if you prefer to use your own laptop, please notify us in advance.

It is important that all speakers adhere to their presentation time and respect their fellow presenters. A visual traffic light aide will be available to warn presenters and the audience as your time decreases.

If you have any questions, please don’t hesitate to approach our AV tech or a member of the Fusion team.

Helpful Tips for Presentation Slides

Aspect Ratio: 4:3 in Presenter View, Landscape in Orientation
Font Size: Minimum font size used should be 24pt.
File Type: Please safe your presentation in PPT or PPTS format.
Video Clips: Please save these separately and do not build them into the PowerPoint. Videos will be played via the AV control desk using the master laptop.

Download Abstract Template

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If you're interested in sponsoring this conference please contact us.

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

Posters

We have a number of poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Please take note of the poster submission deadline: 05 January 2016

Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.

Displaying & Presenting Your Poster

During conference registration if you are presenting a poster please request a poster number from the registration desk. Please do not put up your poster without notifying a member of the Fusion team. Certain adhesive agents are not permitted at some venues therefore; Fusion will be the sole provider of all poster fixings.

You can display your poster from registration. Your poster can remain on display for the entire duration of the conference and we ask that posters are taken down on the final day of the meeting. The poster session is usually scheduled on Day 3, but please check the official programme for exact timings. Refreshments will be provided and the poster prizes will be awarded during the conference Gala Night that evening.

2016 DDRC Poster Prize

The conference chairs will be awarding five exceptional poster prizes for the best poster display and presentation. To be in with a chance of winning, submit your poster by 26 January 2016. The winners will be selected shortly after the Poster Session and the following prizes/travel grants will be awarded. 1^st Place $400, 2^nd Place $400, 3^rd Place $350, 4^th Place $250 and 5^th Place $150.

In addition to the monetary prize provided by Fusion, F1000 have kindly provided the following prizes for all five winners.

1) A personalised F1000 Poster Prize certificate.
2) A free personal subscription to F1000 allowing access to all recommendations and our new collaborative authoring tool.
3) A free article submission to F1000Research worth up to $1,000.

Download Abstract Template

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If you're interested in sponsoring this conference please contact us.

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs

Conference History

12 Feb 2014, 15 Feb 2014

Dynamic Structures in DNA Damage Responses and Cancer

Fiesta Americana Condesa, Cancun, Mexico

Key sessions will include: DNA and RNA complexes Chromatin Remodeling Post-translational modifications - Ub, SUMO kinases The repair interface with Replication Transcription, and Recomb...

22 Feb 2016, 25 Feb 2016

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

Fiesta Americana Condesa, Cancun, Mexico

This conference will focus on insights into dynamic DNA and RNA complexes involved in the damage response and cancer. It will emphasize informal as well as formal discussions together with informative talks and...

11 Feb 2018, 15 Feb 2018

3^rd DNA Replication/Repair Structures and Cancer Conference

Fiesta Americana Condesa, Cancun, Mexico

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a...

16 Feb 2020, 20 Feb 2020

4^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC20

Melia Nassau Beach All Inclusive, Nassau, Bahamas

The remarkable stability of the human genome is lost in cancer cells due to the failure of efficient and accurate DNA repair in the context of oncogene-induced replication stress and elevated transcription. Intertwined roles of repair with replica...

27 Apr 2022, 01 May 2022

5^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC22

Fiesta Americana Condesa Cancun All Inclusive, Cancun, Mexico

Future master keys to cancer biology and advanced therapies are being forged from mechanistic understanding of the intertwined roles of DNA repair with DNA replication stress, transcription and immune responses. The remarkable stability of the hum...

14 Feb 2024, 18 Feb 2024

6^th DNA Repair/Replication Structures and Cancer Conference

#DRRSC24

Fiesta Americana Condesa Cancun All Inclusive, Cancun, Mexico

Important fundamental breakthroughs in cancer biology have come from the basic research discovery that defects in the tumor suppressor and DNA repair genes BRCA1/2 genes predispose to breast, ovarian, prostate, and pancreatic cancers. Furthermore,...

Supported By

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^nd Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference

22 Feb 2016 - 25 Feb 2016

Cancun, Mexico

Chairs