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- DNA & Interacting Proteins as Single Molecules - In Vitro & In Vivo Conference
DNA & Interacting Proteins as Single Molecules - In Vitro & In Vivo Conference
21 Feb - 24 Feb 2018
Cancun, Mexico
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Synopsis
The advent of single-molecule approaches has revolutionized our understanding of Molecular Biology. Combined advances in light microscopy, microfluidics, atomic force microscopy, and DNA sequencing have opened ways to bypass population averages and study individual molecular events for a variety of cellular processes. This meeting aims to present the most recent advances in the mechanistic understanding of biological processes involving DNA at the single-molecule level, using both in vivo and in vitro approaches.
Key Sessions will cover various aspects of:
- DNA replication
- DNA recombination
- DNA repair
- Transcription
- Chromosome dynamics
- Genomics
Each session will be divided into in vitro and in vivo sections to highlight differences and complementary information obtained.
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Target Audience
This conference will appeal to researchers interested in the study of DNA metabolic events at the single molecule level: both in vitro and in vivo. There will be significant focus on DNA replication, DNA recombination, DNA repair and transcription. In addition, we would encourage participation from groups involved in single cell sequencing/genomics.
Learning Objectives
To further understanding of:
- DNA metabolic processes
- Single molecule approaches in vitro and data analyses
- Live cell single molecule approaches
- Single cell genomics
Student Offer
Take advantage of this fantastic opportunity for students! Register an academic at the normal rate and bring a student for only $745. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 21, 22, 23 Feb 2018 (on a shared basis for students, note guest rooms are open plan) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact Emily Bicknell (emily@fusion-conferences.com) to obtain a special registration link for your student.
Keynote Speaker
Steve Kowalczykowski (UC Davis)
Plenary Speakers
Yuri L. Lyubchenko (University of Nebraska Medical Center)
Achillefs Kapanidis (University of Oxford)
Fuchou Tang (Peking University)
Dave Sherratt (University of Oxford)
Peter Fraser (Babraham Institute)
Invited Speakers
Eli Rothenberg (New York University School of Medicine)
Michael O'Donnell (Rockefeller University)
Joseph Loparo (Harvard University)
Eric Galburt (Washington University in St. Louis)
Will Greenleaf (Stanford University)
Johan Elf (Uppsala University)
Mark Leake (University of York)
Jie Yan (National University of Singapore)
Jie Xiao (John Hopkins University)
Terence Strick (University of Paris)
Richard Ebright (Rutgers)
Nick Dixon (University of Wollongong)
Myron Goodman (University of Southern California)
Samir Hamdan (King Abdullah University of Science and Technology)
Kiyoshi Mizuuchi (NIDDK)
Stephan Uphoff (University of Oxford)
Long Cai (Caltech)
Confirmed Speakers
Chairs
Plenary Speakers
Steve Kowalczykowski
Professor, University of California, Davis
Yuri Lyubchenko
Professor, University of Nebraska Medical Center
Achillefs Kapanidis
Professor of Biological Physics, University of Oxford
David Sherratt
Professor and group head, University of Oxford
Peter Fraser
Professor, Florida State University
Fuchou Tang
Principal Investigator, Peking University
Steven Block
Professor, Stanford University
Invited Speakers
Michael O'Donnell
Investigator, Rockefeller University
Jie Xiao
Professor, Johns Hopkins University School of Medicine
Eric Galburt
Assistant Professor, Washington University School of Medicine
Joseph Loparo
Professor, Harvard Medical School
Eli Rothenberg
Professor, New York University School of Medicine
Johan Elf
Professor, Uppsala University
Nicholas Dixon
Professor of Biological Chemistry, University of Wollongong
Richard H. Ebright
Professor, Rutgers
Stephan Uphoff
Sir Henry Dale Fellow, University of Oxford, Department of Biochemistry
Myron Goodman
Porfessor, Biologiogical Sciences and Chemistry, University of Southern California
Samir Hamdan
Assistant Professor of Bioscience, King Abdullah University of Science and Technology
Timothy Lohman
Professor, Washington University in St. Louis
Kiyoshi Mizuuchi
Section Chief, National Institutes of Health
Mark Leake
Professor, University of York
Linda Kenney
Prof, Mechanobiology Institute
William Greenleaf
Associate Professor, Stanford University
Jie Yan
Principal Investigator, Mechanobiology Institute, NUS
Terence Strick
Research Director, Ecole normale supérieure/CNRS
Long Cai
Research Professor, Caltech
Sabrina Leslie
Associate Professor, McGill University
Programme
WEDNESDAY 21ST FEBRUARY |
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14:00 – 15:00 |
Registration & Reception |
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14:00 – 15:00 |
Welcome Lunch |
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15:00 – 15:15 |
Opening Comments |
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DNA Recombination |
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15:15 – 16:00 |
Steve Kowalczykowski |
SINGLE-MOLECULE VISUALIZATION OF PROTEIN-DNA COMPLEXES: UNDERSTANDING BIOLOGY, ONE MOLECULE AT A TIME |
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16:00 – 16:30 |
Eli Rothenberg |
SINGLE-MOLECULE STUDIES OF HUMAN DNA DOUBLE STRAND BREAK REPAIR PATHWAYS IN VITRO AND IN CELLS |
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16:30 – 17:00 |
Jie Yan |
LABEL-FREE QUANTIFICATION OF SEQUENCE AND STRUCTURE SPECIFIC DNA-PROTEIN INTERACTIONS |
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17:00 – 17:30 |
Refreshments |
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17:30 – 18:00 |
Jie Xiao |
MULTISTABLE CELL FATE DECISION - A SINGLE-MOLECULE STUDY OF GENE REGULATION |
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18:00 – 18:30 |
Joseph Loparo |
VISUALIZING DNA BREAK REPAIR: HOW THE NHEJ MACHINERY MINIMIZES MISTAKES |
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18:30 – 18:45 |
Sharonda LeBlanc |
THE DYNAMICS OF MISMATCH REPAIR INITIATION |
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18:45 – 19:00 |
Kata Sarlós University of Copenhagen |
SINGLE-MOLECULE AND BIOCHEMICAL RECONSTITUTION OF ANAPHASE DNA BRIDGE DISJUNCTION
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19:00 – 19:30 |
Piero Bianco |
INSIGHT INTO STALLED DNA REPLICATION FORK RESCUE IN E.COLI |
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19:30 |
Dinner at Leisure |
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THURSDAY 22ND FEBRUARY |
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07:00 – 08:30 |
Breakfast *Kalmia Buffet Restaurant* |
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Chromosome Dynamics Tim Lohman |
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08:30 – 09:15 |
Dave Sherratt |
THE ACTION OF SINGLE MukBEF SMC COMPLEXES IN LIVE E. COLI CELLS |
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09:15 – 09:30 |
Hong Wang |
COHESIN SA1 AND SA2 RECOGNIZE SPECIFIC DNA SEQUENCES AND STRUCTURES: A TALE OF TWO PROTEINS
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09:30 – 10:00 |
Sunney Xie |
3D GENOME STRUCTURES OF SINGLE DIPLOID HUMAN CELLS |
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10:00 – 10:30 |
Refreshments |
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10:30 – 11:00 |
Terence Strick |
CORRELATIVE SINGLE-MOLECULE ANALYSIS OF DNA REPAIR SYSTEMS |
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11:00 – 11:30 |
Long Cai |
SPATIAL GENOMICS AND SINGLE CELL LINEAGE DYNAMICS BY SEQFISH AND MEMOIR |
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11:30 – 12:00 |
Johan Elf |
CHARACTERIZING A LIBRARY OF CELLS AT SINGLE MOLECULE SENSITIVITY |
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12:00 – 16:30 |
Lunch at Leisure & Free Time |
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12:30 – 16:00 |
Snorkel Trip (Sign-ups required in advance) |
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DNA Replication |
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16:30 – 17:00 |
Nick Dixon |
THE BACTERIAL REPLISOME – DESIGN PRINCIPLES FOR A DYNAMIC MOLECULAR MACHINE |
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17:00 – 17:30 |
Mike O’Donnell |
OPTICAL TRAPS, FLUORESCENT PROTEINS AND MICROFLUIDICS REVEAL UNEXPECTED DYNAMICS OF EUKARYOTIC CMG HELICASE |
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17:30 – 18:00 |
Kiyoshi Mizuuchi |
INTRACELLULAR LONG-RANGE COMMUNICATION IN BACTERIAL PLASMID SEGREGATION AND SEPTUM POSITIONING |
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18:00 – 18:30 |
Refreshments |
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18:30 – 19:00 |
Rodrigo Reyes Lamothe |
REPLISOME DYNAMICS IN LIVE BACTERIA AND BUDDING YEAST |
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19:00 – 19:30 |
Samir Hamdan |
SINGLE MOLECULE VIEW OF THE STRUCTURE SPECIFIC 5’ NUCLEASES |
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19:30 – 19:45 |
Enrico Monachino |
SINGLE-MOLECULE AND BULK BIOPHYSICAL STUDIES OF ESCHERICHIA COLI DNA REPLICATION REVEAL A CONFORMATIONAL SWITCH CONTROLLING REPLISOME STABILITY |
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19:45 – 20:00 |
Lisanne Spenkelink |
SINGLE-MOLECULE VISUALIZATION OF YEAST LEADING-STRAND SYNTHESIS REVEALS DYNAMIC INTERACTION BETWEEN MTC AND THE REPLISOME |
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20:00 |
Dinner at Leisure |
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FRIDAY 23RD FEBRUARY |
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07:00 – 08:30 |
Breakfast *Kalmia Buffet Restaurant* |
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DNA Repair |
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08:30 – 09:15 |
Yuri Lyubchenko |
DYNAMICS OF PROTEIN-DNA COMPLEXES AT NANOSCALE |
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09:15 – 09:30 |
Andrew Robinson |
SINGLE-MOLECULE IMAGING OF TRANSLESION DNA POLYMERASES IN E. COLI |
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09:30 – 10:00 |
Mark Leake |
PROBING GENE CONTROL IN LIVE CELLS USING HIGH-SPEED SINGLE-MOLECULE FLUORESCENCE MICROSCOPY |
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10:00 – 10:30 |
Refreshments |
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10:30 – 11:00 |
Stephan Uphoff |
ILLUMINATING THE REGULATION OF BACTERIAL DNA REPAIR AND MUTAGENESIS USING SINGLE-MOLECULE AND SINGLE-CELL MICROSCOPY |
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11:00 – 11:30 |
Myron Goodman |
A SINGLE MOLECULE WINDOW INTO ATP REGULATION OF THE DNA POLYMERASE V MUTASOME |
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11:30 – 12:00 |
Tim Lohman |
LARGE DOMAIN MOVEMENTS REGULATE UvrD HELICASE ACTIVITY |
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12:00 – 16:00 |
Lunch at Leisure & Free Time |
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Genomics |
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16:00 – 16:45 |
Fuchou Tang |
SINGLE-CELL MULTI-OMICS SEQUENCING OF MOUSE EARLY EMBRYOS AND EMBRYONIC STEM CELLS |
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16:45 – 17:00 |
Manal Zaher |
MISSED CLEAVAGE OPPORTUNITIES BY FEN1 LEAD TO OKAZAKI FRAGMENT MATURATION VIA THE LONG-FLAP PATHWAY |
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17:00 – 17:30 |
Will Greenleaf |
SINGLE-CELL EPIGENOMICS MAPS THE CONTINUOUS REGULATORY LANDSCAPE OF HUMAN HEMATOPOIETIC DIFFERENTIATION |
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17:30 – 18:00 |
Refreshments |
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18:00 – 18:15 |
Wei Ting Chelsea Lee |
SPATIOTEMPORAL ASSOCIATIONS OF DNA G4 AND REPLICATION IN HUMAN CELLS |
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18:15 – 19:00 |
Peter Fraser |
3D CHROMOSOME AND GENOME DYNAMICS |
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19:00 – 19:30 |
Linda Kenney |
CHARGED RESIDUES IN THE H-NS LINKER DRIVE DNA BINDING AND GENE SILENCING IN SINGLE CELLS |
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20:00 |
*Gala Dinner* |
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SATURDAY 24TH FEBRUARY |
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07:00 – 08:30 |
Breakfast *Kalmia Buffet Restaurant* |
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Transcription |
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08:30 – 09:15 |
Steve Block |
RIBOSWITCH FOLDING, STRUCTURE AND FUNCTION |
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09:15 – 09:45 |
Richard Ebright |
REPURPOSING NANOPORE DNA SEQUENCING TO ANALYZE RNA POLYMERASE TRANSLOCATION WITH SUB-NUCLEOTIDE, SUB-MILLISECOND RESOLUTION |
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09:45 – 10:15 |
Eric Galburt |
DNA UNWINDING AT A DISTANCE DURING EUKARYOTIC TRANSCRIPTION INITIATION |
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10:15 – 10:45 |
Refreshments |
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10:45 – 11:30 |
Achillefs Kapanidis |
UNCOVERING TRANSCRIPTION MECHANISMS VIA SINGLE-MOLECULE FLUORESCENCE IMAGING |
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11:30 – 12:00 |
Sabrina Leslie |
HOW BIOMOLECULES BEHAVE IN A SQUEEZE |
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12:00 – 12:15 |
Avin Ramaiya |
QUICKER THAN QUICK? CORRELATIVE FLUORESCENCE-FORCE MICROSCOPY AS A VERSATILE TOOL FOR DNA-MECHANICS |
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12:15 – 12:35 |
Panel Discussion |
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12:35 – 12:45 |
Closing Comments |
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Supported by
Venue & Location
Fiesta Americana Condesa
This stylish hotel features contemporary Mexican architecture, including one of the largest and most impressive thatched-roof "palapas" in the entire country. There are cultural activities, arts and crafts and sports programs to keep you constantly entertained, plus time to relax and enjoy the Mayan culture, soak up the Caribbean sunshine and revel in the international ambiance that settles in after the sun goes down.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the aromatic Asian delights at Kaumbu, traditional fare at El Mexicano, delicious international cuisine at Kalmia Buffet or perhaps sample the sumptuous Italian dishes at Rosato. There are also several other dining opportunities such as the Cevichería, Pizzeria, Sushi Corner, pool and lounge bar areas. The Gala Night with either a Mayan or Caribbean theme takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
Hotel Facilities
- Lagoon Pool
- Extensive Health Club and Spa
- Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
The Fiesta Americana Condesa, Cancun is the 2015 Winner of the Trip Advisor Certificate of Excellence and also received the Travellers Choice Award in 2014.
The remains of ancient Mayan cities are scattered throughout the Yucatan Peninsula and no trip to Cancun would be complete without a visit to these majestic temples and pyramids set amongst lush tropical vegetation. We will be working very closely with a reputable tour company who will be organising trips to Tulum, Chichen Itza, Coba and Xcaret to name a few, some of which may require a full day. Full day excursions will be arranged pre or post conference and may be on an individual or group booking so we would recommend booking extra nights to extend your stay as early as possible to avoid disappointment should these excursions be of interest to you and/or your party. For further information please contact us.
General Information
Venue Rating
★ ★ ★ ★ ★
Currency
US Dollar (USD)
Address
Fiesta Americana Condesa, Blvd.Kukulkán km 16.5 Zona Hotelera, Cancun, 77500 Mexico
Nearest Airport
Cancun International Airport
Location
Cancun is a delightful combination of natural beauty, islands, ecological reserves and white sandy beaches. However, besides sun, sand and sea, this destination also offers an infinite variety of underwater activities to choose from: the diving, snorkelling and fishing here are outstanding and you will find an undersea world packed with tropical fish that live on the second largest barrier reef in the world. Sports enthusiasts might choose one of the many eco-tourism activities, such as cycling or hiking through the tropical forest or kayaking through mangroves, or something a little more adventuresome, like zip lining through the treetops.
Apart from the more well-known ancient Mayan archealogical sites such as Tulum, Cobá and Chichén Itzá you may like to visit the Aktun Chen caverns, voted one of the Top 10 underwater walks by National Geographic described as a truly magical experience.
Gallery
View on Flickr
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Conference Manager
Emily Meen
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