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2^nd Cell Death, Cell Stress & Metabolism Conference

Past Conference

2^nd Cell Death, Cell Stress & Metabolism Conference

From Basic Mechanisms to Novel Treatment Options

Date

27 May - 30 May 2019

Location

Puerto Vallarta, Mexico

Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired

2^nd Cell Death, Cell Stress & Metabolism Conference

27 May - 30 May 2019 • Puerto Vallarta, Mexico

Conference Manager

Meredith Willmott

Synopsis

The interplay between cell death, cell stress and metabolism plays a crucial role in shaping normal turnover of tissues, in sensing of danger posed by pathogens or other damage and the immunological response that is mounted to response to them. At this conference we will discuss the basic biological principles that govern cell death, cell stress and metabolism. We will also cover how cellular stress and alterations in metabolism influence the cellular death programs such as apoptosis, necroptosis, ferroptosis and others. Importantly, this conference aims to become the go-to forum at which the most current and up-to-date therapeutic avenues in the fields of cell death, cell stress and metabolism will be presented and discussed.

For those interested, this meeting follows the Metabolism in Health and Disease Conference, taking place from 24 - 27 May 2019 at the same venue.

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the standard rate of $1,775 and bring a student for only $700. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 27, 28 and 29 May 2019 (on a shared basis for students) and food and beverage package for the conference period. Academic registrations must be completed by 10th May 2019. Once registered, please contact Chloe Trundle to obtain a special registration link for your student.

Confirmed Invited Speakers:

Martin Aichinger (Boehringer Ingelheim)
TARGETING IAP IN CANCER: FROM CELL DEATH INDUCTION TO IMMUNE CELL ACTIVATION
Matthew Albert (Insitro)
CHEMOTHERAPY INDUCED DNA DAMAGE ENHANCES THE IMMUNOGENICITY OF DYING CELLS
Alessandro Annibaldi (Queen Mary University of London)
CHECKPOINTS IN TNF-INDUCED CELL DEATH
Petr Broz (University of Lausanne)
GBPS AND CASPASE-4 ASSEMBLE THE NON-CANONICAL INFLAMMASOME AT THE OUTER MEMBRANE OF CYTOSOLIC BACTERIA
Mathieu Bertrand (Ghent University)
REGULATION OF RIPK1-DEPENDENT CELL DEATH IN MODELS OF INFECTION AND INFLAMMATION
Francis Chan (Duke University)
PARADOXICAL ROLES OF RIP KINASES IN INJURY-INDUCED INFLAMMATION
Ralph Deberardinis (UT Southwestern Medical Center)
METABOLIC REPROGRAMMING IN HUMAN DISEASES
Shoukat Dedhar (BC Cancer Agency)
HYPOXIA AND ACIDOSIS MEDIATED STRESS SIGNALING: TARGETING CARBONIC ANHYDRASE IX/XII
Vishva Dixit (Genentech)
NON - CANONICAL INFLAMMASOME PATHWAY
Scott Dixon (University of Stanford)
A NOVEL MECHANISM OF NON-APOPTOTIC LIPOTOXICITY
Gerard Evan (University of Cambridge)
BUILDING AND KILLING CANCERS
Ana García-Sáez (University of Tübingen)
STRUCTURAL REARRANGEMENTS DURING MLKL ACTIVATION
Kairbaan Hodivala-Dilke (Barts Cancer Institute)
SURPRISES FROM TARGETING THE TUMOUR MICROENVIRONMENT
Philipp Jost (Technical University of Munich)
XIAP PROTECTS AGAINST TNF RECEPTOR-DEPENDENT INFLAMMATION IN INTESTINAL HOMEOSTASIS
Andreas Linkermann (University Hospital Dresden)
REGULATED NECROSIS IN ISCHEMIC TISSUES
Scott Lowe (Memorial Sloan Kettering Cancer Center)
RESTORING TUMOR SUPPRESSION IN ADVANCED CANCERS
Najoua Lalaoui (Walter and Eliza Hall Institute of Medical Research)
MUTATIONS THAT PREVENT CASPASE-8 CLEAVAGE OF RIPK1 CAUSE INFLAMMATION IN HUMANS AND MOUSE
Claudio Mauro (University of Birmingham)
METABOLITE-MEDIATED REGULATION OF INFLAMMATION
Cristina Muñoz Pinedo (IDIBELL)
CELL-CELL RESPONSES TO STARVATION
Lynne-Marie Postovit (University of Alberta)
TRANSLATIONAL CONTROL OF BREAST CANCER PLASTICITY
Shigekazu Nagata (Osaka University)
PHOSPHOLIPID FLIPPASE AND SCRAMBLASE
Andrew Oberst (University of Washington)
NECROPTOSIS WITHOUT CELL DEATH: HOW THE RIP KINASES CONTROL VIRAL INFECTION IN THE BRAIN
Davide Ruggero (University of California, San Francisco)
TRANSLATING THE CANCER GENOME ONE CODON AT A TIME AND ITS THERAPEUTIC IMPLICATIONS.
Massimo Santoro (University of Padua)
REDOX METABOLISM IN ANGIOGENESIS AND CANCER PROGRESSION
Nahum Sonenberg (McGill University)
TRANSLATIONAL CONTROL OF CANCER BY EIF4E VIA THE PI3K/MTOR AND RAS/MAPK PATHWAYS
Stephen Tait (University of Glasgow)
FIRST AMONG EQUALS - MITOCHONDRIAL HETEROGENEITY, CELL DEATH AND CANCER
Ivan Topirisovic (McGill University)
TRANSLATIONAL REGULATION OF METABOLIC PLASTICITY
Domagoj Vucic (Genentech)
REGULATION OF INFLAMMATORY CELL DEATH SIGNALING BY RIP KINASES
Tom Vanden Berghe (Universiteit Antwerpen)
FERROPTOSIS AND INFLAMMATION RESEARCH IN CRITICAL ILLNESS
Christine Watson (University of Cambridge)
CELL DEATH INITIATES DYNAMIC ARCHITECTURAL CHANGES IN THE EPITHELIUM AND ASSOCIATED IMMUNE CELLS AND VASCULATURE DURING MAMMARY GLAND INVOLUTION

Target Audience

From basic researchers interested in cell death all the way to people in the biotech and pharma industries who would like to be on top of these fields and want to form part of a meeting which is specifically geared towards providing a platform for the presentation and discussion of the most up-to-date preclinical and clinical work in these fields.

Confirmed Speakers

Chairs

Poul Sorensen

Principle Investigator, BC Cancer Research Centre

Henning Walczak

Chair of the Department of Biochemistry I, University of Cologne / University College London

Invited Speakers

Andrew Oberst

Associate Professor, University of Washington, Department of Immunology

Stephen Tait

Group Leader, Cancer Research UK Beatson Institute

Nahum Sonenberg

Gilman Cheney Chair in Biochemistry, McGill University

Gerard Evan

Head of Department, University of Cambridge, Department of Biochemistry

Shoukat Dedhar

Distinguished Scientist, BC Cancer Research Centre

Lynne-Marie Postovit

Associate professor, University of Alberta

Ivan Topisirovic

Investigator/Associate Professor, Lady Davis Institute/McGill University

Vishva Dixit

Vice President, Research, Genentech Inc

Claudio Mauro

Professor of Metabolism and Inflammation (Professorial Fellow), Univ of Birmingham

Scott Dixon

Associate Professor, Stanford University

Francis Chan

Professor, Duke University

Petr Broz

Professor, Univeristy of Lausanne

Davide Ruggero

Professor, UCSF

Ralph DeBerardinis

Associate Professor, UT Southwestern Medical Center

Christine Watson

Professor of Cell and Cancer Biology, University of Cambridge

Alessandro Annibaldi

Junior Research Group Leader, Center for Molecular Medicine Cologne

Tom Vanden Berghe

Assistant Professor, University of Antwerp

Massimo Santoro

Full Professor, University of Padua

Ana J. Garcia Saez

Professor, University of Tuebingen

Kairbaan Hodivala-Dilke

Deputy Director,, Barts Cancer Institute (Centre for Tumour Biology)

Martin Aichinger

Principal Scientist, Boehringer Ingelheim RCV GmbH & Co KG

Shigekazu Nagata

Distinguished Professor, Immunology Frontier Research Center, Osaka University

Domagoj Vucic

Senior Fellow, Genentech

Cristina Muñoz-Pinedo

Group leader, IDIBELL

Andreas Linkermann

Deputy Director - Department of Nephrology, UKD Dresden

Philipp Jost

Consultant, Technical University of Munich

Mathieu Bertrand

Associate Professor, VIB Center for Inflammation Research / Ghent university

Scott Lowe

Chair, Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center

Matthew Albert

VP, Immunology and Infectious Diseases, insitro

Najoua Lalaoui

Senior Postdoc, The Walter and Eliza Hall Institute of Medical Research

Programme

MONDAY 27^TH MAY 2019
14:00 – 15:00	Registration & Welcome Reception
Tumor Metabolism and Cell Intrinsic Pathways Session Chair: Henning Walczak
15:00 – 15:10	Opening Comments
15:10 – 15:35	Ralph Deberardinis UT Southwestern Medical Center	METABOLIC REPROGRAMMING IN HUMAN DISEASES
15:35 – 16:00	Cristina Muñoz Pinedo IDIBELL	CELL-CELL RESPONSES TO STARVATION: INFLAMMATION
16:00 – 16:25	Claudio Mauro University of Birmingham	METABOLITE-MEDIATED REGULATION OF INFLAMMATION
16:25 – 16:50	Shigekazu Nagata Osaka University	PHOSPHOLIPID FLIPPASE AND SCRAMBLASE
16:50 – 17:35	Refreshments
17:35 – 18:10	Poster Presenter Short Teaser Talks
18:10 – 18:35	Vishva Dixit Genentech	NON - CANONICAL INFLAMMASOME PATHWAY
18:35 – 19:00	Scott Lowe Memorial Sloan Kettering Cancer Center	RESTORING TUMOR SUPPRESSION IN ADVANCED CANCERS
19:00 – 19:15	Rute Ferreira UCL Cancer Institute	CD9 IDENTIFIES PANCREATIC CANCER STEM CELLS AND MODULATES GLUTAMINE METABOLISM TO FUEL TUMOUR GROWTH
19:15 – 19:40	Gerard Evan University of Cambridge	BUILDING AND KILLING CANCERS
19:40	Group Dinner

TUESDAY 28^THMAY 2019
07:00 – 08:45	Buffet Breakfast at Chulavista
Cancer Biology and the Tumor Microenvironment Session Chair: Shoukat Dedhar
08:45 – 09:10	Matthew Albert Insitro	CHEMOTHERAPY INDUCED DNA DAMAGE ENHANCES THE IMMUNOGENICITY OF DYING CELLS
09:10 – 09:25	Tania Løve Aaes VIB-UGent Center for Inflammation Research	NECROPTOSIS UNLIKE APOPTOSIS INDUCES IMMUNOGENICITY AGAINST NEO-EPITOPES IN A TUMOR VACCINATION SETTING
09:25 – 09:50	Stephen Tait University of Glasgow	FIRST AMONG EQUALS - MITOCHONDRIAL HETEROGENEITY, CELL DEATH AND CANCER
09:50 – 10:15	Kairbaan Hodivala-Dilke Barts Cancer Institute	SURPRISES FROM TARGETING THE TUMOUR MICROENVIRONMENT
10:15 – 10:45	Refreshments & Poster Viewing
10:45 – 11:10	Massimo Santoro University of Padua	METABOLIC SIGNALING IN ANGIOGENESIS AND CANCER PROGRESSION
11:10 – 11:35	Shoukat Dedhar BC Cancer Agency	HYPOXIA AND ACIDOSIS MEDIATED STRESS SIGNALING: TARGETING CARBONIC ANHYDRASE IX/XII
11:35 – 17:30	Lunch at Leisure & Free Time
12:00 – 17:00	Group Snorkeling Trip (sign-ups required in advance)
Translational Control Mechanisms and Oncogenesis Session Chair: Poul Sorensen
17:30 – 17:55	Nahum Sonenberg McGill University	TRANSLATIONAL CONTROL OF CANCER BY EIF4E VIA THE PI3K/MTOR AND RAS/MAPK PATHWAYS
17:55 – 18:20	Davide Ruggero University of California San Francisco	TRANSLATING THE CANCER GENOME ONE CODON AT A TIME AND ITS THERAPEUTIC IMPLICATIONS
18:20 – 18:45	Poul Sorensen BC Cancer Research Centre	TUMOR CELLS EXPLOIT THE MICROENVIRONMENTAL STRESS RESPONSE TO ENHANCE METASTATIC CAPACITY
18:45 – 19:30	Refreshments & Poster Viewing
19:30 – 19:55	Lynne-Marie Postovit University of Alberta	TRANSLATIONAL CONTROL OF BREAST CANCER PLASTICITY
19:55 – 20:20	Ivan Topirisovic McGill University	TRANSLATIONAL REGULATION OF METABOLIC PLASTICITY
20:20	Dinner at Leisure

WEDNESDAY 29^TH MAY 2019
07:00 – 09:00	Buffet Breakfast at Chulavista
Cell Death and Inflammation Signaling I Session Chair: Ana García-Sáez
09:00 – 09:25	Francis Chan Duke University	PARADOXICAL ROLES OF RIP KINASES IN INJURY-INDUCED INFLAMMATION
09:25 – 09:50	Alessandro Annibaldi Queen Mary University of London	CHECKPOINTS IN TNF-INDUCED CELL DEATH
09:50 – 10:15	Philipp Jost Technical University of Munich	TNF SIGNALING CONTROLS RIP KINASE-DEPENDENT CELL DEATH IN LEUKEMIA
10:15 – 10:40	Mathieu Bertrand Ghent University	REGULATION OF RIPK1-DEPENDENT CELL DEATH IN MODELS OF INFECTION AND INFLAMMATION
10:40 – 11:25	Group Photo, Refreshments & Poster Viewing
Cell Death and Inflammation Signaling II Session Chair: Kairbaan Hodivala-Dilke
11:25 – 11:50	Henning Walczak UCL Cancer Institute	CELL DEATH-INDUCED INFLAMMATION – TNF AND BEYOND
11:50 – 12:05	Diego de Miguel University College London	A NEW KINASE-MEDIATED CHECKPOINT IN TNFR1 SIGNALLING
12:05 – 12:30	Andrew Oberst University of Washington	NECROPTOSIS WITHOUT CELL DEATH: HOW THE RIP KINASES CONTROL VIRAL INFECTION IN THE BRAIN
12:30 – 12:35	Ronny Schmidt Sciomics GmbH	USP11 KNOCK OUT, IN-DEPTH UBIQUITINATION AND PROTEIN EXPRESSION LEVEL PROFILING
12:35 – 16:30	Lunch at Leisure & Free Time
Cell Death and Inflammation Signaling II - Continued Session Chair: Kairbaan Hodivala-Dilke
16:30 – 16:55	Najoua Lalaoui Walter and Eliza Hall Institute of Medical Research	MUTATIONS THAT PREVENT CASPASE-8 CLEAVAGE OF RIPK1 CAUSE INFLAMMATION IN HUMANS AND MOUSE
Necroptosis, Ferroptosis and Beyond I Session Chair: Petr Broz
16:55 – 17:20	Scott Dixon University of Stanford	A NOVEL MECHANISM OF NON-APOPTOTIC LIPOTOXICITY
17:20 – 17:45	EMBO YOUNG INVESTIGATOR LECTURE Ana García-Sáez University of Tübingen	STRUCTURAL REARRANGEMENTS DURING MLKL ACTIVATION
17:45 – 18:00	David Armenta Stanford University	INVESTIGATING MACROPINOCYTOSIS AS A MEANS TO PREVENT FERROPTOSIS
18:00 – 18:45	Refreshments & Poster Viewing
18:45 – 19:10	Tom Vanden Berghe Universiteit Antwerpen	FERROPTOSIS AND INFLAMMATION RESEARCH IN CRITICAL ILLNESS
19:10 – 19:25	Marcos Perez Washington State University	DIETARY FATTY ACIDS INDUCE FERROPTOSIS IN THE C. ELEGANS GERM LINE
19:25 – 19:40	Samya Van Coillie IRC VIB-UGent	NOVEL THIRD-GENERATION FERROSTATINS PROTECT AGAINST ACUTE IRON POISONING-INDUCED ORGAN INJURY
20:00	Gala Dinner

THURSDAY 30^TH MAY 2019
07:00 – 09:30	Buffet Breakfast at Chulavista
Necroptosis, Ferroptosis and Beyond II Session Chair: Scott Dixon
09:30 – 09:55	Petr Broz University of Lausanne	GBPS AND CASPASE-4 ASSEMBLE THE NON-CANONICAL INFLAMMASOME AT THE OUTER MEMBRANE OF CYTOSOLIC BACTERIA
09:55 – 10:20	Christine Watson University of Cambridge	CELL DEATH INITIATES DYNAMIC ARCHITECTURAL CHANGES IN THE EPITHELIUM AND ASSOCIATED IMMUNE CELLS AND VASCULATURE DURING MAMMARY GLAND INVOLUTION
10:20 – 10:45	Andreas Linkermann University Hospital Dresden	REGULATED NECROSIS IN ISCHEMIC TISSUES
10:45 – 11:10	Mahvash Tavassoli King's College London	TUMOUR-DERIVED EGFR-CONTAINING EXOSOMES MODULATE TUMOUR HYPOXIA TO INFLUENCE RADIATION-INDUCED CELL DEATH IN HEAD AND NECK CANCERS
11:10 – 11:25	Martin Aichinger Boehringer Ingelheim	TARGETING IAP IN CANCER: FROM CELL DEATH INDUCTION TO IMMUNE CELL ACTIVATION
11:25 – 11:35	Closing Comments
11:35	Refreshments

Supported by

Bronze Sponsors

Exhibitors

Media Partners

Interested in sponsoring this conference?

Venue & Location

Fiesta Americana Puerto Vallarta All Inclusive

The Fiesta Americana Puerto Vallarta All Inclusive is in the beautiful Bahía de Banderas on the Pacific Coast of Mexico. With a mix of contemporary Mexican architecture and the more traditional Mexican styles of Jalisco, the buildings blend perfectly with the surrounding landscape of the Western Sierra Madre Mountains.

Located just 13km from Licenciado Gustavo Díaz Ordaz International Airport and within easy reach of the town of Puerto Vallarta with its array of boutique shops and set alongside one of the most beautiful beaches in the area, this provides the perfect setting for a conference.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from the wonderful selection of restaurants such as Chulavista, a contemporary buffet restaurant overlooking the beach offering Mexican and International cuisine, Rosato, offering mediterranean cuisine with an Italian twist, El Mexicano, serving traditional Mexican fare, Tiatang, adults-only restaurant serving Asian cuisine nightly for dinner and L'Isola, a sophisticated restaurant serving lobster and fine meat cuts in a poolside setting - there is a surchage for dining at this venue. There are also several other dining opportunities such as the Cevichería, Fajita House and Grill as well as the Terrace and Pool Bars. The Café / Deli Express is also open daily for coffee, teas, cakes and pastries.

The themed Gala Night takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel facilities include;

Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
Lagoon Pool
Spa
Fitness Center
8 Restaurants
Kids Club
Private Beach

General Information

Venue Rating

★ ★ ★ ★

Currency

US Dollar (USD)

Address

Blvd Francisco Medina Ascencio Km 2.5, Puerto Vallarta 48300, Mexico

Nearest Airport

Licenciado Gustavo Diaz Ordaz International Airport (PVR)

Location

Originally a bustling mining town known as the ‘Las Peñas’ in the 19^th century, Puerto Vallarta is framed by the stunning mountains of the Sierra Madre Occidental of Jalisco and the immense Mexican Pacific. This fascinating destination with red roofs, golden sunsets, cobbled streets and beautiful beaches possesses everything that makes for an incredible place to visit.

Puerto Vallarta’s art offering is amazing, from crafts found in the flea market to the fleeting creations made by artists with the sand on the beach. Its art galleries, boardwalk, calm Banderas Bay waters - loved by scuba diving enthusiasts and bustling nightlife bare some of the contrasts that Vallarta holds.

There are many activities you can enjoy during your fee time such as visiting the El Salado estuary, going on horseback up the Quimixto waterfall or taking a tour of Banderas Bay. You may also like to explore the Jardín Botánico de Vallarta where you will find orchids, bromeliads, agaves, wild palms and fern grottos along the paths of this gorgeous nature park.

Bronze Sponsors

Exhibitors

Media Partners

If you're interested in sponsoring this conference please contact us.

Conference Manager

Meredith Willmott

Need some help? Chat to the Fusion team today

As a family run business, our dedication runs deep. We’re committed to each other and, even more so, to every attendee’s experience, delivering a level of care and passion that’s truly unmatched.

Call us

+44 (0) 1638 555057

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2nd Cell Death, Cell Stress & Metabolism Conference

Synopsis

Student Offer

Confirmed Invited Speakers:

Target Audience

Confirmed Speakers

Chairs

Invited Speakers

Programme

MONDAY 27TH MAY 2019

TUESDAY 28TH MAY 2019

WEDNESDAY 29TH MAY 2019

THURSDAY 30TH MAY 2019

Supported by

Bronze Sponsors

Exhibitors

Media Partners

Venue & Location

General Information

Location

Conference History

Bronze Sponsors

Exhibitors

Media Partners

Need some help? Chat to the Fusion team today

Looking for forthcoming conferences?

2^nd Cell Death, Cell Stress & Metabolism Conference

MONDAY 27^TH MAY 2019

TUESDAY 28^THMAY 2019

WEDNESDAY 29^TH MAY 2019

THURSDAY 30^TH MAY 2019