2 nd&nbsp; Nuclear Receptors Conference

Report

The second Fusion conference on Nuclear Receptors in Health, Development & Disease was held in Nassau, 24-27 Feb 2020 and was an outstanding success. The focus of the meeting was on defining the state of the field and its impact, past, present and future, on diverse areas of biology and healthcare. Reflecting this, our keynote speaker was the hugely influential Ron Evans, first to clone a nuclear receptor (the glucocorticoid receptor) 35 years ago. His talk recalled the serendipity of collaborations and competition that facilitated the discovery and cloning of this exciting transcription factor superfamily, noting the seminal contributions of others talking at the meeting such as Wayne Tilley (androgen receptor), Vincent Giguere, David Moore, John Cidlowski and Geoff Greene (estrogen receptor). He then moved on to his most recent intriguing work on the bile acid receptor FXR, and its role in colon cancer, coining a term new to us – the “bileome”! Another legend in the field – Benita Katzenellenbogen – gave a tour de force talk “Estrogen Receptors in Breast Cancer, and Overcoming Therapy Resistance and Aggressiveness Factors”

The meeting attracted a total of 65 participants from the USA, Canada, Australia, Sweden, France, Switzerland, Spain, The Netherlands, Germany and the United Kingdom. We were also extremely proud to have had a predominate female attendance of 52%.

The opening session on nuclear receptors in cancer sparked a lively, interactive and inclusive panel debate. A subsequent session on translating NRs to the clinic reflected the expanding use of nuclear receptors as drug targets, and cancer also featured largely here. A heated debate ensued on how efficiently we should be looking to inhibit steroid receptors in endocrine cancers – could we be driving the disease to a therapy resistant state, and what are the alternatives?

Other sessions enlightened us on nuclear receptor roles in fertility and reproduction, with not only steroid receptors but some less obvious suspects, such as liver X receptors, being implicated in fertility conditions. Metabolism and adrenal gland function will both impact on cancer, fertility and a host of other conditions and systems, and David Moore, Saskia van Mil and Gary Hammer showed us some fascinating unpublished new data on NRs in these contexts. The immune system, likewise, has an overarching effect and Inez Rogatsky presented compelling work on NR cofactors in neuroinflammation, with implications for multiple sclerosis. The effects on the brain of NR activation and antagonism is an aspect that is coming to the fore in clinical use, and fascinating talks from Jessica Tolkuhn and Holly Ingraham gave all present much to discuss – in the panel discussion and also during the social networking breaks. Our final session, on new advances in the field, highlighted not only new methodology but also featured paradigm – busting work on how type 2 nuclear receptors function, from Irina Bochkis (UVA). Throughout the meeting another hot topic of discussion was the gender imbalance in many conditions and diseases, attributable doubtless to the effects of steroid hormones and impacting on treatment and trial design.

The participants at the meeting were a healthy mix of eminent PIs, up and coming faculty and outstanding postdocs and postgraduate students. The talks reflected this, with 18 invited speakers, 17 selected from abstracts, including 2 given by students. Students also benefitted from a networking lunch with our Keynote and other field leaders, including representatives from industry and publishing. Our amazing sponsors happily contributed to this as well as to the meeting as a whole, their attendees being much in evidence during the sessions as well at the social events! We were very happy to welcome Mehrad Tavalli from Foundation Medicine, Ann Greer from Janssen and Alison Pope from Society for Endocrinology Journals to thank them for being such an integral part of the meeting.

Networking opportunities were readily available, with time in the afternoons for mini-meetings, sporting competitions and excursions. Three poster sessions afforded time to talk in depth about ongoing studies, and 4 of the many excellent posters were selected for a prize, 2 of the prizewinners being postgraduate students. At the start of the meeting, a “Meet the Poster Presenter” session allowed each to briefly introduce themselves and their work, which both the presenters and the wider audience found hugely helpful to prime subsequent discussion. The gala dinner was well attended and featured some enthusiastic Bahamian dancing, impromptu karaoke, and after-partying until the small hours. The venue, on white sands with cooling breezes, was a beautiful backdrop for this as for the whole conference. The crystal-clear sea was a great place to cool off, relax and for some, meet a very friendly but large Shark swimming in the bay trying to catch conference truants for lunch!

Meeting organisation ran smoothly, any hiccups being swiftly sorted by the ever-present, responsive and efficient Fusion team headed for us by Amy Johnson who did an excellent job, especially as it was her first Fusion meeting.

The feedback has been overwhelmingly positive and all felt the meeting to be enormously useful in assessing state of play of this important field and fostering new as well as nurturing existing collaborations to drive the research forward.

A fantastic blog was also written by postdoc Amy Mandigo (Thomas Jefferson University) highlighting the importance of the meeting from an early-career perspective. “Fusion never disappoints. The meetings are always very well organized with a lot of attendee interaction. The casual environment and generous amounts of free time really fosters an ideal environment for networking and building long term relationships with both established advisors as well as early-career trainees/peers in the field.”

We are therefore keen to hold a 3rd meeting in 2022 and welcome suggestions for topics, speakers, sponsors, and networking events!

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2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Synopsis

Nuclear Receptors are, physiologically and pharmacologically, a critical superfamily of transcription factors. They drive key processes at every stage from development and reproduction to ageing and cancer. They are critical determinants of everyday health via their roles in metabolism and circadian rhythms. Nuclear receptors allow external factors to influence cellular pathways and the fact that many bind and are activated by small molecules means they represent highly druggable targets; currently, 13% of FDA-approved drugs target nuclear receptors.

This meeting will address the new roles and novel crosstalk mechanisms that are emerging for many of the 48 human nuclear receptors, in health and disease. For example, it has long been known that the estrogen receptor drives progression of breast cancer, and patients with estrogen receptor-positive disease are treated using antiestrogens or aromatase inhibitors to inhibit estrogen signalling. Now however, it is apparent that the androgen receptor can in some cases drive breast cancer progression and is a therapeutic target, resulting in clinical trials for androgen receptor-targeting therapies in advanced breast cancer. The androgen receptor, itself long the main therapeutic target in prostate cancer, is emerging as a key player in metabolic disease, while conversely other nuclear receptor including the glucocorticoid receptor and several orphan nuclear receptors are implicated in prostate cancer progression. Meanwhile, given the impact of many nuclear receptors on the central nervous system, it is unsurprising that they are being explored in the context of neurological disorders and depression. Thus there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases.

Crosstalk between nuclear receptors and other fundamental processes is another exciting expanding area that will also be covered. DNA damage repair pathways are inextricably linked to steroid signalling via transcriptional processes, with implications for drug combinations in several diseases. Hitherto unsuspected roles of nuclear receptors in epigenetic control and the processing and function of non-coding RNAs opens up to capacity of this superfamily to further means of impacting on development and normal functioning, but also on disease development.

This unique meeting will bring together many of the leading figures in nuclear receptor research from across the globe, to discuss emerging roles and their implications for health and disease – and both human and drug development – in an intimate meeting that will generate meaningful idea exchange and interaction that will help to further shape this influential field.

Key Sessions

Nuclear receptors and cancer
Nuclear receptors in reproduction, development and metabolism
Nuclear receptors in central systems
Translating nuclear receptors to the clinic
Nuclear receptors in non-malignant disorders
New advances in nuclear receptors research

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic and bring a student for only $850. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 24, 25, 26 February 2020 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Once registered, please contact Amy Johnson to obtain a special registration link for your student.

Confirmed Keynote Speaker:

Ronald Evans (Salk Institute)
THE NUCLEAR RECEPTOR SUPERFAMILY: PHYSIOLOGY’S ROSETTA STONE

Confirmed Invited Speakers:

Mohamed Bentires-Alj (University Hospital, Basel)
BREAST TUMOR HETEROGENEITY: ACT LOCALLY, THINK GLOBALLY
Charlotte Bevan (Imperial College London)
LIVER X RECEPTOR IN MALE REPRODUCTION
Jason Carroll (University of Cambridge)
NEW INSIGHTS INTO ESTROGEN RECEPTOR GENE REGULATION IN BREAST CANCER
Edwin Cheung (University of Macau)
NUCLEAR RECEPTORS AND COREGULATORS IN GENE TRANSCRIPTION
John Cidlowski (National Insitute of Enviromental Health Sciences)
Vincent Giguère (McGill University)
TRANSCRIPTIONAL CONTROL OF BIOENERGETICS PATHWAYS BY NUCLEAR RECEPTORS
Geoffrey Greene (University of Chicago)
NOVEL STRATEGIES FOR THE TREATMENT AND PREVENTION OF ER-POSITIVE BREAST CANCER.
Gary Hammer (University of Michigan)
ENIGMA OF THE ADRENAL SHH PROGENITOR
Stephan Herzig (Helmholtz Diabetes Center)
COORDINATION OF SYSTEMIC METABOLISM BY NUCLEAR RECEPTOR COMPLEXES
Holly Ingraham (University of California, San Francisco)
HORMONE-SENSITIVE NEUROCIRCUITS IN FEMALE PHYSIOLOGY
Karen Knudsen (Thomas Jefferson University)
TARGETING DNA REPAIR FACTOR ALTERATIONS IN PROSTATE CANCER: NEW NODES FOR THERAPEUTIC INTERVENTION
Benita Katzenellenbogen (University of Illinois and College of Medicine)
ESTROGEN RECEPTORS IN BREAST CANCER, AND OVERCOMING THERAPY RESISTANCE AND AGGRESSIVENESS FACTORS
Anastasia Kralli (Johns Hopkins Medical School)
REGULATORY PATHWAYS THAT CONTROL ADAPTIVE METABOLIC RESPONSES IN ADIPOSE AND SKELETAL MUSCLE TISSUES
Lee Kraus (UT Southwestern)
MOLECULAR MECHANISMS OF ESTROGEN SIGNALING IN HORMONE-RESPONSIVE TARGET TISSUES
Susanne Mandrup (University of Southern Denmark)
MOLECULAR DETERMINANTS OF PPARgamma SUBTYPE SPECIFIC ACTIONS
David Mangelsdorf (University of Texas)
TARGETING NUCLEAR RECEPTOR REGULATION OF PARASITIC DISEASES
Donald Patrick McDonnell (Duke University)
MECHANISM BASED DRUG DISCOVERY OF ENDOCRINE THERAPIES FOR BREAST AND PROSTATE CANCER
David Moore (Baylor College of Medicine)
TARGETING NUCLEAR RECEPTORS TO TREAT INFLAMMATORY BOWEL DISEASE
Ciara Metcalfe (Genentech)
QUIETING THE ESTROGEN RECEPTOR FOR THERAPEUTIC BENEFIT IN ER+ BREAST CANCER
Inez Rogatsky (Hospital for Special Surgery and Weill Cornell Medical College)
THE ROLE OF TRANSCRIPTIONAL COREGULATOR GRIP1/NCOA2 IN NEUROINFLAMMATION
Wayne Tilley (University of Adelaide)
AGONISING OVER ANTAGONISING AR IN ER-POSITIVE BREAST CANCER
Carol Sartorius (University of Colorado)
PROGESTERONE RECEPTOR REGULATION OF BREAST CANCER HETEROGENEITY

Target Audience

Scientists and Clinician Scientists at a range of levels from postdoctoral and up: Principal Investigators, Junior Team Leaders, Research Fellows. Ambitious postgraduate students in the field will also be encouraged to attend.

Relevant specialties are wide-ranging, reflecting the importance of nuclear receptors in many aspects of health and disease. These include Endocrinology, Oncology, Paediatrics, Urology, Gynaecology, Obstetric Medicine, Neuroscience, Cardiology.

Educational Need

Since the first cloning of the nuclear receptors in the 1980s, they have been the subject of detailed molecular investigation due to their critical roles in every aspect of cellular and physiological functioning. This has led to enormous progress in our understanding of how external factors can act via nuclear receptors to drive processes such as development, metabolism, reproduction, sexual function, and influence diseases such as metabolic syndrome, depression and cancer. Currently, around 13% of FDA-approved drugs target nuclear receptors, reflecting their unique druggability among transcription factors and pharmacological importance. Although we have known for some time that growth factor signalling can influence nuclear receptor signalling and vice versa, over the last few years, some hitherto unsuspected roles for nuclear receptors have emerged. Notable among these is the crosstalk between steroid receptors and DNA damage repair pathways, and more recently the mutual regulation between nuclear receptor signalling and microRNA action, which has far-reaching implications. Further, it is increasingly apparent that nuclear receptors have influence and action outside of the roles we have traditionally ascribed to them, and can drive processes and diseases either in normal function or in as a consequence of advanced disease (e.g. androgen receptor driving some forms of breast cancer, or glucocorticoid receptor “hijacking” androgen receptor-driven transcription in some advanced prostate tumours). There is an urgent need for integration of this knowledge across the many disciplines which nuclear receptors impact – although endocrinology meetings can combine many of these they do not encompass al. Further, as nuclear receptor research is frequently marginalised at these meetings, they are not traditionally well attended by, for examples, those in the hormone-dependent cancer field or neuroscientists. This meeting will bring together the scientists and clinicians who have made these surprising discoveries, those who are further delineating the novel mechanisms and those who are applying the new knowledge in clinical development, to discuss the ramifications and implication, the common ground and the idiosyncrasies. There is an urgent need to use this knowledge to drive both drug repurposing for existing nuclear receptor-targeted therapies, and new drug development. The intimate venue and small size will provide a unique platform for new collaborations to be formed and existing ones cemented, and meaningful knowledge and idea exchange, to really drive the next decade of research in this important area.

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2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Speakers

Plenary Speakers

Ronald Evans

Professor, Head of Gene Expression Laboratory, Salk Institute

Invited Speakers

Gary Hammer

Clinician/Researcher, University of Michigan

Ciara Metcalfe

Scientist, Genentech

Benita Katzenellenbogen

Professor of Physiology and Cell Biology, University of Illinois at Urbana-Champaign

Mohamed Bentires-Alj

Professor of Experimental Surgical Oncology, University of Basel

Geoffrey Greene

Professor and Chair, University of Chicago

Donald McDonnell

Professor and Chairman, Department of Pharmacology and Cancer Biology, Duke University School of Medicine

John Cidlowski

Chief, NIH/NIEHS

David Mangelsdorf

Professor, University of Texas Southwestern Medical Center

Jason Carroll

Professor, University of Cambridge

Carol Sartorius

Professor, University of Colorado Anschutz Medical Center

W. Lee Kraus

Professor and Director, UT Southwestern Medical Center

Stephan Herzig

Director, Helmholtz Diabetes Center

Vincent Giguère

Profesor, Goodman Cancer Research Centre

Anastasia Kralli

Professor, Johns Hopkins University

David Moore

Professor, Baylor College of Medicine

Holly Ingraham

Professor and Vice Chair, UCSF

Inez Rogatsky

Professor, Senior Scientist, Hospital for Special Surgery and Weill Cornell Medical College

Daniel Gioeli

Associate Professor, University of Virginia

Supported By

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Silver

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2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Programme

MONDAY 24^TH FEBRUARY 2020
13:00 – 14:00	Student Networking Lunch
14:00 – 15:00	Registration & Welcome Reception
NUCLEAR RECEPTORS AND CANCER Donald McDonnell and Gary Hammer
15:00 – 15:10	Opening Comments
15:10 – 15:35	Wayne Tilley The University of Adelaide	AGONISING OVER ANTAGONISING AR IN ER-POSITIVE BREAST CANCER
15:35 – 16:00	Carol Sartorius University of Colorado Anschutz Medical Campus	PROGESTERONE RECEPTOR REGULATION OF BREAST CANCER HETEROGENEITY
16:00 – 16:15	Isabella Goldsbrough Imperial College London	INVESTIGATING THE FUNCTIONAL IMPORTANCE OF MUTATIONS IN THE ESTROGEN RECEPTOR-Α GENE PRESENT IN METASTATIC, ENDOCRINE-RESISTANT BREAST CANCER
16:15 – 16:40	Mohammed Bentires-Alj University of Basel	BREAST TUMOR HETEROGENEITY: ACT LOCALLY, THINK GLOBALLY
16:40 – 16:55	Ayesha Shafi Thomas Jefferson University	CIRCADIAN CRYPTOCHROME 1 (CRY1) RHYTHMICALLY MODULATES DNA DAMAGE RESPONSE IN PROSTATE CANCER
16:55 – 17:40	Refreshments
17:40 – 18:05	Geoff Greene The University of Chicago	NOVEL STRATEGIES FOR THE TREATMENT AND PREVENTION OF ER-POSITIVE BREAST CANCER.
18:05 – 18:20	Cecilia Williams KTH Royal Institute of Technology / Karolinska Institute	INTESTINAL ESTROGEN RECEPTOR BETA SUPPRESSES COLON INFLAMMATION AND TUMORIGENESIS IN BOTH SEXES
18:20 – 18:35	Hisham Mohammed The Knight Cancer Institute – OHSU	MULTI-OMIC SINGLE-CELL APPROACH REVEALS TRANSCRIPTIONAL AND EPIGENETIC PLASTICITY IN HORMONE DRIVEN CANCERS
18:35 – 18:50	Moray Campbell The Ohio State University	CONVERGENT EPIGENETIC TARGETING OF RARg RE-WIRES AR SIGNALING AND PROMOTES PROSTATE CANCER PROGRESSION.
18:50 – 19:20	PM Panel Discussion
19:20 – 19:50	Meet the Poster Presenters
KEYNOTE – CELEBRATING 35 YEARS OF THE NUCLEAR RECEPTOR FAMILY Charlotte Bevan & Wayne Tilley
19:50 – 20:25	Ronald Evans Salk Institute/ HHMI	THE NUCLEAR RECEPTOR SUPERFAMILY: PHYSIOLOGY’S ROSETTA STONE
20:25	Group Dinner

TUESDAY 25^TH FEBRUARY 2020
07:00 – 09:00	Buffet Breakfast at The Market Place
NUCLEAR RECEPTORS IN REPRODUCTION, DEVELOPMENT AND METABOLISM Catherine Williamson and David Moore
09:10 – 09:25	Sarah Cunningham Duke University	GLUCOCORTICOID REGULATED KCNA5 MEDIATES CELL CYCLE IN FETAL MEMBRANES
09:25 – 09:50	Darryl Russell University of Adelaide	PROGESTERONE RECEPTOR TISSUE SPECIFIC MECHANISMS OF ACTION IN FEMALE REPRODUCTIVE ORGANS.
09:50 – 10:35	Group Photo, Refreshments & Poster Viewing
10:35 – 11:00	Vincent Giguerre McGill University	TRANSCRIPTIONAL CONTROL OF BIOENERGETICS PATHWAYS BY NUCLEAR RECEPTORS
11:00 – 11:25	Charlotte Bevan Imperial College London	LIVER X RECEPTOR, THE TESTIS, AND MALE (IN)FERTILITY
11:25 – 11:50	Gary Hammer University of Michigan	ENIGMA OF THE ADRENAL SHH PROGENITOR
11:50– 12:20	AM Panel Discussion
12:20 – 16:35	Lunch at Leisure & Free Time
NUCLEAR RECEPTORS IN CENTRAL SYSTEMS Melissa Cunningham and Ray Blind
16:35 – 17:00	John Cidlowski National Insitute of Enviromental Health Cciences	PHYSIOLOGICAL AND MOLECULAR CROSSTALK AMONG NUCLEAR RECEPTORS
17:00 – 17:25	Natasha Kralli Johns Hopkins Medical School	REGULATORY PATHWAYS THAT CONTROL ADAPTIVE METABOLIC RESPONSES IN ADIPOSE AND SKELETAL MUSCLE TISSUES
17:25 – 17:40	Saskia van Mil UMC Utrecht	FXR ISOFORMS CONTROL DISTINCT HEPATIC METABOLIC FUNCTIONS VIA SELECTIVE DNA BINDING.
17:40 – 17:55	Andrew Holding University of York	COMBINING MACHINE LEARNING WITH CHIP-SEQ TO PREDICT TRANSCRIPTION FACTOR INTERACTIONS.
17:55 – 18:20	Holly Ingraham UCSF	ESTROGEN SIGNALING IN THE HYPOTHALAMUS: IMPLICATIONS FOR WOMEN’S HEALTH
18:20 – 18:50	PM Panel Discussion
18:50 – 20:20	Poster Session & Refreshments
20:20	Dinner

WEDNESDAY 26^TH FEBRUARY 2020
07:00 – 09:00	Buffet Breakfast at The Market Place
TRANSLATING NUCLEAR RECEPTORS TO THE CLINIC Jason Carroll and Marianne Greene
09:00 – 09:25	Ciara Metcalfe Genentech	QUIETING THE ESTROGEN RECEPTOR FOR THERAPEUTIC BENEFIT IN ER+ BREAST CANCER
09:25 – 09:40	Claire Fletcher Imperial College London	LONG NON-CODING RNA/MICRORNA INTERACTIONS COORDINATELY MODULATE ANDROGEN RECEPTOR SIGNALLING, DNA DAMAGE RESPONSE AND IMMUNE ACTIVATION IN ADVANCED PROSTATE CANCER
09:40 – 10:05	Daniel Gioeli University of Virginia	CELL CYCLE CHECKPOINT AND ANDROGEN RECEPTOR CROSS TALK
10:05 – 10:30	Donald McDonnell Duke University	MECHANISM BASED DRUG DISCOVERY OF ENDOCRINE THERAPIES FOR BREAST AND PROSTATE CANCER
10:30 – 11:15	Refreshments & Poster Viewing
11:15 – 11:40	Benita Katzenellenbogen University of Illinois	ESTROGEN RECEPTORS IN BREAST CANCER, AND OVERCOMING THERAPY RESISTANCE AND AGGRESSIVENESS FACTORS
11:40 – 11:55	Onno Meijer Leiden University Medical Center	SELECTIVE GR MODULATORS AS POTENTIAL THERAPEUTICS AND RESEARCH TOOLS TO UNRAVEL GLUCOCORTICOID EFFECTS
11:55 – 12:20	Inez Rogatsky HSS Research Institute	THE ROLE OF TRANSCRIPTIONAL COREGULATOR GRIP1/NCoA2 IN NEUROINFLAMMATION
12:20 – 12:35	Mehrad Tavallai Foundation Medicine	COMPREHENSIVE GENOMIC PROFILING ILLUMINATES POTENTIAL THERAPEUTIC OPTIONS FOR HORMONE RECEPTOR-POSITIVE MALE BREAST CANCER
12:35 – 13:05	AM Panel Discussion
13:05 – 17:15	Lunch at Leisure & Free Time
NUCLEAR RECEPTORS IN NON-MALIGNANT DISORDERS Ciara Metcalfe and Amy Mandigo
17:15 – 17:40	David Moore Baylor College of Medicine	TARGETING NUCLEAR RECEPTORS TO TREAT INFLAMMATORY BOWEL DISEASE
17:40 – 17:55	Jessica Tollkuhn Cold Spring Harbor Laboratory	ESTROGEN RECEPTOR GENE REGULATION IN THE BRAIN
17:55 – 18:20	Stephan Herzig Helmholtz Zentrum Munich	COORDINATION OF SYSTEMIC METABOLISM BY NUCLEAR RECEPTOR COMPLEXES
18:20 – 18:50	Refreshments & Poster Viewing
18:50 – 19:05	Eric Kalkhoven UMC Utrecht	A NATURAL HUMAN LXRΒ VARIANT DISPLAYS BOTH LOSS- AND GAIN-OF-FUNCTION ACTIVITY
19:05 – 19:30	David Mangelsdorf University of Texas	TARGETING NUCLEAR RECEPTOR REGULATION OF PARASITIC DISEASES
19:30 – 20:00	PM Panel Discussion
20:00	Gala Dinner & Poster Awards

THURSDAY 27^TH FEBRUARY 2020
07:30 – 09:00	Buffet Breakfast at The Market Place
NEW ADVANCES Iain McEwan and John Katzenellenbogen
09:00 – 09:25	Lee Kraus University of Texas	MOLECULAR MECHANISMS OF ESTROGEN SIGNALING IN HORMONE-RESPONSIVE TARGET TISSUES
09:25 – 09:40	Cyrille de Joussineau Université Clermont Auvergne	DROSOPHILA ACCESSORY GLAND, A 3R-COMPATIBLE IN VIVO MODEL TO STUDY THE ROLE OF SEX STEROIDS IN EARLY TUMORIGENESIS
09:40 – 09:55	Irina Bochkis University of Virginia	ROLE OF FOXA2 IN LIGAND-DEPENDENT ACTIVATION OF NUCLEAR RECEPTORS
09:55 – 10:20	Jason Carroll University of Cambridge	NEW INSIGHTS INTO ESTROGEN RECEPTOR GENE REGULATION IN BREAST CANCER
10:20 – 10:45	Eva Estebanez-Perpina University of Barcelona	ACROSS THE SPECTRUM OF GR AND AR OLIGOMERIZATION COMPLEXES
10:45 – 11:15	AM Panel Discussion
11:15 – 11:30	Closing Comments

Supported By

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If you're interested in sponsoring this conference please contact us.

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Prices

Ticket Type	Early Bird	Full Price
Single Choose this option if you will be attending the conference alone, or if you will bring accompanying guests that will not attend the meeting.	$1845	$1945
Shared Choose this option if you wish to share with a colleague who is also attending the conference, or if you wish to be paired with another attendee of the same sex.	$1845	$1945
Student Choose this option if you are a student. Please note all students will be paired with another attendee of the same sex if a room sharer is not specified. If you wish to have your own room, please register under the Single option.	$1556	$1656

Additional Person

This is the cost for an additional adult or child to join you in the same room, for the entire conference period. Accompanying persons are not permitted access to the conference. If you wish to extend your stay, please see our 'Extra night' prices.

Adult

$684

Child

$263

Extra nights

Prices are per person.

Adult

$321

Child

$88

All registration fees include 3 nights accommodation and meals during the conference period. Exact inclusions are detailed below.

What's Included in our Registration Fees?

Our registration fees are inclusive of the following during the conference period only:

- Conference registration
- 3 Nights’ fixed accommodation (24, 25, 26 Feb 2020) on a single basis for academics and industry, on a shared basis for students/Postdocs
- Breakfast, lunch and dinner available at all restaurants according to their operational hours (excluding Black Angus and Starbucks)
- Unlimited select brand liquors, wines by the glass, local domestic beer, bottled water and soft drinks
- Gala Dinner (includes an open bar)
- Room service
- Guest room mini bar
- Non motorized water sports equipment
- Complimentary WIFI in both conference rooms and your guest room

What's Included in our Accompanying Adult Fees?

Our accompanying adult fees are inclusive of the following during the conference period only:

- 3 Nights’ fixed accommodation (24, 25, 26 Feb 2020) on a shared basis with a conference participant
- Breakfast, lunch and dinner available at all restaurants according to their operational hours (excluding Black Angus and Starbucks)
- Unlimited select brand liquors, wines by the glass, local domestic beer, bottled water and soft drinks
- Gala Dinner (includes an open bar)
- Room service
- Guest room mini bar
- Non motorized water sports equipment
- Complimentary WIFI in your guest room

Important Note: Accompanying persons are not permitted access to the conference.

What's Included in our Accompanying Child Fees?

Our accompanying child fees are inclusive of the following during the conference period only:

- 3 Nights’ fixed accommodation (24, 25, 26 Feb 2020) on a shared basis with the parent/s
- Breakfast, lunch and dinner available at all restaurants according to their operational hours (excluding Black Angus and Starbucks)
- Unlimited bottled water and soft drinks
- Gala Dinner
- Room service
- Non motorized water sports equipment
- Complimentary WIFI in your guest room

Important Note: Accompanying child fees are applicable for children aged 2-12 years. Children younger than 2 years stay free of charge with a parent. Children aged 13-17 years will be charged $377 per child. 18 years + will be classified as an adult at this venue (Melia Nassau Beach, Bahamas).

Please kindly ensure your child / children are supervised at all times during conference and related events. Childcare services are available at the hotel, please contact Amy Johnson for further information.

What's Included in our Extra Night Fees?

- 1 night’s accommodation for 1 person
- Breakfast, lunch and dinner available at all restaurants according to their operational hours (excluding Black Angus and Starbucks)
- Unlimited select brand liquors, wines by the glass, local domestic beer, bottled water and soft drinks
- Room service
- Guest room mini bar
- Non motorized water sports equipment
- Complimentary WIFI in your guest room

Important Note: Extra night child fees are applicable for children aged 2-12 years. Children younger than 2 years stay free of charge with a parent. Children aged 13-17 years will be charged $126 per night, per child. 18 years + will be classified as an adult at this venue (Melia Nassau Beach, Bahamas).

Supported By

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Silver

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Media Partners

If you're interested in sponsoring this conference please contact us.

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Grants

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Supported By

Gold

Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

LinkedIn forum

The Nuclear Receptors Research Network is an excellent platform to bring together the global community of researchers and scientists interested Nuclear Receptors. To join, please follow the link below

Join our group

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Media Partners

If you're interested in sponsoring this conference please contact us.

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Venue

Melia Nassau Beach All Inclusive

Overlooking one of the finest beaches in the world the Meliá Nassau Beach is surrounded by crystal blue waters and white sandy beaches. Located on the stunning Cable Beach, you are just a few minutes walk from the center, shops and restaurants. The beautiful Nassau Botanical Gardens are within easy reach (7km) and Lynden Pindling International Airport is situated only 9km away.

Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from Cilantro where you can experience the natural textures, aromas and flavors of Mexico, Nikkei, celebrated for its exquisite fusion of Japanese, Cantonese and Peruvian cuisine featuring a sushi bar and Teppanyaki tables, Estavida, an upbeat tapas lounge located in the hotel lobby serving innovative tapas and a wide selection of cocktails, Aqua, an A la carte restaurant specializing in exquisite, rustic Italian cuisine, The Market Place, where you will find an International buffet serving an array of exquisite dishes, O'Grille, an open air restaurant with fabulous views of the sea and pool serving casual beach fare and light bites and finally The Black Angus, a steakhouse featuring hip, contemporary jazz and modern decor, offering guests the finest quality prime cuts and the freshest ingredients.(This restaurant is not included in the all inclusive package, additional charges apply). The Gala Night takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!

Hotel Facilities

24 hour reception
Room service
3 heated outdoor pools
Complimentary resort wide Wi-Fi (guest rooms, throughout hotel, beach and conference areas)
24-hour Fitness Center
7 dining venues
4 bars.
non-motorised water sports

The Bahamas is formed by over 700 islands, keys and islets located in the Atlantic Ocean and renowned for its warm sunshine, mild climate, fine, white sandy beaches, turquoise, crystal clear water and friendly people, making this the perfect environment to relax and unwind in your free time during the conference.

Venue Rating

Currency

US Dollar (USD)

Address

Nassau W Bay St. Nassau Bahamas

Nearest Airport

Lynden Pindling International Airport

Location

The Melia Nassau Beach All-Inclusive is located right on the stunning Cable Beach just a few minutes away from the airport and city center; Nearby in Downtown Nassau you can experience the flavours of new foods at local restaurants, shop 'til you drop at Straw market or take a trip through time at the Pirates Museum. The beautiful Nassau Botanical Gardens are close by and water enthusiasts can enjoy non-motorized water sports right on property.

Nassau is the capital of the Bahamas. It lies on the island of New Providence, with neighboring Paradise Island accessible via Nassau Harbor bridges. The city has a hilly landscape and is known for it's fabulous beaches as well as its offshore coral reefs, popular for diving and snorkeling. It retains many of its typical pastel-colored British colonial buildings, like the pink-hued Government House.

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If you're interested in sponsoring this conference please contact us.

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

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Transportation

The Melia Nassau Beach Resort is located just 9km from Lynden Pindling International Airport, approximately 10-15 minutes journey time. Formerly known as Nassau International Airport, it is the largest airport in the Bahamas and provides an international gateway into the country.

Taxis

There’s no shortage of available taxi cabs at Lynden Pindling International Airport. Taxis are available outside the U.S., International and Domestic terminals. Taxis charge approximately $25 one way to the Melia Nassau Hotel, however charges may increase if there are more than two passengers and/or two large suitcases.

Pre-Booked Airport Transfers

There are various suppliers that offer pre-booked airport transfer services to and from Lynden Pindling Airport. Please find details of a few that we are aware of below. However, should you require further information or would like to make a booking, please contact the company directly. Pre-booked transportation prices range from $70 - $145 one way.

Simon's Transports Ltd
Contact Name: Jocelyne Casimir
Contact Email: info@simonstransports.com
Website: https://simonstransportsbahamas.com/nassau-airport-transfers/

Majestic Tours
Contact Name: Betty Fox
Contact Email: betty@MajesticHolidays.com
Website: http://www.majestictoursbahamas.com/

Cheryl Bahamas Taxi & Tours
Contact Email: cherylfoxferguson@live.com
Website: http://www.cherylbahamastaxiandtours.com/

Black Diamond Transportation (BDT Bahamas)
Website: https://bdtbahamas.com

**Any bookings and transactions made with the above suppliers are the sole responsibility of the individual.

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Silver

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Media Partners

If you're interested in sponsoring this conference please contact us.

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

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Local Activities

Several free activities are available within the resort and include:

Trip to Balmoral Island during your stay; a taxi boat to and from Balmoral Island and access to the VIP Balmoral Beachside is included. Please ask reception for the boat departure/return schedule.
Daily fitness activities: gym classes, yoga, zumba, pool aerobics, etc.
In the water: paddleboards, glass-bottom kayaks, ocean duo kayaks, reef-board zayaks, cabana floating mats, water hammocks, etc.
Workshops: jewellery making, henna tattoo, scent creation, Bahamian crafts, etc.
Classes: mixology, scuba diving, dancing, etc.
Friendly competitions: beach volleyball, beach soccer, ping pong, darts, water balloon toss, deep dive contest, etc.
Free shuttle to Baha Mar and direct access to its spectacular 100,000 sq. ft. casino, Royal Blue™ tournament player’s golf course with special rates for Meliá guests, tennis court, spa, retail outlets and over 30 dining venues and lounges.

Supported By

Gold

Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Group Activities

Unfortunately, due to the recent shark attacks, we will no longer be offering a group snorkelling trip for our conferences in the Bahamas next year.

For those of you who still wish to enjoy tours/excursions outside of the resort during free time, Majestic Tours is a local tour operator offering individual or small group trips which can be pre-booked or organised through their hospitality desk within the hotel. For more information, please contact Majestic Tours directly.

Majestic Tours
Contact Name: Betty Fox
Contact Email: betty@MajesticHolidays.com
Website: http://www.majestictoursbahamas.com/

A number of free activities are also available within the resort, please visit our ‘Local Activities’ tab for more information.

Supported By

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Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Childcare

Supported By

Gold

Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Oral Presenters

We have several oral opportunities available at this meeting. To be considered for a talk, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.

Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.

If you are accepted for a talk, we recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference website.

Your Presentation

On the day of your presentation please make yourself known to our AV technician who will be present in the conference room. We advise running through your presentation at least 30minutes prior to your session commencing to ensure your slides and any videos or animations appear as expected. We prefer our speakers to run their presentation from the master PC or Mac, however, if you prefer to use your own laptop then please notify us prior to the session. A HDMI or VGA cable is usually available on the podium.

Our AV technician will apply your microphone and provide a combined slide advancer and laser pointer.

We ask all speakers to adhere to their time slots and respect their fellow presenters. A visual traffic light aide will be available to warn presenters as their time decreases.

Please make sure your presentation adheres to the following guidelines.

Aspect Ratio: On Screen Show 16:9 (we can also accommodate 4:3 presentations)
File Type: Please save your presentation in PPT, PPTS or Keynote format.

Download Abstract Template

Supported By

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Media Partners

If you're interested in sponsoring this conference please contact us.

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs

Posters

We have several poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.

Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.

Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.

Displaying & Presenting Your Poster

Please bring your poster to registration and hand this to a member of the Fusion team. They will advise of your poster number and display your poster for you.

Your poster will remain on display for the duration of the conference, allowing presenters to take advantage of the refreshment breaks and free time for valuable networking opportunities, in addition to the official poster session.

Please check the programme and note the date and time of the poster session(s). Your poster will be judged during the poster session and prizes will be awarded at the Gala Dinner.

Posters will be taken down by the Fusion team and will be ready for collection at the Fusion desk on the final day of the conference.

Download Abstract Template

Supported By

Gold

Silver

Bronze

Media Partners

If you're interested in sponsoring this conference please contact us.

2^ndNuclear Receptors Conference

New Roles for Nuclear Receptors in Development, Health and Disease #NR2020

24 Feb 2020 - 27 Feb 2020

Nassau, Bahamas

Chairs