Registration deadlines

Early Bird - 01 May 2025

Talk Submission - 01 May 2025

Poster Submission - 14 Aug 2025

Registration Deadline - 14 Aug 2025

Register

Conference Manager

Emily Meen

Emily Meen

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Synopsis

The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility premature ageing, and neurodegeneration. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication & repair, chromosome segregation and cellular responses to DNA damage, such as cellular senescence, with those interested in how chromosomal instability can influence human pathology, with a special focus on aging and age-related pathologies. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities.

Key Sessions

  • Pathways for repair of DNA damage and disrupted DNA replication forks
  • Screening tools for analysis of genome maintenance pathways and for development of new therapeutics
  • Molecular and cellular determinants of aging, with a particular focus on cellular senescence.
  • Chromosome instability as a driver of tumorigenesis, neurodegeneration and ageing
  • Exploitation of defects in chromosome maintenance in cancer treatment

Confirmed Invited Speakers

Peter Baumann (Johannes Gutenberg University of Mainz)
Ivana Bjedov (University College London)
Dan Durocher (Lunenfeld-Tanenbaum Research Institute)
Maria Ermolaeva (Leibniz Institute on Aging)
Daniele Fachinetti (Institut Curie)
Daniel Gerlich (Institute of Molecular Biotechnology)
Jesus Gil (MRC Laboratory of Medical Sciences)
Myriam Gorospe (National Institutes of Health)
Andrew Jackson (University of Edinburgh)
Oscar Llorca (Spanish National Cancer Center)
Niels Mailand (Novo Nordisk Foundation Center for Protein Research)
Cristina Mayor-Ruiz (IRB Barcelona)
Juan Mendez (Spanish National Cancer Center)
Daniel Munoz-Espin (University of Cambridge)
Serena Nik-Zainal (University of Cambridge)
Andre Nussenzweig (National Institutes of Health)
KJ Patel (Weatherall Institute of Molecular Medicine (WIMM), University of Oxford)
Lorenza Penengo (Institute of Molecular Cancer Research)
Evi Soutoglou (University of Sussex)
Zuzana Storchova (University of Kaiserslautern-Landau)
Dario Valenzano (Leibniz Institute on Aging)
Steve West (Francis Crick Institute)

Target Audience

This meeting will appeal to Molecular/Cell Biologists/Geneticists & Biochemists interested in genome stability. Researchers interested in the molecular basis of cancer, neurodegenerative diseases and ageing and those with an interest in high throughput genetic and pharmacological screening methods will also find the conference highly relevant along with those wishing to exploit genome maintenance abnormalities in tumour cells for therapeutic benefit.

Educational Need

Chromosome instability is involved in several human diseases and is a feature of natural ageing. This conference will bridge fundamental studies on the mechanisms by which cells maintain genome stability with applications of these studies aimed at the development of new therapies. Hence, the conference will bridge basic biology and clinical applications in this rapidly advancing field. Attendees should be able to obtain a full picture of the current status of the field, as well as to interact with prominent research leaders driving the clinical application of the latest research.

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Speakers

Invited Speakers

Peter Baumann

Johannes Gutenberg University of Mainz

Ivana Bjedov

University College London

Dan Durocher

Lunenfeld-Tanenbaum Research Institute

Maria Ermolaeva

Leibniz Institute on Aging

Daniele Fachinetti

Institut Curie

Daniel Gerlich

Institute of Molecular Biotechnology

Jesus Gil

MRC Laboratory of Medical Sciences

Myriam Gorospe

National Institutes of Health

Andrew Jackson

University of Edinburgh

Oscar Llorca

Spanish National Cancer Center

Niels Mailand

Novo Nordisk Foundation Center for Protein Research

Cristina Mayor-Ruiz

IRB Barcelona

Juan Mendez

Spanish National Cancer Center

Daniel Munoz-Espin

University of Cambridge

Serena Nik-Zainal

University of Cambridge

Andre Nussenzweig

National Institutes of Health

KJ Patel

Weatherall Institute of Molecular Medicine (WIMM), University of Oxford

Lorenza Penengo

Institute of Molecular Cancer Research

Evi Soutoglou

University of Sussex

Zuzana Storchova

University of Kaiserslautern-Landau

Dario Valenzano

Leibniz Institute on Aging

Steve West

Francis Crick Institute

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Programme

Although the programme has not yet been released, we are able to confirm that the conference should begin no earlier than 14:00 with opening comments on Tuesday 07 October 2025. The conference will conclude no later than 12:30 on Friday 10 October 2025.


4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Prices

Ticket Type Early Bird Full Price
Single
Choose this option if you will be attending the conference alone, or if you will bring accompanying guests that will not attend the meeting.
€2036 €2132
Shared
Choose this option if you wish to share with a colleague who is also attending the conference, or if you wish to be paired with another attendee of the same sex.
€1733 €1829
Student
Choose this option if you are a student. Please note all students will be paired with another attendee of the same sex if a room sharer is not specified. If you wish to have your own room, please register under the Single option.
€1118 €1118
Additional Person
This is the cost for an additional adult or child to join you in the same room, for the entire conference period. Accompanying persons are not permitted access to the conference. If you wish to extend your stay, please see our 'Extra night' prices.

Adult

€520

Child

€7

Extra nights
Prices are per person.

Adult

€267

Child

€0


All registration fees include 3 nights accommodation and meals during the conference period. Exact inclusions are detailed below.

What's Included in our Registration Fees?

Our registration fees are inclusive of the following during the conference period only:

- Conference registration 
- 3 nights’ fixed accommodation (07,08,09 October 2025) on a single or shared basis. 
- Buffet breakfast in Oceana restaurant
- Buffet lunch in the in Oceana restaurant with two soft drinks or juices, coffee/tea and water
- Buffet dinner in the in Oceana restaurant, plus two drinks vouchers (can be exchanged for a glass of house wine, glass of house beer, or soft drink)
- BBQ Gala Dinner with three drink tickets (can be exchanged for a glass of house wine, glass of house beer or soft drink)
- Two drink tickets during the poster session (can be exchanged for a glass of house wine, glass of house beer or soft drink)
- Complimentary WIFI in both conference rooms and guest room

What's Included in our Accompanying Adult Fees?

Our accompanying adult fees are inclusive of the following during the conference period only:
- 3 nights’ fixed accommodation (07,09,10 October 2025) on a shared basis with a conference participant
- Buffet breakfast in Oceana restaurant
- Buffet lunch in the in Oceana restaurant with two soft drinks or juices, coffee/tea and water
- Buffet dinner in the in Oceana restaurant, plus two drinks vouchers (can be exchanged for a glass of house wine, glass of house beer, or soft drink)
- BBQ Gala Dinner with three drink tickets (can be exchanged for a glass of house wine, glass of house beer or soft drink)
- Complimentary WIFI in guest room

Important Note: Accompanying persons are not permitted access to the conference. Meals are only available during the times listed in the conference programme and accompanying guests must dine with the group.

What's Included in our Accompanying Child Fees?

Our accompanying child fees are inclusive of the following during the conference period only:

- 3 nights’ fixed accommodation (07,08,09 October 2025) on a shared basis per adult
- Buffet breakfast in Oceana restaurant
- Buffet lunch in the in Oceana restaurant
- Buffet dinner in the in Oceana restaurant
- BBQ Gala Dinner
- Complimentary WIFI in guest room

Important Note: Meals are only available during the times listed in the conference programme and accompanying children must dine with the group. No beverages are included for children and must be paid on consumption.

Accompanying child fees are applicable for children aged 0-10 years. Children aged 11+ years are classified as an adult.

Please kindly ensure your child / children are supervised at all times during conference and related events. Childcare services are available at the hotel, please contact Emily for further information.

What's Included in our Extra Night Fees?

- 1 night’s accommodation for 1 person
- Buffet breakfast in Oceana restaurant
- Complimentary WIFI in your guest room

Important Note: Extra night child fees are applicable for children aged 0-11 years when accompanied by an adult. Children aged 11+ years are classified as an adult.

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Grants

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

LinkedIn forum

The DNA Research Network is an excellent platform to connect with fellow attendees and likeminded researchers prior to the conference. 

The Linkedin Group is designed to bring together the global community of researchers and scientists interested in the study of DNA. Relevant specialties are wide-ranging, reflecting the importance of DNA Research in many aspects of health and disease, including; DNA Repair, DNA Replication, DNA Damage, Cancer, Chromosomal Instability, RNA and Nucleic Acids. The group is open to all and is intended as a networking forum for past, present and future participants of Fusion Conferences as well as those interested in the related topics.

Join our group

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Venue

Hilton Malta

We are excited to be visiting this beautiful Mediterranean destination in autumn 2025 – the Hilton Malta in St Julian’s, Malta. The oceanfront resort overlooks the stunning Portomaso Marina in St. Julian’s.

This beautiful hotel is located only 15 minutes from the ancient capital city of Valletta, a UNESCO World Heritage Site. Megaliths, medieval dungeons and Calypso’s Cave – The Maltese Islands are positively mythic. As the countryside is dotted with medieval towers, wayside chapels and the oldest known human structures in the world, the Islands have rightly been described as an open-air museum.

This is not an all-inclusive property, but we have arranged a full food and beverage package for delegates during the conference period which is included within the registration fee. Breakfast will be at leisure each morning, but participants will dine together for conference lunches and dinners. For anyone staying any extra nights, the rate will be bed and breakfast only so delegates can choose whether to dine at the hotel or explore and eat elsewhere. 

Hotel facilities include;
•    Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
•    4 Seasonal Outdoor Pools
•    Spa with Indoor Swimming Pool
•    Fitness Center and Tennis Court
•    3 Restaurants
•    2 Bars

Venue Rating

Currency

Euro (EUR)

Address

Vjal Portomaso St Julian's PTM, 01, Malta

Nearest Airport

Malta International Airport

Location

The Hilton Malta overlooks the stunning Portomaso Marina in St. Julian’s. This beautiful hotel is located only 15 minutes from the ancient capital city of Valletta, a UNESCO World Heritage Site. 

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Transportation

The hotel is approximately 20 minutes from Malta International Airport, the official airport of the Maltese Islands.

Taxis

Taxis are available outside the airport, however we would strongly recommend you use one of the transport app providers below.

There are 3 options for booking transport with an app- Uber, Bolt and eCabs. They all operate in and around Malta, and the fares are generally cheaper than a taxi. The cost of transfers between Malta International Airport and the city of St Julians generally ranges from €15 to €20.

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Local Activities

Local activity details will be announced here soon. 

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Group Activities

Group activities will be announced here soon.

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Childcare

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Oral Presenters

We have several oral opportunities available at this meeting. To be considered for a talk, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.

Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.

If you are accepted for a talk, we recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference website.

Your Presentation

On the day of your presentation please make yourself known to our AV technician who will be present in the conference room. We advise running through your presentation at least 30 minutes prior to your session commencing to ensure your slides and any videos or animations appear as expected. We prefer our speakers to run their presentation from the master PC or Mac, however, if you prefer to use your own laptop then please notify us prior to the session. A HDMI or VGA cable is usually available on the podium.

Our AV technician will apply your microphone and provide a combined slide advancer and laser pointer.

We ask all speakers to adhere to their time slots and respect their fellow presenters. A visual traffic light aide will be available to warn presenters as their time decreases.

Please make sure your presentation adheres to the following guidelines.

Aspect Ratio: On Screen Show (16:9)
File Type: Please save your presentation in PPT, PPTS or Keynote format.

Download Abstract Template

Download Abstract Template

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Posters

We have several poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and upload your abstract when prompted to do so. You will be able to monitor the status of your abstract through your Fusion account and you will also receive an email if you are successful or unsuccessful.

Please use the abstract template provided (see below) and ensure your abstract is no longer than one page in length.

Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.

Displaying & Presenting Your Poster

Please bring your poster to registration and hand this to a member of the Fusion team. They will advise of your poster number and display your poster for you.

Your poster will remain on display for the duration of the conference, allowing presenters to take advantage of the refreshment breaks and free time for valuable networking opportunities, in addition to the official poster session.

Please check the programme and note the date and time of the poster session(s). Your poster will be judged during the poster session and prizes will be awarded at the Gala Dinner.

Posters will be taken down by the Fusion team and will be ready for collection at the Fusion desk on the final day of the conference.

Download Abstract Template

Download Abstract Template

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25


07 Oct 2025 - 10 Oct 2025

St. Julians, Malta

Chairs

Oscar Fernandez-Capetillo
Spanish National Cancer Center/ Karolinska Institute
Ian Hickson
University of Copenhagen

Conference History

30 Sep 2014, 03 Oct 2014

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From Molecules to Human Health

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More Information

03 Jul 2017, 06 Jul 2017

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health

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14 Oct 2023, 17 Oct 2023

3rd Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD23

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All spaces for this conference have been filled and so we have had to close registration before the deadline. If you would like to be added to our wait list, please contact

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07 Oct 2025, 10 Oct 2025

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25

Hilton Malta, St. Julians, Malta

The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility premature ageing, and neurodegeneration. Destabilization of the genome can occur as a result of several ...

More Information