Past Conference

3rd Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD23

Date

14 Oct - 17 Oct 2023

Location

Dubrovnik, Croatia

  • Ian Hickson

    University of Copenhagen

  • Oscar Fernandez-Capetillo

    Spanish National Cancer Research Centre

Early Bird - Expired  •  Talk Submission - Expired  •  Poster Submission - Expired  •  Registration & Payment Deadline - Expired

Synopsis

All spaces for this conference have been filled and so we have had to close registration before the deadline. If you would like to be added to our wait list, please contact Rosie to be notified if a slot becomes available. 

This conference is a continuation of the DNA Replication as a Source of DNA Damage series.

The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility and neurodegeneration. Moreover, the accumulation of unrepaired errors in DNA is commonly cited as a likely cause of tissue and organismal ageing. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication, DNA repair and chromosome segregation with those interested in how chromosomal instability can influence human pathology. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities.

Key Sessions

  • Pathways for repair of DNA damage and disrupted DNA replication forks
  • Screening tools for analysis of genome maintenance pathways and for development of new therapeutics
  • Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins
  • Chromosome instability as a driver of tumorigenesis, neurodegeneration and ageing
  • Exploitation of defects in chromosome maintenance in cancer treatment

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying 'single' or 'shared' registrants can bring a student for only €882. Unfortunately, Postdocs are not eligible for this offer. Both registration packages include; accommodation for the 14, 15, 16 October 2023 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Rosie Johnson to obtain a special registration link for your student.

Confirmed Invited Speakers

Monica Bettencourt-Dias (Instituto Gulbenkian de Ciência)
CENTROSOME REGULATION IN DEVELOPMENT AND DISEASE
Thijn Brummelkamp (Netherlands Cancer Institute)
TRAITMAP: LINKING GENES TO CELLULAR TRAITS IN HAPLOID HUMAN CELLS
Keith Caldecott (University of Sussex)
DNA STRAND BREAK REPAIR AND HUMAN DISEASE
Vincenzo Costanzo (IFOM)
CAUSES AND CONSEQUENCES OF DNA REPLICATION STRESS IN VERTEBRATE ORGANISMS
Daniel Durocher (Lunenfeld-Tanenbaum Research Institute)
PROBING DNA REPAIR WITH SYNTHETIC LETHALITY
Daniel Gerlich (Institute of Molecular Biotechnology)
THE ROLE OF CHROMOSOME CONFORMATION IN DNA DOUBLE-STRAND BREAK REPAIR
Thanos Halazonetis (University of Geneva)
MAPPING DNA REPLICATION ORIGINS IN NORMAL AND CANCER CELLS
Andrew Jackson (University of Edinburgh)
RIBONUCLEOTIDE EXCISION REPAIR - GENOME INSTABILITY, MUTAGENESIS, AND INFLAMMATION
Steve Jackson (CRUK-Cambridge Institute)
CELLULAR RESPONSES TO DNA DOUBLE-STRAND BREAKS:  MECHANISTIC INSIGHTS AND THERAPEUTIC APPLICATIONS
Ana Losada (Spanish National Cancer Research Center)
CONTRIBUTION OF COHESIN MUTATIONS TO AGGRESSIVE EWING SARCOMA
Niels Mailand (Novo Nordisk Foundation Center for Protein Research)
DEFINING THE ESSENTIAL ROLES OF SUMOylation IN CHROMOSOME STABILITY
Marcos Malumbres (Spanish National Cancer Research Center)
UNCONVENTIONAL CDKS IN GENOME STABILITY
René Medema (Netherlands Cancer Institute)
(UN)TANGLING DNA REPAIR AND EPIGENETICS
Serena Nik-Zainal (MRC Cancer Unit)
RECENT INSIGHTS INTO MUTATIONAL SIGNATURES FOLLOWING EXPERIMENTAL DISSECTION
Andre Nussenzweig (National Institutes of Health)
NEURONAL GENOME STABILITY AND PLASTICITY 
Mark O'Connor (AstraZeneca)
TARGETING REPLICATION STRESS IN CANCERS AS A THERAPEUTIC STRATEGY
KJ Patel (University of Oxford)
METABOLIC ORIGINS OF ENDOGENOUS DNA DAMAGE AND MUTATION
Christopher E. Pearson (The Hospital for Sick Children)
MOLECULAR CAUSE OF FRA9A IN AN UNSTABLE LOCUS
Zuzana Storchova (TU Kaiserslautern)
CELLULAR CONSEQUENCES OF CHROMOSOME GAINS AND LOSSES
Steve West (Francis Crick Institute)
CRYO-EM STRUCTURES AND FUNCTIONS OF PROTEINS INVOLVED IN RECOMBINATIONAL DNA REPAIR

Target Audience

This meeting will appeal to Molecular/Cell Biologists/Geneticists & Biochemists interested in genome stability. Researchers interested in the molecular basis of cancer, neurodegenerative diseases and ageing and those with an interest in high throughput genetic and pharmacological screening methods will also find the conference highly relevant along with those wishing to exploit genome maintenance abnormalities in tumour cells for therapeutic benefit.

Educational Need

Chromosome instability is involved in several human diseases and is a feature of natural ageing. This conference will bridge fundamental studies on the mechanisms by which cells maintain genome stability with applications of these studies aimed at the development of new therapies. Hence, the conference will bridge basic biology and clinical applications in this rapidly advancing field. Attendees should be able to obtain a full picture of the current status of the field, as well as to interact with prominent research leaders driving the clinical application of the latest research.

 

AstraZeneca has provided a sponsorship grant towards this independent Programme.

Confirmed Speakers

Chairs
Ian Hickson

Ian Hickson

Professor of Molecular Aging, University of Copenhagen

Oscar Fernandez-Capetillo

Oscar Fernandez-Capetillo

Genomic Instability Group Leader, Spanish National Cancer Research Centre

Invited Speakers
Monica Bettencourt-Dias

Monica Bettencourt-Dias

Instituto Gulbenkian de Ciência

Thijn Brummelkamp

Thijn Brummelkamp

Netherlands Cancer Institute

Keith Caldecott

Keith Caldecott

University of Sussex

Vincenzo Costanzo

Vincenzo Costanzo

IFOM

Daniel Durocher

Daniel Durocher

Lunenfeld-Tanenbaum Research Institute

Daniel Gerlich

Daniel Gerlich

Institute of Molecular Biotechnology

Thanos Halazonetis

Thanos Halazonetis

University of Geneva

Andrew Jackson

Andrew Jackson

The University of Edinburgh

Ana Losada

Ana Losada

Spanish National Cancer Research Center

Niels Mailand

Niels Mailand

Novo Nordisk Foundation Center for Protein Research

Marcos Malumbres

Marcos Malumbres

Spanish National Cancer Research Center

René Medema

René Medema

Netherlands Cancer Institute

Serena Nik-Zainal

Serena Nik-Zainal

MRC Cancer Unit

Andre Nussenzweig

Andre Nussenzweig

National Institutes of Health

Mark O'Connor

Mark O'Connor

AstraZeneca

KJ Patel

KJ Patel

University of Oxford

Christopher Pearson

Christopher Pearson

The Hospital for Sick Children

Zuzana Storchova

Zuzana Storchova

TU Kaiserslautern

Steve Jackson

Steve Jackson

CRUK- Cambridge Institute

Steve West

Steve West

Francis Crick Institute

Programme

All spaces for this conference have been filled and so we have had to close registration before the deadline. If you would like to be added to our wait list, please contact Rosie to be notified if a slot becomes available. 

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Grants

Please see below opportunties for financial support for students, short talk, and poster presenters. If you have any questions, please reach out to the Conference Manager, Rosie Johnson.

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying 'single' or 'shared' registrants can bring a student for only €882. Unfortunately, Postdocs are not eligible for this offer. Both registration packages include; accommodation for the 14, 15, 16 October 2023 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Rosie Johnson to obtain a special registration link for your student.

Short Talk & Poster Grants

We have set aside several €500 grants to support short talk and poster presenters. To be considered, please ensure you have registered for the meeting, submitted an abstract (must have been accepted for a short talk or poster), and emailed Rosie Johnson a short statement as to why you think you should receive a grant. Grants will be awarded post-conference.

Supported by

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Bronze Sponsors
Media Partners

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Venue & Location

Sun Gardens Dubrovnik

We are excited to be adding a beautiful Adriatic destination to our portfolio for autumn 2023 – the Sun Gardens Dubrovnik in Croatia. The resort is nestled into the hillside with uninterrupted, stunning views of the ocean. 

This beautiful hotel is located only 11 km from Dubrovnik city centre, in the small village of Orašac, nestled amongst the citrus groves, palm trees and gorgeous blue sea that characterize the city. The Old City, a UNESCO World Heritage Site with magnificent defensive walls surrounding it, is just one of the wonderful places to visit. With stunning architecture, scenic walks, wine tasting, boat trips and beautiful beaches, there is plenty to inspire when exploring beyond the hotel. We truly believe Croatia will become a firm favourite with our delegates.

The hotel boasts several wonderful dining options with a mix of Dalmatian, Mediterranean, international and fusion culinary experiences. Or you may want to take in the stunning views of the sea and the nearby islands as you unwind, relax and catch up on the day’s events in one of the hotels bars. Pools, a promenade, spa, sports centre and beaches are just a few of the other facilities you will find available during your stay. 

This is not an all-inclusive property, but we have arranged a full food and beverage package for delegates during the conference period which is included within the registration fee. Breakfast will be at leisure each morning, but participants will dine together for conference lunches and dinners. For anyone staying any extra nights, the rate will be bed and breakfast only so delegates can choose whether to dine at the hotel or explore and eat elsewhere. 

Hotel facilities include;
•    Complimentary Wi-Fi in guest rooms and throughout hotel and
conference areas
•    3 Pools
•    Spa
•    Gym & Sports Center
•    8 Restaurants
•    9 Bars
•    Kids Club
•    Beach
 

General Information

Venue Rating

★ ★ ★ ★ ★

Currency

Euro (EUR)

Address

Dubrovački Vrtovi Sunca d.o.o. Na Moru 1, 20235 Orašac, Dubrovnik

Nearest Airport

Dubrovnik International Airport

Location

This beautiful hotel is located only 11 km from Dubrovnik city centre, in the small village of Orašac, nestled amongst the citrus groves, palm trees and gorgeous blue sea that characterize the city. The Old City, a UNESCO World Heritage Site with magnificent defensive walls surrounding it, is just one of the wonderful places to visit. With stunning architecture, scenic walks, wine tasting, boat trips and beautiful beaches, there is plenty to inspire when exploring beyond the hotel. We truly believe Croatia will become a firm favourite with our delegates.

Gallery

Silver Sponsors

Bronze Sponsors

Media Partners

If you're interested in sponsoring this conference please contact us.

Conference Manager

Rosie Johnson

Need some help? Chat to the Fusion team today

As a family run business, our dedication runs deep. We’re committed to each other and, even more so, to every attendee’s experience, delivering a level of care and passion that’s truly unmatched.

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+44 (0) 1638 555057

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