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Laura Trundle

Laura Trundle

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Report

The meeting was chaired again by Profs. Oscar Fernandez-Capetillo (CNIO, Spain and Karolinska Institute, Sweden) and Ian D. Hickson (University of Copenhagen, Denmark).

The invited speakers included several of the worlds leading scientists studying DNA replication stress, DNA repair pathways and the relationship between genomic instability and human disease. The faculty members who presented their latest research findings were:

Andre Nussenzweig (NIH/NCI, Bethesda, USA)
Johannes Walter (Harvard Medical School, USA)
Jiri Lukas (University of Copenhagen, Denmark)
Stephen West (The Francis Crick Institute, London, UK)
Philippe Pasero (CNRS, France)
John Diffley (The Francis Crick Institute, London, UK)
Thanos Halazonetis (University of Geneva, Switzerland)
Andrew Jackson (University of Edinburgh, UK)
Thomas Helleday (Karolinska Institute, Stockholm, Sweden)
Juan Mendez (CNIO, Madrid, Spain)
Jos Jonkers (Netherlands Cancer Institute, Amsterdam)
Evi Soutoglou (IGBMC, France)
Madalena Tarsounas (University of Oxford, UK)
K.J. Patel (University of Cambridge, UK)
Andres Lopez-Contreras (University of Copenhagen, Denmark)
Luis Toledo (University of Copenhagen, Denmark)
Arne Lindqvist (Karolinska Institute, Stockholm, Sweden)
Wojciech Niedzwiedz (University of Oxford, UK)
Philip Zegerman (The Gurdon Institute, Cambridge, UK)
Angelos Constantinou (CNRS, France)
Michael Lisby (University of Copenhagen, Denmark)
Manuel Mendoza (Centre de Regulacio Genomica, Spain)

As with the first meeting in this series, a key feature of the conference was the number of speakers who were selected from the submitted abstracts. These included PhD students/postdocs, as well as several group heads who are early in their career. The fundraising efforts of the organizers permitted many of the selected speakers to have their costs covered by travel awards. There were also two very lively and well attended poster sessions. Sufficient time was set aside for networking and meetings between new and established collaborators. This was facilitated by the pleasant hotel environment.

The combination of a high quality conference venue, the attentive Fusion staff and the Italian summer weather, meant that the meeting had a very comfortable informal atmosphere that facilitated informal discussions, as well as interesting and informative discussion periods after virtually all of the talks. This also encouraged a large proportion of the participants to join in with the discussions.

The conference was very well attended (134 participants), which attests to the growing interest in this field of research – even though several other related conferences are scheduled during 2017. The organizers were satisfied that the conference was a major success.

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2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Synopsis

The maintenance of genome integrity is critical for the suppression of cancer and premature ageing. Only recently has it become appreciated that DNA replication stress is a crucial driver of genomic instability. The timely progression of replisomes can be disrupted by lesions and secondary structures in the template, by bound proteins and by conflicts with the transcription machinery. A prolonged pause of the replisome then exposes single stranded DNA, which, due to its recombinogenic nature, can lead to genome rearrangements, fragile site expression and cell death. Importantly, some cancers present excessive endogenous levels of replication stress, which can be exploited for their clearance. In this conference, we aim to bring together scientists studying DNA replication and repair, with those interested in how DNA damage can influence cancer and ageing.

Join the conference LinkedIn group to keep up to date with annoucements and latest news concerning the conference.

Key Sessions

  • Pathways for repair of damaged replication forks
  • Systems for site-specific perturbation of replication
  • Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins
  • Replication perturbation as a driver of tumorigenesis and ageing
  • Exploitation of replication defects in cancer treatment

Confirmed Speakers

Andre Nussenzweig (NIH/NCI)
'GENOME ORGANIZATION DRIVES CHROMOSOME FRAGILITY'

Johannes Walter (Harvard Medical School)
'A ROLE FOR REPLICATION FORK REVERSAL DURING DNA INTERSTRAND CROSSLINK REPAIR'

Jiri Lukas (University of Copenhagen)
'CONFINEMENT AND HERITABILITY OF CELLULAR RESPONSES TO DNA REPLICATION STRESS'

Stephen West  (The Francis Crick Institute)
'UNRESOLVED RECOMBINATION INTERMEDIATES AS A SOURCE OF DNA BREAKS AND CHROMOSOME ABERRATIONS'

Philippe Pasero (CNRS)
'SAMHD1 ACTS AT STALLED FORKS TO PREVENT INFLAMMATION'

John Diffley (The Francis Crick Institute)
'HOW THE REPLICATIVE HELICASE IS LOADED AND ACTIVATED'

Thanos Halazonetis (University of Geneva)
'MECHANISMS OF ONCOGENE-INDUCED DNA REPLICATION STRESS'

Andrew Jackson (University of Edinburgh)
'DONSON ENCODES A NOVEL  REPLICATION FORK PROTECTION FACTOR MUTATED IN MICROCEPHALIC DWARFISM'

Thomas Helleday (Karolinska Institutet)
'IMPORTANCE OF ACCURATE AND TIMELY SUPPLY OF dNTPs FOR REPLICATION AND REPAIR'

Juan Mendez (CNIO)
'NEW MECHANISMS THAT PREVENT DNA OVER-REPLICATION'

Jos Jonkers (Netherlands Cancer Institute)
'GENETIC DETERMINANTS OF TUMOR DEVELOPMENT, THERAPY RESPONSE AND RESISTANCE IN MOUSE MODELS OF BRCA-DEFICIENT BREAST CANCER'

Evi Soutoglou (IGBMC)
'DNA REPAIR PATHWAYS IN DIFFERENT HETEROCHROMATIN STRUCTURES'

Madalena Tarsounas (University of Oxford)
'REPLICATION STRESS TOLERANCE AS A TARGET FOR SELECTIVE ELIMINATION OF BRCA1/2-DEFICIENT CELLS AND TUMOURS'

KJ Patel (University of Cambridge)
'ALDEHYDES AND ENDOGENOUS DNA DAMAGE'

Andres Lopez-Contreras (University of Copenhagen)
'PICH IS ESSENTIAL FOR EARLY EMBRYONIC DEVELOPMENT'

Luis Ignacio Toledo Lazaro (University of Copenhagen)
'EXPLORING THE UNCOUPLING OF ENZYMATIC ACTIVITIES AT REPLICATION FORKS'

Arne Lindqvist (Karolinska Institutet)
'DNA REPLICATION IS AN INTEGRAL COMPONENT OF THE CELL-CYCLE ENGINE'

Wojciech Niedzwiedz (University of Oxford)
'EXD2 NUCLEASE SAFEGUARDS THE GENOME AGAINST REPLICATIVE STRESS'

Philip Zegerman (The Gurdon Institute)
'CHECKPOINT KINASE TARGETTING OF DNA REPLICATION COMPLEXES'

Angelos Constantinou (CNRS)
'DIHYDROPYRIMIDINASE PROTECTS AGAINST DNA REPLICATION STRESS INDUCED BY PYRIMIDINE METABOLITES'

Michael Lisby (University of Copenhagen)
'Mte1/ZGRF1 MAINTAINS GENOME STABILITY DURING REPLICATION STRESS'

Manuel Mendoza (Centre de Regulació Genòmica)
'CELLULAR DETECTION OF CHROMATIN BRIDGES BY THE NoCut ABSCISSION CHECKPOINT'

Target Audience 

The conference aims to target a wide spectrum of scientists interested on how chromosomal rearrangements are generated, and their impact on cancer and ageing: The talks will include studies at various levels ranging from basic molecular biology to clinical studies on human patients. The conference will also appeal to oncologists and pharmaceutical companies with an interest in targeting replication stress as an Achilles’ heel in cancer.

Supported By

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Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Speakers

Invited Speakers

Steve West

Senior Group Leader, Francis Crick Institute

John Diffley

Associate Research Director, The Francis Crick Institute

Johannes Walter

Professor, Harvard Medical School

Thomas Helleday

Professor, Karolinska Institutet

Jiri Lukas

Managing Director, Novo Nordisk Foundation Center for Protein Research

Andre Nussenzweig

Branch Chief, Laboratory of Genome Integrity, National Insitutes of Health

Angelos Constantinou

Principal Investigator, IGH-Institute of Human Genetics, CNRS UPR 1142

Manuel Mendoza

Main Investigator, Centre for Genomic Regulation

Andrew Jackson

Group Leader, MRC Human Genetics Unit

Andres J Lopez-Contreras

Group Leader, University of Copenhagen

Jos Jonkers

Division Head, Netherlands Cancer Institute

Michael Lisby

Professor, University of Copenhagen

Luis Toledo

Postdoc, Center for Chromosome Stability - 18.1

Philip Zegerman

Group leader, Gurdon Institute

Wojciech Niedzwiedz

Group Head, Oxford University

Evi Soutoglou

Group Leader, Genome Damage and Stability Centre, University of Sussex

Arne Lindqvist

Group Leader, Karolinska Institutet

Thanos Halazonetis

Professor, University of Geneva

Juan Méndez

Lab Head, Spanish National Cancer Research Centre (CNIO)

Madalena Tarsounas

CR-UK Senior Group Leader, The CR-UK/MRC Oxford Institute for Radiation Oncology, University of Oxford

Philippe Pasero

Dr, IGH, CNRS UPR 1142

Ketan Patel

PI, MRC LMB

Vincenzo Costanzo

Senior Group Leader, IFOM

Supported By

Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Programme

MONDAY 03RD JULY 2017

14:00 – 15:00

Registration & Reception

14:00 – 14:45

Group Welcome Lunch

Session #1
Session Chair: Ian Hickson

14:45 – 15:00

Opening Comments by Ian Hickson & Oscar Fernandez-Capetillo

15:00 – 15:25

KJ Patel
University of Cambridge

ALDEHYDES AND ENDOGENOUS DNA DAMAGE

15:25 – 15:40

Rodrigo Bermejo
Center for Biological Research (CIB-CSIC)

COHESIN UBIQUITYLATION AND MOBILIZATION PROMOTES STALLED REPLICATION FORK DYNAMICS AND INTEGRITY

15:40 – 16:05

Manuel Mendoza
Centre for Genomic Regulation

CELLULAR DETECTION OF CHROMATIN BRIDGES BY THE NoCut ABSCISSION CHECKPOINT

16:05 – 16:20

Kara Bernstein
University of Pittsburgh School of Medicine

THE FUNCTION OF THE SHU COMPLEX AND THE RAD51 PARALOGS IN REPAIR OF REPLICATION INTERMEDIATES BY PROMOTION OF RAD51 PRESYNAPTIC FILAMENT ASSEMBLY

16:20 – 16:45

Vincenzo Costanzo
IFOM

MECHANISMS OF REPLICATION FORK PROTECTION

16:45 – 17:00

Jon Houseley
Babraham Institute

ENVIRONMENTAL CHANGE DRIVES ACCELERATED ADAPTATION THROUGH STIMULATED COPY NUMBER VARIATION

17:00 – 17:30

Refreshments

Session #2
Session Chair: KJ Patel

17:30 – 17:55

Ian Hickson
University of Copenhagen

ANALYSIS OF MUTAGENIC EVENTS OCCURRING AT A STALLED REPLICATION FORK

17:55 – 18:10

Pavel Janscak
University of Zurich

RECQ5 HELICASE COOPERATES WITH MUS81 ENDONUCLEASE IN PROCESSING OF STALLED REPLICATION FORKS AT COMMON FRAGILE SITES DURING MITOSIS

18:10 – 18:25

Jennifer Cobb
University of Calgary

NEJ1/XLF REGULATES REPAIR PATHWAY CHOICE BY INHIBITING SGS1/BLM –MEDIATED RESECTION

18:25 – 18:50

Stephen West
Francis Crick Institute

UNRESOLVED RECOMBINATION INTERMEDIATES AS A SOURCE OF DNA BREAKS AND CHROMOSOME ABERRATIONS

18:50 – 19:05

Matthias Dobbelstein
Universitätsmedizin Goettingen

P53 AND Mdm2 AS DETERMINANTS OF CHROMATIN STRUCTURE AND DNA REPLICATION STRESS

19:05 – 19:20

Ana Rojas
Institute of Biomedicine of Seville (IBIS)

COMPUTATIONAL AND EVOLUTIONARY ANALYSES OF NUCS: A NOVEL PROTEIN INVOLVED IN PROKARYOTIC NON-CANONICAL MMR

19:30

Group Dinner

TUESDAY 04TH JULY 2017

07:00 – 09:00

Breakfast

Session #3
Session Chair: Johannes Walter

09:00 – 09:25

Jiri Lukas
Novo Nordisk Foundation Center for Protein Research

CONFINEMENT AND HERITABILITY OF CELLULAR RESPONSES TO DNA REPLICATION STRESS

09:25 – 09:40

Jean-Sébastien Hoffmann
INSERM

REPLICATION STRESS INFLUENCES THE TIMING OF DNA REPLICATION INITIATION OF THE NEXT CELL GENERATION

09:40 – 10:05

Juan Méndez
CNIO

NEW MECHANISMS THAT PREVENT DNA OVER-REPLICATION

10:05 – 10:20

Kevin Hiom
University of Dundee

DHX9 LINKS RNA SPLICING TO THE GENERATION OF REPLICATION BLOCKING R-LOOPS

10:20 – 10:35

Matthias Samwer
Institute for Molecular Biotechnology

A MECHANISM COUNTERACTING MICRONUCLEATION FOR MAINTENANCE OF GENOMIC INTEGRITY

10:35 – 11:05

Refreshments & Group Photo

Session #4
Session Chair: Steve West

11:05 – 11:30

Johannes Walter
Harvard Medical School

A ROLE FOR REPLICATION FORK REVERSAL DURING DNA INTERSTRAND CROSSLINK REPAIR

11:30 – 11:45

Aura Carreira
Institut Curie

A NEW DNA BINDING SITE IN BRCA2 THAT MEDIATES HOMOLOGOUS RECOMBINATION

11:45 – 12:10

Andres Lopez-Contreras
University of Copenhagen

PICH IS ESSENTIAL FOR EARLY EMBRYONIC DEVELOPMENT

12:10 – 12:25

Alberto Ciccia
Columbia University

RESTORATION OF FORK STABILITY IN BRCA1- AND BRCA2-DEFICIENT CELLS

12:25 – 12:50

Angelos Constantinou
IGH-Institute of Human Genetics, CNRS UPR 1142

DIHYDROPYRIMIDINASE PROTECTS AGAINST DNA REPLICATION STRESS INDUCED BY PYRIMIDINE METABOLITES

12:50 – 17:00

Group Lunch & Free Time

Session #5
Session Chair: John Diffley

17:00 – 17:25

Philippe Pasero
CNRS

SAMHD1 ACTS AT STALLED FORKS TO PREVENT INFLAMMATION

17:25 – 17:40

Åsa Ehlén
Institut Curie Research Center

CHARACTERIZATION OF A CLUSTER OF PLK1 PHOSPHORYLATION SITES IN BRCA2 THAT CONTROL MITOTIC ONSET

17:40 – 17:55

Job de Lange
Cancer Center Amsterdam

COHESION WEAKNESS: A UNIQUE VULNERABILITY OF CANCER CELLS

17:55 – 18:10

Lorenza Garribba
University of Copenhagen

INSTABILITY OF A LONG CGG TRIPLET REPEAT IN RESPONSE TO FOLATE DEFICIENCY

18:10 – 18:35

Thanos Halazonetis
University of Geneva

MECHANISMS OF ONCOGENE-INDUCED DNA REPLICATION STRESS

18:35 – 19:05

Refreshments

Session #6
Session Chair: Thanos Halazonetis

19:05 – 19:30

John Diffley
The Francis Crick Institute

HOW THE REPLICATIVE HELICASE IS LOADED AND ACTIVATED

19:30 – 19:45

Stephen Gregory
University of Adelaide

CHROMOSOMAL INSTABILITY CAUSES SUSCEPTIBILITY TO METABOLIC INTERVENTION

19:45 – 20:45

Poster Session & Refreshments

20:45

Group Dinner

WEDNESDAY 05TH JULY 2017

07:00 – 09:00

Breakfast

Session #7
Session Chair: Oscar Fernandez-Capetillo

09:00 – 09:15

Julien Duxin
University of Copenhagen

MECHANISM OF DNA-PROTEIN CROSSLINK PROTEOLYSIS

09:15 – 09:30

Jessica Williams
National Institute of Environmental Health Sciences

THE ROLE OF RNASE H2 IN PROCESSING RIBONUCLEOTIDES INCORPORATED DURING DNA REPLICATION

09:30 – 09:45

Vincent Geli
CRCM

THE NUCLEAR PORE COMPLEX REGULATES REPLICATION STRESS AND TELOMERE RECOMBINATION

09:45 – 10:00

Zee-Fen Chang
National Taiwan University

BCR-ABL TRANSFORMATION LEADS TO REPLICATION STRESS AND INCREASES CELL VULNERABILITY TO THYMIDYLATE KINASE INHIBITION

10:00 – 10:25

Jos Jonkers
Netherlands Cancer Institute

GENETIC DETERMINANTS OF TUMOR DEVELOPMENT, THERAPY RESPONSE AND RESISTANCE IN MOUSE MODELS OF BRCA-DEFICIENT BREAST CANCER

10:25 – 10:55

Refreshments

Session #8
Session Chair: Jiri Lukas

10:55 – 11:20

Andrew Jackson
MRC Human Genetics Unit

DONSON ENCODES A NOVEL  REPLICATION FORK PROTECTION FACTOR MUTATED IN MICROCEPHALIC DWARFISM

11:20 – 11:45

Wojciech Niedzwiedz
Oxford University

EXD2 NUCLEASE SAFEGUARDS THE GENOME AGAINST REPLICATIVE STRESS

11:45 – 12:00

John Tainer
LBL / MD Anderson Cancer Center

FLAP ENDONUCLEASE 1 EMPLOYS PHOSPHATE STEERING TO INSURE SPECIFIC 5´-FLAP INCISION TO PREVENT GENOME INSTABILITY

12:00 – 12:25

Luis Toledo
University of Copenhagen

EXPLORING THE UNCOUPLING OF ENZYMATIC ACTIVITIES AT REPLICATION FORKS

12:25 – 16:20

Group Lunch & Free Time

Session #9
Session Chair: Philippe Pasero

16:20 – 16:45

André Nussenzweig
NIH

GENOME ORGANIZATION DRIVES CHROMOSOME FRAGILITY

16:45 – 17:00

Alessandro Vindigni
Saint Louis University School of Medicine

MRE11 AND EXO1 NUCLEASES DEGRADE REVERSED FORKS IN BRCA-DEFICIENT CELLS AND LEAD TO MUS81-DEPENDENT FORK RESTART

17:00 – 17:25

Arne Lindqvist
Karolinska Institutet

DNA REPLICATION IS AN INTEGRAL COMPONENT OF THE CELL-CYCLE ENGINE

17:25 – 17:40

Katharina Schlacher
MD Anderson Cancer Center

EPIGENETICS-ENABLED MRE11 REPLICATION RESTART BY p53 PROMOTES REPLICATION PATHWAY HOMEOSTASIS TO SUPPRESS OPPORTUNISTIC TRANSCRIPTION REPROGRAMMING

17:40 – 18:05

Michael Lisby
University of Copenhagen

Mte1/ZGRF1 MAINTAINS GENOME STABILITY DURING REPLICATION STRESS

18:05 – 18:20

Olga Murina
MRC Human Genetics Unit

RIBONUCLEOTIDES INCORPORATED DURING GENOME REPLICATION PROVIDE A NOVEL VULNERABILITY TO PARP INHIBITION

18:20 – 18:50

Refreshments

Session #10
Session Chair: Andre Nussenzweig

18:50 – 19:15

Philip Zegerman
Gurdon Institute

CHECKPOINT KINASE TARGETTING OF DNA REPLICATION COMPLEXES

19:15 – 19:40

Madalena Tarsounas
The CR-UK/MRC Oxford Institute for Radiation Oncology, University of Oxford

REPLICATION STRESS TOLERANCE AS A TARGET FOR SELECTIVE ELIMINATION OF BRCA1/2-DEFICIENT CELLS AND TUMOURS

19:40 – 20:40

Poster Session & Refreshments

20:45

*Gala Dinner & Poster Awards*

THURSDAY 06TH JULY 2017

07:00 – 09:15

Breakfast

Session #11
Session Chair: Madalena Tarsounas

09:15 – 09:30

Néstor García-Rodríguez
Institute of Molecular Biology

CHECKPOINT SIGNALING IN RESPONSE TO REPLICATION-BLOCKING LESIONS INITITATES AT DAUGHTER-STRAND GAPS AND ENABLES POSTREPLICATIVE DNA DAMAGE BYPASS

09:30 – 09:55

Thomas Helleday
Karolinska Institutet

IMPORTANCE OF ACCURATE AND TIMELY SUPPLY OF dNTPs FOR REPLICATION AND REPAIR

09:55 – 10:10

Robertus de Bruin
University College London

INCREASED E2F ACTIVITY DURING SPECIFIC PHASES OF THE CELL CYCLE HAS THE POTENTIAL TO INDUCE REPLICATION STRESS VIA DIFFERENT MECHANISMS

10:10 – 10:35

Evi Soutoglou
IGBMC

DNA REPAIR PATHWAYS IN DIFFERENT HETEROCHROMATIN STRUCTURES

10:35 – 10:50

Sabrina Florencia Mansilla
Fundación Instituto leloir

THE ALTERNATIVE POLYMERASE IOTA PROMOTES CHECKPOINT ACTIVATION

10:50 – 11:05

Guillaume Rieunier
University of Oxford

TARGETING THE INSULIN-LIKE GROWTH FACTOR AXIS INDUCES REPLICATION STRESS

11:05 – 11:30

Oscar Fernandez-Capetillo
CNIO / Karolinska Institute

EXPLORING THE ROLE OF THE SMC5/6 COMPLEX IN CANCER AND AGE-RELATED DISEASES

11:30 – 11:45

Closing Comments by Ian Hickson & Oscar Fernandez-Capetillo

Supported By

Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Prices

Ticket Type Early Bird Full Price
Single
Choose this option if you will be attending the conference alone, or if you will bring accompanying guests that will not attend the meeting.
$1173 $1236
Shared
Choose this option if you wish to share with a colleague who is also attending the conference, or if you wish to be paired with another attendee of the same sex.
$1173 $1263
Student
Choose this option if you are a student. Please note all students will be paired with another attendee of the same sex if a room sharer is not specified. If you wish to have your own room, please register under the Single option.
$1008 $1098
Additional Person
This is the cost for an additional adult or child to join you in the same room, for the entire conference period. Accompanying persons are not permitted access to the conference. If you wish to extend your stay, please see our 'Extra night' prices.

Adult

$633

Child

$0

Extra nights
Prices are per person.

Adult

$152

Child

$0


All registration fees include 3 nights accommodation and meals during the conference period. Exact inclusions are detailed below.

We are pleased to confirm that for this particular meeting, the Student registration fee is also applicable to Postdocs.

What's Included in our Registration Fees?

Our registration fees are inclusive of the following during the conference period only:

- Conference registration
- 3 Nights’ fixed accommodation (03, 04, 05 July 2017) on a single basis for academics and industry, on a shared basis for students/Postdocs
- Buffet Breakfast with a selection of hot beverages and fresh juices
- 2 Course Buffet Lunch with a selection of free flow soft drinks
- 3 Course Buffet Dinner with a selection of free flow soft drinks and wine
- Gala Night entry (includes complimentary drink tickets)
- Complimentary WIFI in both conference rooms and your guest room

What's Included in our Accompanying Adult Fees?

Our accompanying adult fees are inclusive of the following during the conference period only:

- 3 Nights’ fixed accommodation (03, 04, 05 July 2017) on a shared basis with a conference participant
- Buffet Breakfast with a selection of hot beverages and fresh juices
- 2 Course Buffet Lunch with a selection of free flow soft drinks
- 3 Course Buffet Dinner with a selection of free flow soft drinks and wine
- Gala Night entry (includes complimentary drink tickets)
- Complimentary WIFI in both conference rooms and your guest room.

Important Note: Accompanying persons are not permitted access to the conference.

What's Included in our Accompanying Child Fees?

Our accompanying child fees are inclusive of the following during the conference period only:

- 3 Nights’ fixed accommodation (03, 04, 05 July 2017) on a shared basis with the parent/s (roll out bed supplied)
- Buffet Breakfast with a selection of hot beverages and fresh juices

Important Note: Accompanying child fees are applicable for children aged 10 years and younger. Children aged 11 years and older will be charged a €30 supplement per night. Children will be charged on consumption for all food and beverage (a supplement of €20 per child, per meal will be charged if you wish them to join conference lunches and dinner).

What's Included in our Extra Night Fees?

Additional nights are inclusive of one night’s accommodation and buffet breakfast only (applicable for adults and children aged 10 years or younger).

Supported By

Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Grants

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Supported By

Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Venue

Sheraton Roma Hotel & Conference Center

The Sheraton Roma is ideally situated in the EUR Monumental neighbourhood, between the ancient city centre and Fiumicino Airport, providing an ideal location for all conference attendees to enjoy the magnificent historical and cultural sites this ancient and beautiful city has to offer.
 
Throughout the conference period you will enjoy a delicious buffet breakfast, followed by lunch served by the pool (weather permitting) and will round off the day with a delectable buffet dinner. The themed Gala Night takes place on the third evening of the conference with a mouth-watering feast exclusively designed by the head chef and entertainment provided by a live band.  We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
 

Hotel Facilities:

  • AQVI Pool Restaurant & Bar
  • Gymnasium
  • Putting green
  • Garden pathway - Walk, race, jog, sprint, dash or run in the circular garden pathway that surrounds the hotel
  • Outdoor tennis court
  • Squash courts
  • Outdoor pool (seasonal)
  • Golf courses nearby
  • Laundry/valet service
  • 24-hour room service
  • Cash machine (ATM)
  • Air conditioned facilities
  • Free Wi-Fi
  • Bus service to downtown (limited)
  • Car rental desk
  • Shopping arcade in Hotel
  • Business Center
  • Parking Available

Venue Rating

Currency

US Dollar (USD)

Address

Viale del Pattinaggio, 100 00144 Rome Italy

Nearest Airport

Fiumicino Airport

Location

The Sheraton Roma is ideally situated in the green EUR Monumental neighbourhood, between the ancient city centre and Fiumicino Airport, providing an ideal location for all conference attendees to enjoy the magnificent historical and cultural sites this ancient and beautiful city has to offer.

Just a short taxi or bus ride, no more than 6 miles,  will take you to the majestic Colosseum, Sistine Chapel, Vatican City, Trevi Fountain, Pantheon, Spanish Steps and the numerous wondrous museums and gardens. 

Fiumicino Airport is just 13 miles (21km) from the Sheraton Roma and Ciampino Airport 11.8 miles (19km) with the drive time approximately 20 minutes.

Supported By

Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Transportation

Fiumicino Airport is just 13 miles (21km) from the Sheraton Roma and Ciampino Airport 11.8 miles (19km) with the drive time approximately 20 minutes. Both airports are easily accessible from almost every country in the world with many major international airlines providing direct or interconnecting flights on a daily basis. 

Private Airport Transfers

RydeItaly are a reputable and trustworthy transportation company based in Rome. The RydeItaly team will be available 24/7 to provide a seamless transfer service to and from both Fiumicino and Ciampino Airports. To arrange transportation please contact RydeItaly directly via email or phone as they will manage and confirm all transfers.  

RydeItaly offer a private transfer service for those travelling outside of the available shuttle times mentioned below. The private transfer service vehicles can accommodate a maximum of 8 persons, plus luggage.

Car - €48 each way (excluding taxes)

7 Seater Minivan - €75 each way (excluding taxes)

8 Seater minivan - €85 each way (excluding taxes)

Payment is required on arrival and RydeItaly are able to accept both card and cash payments (Euro’s). In the event of any delays or cancellations, please ensure you contact RydeItaly at least 24hours in advance; if RydeItaly are not informed within 24hours full cancellation charges will apply.

Upon arrival at the airport, please exit the terminal and you will find a member of the RydeItaly team handling a greeting sign with the Fusion logo at the meeting point column.

Telephone: +39 388 69 87 391
Email: fusionconferences@rydeitaly.com

** Please note Fusion Conferences accept no responsibility for any bookings made with RydeItaly or any other transportation supplier **

Hotel Shuttle Service

Sheraton Roma has a convenient bus service from and to Fiumicino Airport which will run at scheduled times. The Sheraton Roma shuttle schedule can be found below.

Arrivals (Fiumicino Airport – Sheraton Roma) Please note that this service cannot be pre-booked, seats are based on availability.

7.45, 9.15, 12.15

Departures (Sheraton Roma – Fiumicino Airport) Please note an advanced reservation must be made with reception, seats are based on availability.

7.00, 8.30, 11.30

€7 per person, each way.

Upon arrival at the airport, exit the arrivals terminal, turn right and follow the “Polo Bus” signs. Look for bus stop number 29.

Taxis

For those who do not wish to make a reservation in advance there are taxi ranks outside both airports and also just outside the front of the hotel.

If arriving at Fiumicno Airport the taxi ranks can be found at Terminal 1 and Terminal 3 Arrival areas.

If arriving at Ciampino Airport the taxi rank is at the arrivals terminal.

Please check that the vehicle and driver are licensed and be vigilant at all times; if you are unsure about the driver or if the vehicle is unmarked wait until another taxi becomes available or telephone RydeItaly to see if they can immediately send a car.

CAUTION: Authorized Taxi vehicles are white with a “TAXI” sign on the roof. The symbol of the Municipality of reference is fixed to the front doors and the license number is located on the doors, on the back and inside the vehicle. Any other vehicle could be driven by persons not in possession of a valid taxi permit.

Supported By

Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Local Activities

To add convenience to your during your stay in Rome, Sheraton Roma offers a bus to and from the city center operating daily. The city center route includes stops at Magliana Underground Station and the nearby EUR district/shopping area. The final stop is in Via del Teatro Marcello, near Piazza Venezia, in the very heart of the city

  • One way 6€
  • Round Trip 10€

From hotel to the city center

9.30, 11.00, 12.30, 14.00, 15.30, 17.00, 18.30, 20.00, 21.30, 23.00

From center to the hotel

10.15, 11.45, 13.15, 14.45, 16.15, 17.45, 19.15, 20.45, 22.15, 23.30

Admire ancient ruins at the Roman Forum

Entering the huge archeological site of the Roman Forum and strolling through the ruins, you can almost imagine the citizens of Ancient Rome walking the cobblestoned streets in togas and bringing sacrifices to the temples. Of course, it helps to have a guide who can bring the stories to life, or you might mistake Augustus’s house for Livia’s, as there are no signs within the complex indicating what’s what.

Visit the colosseum

The most internationally recognized symbol of Rome, the Colosseum has a long and bloody history. It was inaugurated in 80 A.D. with 100 days of games, including gladiatorial combats and animal fights. It was the largest amphitheater in the Roman Empire and is believed to have packed up to 50,000 people inside. Despite centuries of neglect—it was used as a quarry until the eighteenth century—it has remained intact (for the most part).

Gaze at the architectural marvel that is the Pantheon

Though the name refers to a temple for all the gods, the Pantheon is actually the burial place of Rome’s kings and other prominent figures, including Raphael. The temple was built between 118 and 128 A.D. on the site of an older temple. A feat of architectural ingenuity, it was the world’s largest dome until the modern era, has been called the world’s only architecturally perfect building, and is the best-preserved monument of Imperial Rome. Walk inside and look up—the oculus in the dome is open to the sky, letting sunlight filter in.

Transport yourself to Baroque Rome at Piazza Navona

One of the most popular public spaces in Rome, the magnificent, oval-shaped Piazza Navona is lined with restaurants, gelaterias, souvenir shops, and the Museo di Roma inside the Renaissance Palazzo Braschi. The city’s Baroque art is on full display here. Bernini’s Fontana dei Quattro Fiumi features exquisitely carved figures representing the world’s four great rivers, and legend has it that the figure with his arms extended is recoiling in horror from the church of Sant’Agnese in Agone by Borromini, Bernini’s rival.

Pay your respects to the Vatican and its Museums

You could easily spend a whole day exploring the area around the Vatican. Start at the Piazza di San Pietro, which Bernini designed to look like arms extended in an embrace. Besides St. Peter’s Basilica, the absolute must-see is the Vatican Museums, which contain Michelangelo’s Sistine Chapel. Other highlights in the 1,400-room palace include the Raphael Rooms, old master paintings, and antique sculptures.

Visit St. Peter’s Basilica

St. Peter’s Basilica may be a pilgrimage site for Catholics, but even non-believers can appreciate the church’s architectural majesty. The original dates back to 349 A.D., when Constantine had a basilica built over the tomb of St. Peter, the first pope. That church was razed to make way for the current one, the world’s largest church at 18,000 square yards, which has been standing on this spot since 1626. Inside you’ll find Bernini’s masterful altarpiece—the great bronze baldacchino—and Michelangelo’s Pietà.

Climb the Spanish Steps

Fascinating in its contradictions, the Piazza di Spagna is both democratic and home to the city’s fanciest boutiques on Via dei Condotti, Rome’s legendary shopping street. Climb the famous steps leading to the Trinità dei Monti church to admire the piazza and Bernini’s ship-shaped fountain from above. If you’re feeling ambitious, climb to the Villa Medici for stunning views of the Centro Storico. Off to the side of the steps, you’ll find the Keats-Shelley Memorial House, one of Rome’s excellent under-the-radar museums.

Explore Trastevere

Trastevere means “across the Tiber,” and once you cross the river, you’ll notice the difference. The vibe is hip and bohemian, and you’ll find plenty of boutiques selling jewelry, perfumes, and handicrafts in a neighborhood where you can stroll aimlessly through the cobblestoned streets flanked by ochre buildings and stumble upon amazing discoveries.

Throw a coin in the Trevi Fountain

Any trip to Rome would be incomplete without a visit to the Trevi Fountain. Nicola Salvi’s awe-inspiring Baroque masterpiece features a marble statue of Neptune at the center, surrounded by tritons. Legend has it that anyone who throws a coin in the fountain will return to Rome.

Admire masterpieces in Galleria Borghese and stroll through Villa Borghese

Nowhere in Rome—or dare we say, the world—will you find such a magnificent collection of Baroque art. The villa itself is a masterpiece, commissioned by seventeenth-century Cardinal Scipione Borghese to house his treasures, including Antonio Canova’s sculpture of Napoleon Bonaparte’s sister as Venus Victrix, Bernini’s Apollo and Daphne, and Caravaggio’s self-portrait as Bacchus. Tickets must be reserved in advance for slotted times.

 

 

Supported By

Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Group Activities

We have arranged two exciting group activities for the 2017 DRSDD participants. Please find the details, timings and approximate prices for the activities below. One of the activities falls during conference free time and the other is scheduled the day before the meeting commences. This is a great opportunity to socialise with fellow colleagues outside of the conference whilst taking in the beautiful sights of Rome.

Ancient Rome Tour – Tuesday 04th July 2017

The story of an ancient civilisation, its power, mentality, ambitions, passions, organisation and mistakes expressed through an entertainment building, the palaces of the rulers and the centre of a city! We will start this voyage back in time directly from the sand, blood, dirt and the luxury of the imperial arena and we will continue in the monumental Roman Forum, the financial, economical, religious centre of the roman civilisation that create "the modern us". 

This activity will include a VIP tour of the Colosseum (1hour inside) followed by a tour of the Roman Forum (1hour). A tour guide is included and headsets will be provided should the group reach 10 or more participants. 

Itinerary:

  • Restricted area Colosseum Arena
  • Colosseum ground floor and first ring
  • Constantine’s Arch
  • Roman Forum
  • Palatine Hill 

Price: approx. €70 per person *
Tour duration: 3 hours including travel time
Level of difficulty: easy
Starting time: 13:40 (subject to change)
Meeting Point: Sheraton Roma Hotel Foyer 

*Please note the price may vary slightly depending on final numbers, we will confirm the final price 1-2 days prior to registration. 

Important information: 

As walking is involved in this tour we suggest you wear comfortable shoes, something to cover and protect your head during a hot day, to wear sun cream or to cover your body in order to protect yourself from the sun and to carry plastic bottle with water in order to stay hydrated!

There will be metal detector control for the Colosseum and Roman Forum.

Liquids are allowed but only if in plastic bottles. You can refill your containers at the fountains inside the Colosseum or Roman Forum. 

Back bags are allowed inside the Colosseum if they are very small in size. Shoulder bags or handbags are permitted if regular size. No big bags, Back packs or trolleys are accepted inside, and in the archeological area of the Colosseum there is no place to store your luggage in case they are not accepted by the security control!

*Minimum of 10 people required*

Please note that sign-ups are required by Friday 16th June 2017, please contact laura@fusion-conferences.com if you’d like to participate. Payment for the trip will need to be made to Fusion by cash (Euro’s only) during the first day of the conference at the registration desk.

Payment is non-refundable should you later change your mind and decide not to participate in the trip. 

Splendors of Baroque Tour – Sunday 02nd July 2017

A pleasant walking tour in the centre of Rome shaped by the Popes Baroque ideology and style expressed through architecture, sculpture and paintings. 

A tour guide is included and headsets will be provided should the group reach 10 or more participants. 

Itinerary:

Spanish Steps & Barcaccia Fountain, Trevi Fountain, Galleria Alberto Sordi & Colonna Square, Di Pietra Square, Saint Ignazio Church and Square, Pantheon & Della Rotonda Square, Navona Square & St. Agnese Church, Campo dei Fiori Square (the place where Julius Caesar was assassinated) and Farnese Square and a gelato/coffee stop. 

Price: approx. €65 per person *
Tour duration: 3.5 - 4 hours including travel
Level of difficulty: easy
Starting time: 17:00 (subject to change)
Meeting Point: Sheraton Roma Hotel Foyer 

*Please note the price may vary slightly depending on final numbers, we will confirm the final price 1-2 days prior to registration. 

Important information: 

As walking is involved in this tour we suggest you wear comfortable shoes, something to cover and protect your head during a hot day, to wear sun cream or to cover your body in order to protect yourself from the sun and to carry plastic bottle with water in order to stay hydrated! You can refill your containers at the fountains along the way.

*Minimum of 10 people required*

Please note that sign-ups are required by Friday 16th June 2017, please contact laura@fusion-conferences.com if you’d like to participate. Payment for the trip will need to be made to Fusion by cash (Euro’s only) during the first day of the conference at the registration desk.

Payment is non-refundable should you later change your mind and decide not to participate in the trip.

Supported By

Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Childcare

Supported By

Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Oral Presenters

We have a number of oral opportunities available at this meeting. To be considered for a talk, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Please take note of the oral submission deadline: 06 February 2017.

Please check the conference programme carefully to note your presentation time (inclusive of Q&A) should you be accepted for an oral presentation. We recommend you check our website regularly as the conference approaches. Regular programme updates will be released under the ‘Programme’ tab on the conference page.

Your Presentation on the Day

If you have prepared some slides to accompanying your talk please ensure you bring these with you on a USB or portable file saving device.

For those presenting on the first day, please email your slides to us so we can have everything prepared and ready for the first session. Please email your slides to: admin@fusion-conferences.com

On the day of your presentation please make yourself known to the AV team who will be available in the conference room. If you have any animations or videos we do advise to run through the presentation with the AV tech to make sure everything is compatible. We also advise that all speakers make themselves known to the AV tech in the conference room immediately before your session beings. The AV tech will apply your microphone and provide a laser pointer should you have an accompanying presentation. We prefer speakers to use our master laptop to run presentations from, however, if you prefer to use your own laptop, please notify us in advance.

It is important that all speakers adhere to their presentation time and respect their fellow presenters. A visual traffic light aide will be available to warn presenters and the audience as your time decreases.

If you have any questions, please don’t hesitate to approach our AV tech or a member of the Fusion team.

Helpful Tips for Presentation Slides

Aspect Ratio: On Screen Show (16:9) and in Landscape Orientation; in any other format (i.e 4:3) your presentation will not fill our screens.
Font Size: Minimum font size used should be 24pt. 
File Type: Please safe your presentation in PPT or PPTS format. 
Video Clips: Please save these separately and do not build them into the PowerPoint. Videos will be played via the AV control desk using the master laptop.

Download Abstract Template

Supported By

Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Posters

We have a number of poster opportunities available at this meeting. To be considered for a poster presentation, please register for the conference and you will be able to submit your abstract online and monitor the status of your abstract through your Fusion account. Please use the abstract template provided and ensure your abstract is no longer than one page in length. Any abstracts exceeding this size may be cut short during print.

Please take note of the poster submission deadline: 26 May 2017.

Our poster boards can accommodate a maximum poster size of A0 (1189H x 841W mm), portrait in orientation. Posters exceeding this size may not fit on the poster boards provided and therefore we may be unable to display your poster, so please kindly keep to these measurements.

Displaying & Presenting Your Poster

During conference registration if you are presenting a poster please request a poster number from the registration desk. Please do not put up your poster without notifying a member of the Fusion team. Certain adhesive agents are not permitted at some venues therefore; Fusion will be the sole provider of all poster fixings.

You can display your poster from registration. Your poster can remain on display for the entire duration of the conference and we ask that posters are taken down on the final day of the meeting. The poster session is usually scheduled on Day 3, but please check the official programme for exact timings. Refreshments will be provided and the poster prizes will be awarded during the conference Gala Night that evening. 

2017 DNA Poster Prize

The conference chairs will be awarding 3 poster prizes for the best poster display and presentation. To be in with a chance of winning, submit your poster by 26 May 2017. The winners will be selected shortly after the Poster Session and the following prizes will be awarded: 1st Place €300, 2nd Place €200, 3rd Place €100.

Download Abstract Template

Supported By

Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Conference History

30 Sep 2014, 03 Oct 2014

DNA Replication as a Source of DNA Damage

From Molecules to Human Health

Mazagan Beach Resort, El Jadida, Morocco

The maintenance of genome integrity is critical for the suppression of cancer and premature ageing. Only recently has it become appreciated that DNA replication stress is a crucial driver of genomic instability. The timely progression of replisome...

More Information

03 Jul 2017, 06 Jul 2017

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health

Sheraton Roma Hotel & Conference Center, Rome, Italy

The maintenance of genome integrity is critical for the suppression of cancer and premature ageing. Only recently has it become appreciated that DNA replication stress is a crucial driver of genomic instability. The timely progression of replisome...

More Information

14 Oct 2023, 17 Oct 2023

3rd Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD23

Sun Gardens Dubrovnik, Dubrovnik, Croatia

All spaces for this conference have been filled and so we have had to close registration before the deadline. If you would like to be added to our wait list, please contact

More Information

07 Oct 2025, 10 Oct 2025

4th Chromosomal Instability as a Driver of Human Disease Conference

#CIDHD25

Hilton Malta, St. Julians, Malta

The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility premature ageing, and neurodegeneration. Destabilization of the genome can occur as a result of several ...

More Information

Supported By

Bronze
Media Partners
If you're interested in sponsoring this conference please contact us.

2nd DNA Replication as a Source of DNA Damage Conference

From Molecules to Human Health


03 Jul 2017 - 06 Jul 2017

Rome, Italy

Chairs

Ian Hickson
University of Copenhagen
Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre

Cant see images? See gallery on Flickr