Past Conference

3rd Ubiquitin Function in Health & Disease Conference

#Ubiq24

Date

07 Jul - 10 Jul 2024

Location

Lisbon, Portugal

  • Henning Walczak

    University of Cologne / University College London

  • Florian Bassermann

    Technical University of Munich

  • Vishva Dixit

    Genentech

Early Bird - Expired  •  Talk Submission - Expired  •  Poster Submission - Expired  •  Registration & Payment Deadline - Expired

Synopsis

We have reached a fascinating point in our research on the ubiquitin system’s function, physiology and roles in disease. The attachment of ubiquitin to a protein in the cytosol was first identified as a means to enable degradation of proteins in the cytosol by the proteasome. It was much later that it was discovered that the ubiquitin system fulfils another crucial cellular function: through the dynamics offered by ubiquitination and subsequent deubiquitination it gives a multitude of signalling pathways the required plasticity to initiate but also to limit their signalling output in an exquisitely controlled manner. Whereas certain signalling-related functions employ ubiquitin’s proteasome-targeting function, e.g. the activation of NF-kB following degradation of I-kB, most signalling-related functions of the ubiquitin system are mediated by different types of ubiquitin chains acting as scaffolds for the recruitment of signalling modules to protein complexes which serve as platforms for the triggering of specific signalling complexes.

Rather than discussing mainly structural aspects of the ubiquitin system, this conference is dedicated to the study of functional roles of the ubiquitin system, how it works to ensure normal signal transduction, what are the pathological consequences when it is perturbed and how can we harness our knowledge of the ubiquitin system therapeutically for more efficacious treatment of diseases with high unmet clinical need, including cancer, chronic inflammatory and autoimmune disorders as well as neurodegenerative diseases.

Importantly, this conference aims to become the go-to forum at which the most current and up-to-date therapeutic avenues that emerge from the study of the ubiquitin system will be presented and discussed.

A message from our Chairs... 'The field of ubiquitin biology and applications to clinical medicine is one of the most exciting topics in Biomedicine. With the realization that widely prescribed powerful immunomodulatory drugs (IMIDs) including thalidomide and its analogues lenalidomide and pomalidomide work by engaging ubiquitin mediated degradation of critical targets, the field has exploded. A PROTAC strategy (Proteolysis targeting chimera) is now underway at all major Biopharma enterprises to extend the lessons from the IMID field to specifically target unwanted proteins. The impact of the field is far reaching. Indeed, the Nobel Prize was recently given to researchers who worked out how hypoxia engages the ubiquitin system to regulate oxygen availability. The future for the field has never been brighter. Clear your calendars and come join what should be a most exciting conference in Portugal. It will focus on the myriad ways ubiquitin controls the signaling circuitry of life. If the regulation exerted by ubiquitin goes awry the consequences are devastating: it promulgates the pathology associated with inflammatory disease states, cancer and neurodegeneration.'

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying 'single' or 'shared' registrants can bring a student for only €926. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 07, 08, 09 July 2024 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Chloe to obtain a special registration code for your student.

Confirmed Speakers

Eric Baehrecke (UMass Chan Medical School)
UBIQUITIN FUNCTION IN THE BALANCE BETWEEN MITOCHONDRIA AND ER CLEARANCE BY AUTOPHAGY
Petra Beli (Institute of Molecular Biology)
DECIPHERING THE FUNCTIONS OF K6-LINKED UBIQUITYLATION IN CELLULAR STRESS RESPONSES
Anja Bremm (Goethe University Frankfurt)
UBIQUITIN-DEPENDENT REGULATION OF PEROXISOME FUNCTION AND TURNOVER
Luca Busino (University of Pennsylvania)
DECIPHERING DCAF15-DEPENDENT COHESIN REGULATION UNVEILS AN ONCOGENIC DEPENDENCY IN ACUTE MYELOID LEUKEMIA
Michael Clague (University of Liverpool)
INTEGRATING UBIQUITIN-DEPENDENT MITOPHAGY AND PEXOPHAGY PATHWAYS
Heran Darwin (NYU Langone Health)
REGULATING DEPUPYLATION OF AN ESSENTIAL ENZYME IN MYCOBACTERIUM TUBERCULOSIS
Virginia De Cesare (University of Dundee)
GAINING INSIGHTS INTO NON-CANONICAL UBIQUITINATION THROUGH MALDI-TOF MS
Ivan Dikic (Goethe University Frankfurt)
UBIQUITIN AND AUTOPHAGY NETWORKS IN REGULATION OF ER REMODELLING 
Paul Elliott (University of Oxford)
UBIQUITIN SIGNALLING IN CELL SURVIVAL AND CELL DEATH
Eric Fischer (Harvard University)
STRUCTURE GUIDED DEGRADOMICS FOR THE DISCOVERY OF MOLECULAR GLUE DEGRADERS
Malte Gersch (Max Planck Institute)
STRUCTURAL BASIS FOR SPECIFIC DEUBIQUITINASE INHIBITION
Alexander Gitlin (Memorial Sloan Kettering Cancer Center)
N4BP1 PROMOTES UBIQUITIN-DEPENDENT CROSSTALK WITHIN THE IkB KINASE FAMILY TO LIMIT TOLL-LIKE RECEPTOR SIGNALING AND INFLAMMATION
Ron Jachimowicz (Max Planck Institute for Biology of Ageing)
UBIQUILINS EXPOSE AN ACTIONABLE TARGET IN CANCER THERAPY
Stefan Knapp (Goethe University Frankfurt)
DEVELOPMENT OF NEW E3 LIGANDS AS CHEMICAL TOOLS AND FOR THE DESIGN OF THE NEXT GENERATION OF PROTACS
Joanna Koszela (University of Glasgow)
TARGETING PARKIN SUBSTRATES
Alena Kroupova (University of Dundee)
DESIGN OF A CEREBLON CONSTRUCT FOR CRYSTALLOGRAPHIC AND BIOPHYSICAL STUDIES OF PROTEIN DEGRADERS
Yogesh Kulathu (University of Dundee)
REGULATION OF ER HOMEOSTASIS BY UFMylation
Gianmaria Liccardi (University of Cologne)
THE ROLE OF LINEAR UBIQUITINATION IN TISSUE HOMEOSTASIS
Pascal Meier (Institute of Cancer Research)
TARGETING CELL DEATH MECHANISMS WITH PROTAC DEGRADERS
Kim Newton (Genentech)
BACTERIAL VIRULENCE FACTORS THAT HIJACK THE HOST UBIQUITIN-PROTEASOME SYSTEM
Nieves Peltzer (CECAD Cologne)
LINEAR UBIQUITINATION MAINTAINS ADIPOSE TISSUE INTEGRITY AND PREVENTS METABOLIC SYNDROME
Simona Polo (IFOM)
HARNESSING SMALL MOLECULES FOR PRECISE NEDD4 MODULATION
Jonathan Pruneda (Oregon Health & Science University)
DYSFUNCTIONAl UFMylation IN PEDIATRIC UBA5-ASSOCIATED ENCEPHALOPATHY
Michael Rapé (University of California, Berkeley)
STRESS RESPONSE SILENCING IN NEURODEGENERATIVE DISEASE
Geert van Loo (VIB Ghent)
OTULIN IN INFLAMMATION, CELL DEATH AND DISEASE
Domagoj Vucic (Genentech)
UBIQUITINATION OF RIP KINASES REGULATES INFLAMMATORY SIGNALING
Achim Werner (NIH)
DISSECTING UBIQUITIN-DEPENDENT CELL-FATE DECISIONS THROUGH HUMAN DISEASE MUTATIONS

Target Audience

This conference will appeal to researchers who are particularly interested in the diverse functions of the ubiquitin system, rather than structural aspects of it, as well the way this system is involved in normal physiology in a whole range of pathologies that have been shown to be associated with abnormal ubiquitin signalling. Naturally this target profile will bring together researchers from both academia and the biotech/pharma industries who want to be on top of the most recent developments in this fascinating and fast developing field.

Learning Objectives

  • To be on top of the field with regards to the diverse functions of the ubiquitin system
  • To comprehend how the ubiquitin system affects health and disease
  • To understand the therapeutic opportunities provided through our increased knowledge of ubiquitin’s functions 
  • To learn which ubiquitin-related drug candidates are presently in preclinical and clinical development and in which clinical entities they are tested
  • To develop a sense for fruitful future research directions and therapeutic opportunities offered by the study of ubiquitin function

Confirmed Speakers

Chairs
Henning Walczak

Henning Walczak

University of Cologne / University College London

Florian Bassermann

Florian Bassermann

Technical University of Munich

Vishva Dixit

Vishva Dixit

Genentech

Invited Speakers
Eric Baehrecke

Eric Baehrecke

UMass Chan

Petra Beli

Petra Beli

Institute of Molecular Biology

Anja Bremm

Anja Bremm

Goethe University Frankfurt

Luca Busino

Luca Busino

University of Pennsylvania

Michael Clague

Michael Clague

University of Liverpool

Heran Darwin

Heran Darwin

NYU Langone Health

Virginia De Cesare

Virginia De Cesare

University of Dundee

Ivan Dikic

Ivan Dikic

Goethe University Frankfurt

Paul Elliott

Paul Elliott

University of Oxford

Eric Fischer

Eric Fischer

Harvard University

Malte Gersch

Malte Gersch

Max Planck Institute

Alexander Gitlin

Alexander Gitlin

Memorial Sloan Kettering Cancer Center

Ron Jachimowicz

Ron Jachimowicz

Max Planck Institute for Biology of Ageing

Stefan Knapp

Stefan Knapp

Goethe University Frankfurt

Joanna Koszela

Joanna Koszela

University of Glasgow

Alena Kroupova

Alena Kroupova

University of Dundee

Yogesh Kulathu

Yogesh Kulathu

University of Dundee

Gianmaria Liccardi

Gianmaria Liccardi

University of Cologne

Pascal Meier

Pascal Meier

Institute of Cancer Research

Kim Newton

Kim Newton

Genentech

Nieves Peltzer

Nieves Peltzer

CECAD Cologne

Simona Polo

Simona Polo

IFOM

Jonathan Pruneda

Jonathan Pruneda

Oregon Health & Science University

Michael Rapé

Michael Rapé

University of California, Berkeley

Geert van Loo

Geert van Loo

VIB-UGhent

Domagoj Vucic

Domagoj Vucic

Genentech

Achim Werner

Achim Werner

NIH

Programme

Page /

Grants

Please see below opportunities for financial support for students. If you have any questions, please reach out to the Conference Manager, Chloe Trundle.

Student Offer

Take advantage of this fantastic opportunity for students! Fully paying 'single' or 'shared' registrants can bring a student for only €926. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 07, 08, 09 July 2024 (on a shared basis for students) and a food and beverage package for the conference period. Once registered, please contact Chloe to obtain a special registration code for your student.

Supported by

Bronze Sponsors
Media Partners

Interested in sponsoring this conference?

Contact us

Venue & Location

Dolce CampoReal Lisboa

Located in Torres Vedras, just a 30-minute drive from Lisbon, Dolce CampoReal Lisboa offers unique tranquillity, as a result of its idyllic environment. The hotel offers stunning views over the golf course, vineyards and the extraordinary landscape of Socorro and Archeira Mountains.

The hotel has three restaurants to provide a variety of gastronomic choices, and two bars including one beside the outdoor pool.

Hotel Facilities

  • Complimentary Wi-Fi in guest rooms and throughout hotel and conference areas
  • Indoor heated swimming pool
  • Outdoor swimming pool with Jacuzzi
  • Spa
  • Gym
  • Golf course
  • 2 Tennis courts

General Information

Venue Rating

★ ★ ★ ★ ★

Currency

Euro (EUR)

Address

R. do Campo (Campo Real) 2565-770 Portugal

Nearest Airport

Lisbon Portela Airport

Location

The Dolce CampoReal Lisboa is nestled between the vineyards and the extraordinary landscape of the Socorro and Archeira Mountains.

Lisbon is only a short 30-minute drive away. The Portuguese capital is constantly recognised as one of the greatest cities in the world, a claim confirmed by the “Lonely Planet Guides", who named Lisbon one of the world’s top 10 cities. Lisbon in one of the world’s oldest cities, predating the likes of London, Rome and Paris by hundreds of years. Hillsides covered in tumbledown houses and a mix of baroque and neoclassical buildings, including cathedrals and palaces, make up Lisbon’s skyline. The city is a combination of old and new, with beautiful modern buildings constructed near renovated historical landmarks and ruins.

Gallery

Bronze Sponsors

Media Partners

If you're interested in sponsoring this conference please contact us.

Conference Manager

Chloe Trundle

Need some help? Chat to the Fusion team today

As a family run business, our dedication runs deep. We’re committed to each other and, even more so, to every attendee’s experience, delivering a level of care and passion that’s truly unmatched.

Call us

+44 (0) 1638 555057

Looking for forthcoming conferences?