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- The Ubiquitin System: Function, Physiology & its Role in Disease Conference
The Ubiquitin System: Function, Physiology & its Role in Disease Conference
03 Jun - 06 Jun 2018
Nassau, Bahamas
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Synopsis
We have reached a fascinating point in the field of ubiquitin research. The attachment of ubiquitin to a protein in the cytosol was first identified as a means to enable the degradation of this protein by the proteasome. Much later it became clear that the ubiquitin system fulfils another crucial cellular function: through the dynamics offered by ubiquitination and subsequent deubiquitination it gives signalling platforms in a plethora of signal transduction pathways the means to initiate but, importantly, also to end the triggering of particular signals originating from these platforms. Whilst some of the signalling-related functions of the ubiquitin system are mediated via its proteasome-targeting function, the majority of these are mediated by different types of ubiquitin chains acting as scaffolds for the recruitment of signalling modules to protein complexes which serve as platforms for the triggering of specific signalling complexes.
Rather than discussing mainly structural aspects of the ubiquitin system, this conference is dedicated to the study of functional roles of the ubiquitin system, how it works to ensure normal signal transduction, what are the pathological consequences when it is perturbed and how we may be able to address such perturbances therapeutically in various diseases including cancer, autoimmunity and neurodegeneration.
Importantly, this conference aims to become the go-to forum at which the most current and up-to-date therapeutic avenues in the ubiquitin field will be presented and discussed.
Join the conference LinkedIn group to keep up to date with announcements and latest news concerning the conference.
See the full list of confirmed speakers below.
Target Audience
This conference will appeal to researchers who are particularly interested in the diverse functions of the ubiquitin system, rather than structural aspects of it, as well the way this system is involved in normal physiology in a whole range of pathologies that have been shown to be associated with abnormal ubiquitin signalling. Naturally this target profile will bring together researchers from both academia and the biotech/pharma industries who want to be on top of the most recent developments in this fascinating and fast developing field.
Learning Objectives
- To be on top of the field with the diversity of functional roles of the ubiquitin system
- To understand how the ubiquitin system affects health and disease
- To develop an understanding for where the treatment options are currently seen in the ubiquitin fields
- To learn which ubiquitin-related drugs are presently in preclinical and clinical development
- To get a feel for the opportunities of the future provided by the ubiquitin system
Student Offer
Take advantage of this fantastic opportunity for students! Register an academic at the earlybird rate of $1,823 and bring a student for only $850. Unfortunately, Postdocs are not eligible for this offer. Both registration packages include; accommodation for the 03, 04, 05 June 2018 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 30th April 2018. Once registered, please contact Emily Bicknell (emily@fusion-conferences.com) to obtain a special registration link for your student.
Confirmed Invited Speakers
Henning Walczak (UCL Cancer Institute)
Vishva Dixit (Genentech Inc)
Michael Rape (UC Berkeley)
Ivan Dikic (Institute of Biochemistry II - Goethe University Frankfurt)
Kim Newton (Genentech Inc)
Domagoj Vucic (Genentech Inc)
Eric Bennett (UC San Diego)
Florian Bassermann (Technical University of Munich)
Mads Gyrd-Hansen (Ludwig Institute for Cancer Research)
Helle Ulrich (Institute of Molecular Biology - IMB)
Eric Baehrecke (UMass Medical School)
Pascal Meier (ICR London)
Anne Bertolotti (LMB Cambridge)
Richard Youle (NIH)
Jonathon Pines (ICR London)
Geert van Loo (VIB-UGent Center for Inflammation Research)
John Silke (WEHI)
Zhijian 'James' Chen (UT Southwestern)
Philip Cohen (University of Dundee)
Felix Randow (LMB Cambridge)
Yifat Merbl (Weizmann Institute)
Nieves Peltzer (UCL)
Alessandro Annibaldi (ICR London)
Adrian Ting (Mount Sinai, NYC)
Daniel Krappmann (Helmholtz Munich)
Paul Elliott (MRC Laboratory of Molecular Biology - LMB)
Mathieu Bertrand (VIB Ghent)
Philipp Jost (TU Munich)
Marc Schmidt-Supprian (TU Munich)
Fumiyo Ikeda (Institute of Molecular Biology - IMBA)
Annika Meinander (Åbo Akademi University, Turku)
Sonja Lorenz (University of Würzburg)
Confirmed Speakers
Chairs
Invited Speakers
Michael Rapé
Investigator, HHMI; Professor, UC Berkeley, HHMI/UC Berkeley
Geert van Loo
PI, VIB/Gent University
Mads Gyrd-Hansen
Associate Professor, University of Oxford
Adrian Ting
Associate Professor, Icahn School of Medicine at Mount Sinai
Helle Ulrich
Scientific Director, Institute of Molecular Biology (IMB)
Marc Schmidt-Supprian
Professor, Klinikum rechts der Isar der Technischen Universität München
Mathieu Bertrand
Associate Professor, VIB Center for Inflammation Research / Ghent university
Fumiyo Ikeda
Group leader, Institute of Molecular Biotechnology (IMBA)
Philip Cohen
Professor of Enzymology, University of Dundee
Annika Meinander
Dr, Ã…bo Akademi University
Richard Youle
Senior Investigator , NIH/NINDS
Daniel Krappmann
Director Research Unit, Helmholtz Zentrum Muenchen
Sonja Lorenz
Group Leader, Rudolf Virchow Center, University of Wuerzburg
Eric Baehrecke
Professor, UMass Medical School
Kim Newton
Senior Scientist, Genentech
Paul Elliott
Investigator Scientist, MRC Laboratory of Molecular Biology
Domagoj Vucic
Senior Fellow, Genentech
John Silke
Joint Division Head, The Walter and Eliza Hall Institute
Florian Bassermann
Chairman, Technical University of Munich
Pascal Meier
Professor, Institute of Cancer Research
Eric Bennett
Associate Professor, University of California San Diego
Jonathon Pines
Head, Division of Cancer Biology, The Institute of Cancer Research
Alessandro Annibaldi
Junior Research Group Leader, Center for Molecular Medicine Cologne
Nieves Peltzer
Junior Group Leader, University of Stuttgart
Philipp Jost
Consultant, Technical University of Munich
Ivan Dikic
Director, Institute of Biochemistry II, Goethe University Frankfurt
Yifat Merbl
Assistant Professor, Weizmann Institute of Science
Anne Bertolotti
Group Leader, MRC Laboratory of Molecular Biology, Medical Research Council
Felix Randow
X, MRC Laboratory of Molecular Biology
Zhijian 'James' Chen
Professor, UT Southwestern Medical Center
Anna Sablina
Group Leader, VIB/KU Leuven
Programme
SUNDAY 3RD JUNE 2018 |
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14:00 – 14:40 |
Registration |
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13:30 – 14:30 |
Group Welcome Lunch |
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14:40 – 14:45 |
Opening Comments |
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SESSION 1 |
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14:45 – 15:15 |
Kim Newton |
UBIQUITIN LIGASES CIAP1 & CIAP2 LIMIT CELL DEATH AND INFLAMMATION |
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15:15 – 15:45 |
Mathieu Bertrand |
RIPK1 LIFE/DEATH DECISION DURING TNF SIGNALING |
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15:45 – 16:15 |
Alessandro Annibaldi |
UBIQUITIN-MEDIATED REGULATION OF RIPK1 KINASE ACTIVITY, INDEPENDENT OF IKK AND MK2 |
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16:15 – 16:45 |
John Silke |
UBIQUITIN MODIFICATION OF THE NECROPTOTIC EFFECTOR MLKL |
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16:45 – 17:15 |
Refreshments |
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17:15 – 17:45 |
Sonja Lorenz |
EMBO YIP LECTURE - MECHANISTIC IDIOSYNCRASIES IN HECT-TYPE UBIQUITIN LIGASES |
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17:45 – 18:15 |
Domagoj Vucic |
UBIQUITINATION OF RIP KINASES REGULATES INFLAMMATORY SIGNALING |
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18:15 – 18:45 |
Nieves Peltzer |
LUBAC AND CELL DEATH: A SURPRISE IN THREE ACTS |
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18:45 – 19:15 |
Henning Walczak |
LUBAC IN THE SKIN: UNDERSTANDING CELL DEATH-DRIVEN LETHAL INFLAMMATION BEYOND TNF |
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19:15 |
Group Dinner Post Dinner Meeting Point: Estavida (lobby bar) |
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MONDAY 4TH JUNE 2018 |
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07:00 – 08:30 |
Breakfast |
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SESSION 2 |
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08:30 – 09:00 |
Vishva Dixit |
OTULIN LIMITS CELL DEATH AND INFLAMMATION BY DEUBIQUITINATING LUBAC |
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09:00 – 09:30 |
Geert van Loo |
A20 AND OTULIN IN TISSUE HOMEOSTASIS AND PATHOLOGY |
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09:30 – 10:00 |
Marc Schmidt-Supprian |
A20 GENE DOSE EFFECTS IN B CELL-MEDIATED AUTOIMMUNITY IN MICE |
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10:00 – 10:30 |
Group Photo & Refreshments |
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10:30 – 11:00 |
Adrian Ting |
FAILURE TO SUPPRESS CYLD-MEDIATED CELL DEATH CAUSES IMMUNE DYSREGULATION |
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11:00 – 11:30 |
Daniel Krappmann |
DISCOVERING NEW CELLULAR FUNCTIONS OF OTULIN USING HIGHLY-SELECTIVE ACTIVITY-BASED PROBES |
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11:30 – 12:00 |
Paul Elliott |
MECHANISTIC INSIGHTS INTO DEUBIQUITINASE REGULATION |
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12:00 – 16:00 |
Lunch & Free Time |
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12:30 – 15:00 |
Snorkel Trip (Sign ups required in advance) |
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SESSION 3 |
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16:00 – 16:30 |
Sir Philip Cohen |
ROLE OF HYBRID UBIQUITIN CHAINS AND TRAF6 IN REGULATING IMMUNE SIGNALING |
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16:30 – 17:00 |
Mads Gyrd-Hansen |
REGULATION OF UBIQUITINATION IN INNATE IMMUNE SIGNALLING |
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17:00 – 17:30 |
Felix Randow |
UBIQUITIN, A SHARED WEAPON IN THE BATTLE BETWEEN BACTERIA AND THEIR HOST CELLS |
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17:30 – 18:00 |
Refreshments |
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18:00 – 18:30 |
Zhijian 'James' Chen |
MECHANISM AND FUNCTION OF DNA-INDUCED AUTOPHAGY |
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18:30 – 19:00 |
Fumiyo Ikeda |
THE IAP PROTEIN FAMILY MEMBERS IN AUTOPHAGY |
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19:00 – 19:30 |
Annika Meinander |
M1-LINKED UBIQUITINATION BY LUBEL DRIVES INFLAMMATORY RESPONSES IN DROSOPHILA |
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19:30 – 21:00 |
Poster Session |
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21:00 |
Group Dinner Post Dinner Meeting Point: Estavida (lobby bar) |
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TUESDAY 5TH JUNE 2018 |
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07:00 – 08:30 |
Breakfast |
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SESSION 4 |
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08:30 – 09:00 |
Anne Bertolotti |
COST-BENEFIT ANALYSIS OF A STRESS-RESPONSE |
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09:00 – 09:30 |
Eric Baehrecke |
A NOVEL FUNCTION FOR UBIQUITIN THAT LINKS MITOCHONDRIAL DYNAMICS AND AUTOPHAGY |
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09:30 – 10:00 |
Yifat Merbl |
FINE-TUNING REGULATION OF GOLGI HOMEOSTASIS IS MEDIATED BY GOLGI-LOCALIZED PROTEASOMAL DEGRADATION |
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10:00 – 10:30 |
Refreshments |
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10:30 – 11:00 |
Eric Fischer DFCI / Harvard |
INDUCED DEGRADATION OF DEVELOPMENTAL TRANSCRIPTION FACTORS UNDERLIES THALIDOMIDE TERATOGENICITY |
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11:00 – 11:30 |
Ivan Dikic |
UNCONVENTIONAL SERINE UBIQUITINATION |
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11:30 – 16:15 |
Lunch & Free Time |
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SESSION 5 |
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16:15 – 16:45 |
Anna Sablina |
THE ROLE OF THE UBIQUITIN SYSTEM IN RAS-DRIVEN DISEASE |
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16:45 – 17:15 |
Najoua Lalaoui |
ROLE OF RIPK1 CASPASE-8 MEDIATED CLEAVAGE |
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17:15 – 17:45 |
Hamid Kashkar |
CHIP MEDIATES K63-LINKED UBIQUITINATION AND LYSOSOMAL DEGRADATION OF NOXA |
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17:45 – 18:15 |
Refreshments |
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18:15 – 18:45 |
Helle Ulrich |
TAILOR-MADE UBIQUITIN LIGASES FOR THE STUDY OF POLYUBIQUITIN CHAIN LINKAGE IN DNA DAMAGE BYPASS |
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18:45 – 19:15 |
Philipp Jost |
FUNCTIONAL IMPACT OF ABERRANT UBIQUITINATION OF RIPK1 IN HEALTHY AND MALIGNANT HEMATOPOESIS |
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19:15 – 19:45 |
Florian Bassermann |
ABERRANT UBIQUITIN-PROTEASOME DEPENDENT NETWORKS IN B-CELL MALIGNANCIES |
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20:15 |
*Gala Dinner & Poster Awards* |
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WEDNESDAY 6TH JUNE 2018 |
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07:00 – 08:30 |
Breakfast |
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SESSION 6 |
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08:30 – 09:00 |
Richard Youle |
SYNTHETIC PHENOTYPES IN MICE LACKING PINK1 AND PARKIN-MEDIATED MITOPHAGY |
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09:00 – 09:30 |
Michael Rape |
UBIQUITIN-DEPENDENT CONTROL OF NEURONAL DEVELOPMENT AND SURVIVAL |
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09:30 – 10:00 |
Eric Bennett |
PROTEIN HOMEOSTASIS CONTROL THROUGH PERVASIVE REGULATORY RIBOSOMAL UBIQUITYLATION |
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10:00 – 10:30 |
Refreshments |
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10:30 – 11:00 |
Pascal Meier |
SUMO-MEDIATED REGULATION OF THE NLRP3 INFLAMMASOME |
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11:00 – 11:30 |
Jonathon Pines |
THE SPINDLE ASSEMBLY CHECKPOINT: WITH GREAT POWER COMES GREAT RESPONSIVENESS |
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11:30 – 11:45 |
Closing Comments |
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Supported by
Venue & Location
Melia Nassau Beach All Inclusive
Overlooking one of the finest beaches in the world the Meliá Nassau Beach is surrounded by crystal blue waters and white sandy beaches. Located on the stunning Cable Beach, you are just a few minutes walk from the center, shops and restaurants. The beautiful Nassau Botanical Gardens are within easy reach (7km) and Lynden Pindling International Airport is situated only 9km away.
Throughout your stay delegates will enjoy a full meal plan, inclusive of beverages. Take your pick from Cilantro where you can experience the natural textures, aromas and flavors of Mexico, Nikkei, celebrated for its exquisite fusion of Japanese, Cantonese and Peruvian cuisine featuring a sushi bar and Teppanyaki tables, Estavida, an upbeat tapas lounge located in the hotel lobby serving innovative tapas and a wide selection of cocktails, Aqua, an A la carte restaurant specializing in exquisite, rustic Italian cuisine, The Market Place, where you will find an International buffet serving an array of exquisite dishes, O'Grille, an open air restaurant with fabulous views of the sea and pool serving casual beach fare and light bites and finally The Black Angus, a steakhouse featuring hip, contemporary jazz and modern decor, offering guests the finest quality prime cuts and the freshest ingredients.(This restaurant is not included in the all inclusive package, additional charges apply). The Gala Night takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and amazing local entertainment. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
Hotel Facilities
- 24 hour reception
- Room service
- 3 heated outdoor pools
- Complimentary resort wide Wi-Fi (guest rooms, throughout hotel, beach and conference areas)
- 24-hour Fitness Center
- 7 dining venues
- 4 bars.
- non-motorised water sports
The Bahamas is formed by over 700 islands, keys and islets located in the Atlantic Ocean and renowned for its warm sunshine, mild climate, fine, white sandy beaches, turquoise, crystal clear water and friendly people, making this the perfect environment to relax and unwind in your free time during the conference.
General Information
Venue Rating
★ ★ ★ ★
Currency
US Dollar (USD)
Address
Nassau W Bay St. Nassau Bahamas
Nearest Airport
Lynden Pindling International Airport
Location
The Melia Nassau Beach All-Inclusive is located right on the stunning Cable Beach just a few minutes away from the airport and city center; Nearby in Downtown Nassau you can experience the flavours of new foods at local restaurants, shop 'til you drop at Straw market or take a trip through time at the Pirates Museum. The beautiful Nassau Botanical Gardens are close by and water enthusiasts can enjoy non-motorized water sports right on property.
Nassau is the capital of the Bahamas. It lies on the island of New Providence, with neighboring Paradise Island accessible via Nassau Harbor bridges. The city has a hilly landscape and is known for it's fabulous beaches as well as its offshore coral reefs, popular for diving and snorkeling. It retains many of its typical pastel-colored British colonial buildings, like the pink-hued Government House.
If you are interested in this meeting but not yet ready to register, you can sign up for updates here and our team will keep you updated regarding deadline reminders and grant opportunities relating to this meeting only.
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Conference Manager
Emily Meen
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