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- DNA Replication as a Source of DNA Damage
DNA Replication as a Source of DNA Damage
From Molecules to Human Health
30 Sep - 03 Oct 2014
El Jadida, Morocco
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Ian Hickson
University of Copenhagen
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Oscar Fernandez-Capetillo
Spanish National Cancer Research Centre
Early Bird - Expired • Talk Submission - Expired • Poster Submission - Expired • Registration & Payment Deadline - Expired
Synopsis
The maintenance of genome integrity is critical for the suppression of cancer and premature ageing. Only recently has it become appreciated that DNA replication stress is a crucial driver of genomic instability. The timely progression of replisomes can be disrupted by lesions and secondary structures in the template, by bound proteins and by conflicts with the transcription machinery. A prolonged pause of the replisome then exposes single stranded DNA, which, due to its recombinogenic nature, can lead to genome rearrangements, fragile site expression and cell death. Importantly, some cancers present excessive endogenous levels of replication stress, which can be exploited for their clearance. In this conference, we aim to bring together scientists studying DNA replication and repair, with those interested in how DNA damage can influence cancer and ageing.
Key Sessions
- Pathways for repair of damaged replication forks
- Systems for site-specific perturbation of replication
- Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins
- Replication perturbation as a driver of tumorigenesis and ageing
- Exploitation of replication defects in cancer treatment
Confirmed Speakers
Chairs
Ian Hickson
Professor of Molecular Aging, University of Copenhagen
Oscar Fernandez-Capetillo
Genomic Instability Group Leader, Spanish National Cancer Research Centre
Plenary Speakers
Josef Jiricny
Professor and Director, Institute of Molecular Cancer Research
Andre Nussenzweig
Branch Chief, LGI, National Institutes of Health
Steve West
Principal Group Leader, Francis Crick Institute
Antony Carr
Director, Genome Damage and Stability Centre
Karlene Cimprich
Professor, Stanford University
Philippe Pasero
Dr, IGH, CNRS UPR 1142
Thanos Halazonetis
Professor, University of Geneva
Camilla Sjögren
Professor, PI, Karolinska Institutet
Michelle Debatisse
Researcher, UMR8200 CNRS
Jiri Lukas
Managing Director, Novo Nordisk Foundation Center for Protein Research
Simon Boulton
Senior Principle Investigator, London Research Institute
Anja Groth
Associate professor, BRIC, University of Copenhagen
Virginia Zakian
Harry C. Wiess Professor in the Life Sciences, Princeton University
George Garinis
Group leader, Institute of Molecular Biology and Biotechnology-FORTH
Madalena Tarsounas
CR-UK Senior Group Leader, The CR-UK/MRC Oxford Institute for Radiation Oncology, University of Oxford
Evi Soutoglou
Group Leader, Genome Damage and Stability Centre, University of Sussex
Junjie Chen
Professor and Chair, The University of Texas MD Anderson Cancer Center
Massimo Lopes
Assistant Professor, University of Zurich
Invited Speakers
Ana Rojas
Head of the Computational Biology and Bioinformatics Group, Institute of Biomedicine of Seville (IBIS)
Claus Sørensen
Dr., University of Copenhagen
Alessandro Vindigni
Associate Professor, Saint Louis University School of Medicine
Dana Branzei
GROUP LEADER, IFOM ETS
Oliver Mortusewicz
Senior Researcher, Science for Life Laboratory / Karolinska Institutet
Xiaolan Zhao
Professor, Memorial Sloan-Kettering Cancer Center
Sophie Polo
PI, Paris Diderot University
Aidan Doherty
Professor of Biochemistry, University of Sussex
Hocine Mankouri
Research Associate Professor, Nordea Center for Healthy Aging
Raimundo Freire
Researcher, Unidad de Investigacion, Hospital Universitario de Canarias
Noel Lowndes
Professor, National University of Ireland Galway
Juan Méndez
Lab Head, Spanish National Cancer Research Centre (CNIO)
Cynthia McMurray
Senior Scientist, Lawrence Berkeley National Laboratory
Programme
Tuesday 30th September 2014 |
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08:00 – 12:00 |
Registration & Reception |
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11:00 – 11:15 |
Opening Comments |
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Session Chair: Stephen West |
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11:15 – 11:40 |
Virginia Zakian |
PROTEOMICS OF BUDDING YEAST TELOMERASE: THE TELOMERASE ASSOCIATED CDC48-NPL4-UFD1 COMPLEX REGULATES EST1 ABUNDANCE AND TELOMERE LENGTH |
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11:40 – 12:05 |
John Rouse |
DISSECTING THE ROLES AND REGULATION OF NUCLEASES INVOLVED IN ICL REPAIR |
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12:05 – 12:20 |
Andres Lopez-Contreras |
A CONSERVED ROLE FOR NUCLEOTIDE BIOSYNTHESIS ON ATR BIOLOGY IN MAMMALS |
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12:20 – 12:45 |
Michelle Debatisse |
RESPECTIVE ROLES OF REPLICATION AND TRANSCRIPTION IN COMMON FRAGILE SITE INSTABILITY |
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12:45 – 13:10 |
Xiaolan Zhao |
REGULATION OF GENOME DUPLICATION |
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13:10 – 16:30 |
Group Welcome Lunch & Free Time |
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Session Chair: Virginia A. Zakian |
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16:30 – 16:55 |
Junjie Chen |
BALANCE BRCA1 AND 53BP1 AT DSB SITES |
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16:55 – 17:20 |
Aidan Doherty |
PRIMPOL, A EUKARYOTIC PRIMASE-POLYMERASE INVOLVED IN LESION BYPASS DURING DNA REPLICATION |
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17:20 – 17:35 |
Jennifer Cobb |
THE NUA4 COMPLEX FUNCTIONS ON THE TRANSLESION SYNTHESIS (TLS) PATHWAY DURING DNA POST REPLICATION REPAIR |
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17:35 – 18:00 |
Stephen West |
STRUCTURE AND FUNCTION OF THE BRCA2 TUMOUR SUPPRESSOR |
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18:00 – 18:25 |
George Garinis |
NUCLEOTIDE EXCISION REPAIR: LESSONS FROM THE MOUSE |
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18:25 – 19:00 |
Refreshments |
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Session Chair: John Rouse |
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19:00 – 19:25 |
Juan Méndez |
CONTROL OF DNA RE-REPLICATION IN VIVO: MOUSE MODELS FOR CDC6 AND CDT1 DEREGULATED EXPRESSION |
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19:25 – 19:50 |
Ivan Ahel |
STRUCTURE AND CATALYTIC MECHANISM OF ADP-RIBOSYLGLYCOHYDROLASES |
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19:50 – 20:15 |
Hocine Mankouri |
ANALYSIS OF SITE-SPECIFIC REPLICATION PERTURBATION IN YEAST |
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20:15 – 20:30 |
Grant Brown |
SLX4 PROMOTES MEC1 SIGNALING BEHIND DAMAGED DNA REPLICATION FORKS |
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20:30 – 21:30 |
Welcome Buffet Dinner Hosted in Pre-function Area |
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Wednesday 1st October 2014 |
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Session Chair: Simon Boulton |
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09:00 – 09:25 |
Noel Lowndes |
ATR ACTIVATES THE S-M CHECKPOINT DURING UNPERTURBED GROWTH TO ENSURE SUFFICIENT REPLICATION PRIOR TO MITOTIC ONSET |
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09:25 – 09:50 |
Andre Nussenzweig |
DNA-DAMAGE INDUCED DIFFERENTIATION OF LEUKEMIC CELLS AS AN ANTI-CANCER BARRIER |
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09:50 – 10:05 |
Makoto Nakanishi |
NECESSARY AND SUFFICIENT ROLE FOR A MITOSIS SKIP IN SENESCENCE INDUCTION |
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10:05 – 10:30 |
Filippo Rosselli |
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10:30 – 11:00 |
Refreshments |
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Session Chair: Antony Carr |
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11:00 – 11:25 |
Sophie Polo |
CHROMATIN LICENSING FOR TRANSCRIPTION RESTART AFTER DNA DAMAGE |
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11:25 – 11:50 |
Massimo Lopes |
REMODELLING OF REPLICATION INTERMEDIATES IN FACE OF REPLICATION STRESS |
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11:50 – 12:05 |
Vincent Geli |
RPA AND PIF1 HELICASE PREVENT SECONDARY STRUCTURES FORMATION DURING TELOMERE AND HUMAN SUBTELOMERIC MINISATELLITE REPLICATION |
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12:05 – 12:30 |
Alessandro Vindigni |
DNA2 AND WRN COORDINATE REPLICATION RESTART BY PROCESSING REVERSED REPLICATION FORKS |
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12:30 – 16:30 |
Group Lunch & Free Time |
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14:00 – 17:00 |
Group Tour to El Jadida (optional) |
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Session Chair: Josef Jiricny |
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17:00 – 17:25 |
Karlene Cimprich |
MECHANISMS FOR RNA-INDUCED GENOME INSTABILITY |
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17:25 – 17:50 |
Madalena Tarsounas |
HIGHLY SPECIFIC KINASE INHIBITORS ENABLE SELECTIVE TARGETING OF BRCA2- DEFICIENT CELLS |
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17:50 – 18:05 |
Kara Bernstein |
SUMO-TARGETED UBIQUITIN LIGASES SLX5-SLX8/RNF4 REGULATE RECQ-LIKE HELICASE SGS1/BLM LOCALIZATION IN YEAST AND HUMAN CELLS |
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18:05 – 18:30 |
Ana Rojas Mendoza |
COMPARATIVE GENOMICS OF DDR: IMPLICATIONS IN DOWSTREAM ANALYSES |
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18:30 – 18:55 |
Thanos Halazonetis |
BREAK-INDUCED REPLICATION MEDIATES REPAIR OF COLLAPSED DNA REPLICATION FORKS AND TANDEM DUPLICATIONS IN CANCER CELLS |
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18:55 – 20:30 |
Poster Session I & Cocktail Reception |
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20:30 |
Beach BBQ Dinner & Free Time |
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Thursday 2nd October 2014 |
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Session Chair: Ian Hickson |
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09:00 – 09:25 |
Cynthia McMurray |
FXS: REPLICATION DEPENDENT BREAKS AT RNA-DNA HYBRIDS |
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09:25 – 09:50 |
Simon Boulton |
DNA REPLICATION AND TELOMERE FUNCTIONS OF RTEL1 |
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09:50 – 10:05 |
Zuzana Storchova |
ANEUPLOIDY DRIVES GENOMIC INSTABILITY BY GENERATING REPLICATION STRESS |
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10:05 – 10:30 |
Claus Sørensen |
FBH1 HELICASE: PROMOTING DNA DAMAGE CHECKPOINT SIGNALING FROM STALLED REPLICATION FORKS |
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10:30 – 11:00 |
Refreshments |
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Session Chair: Karlene Cimprich |
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11:00 – 11:25 |
Philippe Pasero |
SAMHD1 PROCESSES STALLED FORKS AND PROMOTES REPLICATION RESTART |
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11:25 – 11:50 |
Oscar Fernandez-Capetillo |
TARGETING ONCOGENE-INDUCED REPLICATION STRESS FOR CANCER THERAPY |
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11:50 – 12:05 |
Angelos Constantinou |
EARLY RESPONDERS TO DNA REPLICATION IMPEDIMENTS |
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12:05 – 12:30 |
Jiri Lukas |
POLY(ADP-RIBOSE)-DEPENDENT ASSEMBLY OF LOW-COMPLEXITY PROTEINS FUNCTIONS AS A ‘MOLECULAR SIEVE’ DURING THE EARLIEST STAGES OF DNA DAMAGE RESPONSE |
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12:30 – 16:30 |
Group Lunch & Free Time |
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Session Chair: Oscar Fernandez-Capetillo |
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16:30 – 16:55 |
Antony Carr |
MECHANISMS OF REPLICATION-ASSOCIATED GENOME REARRANGEMENT |
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16:55 – 17:20 |
Anja Groth |
CHROMATIN REPLICATION AND EPIGENOME MAINTENANCE |
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17:20 – 17:35 |
Eric Brown |
GENOME-WIDE IDENTIFICATION OF REPLICATION FORK COLLAPSE SITES THROUGH ATR-DEFICIENCY |
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17:35 – 19:05 |
Poster Session II |
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19:05 – 19:30 |
Meeting of Poster Jury |
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21:00 – 00:00 |
*Gala Night, Group Photo & Poster Awards* |
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Friday 3rd October 2014 |
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Session Chair: Jiri Lukas |
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09:35 – 10:00 |
Dana Branzei |
VISUALIZATION OF RECOMBINATION–MEDIATED DAMAGE-BYPASS BY TEMPLATE SWITCHING |
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10:00 – 10:25 |
Oliver Mortusewicz |
PC4 PROMOTES GENOME STABILITY AND DNA REPAIR THROUGH BINDING OF SSDNA AT DNA DAMAGE SITES |
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10:25 – 10:50 |
Camilla Sjögren |
CONNECTING CHROMOSOME REPLICATION AND SEGREGATION: DNA TOPOLOGY AND SMC COMPLEXES |
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10:50 – 11:15 |
Evi Soutoglou |
NUCLEAR COMPARTMENTALIZATION AND GENOME INTEGRITY: DIFFERENTIAL REGULATION OF DNA REPAIR AND DNA DAMAGE RESPONSE AT NUCLEAR LAMINA AND NUCLEAR PORES |
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11:15 – 11:30 |
Refreshments |
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11:30 – 11:55 |
Ian Hickson |
HOW UNFINISHED BUSINESS FROM S-PHASE IMPACTS ON MITOSIS |
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11:55 – 12:20 |
Josef Jiricny |
A NOVEL INSIGHT INTO THE CONTRIBUTIONS OF PROOFREADING AND MISMATCH REPAIR TO REPLICATION FIDELITY |
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12:20 – 12:45 |
Raimundo Freire |
UBIQUITIN HYDROLASES AS NOVEL REGULATORS OF DNA REPLICATION |
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12:45 |
Closing Remarks (Chairs) |
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13:00 |
Farewell & Goodbye |
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Supported by
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Contact usVenue & Location
Mazagan Beach Resort
Relax in the warm Moroccan sun at the Mazagan Beach Resort, a truly beautiful hotel situated along the coast with stunning panoramic views across the Atlantic Ocean. The resort combines traditional Moroccan culture with a modern twist creating an unforgettable conference experience for all.
The resort covers over 250 hectares offering an amazing array of activities and entertainment for delegates to choose from during their free time at the conference.
Throughout your stay delegates will enjoy a buffet feast for breakfast, lunch and dinner. During each meal delegates are entitled to selected beverages and 1 glass of house wine during dinner. The themed Moroccan Gala Night takes place on the third evening of the conference with a mouth-watering feast of local cuisine, an open bar and live performing band. We welcome all delegates and their accompanying persons to the Gala Night – a truly fun filled night not to be missed!
Hotel Facilities
- Beach
- Resort Swimming Pool
- Fitness Centre
- Wellness Spa
- Complimentary WI-FI in guestrooms and conference areas
General Information
Venue Rating
★ ★ ★ ★ ★
Currency
US Dollar (USD)
Address
Nearest Airport
Mohammed V International Airport (CMN)
Location
Morocco has over 2000miles of unspoilt sandy beaches, more than 300 days of sunshine per year and with its warm, friendly, hospitable people and delicious cuisine Morocco creates a perfect and unique location to hold a conference! Morocco is an ethnically diverse country with a rich culture and history. The region offers something for everyone, whether you like exploring the old winding medinas of its cities and towns, strolling along the stunning beaches, hiking the temperate peaks of the Rif mountain range or tasting some of the countries diversified cuisine.
Not far from the Mazagan Beach Resort is the Portuguese City of Mazagan, now known as El Jadida. It is one of the early settlements of the Portuguese explorers in West Africa on the route to India - it is an outstanding example of the interchange of influences between European and Moroccan cultures, well reflected in architecture, technology, and town planning. Popular sites include; The Municipal Theater of El Jadida, The Portuguese Cistern, The Canons and the Fortress and The Old Port. El Jadida is definitely a city worth visiting during your stay.
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Laura Trundle
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