Programme
SUNDAY 3RD JUNE 2018 |
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14:00 – 14:40 |
Registration |
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13:30 – 14:30 |
Group Welcome Lunch |
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14:40 – 14:45 |
Opening Comments |
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SESSION 1 |
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14:45 – 15:15 |
Kim Newton |
UBIQUITIN LIGASES CIAP1 & CIAP2 LIMIT CELL DEATH AND INFLAMMATION |
15:15 – 15:45 |
Mathieu Bertrand |
RIPK1 LIFE/DEATH DECISION DURING TNF SIGNALING |
15:45 – 16:15 |
Alessandro Annibaldi |
UBIQUITIN-MEDIATED REGULATION OF RIPK1 KINASE ACTIVITY, INDEPENDENT OF IKK AND MK2 |
16:15 – 16:45 |
John Silke |
UBIQUITIN MODIFICATION OF THE NECROPTOTIC EFFECTOR MLKL |
16:45 – 17:15 |
Refreshments |
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17:15 – 17:45 |
Sonja Lorenz |
EMBO YIP LECTURE - MECHANISTIC IDIOSYNCRASIES IN HECT-TYPE UBIQUITIN LIGASES |
17:45 – 18:15 |
Domagoj Vucic |
UBIQUITINATION OF RIP KINASES REGULATES INFLAMMATORY SIGNALING |
18:15 – 18:45 |
Nieves Peltzer |
LUBAC AND CELL DEATH: A SURPRISE IN THREE ACTS |
18:45 – 19:15 |
Henning Walczak |
LUBAC IN THE SKIN: UNDERSTANDING CELL DEATH-DRIVEN LETHAL INFLAMMATION BEYOND TNF |
19:15 |
Group Dinner Post Dinner Meeting Point: Estavida (lobby bar) |
MONDAY 4TH JUNE 2018 |
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07:00 – 08:30 |
Breakfast |
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SESSION 2 |
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08:30 – 09:00 |
Vishva Dixit |
OTULIN LIMITS CELL DEATH AND INFLAMMATION BY DEUBIQUITINATING LUBAC |
09:00 – 09:30 |
Geert van Loo |
A20 AND OTULIN IN TISSUE HOMEOSTASIS AND PATHOLOGY |
09:30 – 10:00 |
Marc Schmidt-Supprian |
A20 GENE DOSE EFFECTS IN B CELL-MEDIATED AUTOIMMUNITY IN MICE |
10:00 – 10:30 |
Group Photo & Refreshments |
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10:30 – 11:00 |
Adrian Ting |
FAILURE TO SUPPRESS CYLD-MEDIATED CELL DEATH CAUSES IMMUNE DYSREGULATION |
11:00 – 11:30 |
Daniel Krappmann |
DISCOVERING NEW CELLULAR FUNCTIONS OF OTULIN USING HIGHLY-SELECTIVE ACTIVITY-BASED PROBES |
11:30 – 12:00 |
Paul Elliott |
MECHANISTIC INSIGHTS INTO DEUBIQUITINASE REGULATION |
12:00 – 16:00 |
Lunch & Free Time |
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12:30 – 15:00 |
Snorkel Trip (Sign ups required in advance) |
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SESSION 3 |
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16:00 – 16:30 |
Sir Philip Cohen |
ROLE OF HYBRID UBIQUITIN CHAINS AND TRAF6 IN REGULATING IMMUNE SIGNALING |
16:30 – 17:00 |
Mads Gyrd-Hansen |
REGULATION OF UBIQUITINATION IN INNATE IMMUNE SIGNALLING |
17:00 – 17:30 |
Felix Randow |
UBIQUITIN, A SHARED WEAPON IN THE BATTLE BETWEEN BACTERIA AND THEIR HOST CELLS |
17:30 – 18:00 |
Refreshments |
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18:00 – 18:30 |
Zhijian James Chen |
MECHANISM AND FUNCTION OF DNA-INDUCED AUTOPHAGY |
18:30 – 19:00 |
Fumiyo Ikeda |
THE IAP PROTEIN FAMILY MEMBERS IN AUTOPHAGY |
19:00 – 19:30 |
Annika Meinander |
M1-LINKED UBIQUITINATION BY LUBEL DRIVES INFLAMMATORY RESPONSES IN DROSOPHILA |
19:30 – 21:00 |
Poster Session |
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21:00 |
Group Dinner Post Dinner Meeting Point: Estavida (lobby bar) |
TUESDAY 5TH JUNE 2018 |
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07:00 – 08:30 |
Breakfast |
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SESSION 4 |
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08:30 – 09:00 |
Anne Bertolotti |
COST-BENEFIT ANALYSIS OF A STRESS-RESPONSE |
09:00 – 09:30 |
Eric Baehrecke |
A NOVEL FUNCTION FOR UBIQUITIN THAT LINKS MITOCHONDRIAL DYNAMICS AND AUTOPHAGY |
09:30 – 10:00 |
Yifat Merbl |
FINE-TUNING REGULATION OF GOLGI HOMEOSTASIS IS MEDIATED BY GOLGI-LOCALIZED PROTEASOMAL DEGRADATION |
10:00 – 10:30 |
Refreshments |
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10:30 – 11:00 |
Eric Fischer DFCI / Harvard |
INDUCED DEGRADATION OF DEVELOPMENTAL TRANSCRIPTION FACTORS UNDERLIES THALIDOMIDE TERATOGENICITY |
11:00 – 11:30 |
Ivan Dikic |
UNCONVENTIONAL SERINE UBIQUITINATION |
11:30 – 16:15 |
Lunch & Free Time |
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SESSION 5 |
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16:15 – 16:45 |
Anna Sablina |
THE ROLE OF THE UBIQUITIN SYSTEM IN RAS-DRIVEN DISEASE |
16:45 – 17:15 |
Najoua Lalaoui |
ROLE OF RIPK1 CASPASE-8 MEDIATED CLEAVAGE |
17:15 – 17:45 |
Hamid Kashkar |
CHIP MEDIATES K63-LINKED UBIQUITINATION AND LYSOSOMAL DEGRADATION OF NOXA |
17:45 – 18:15 |
Refreshments |
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18:15 – 18:45 |
Helle Ulrich |
TAILOR-MADE UBIQUITIN LIGASES FOR THE STUDY OF POLYUBIQUITIN CHAIN LINKAGE IN DNA DAMAGE BYPASS |
18:45 – 19:15 |
Philipp Jost |
FUNCTIONAL IMPACT OF ABERRANT UBIQUITINATION OF RIPK1 IN HEALTHY AND MALIGNANT HEMATOPOESIS |
19:15 – 19:45 |
Florian Bassermann |
ABERRANT UBIQUITIN-PROTEASOME DEPENDENT NETWORKS IN B-CELL MALIGNANCIES |
20:15 |
*Gala Dinner & Poster Awards* |
WEDNESDAY 6TH JUNE 2018 |
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07:00 – 08:30 |
Breakfast |
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SESSION 6 |
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08:30 – 09:00 |
Richard Youle |
SYNTHETIC PHENOTYPES IN MICE LACKING PINK1 AND PARKIN-MEDIATED MITOPHAGY |
09:00 – 09:30 |
Michael Rape |
UBIQUITIN-DEPENDENT CONTROL OF NEURONAL DEVELOPMENT AND SURVIVAL |
09:30 – 10:00 |
Eric Bennett |
PROTEIN HOMEOSTASIS CONTROL THROUGH PERVASIVE REGULATORY RIBOSOMAL UBIQUITYLATION |
10:00 – 10:30 |
Refreshments |
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10:30 – 11:00 |
Pascal Meier |
SUMO-MEDIATED REGULATION OF THE NLRP3 INFLAMMASOME |
11:00 – 11:30 |
Jonathon Pines |
THE SPINDLE ASSEMBLY CHECKPOINT: WITH GREAT POWER COMES GREAT RESPONSIVENESS |
11:30 – 11:45 |
Closing Comments |